{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T08:36:43Z","timestamp":1778056603177,"version":"3.51.4"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2013,9,26]],"date-time":"2013-09-26T00:00:00Z","timestamp":1380153600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1007\/s11033-013-2691-3","type":"journal-article","created":{"date-parts":[[2013,9,25]],"date-time":"2013-09-25T10:24:13Z","timestamp":1380104653000},"page":"5853-5859","source":"Crossref","is-referenced-by-count":48,"title":["Plasma-free amino acid profiling of cervical cancer and cervical intraepithelial neoplasia patients and its application for early detection"],"prefix":"10.1007","volume":"40","author":[{"given":"Ayshamgul","family":"Hasim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aixingzi","family":"Aili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aminigul","family":"Maimaiti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Batur","family":"mamtimin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abulizi","family":"Abudula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halmurat","family":"Upur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,9,26]]},"reference":[{"key":"2691_CR1","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1002\/ijc.25516","volume":"127","author":"J Ferlay","year":"2010","unstructured":"Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127:2893\u20132917","journal-title":"Int J Cancer"},{"key":"2691_CR2","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1002\/1097-0142(19951115)76:10+<1888::AID-CNCR2820761305>3.0.CO;2-H","volume":"76","author":"MH Schiffman","year":"1995","unstructured":"Schiffman MH, Brinton LA (1995) The epidemiology of cervical carcinogenesis. Cancer 76:1888\u20131901","journal-title":"Cancer"},{"key":"2691_CR3","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1093\/jnci\/92.9.690","volume":"92","author":"H Zur Hausen","year":"2000","unstructured":"Zur Hausen H (2000) Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis. J Natl Cancer Inst 92:690\u2013698","journal-title":"J Natl Cancer Inst"},{"key":"2691_CR4","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1136\/jcp.55.4.244","volume":"55","author":"FX Bosch","year":"2002","unstructured":"Bosch FX, Lorincz A, Munoz N, Meijer CJ, Shah KV (2002) The causal relation between human papillomavirus and cervical cancer. J Clin Pathol 55:244\u2013265","journal-title":"J Clin Pathol"},{"key":"2691_CR5","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1111\/j.1742-4658.2012.08651.x","volume":"279","author":"BJ Altman","year":"2012","unstructured":"Altman BJ, Dang CV (2012) Normal and cancer cell metabolism: lymphocytes and lymphoma. FEBS J 279:2598\u20132609","journal-title":"FEBS J"},{"issue":"7","key":"2691_CR6","doi-asserted-by":"crossref","first-page":"a006783","DOI":"10.1101\/cshperspect.a006783","volume":"4","author":"PS Ward","year":"2012","unstructured":"Ward PS, Thompson CB (2012) Signaling in control of cell growth and metabolism. Cold Spring Harb Perspect Biol. 4(7):a006783","journal-title":"Cold Spring Harb Perspect Biol."},{"key":"2691_CR7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/00075197-199901000-00009","volume":"2","author":"E Holm","year":"1999","unstructured":"Holm E, Sedlaczek O, Grips E (1999) Amino acid metabolism in liver disease. Curr Opin Clin Nutr Metab Care 2:47\u201353","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"2691_CR8","doi-asserted-by":"crossref","unstructured":"Miyagi Y, Higashiyama M, Gochi A, Akaike M, Ishikawa T, Miura T, Saruki N, Bando E, Kimura H, Imamura F, Moriyama M, Ikeda I, Chiba A, Oshita F, Imaizumi A, Yamamoto H, Miyano H, Horimoto K, Tochikubo O, Mitsushima T, Yamakado M, Okamoto N (2011) Plasma free amino acid profiling of five types of cancer patients and its application for early detection. PLoS One 6(9):e24143","DOI":"10.1371\/journal.pone.0024143"},{"key":"2691_CR9","doi-asserted-by":"crossref","first-page":"945","DOI":"10.3892\/etm.2012.509","volume":"3","author":"Ayshamgul Hasim","year":"2012","unstructured":"Hasim Ayshamgul, Eli Maynur, Mamtimin Batur et al (2012) Metabonomic signature analysis of cervical carcinoma and precancerous diseases in Uighur women by 1H-NMR spectroscopy. Exp Ther Med 3:945\u2013951","journal-title":"Exp Ther Med"},{"key":"2691_CR10","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1158\/1078-0432.CCR-08-1059","volume":"15","author":"JL Spratlin","year":"2009","unstructured":"Spratlin JL, Serkova NJ, Eckhardt SG (2009) Clinical applications of metabolomics in oncology: a review. Clin Cancer Res 15:431\u2013440","journal-title":"Clin Cancer Res"},{"key":"2691_CR11","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1021\/pr0605217","volume":"6","author":"EM Lenz","year":"2007","unstructured":"Lenz EM, Wilson ID (2007) Analytical strategies in metabonomics. J Proteome Res 6:443\u2013458","journal-title":"J Proteome Res"},{"key":"2691_CR12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.aca.2009.11.042","volume":"659","author":"R Madsen","year":"2010","unstructured":"Madsen R, Lundstedt T, Trygg J (2010) Chemometrics in metabolomics\u2014a review in human disease diagnosis. Anal Chim Acta 659:23\u201333","journal-title":"Anal Chim Acta"},{"key":"2691_CR13","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s10334-003-0025-5","volume":"16","author":"B Sitter","year":"2004","unstructured":"Sitter B, Bathen T, Hagen B, Arentz C, Skjeldestad FE, Gribbestad IS (2004) Cervical cancer tissue characterized by high-resolution magic angle spinning MR spectroscopy. MAGMA 16:174\u2013181","journal-title":"MAGMA"},{"key":"2691_CR14","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1593\/neo.81396","volume":"11","author":"S Tiziani","year":"2009","unstructured":"Tiziani S, Lopes V, Gunther UL (2009) Early stage diagnosis of oral cancer using 1H NMR-based metabolomics. Neoplasia 11:269\u2013276","journal-title":"Neoplasia"},{"key":"2691_CR15","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.molonc.2011.02.002","volume":"5","author":"C Roth","year":"2011","unstructured":"Roth C, Kasimir-Bauer S, Pantel K, Schwarzenbach H (2011) Screening for circulating nucleic acids and caspase activity in the peripheral blood as potential diagnostic tools in lung cancer. Mol Oncol 5:281\u2013291","journal-title":"Mol Oncol"},{"key":"2691_CR16","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1093\/ajcn\/81.5.1142","volume":"81","author":"YL Vissers","year":"2005","unstructured":"Vissers YL, Dejong CH, Luiking YC, Fearon KC, von Meyenfeldt MF et al (2005) Plasma arginine concentrations are reduced in cancer patients: evidence for arginine deficiency? Am J Clin Nutr 81:1142\u20131146","journal-title":"Am J Clin Nutr"},{"key":"2691_CR17","first-page":"507","volume":"15","author":"A Cascino","year":"1995","unstructured":"Cascino A, Muscaritoli M, Cangiano C, Conversano L, Laviano A et al (1995) Plasma amino acid imbalance in patients with lung and breast cancer. Anti cancer Res 15:507\u2013510","journal-title":"Anti cancer Res"},{"key":"2691_CR18","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/00000421-200110000-00021","volume":"24","author":"JR Allen","year":"2001","unstructured":"Allen JR, Prost RW, Griffith OW et al (2001) In vivo proton (H1) magnetic resonance spectroscopy for cervical carcinoma. Am J Clin Oncol 24:522\u2013529","journal-title":"Am J Clin Oncol"},{"key":"2691_CR19","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/mrm.1910130216","volume":"13","author":"CE Mountford","year":"1990","unstructured":"Mountford CE, Delikatny EJ, Dyne M et al (1990) Uterine cervical punch biopsy specimens can be analyzed by 1H MRS. Magn Reson Med 13:324\u2013331","journal-title":"Magn Reson Med"},{"key":"2691_CR20","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1148\/radiology.188.3.8351349","volume":"188","author":"EJ Delikatny","year":"1993","unstructured":"Delikatny EJ, Russell P, Hunter JC et al (1993) Proton MR and human cervical neoplasia: ex vivo spectroscopy allows distinction of invasive carcinoma of the cervix from carcinoma in situ and other preinvasive lesions. Radiology 188:791\u2013796","journal-title":"Radiology"},{"key":"2691_CR21","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","volume":"324","author":"MG Vander Heiden","year":"2009","unstructured":"Vander Heiden MG, Cantley LC, Thompson CB (2009) Understanding the War burg effect, the metabolic requirements of cell proliferation. Science 324:1029\u20131033","journal-title":"Science"},{"key":"2691_CR22","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nrc2981","volume":"11","author":"RA Cairns","year":"2011","unstructured":"Cairns RA, Harris IS, Mak TW (2011) Regulation of cancer cell metabolism. Nat Rev Cancer 11:85\u201395","journal-title":"Nat Rev Cancer"},{"issue":"5","key":"2691_CR23","doi-asserted-by":"crossref","first-page":"355","DOI":"10.4196\/kjpp.2012.16.5.355","volume":"16","author":"QZ Li","year":"2012","unstructured":"Li QZ, Huang QX, Li SC, Yang MZ, Rao B (2012) Simultaneous determination of glutamate, glycine, and alanine in human plasma using precolumn derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate and high-performance liquid chromatography. Korean J Physiol Pharmacol 16(5):355\u2013360","journal-title":"Korean J Physiol Pharmacol"},{"issue":"11","key":"2691_CR24","doi-asserted-by":"crossref","first-page":"4918","DOI":"10.1158\/0008-5472.CAN-08-4806","volume":"69","author":"A Hirayama","year":"2009","unstructured":"Hirayama A, Kami K, Sugimoto M, Sugawara M, Toki N, Onozuka H, Kinoshita T, Saito N, Ochiai A, Tomita M et al (2009) Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry. Cancer Res 69(11):4918\u20134925","journal-title":"Cancer Res"},{"issue":"1","key":"2691_CR25","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1021\/pr9006574","volume":"9","author":"CM Rocha","year":"2010","unstructured":"Rocha CM, Barros AS, Gil AM, Goodfellow BJ, Humpfer E, Spraul M, Carreira IM, Melo JB, Bernardo J, Gomes A et al (2010) Metabolic profiling of human lung cancer tissue by 1H high resolution magic angle spinning (HRMAS) NMR spectroscopy. J Proteome Res 9(1):319\u2013332","journal-title":"J Proteome Res"},{"issue":"3","key":"2691_CR26","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.hepres.2005.12.006","volume":"34","author":"Q Zhang","year":"2006","unstructured":"Zhang Q, Takahashi M, Noguchi Y, Sugimoto T, Kimura T, Okumura A, Ishikawa T, Kakumu S (2006) Plasma amino acid profiles applied for diagnosis of advanced liver fibrosis in patients with chronic hepatitis C infection. Hepatol Res 34(3):170\u2013177","journal-title":"Hepatol Res"},{"issue":"10","key":"2691_CR27","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1186\/1471-2407-10-690","volume":"22","author":"J Maeda","year":"2010","unstructured":"Maeda J, Higashiyama M, Imaizumi A, Nakayama T, Yamamoto H, Daimon T, Yamakado M, Imamura F, Kodama K (2010) Possibility of multivariate function composed of plasma amino acid profiles as a novel screening index for non-small cell lung cancer: a case control study. BMC Cancer 22(10):690","journal-title":"BMC Cancer"},{"key":"2691_CR28","first-page":"1","volume":"1","author":"N Okamoto","year":"2009","unstructured":"Okamoto N, Miyagi Y, Chiba A, Akaike M, Shiozawa M et al (2009) Diagnostic modeling with differences in plasma amino acid profiles between non-cachectic colorectal\/breast cancer patients and healthy individuals. Int J Med Med Sci 1:1\u20138","journal-title":"Int J Med Med Sci"},{"key":"2691_CR29","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0261-5614(88)90041-6","volume":"7","author":"A Cascino","year":"1998","unstructured":"Cascino A, Cangiano C, Ceci F, Franchi F, Menichetti ET, Muscaritoli M, Fanelli FR (1998) Plasma amino-acids in human cancer: the individual role of tumour, malnutrition and glucose tolerance. Clin Nutr 7:213\u2013218","journal-title":"Clin Nutr"},{"issue":"4","key":"2691_CR30","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.juro.2011.05.085","volume":"186","author":"A Mustafa","year":"2011","unstructured":"Mustafa A, Gupta S, Hudes GR, Egleston BL, Uzzo RG, Kruger WD (2011) Serum amino acid levels as a biomarker for renal cell carcinoma. J Urol 186(4):1206\u20131212","journal-title":"J Urol"},{"issue":"5","key":"2691_CR31","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/rcm.4420","volume":"24","author":"S Urayama","year":"2010","unstructured":"Urayama S, Zou W, Brooks K, Tolstikov V (2010) Comprehensive mass spectrometry based metabolic profiling of blood plasma reveals potent discriminatory classifiers of pancreatic cancer. Rapid Commun Mass Spectrom 24(5):613\u2013620","journal-title":"Rapid Commun Mass Spectrom"},{"key":"2691_CR32","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.semcancer.2005.04.003","volume":"15","author":"HS Lai","year":"2005","unstructured":"Lai HS, Lee JC, Lee PH, Wang ST, Chen WJ (2005) Plasma free amino acid profile in cancer patients. Semin Cancer Biol 15:267\u2013276","journal-title":"Semin Cancer Biol"},{"issue":"3","key":"2691_CR33","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0090-8258(76)90037-8","volume":"4","author":"EA Wilson","year":"1976","unstructured":"Wilson EA, Sprague AD, Hurst ME, Roddick JK Jr (1976) Free serum amino acids in patients with advanced cervical carcinoma. Gynecol Oncol 4(3):311\u2013313","journal-title":"Gynecol Oncol"},{"key":"2691_CR34","first-page":"474907","volume":"2012","author":"J Fan","year":"2012","unstructured":"Fan J, Hong J, Hu JD, Chen JL (2012) Ion chromatography based urine amino acid profiling applied for diagnosis of gastric cancer. Gastroenterol Res Pract 2012:474907","journal-title":"Gastroenterol Res Pract"},{"key":"2691_CR35","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1002\/1097-0142(19920501)69:9<2343::AID-CNCR2820690924>3.0.CO;2-S","volume":"69","author":"A Kubota","year":"1992","unstructured":"Kubota A, Meguid MM, Hitch DC (1992) Amino acid profiles correlate diagnostically with organ site in three kinds of malignant tumors. Cancer 69:2343\u20132348","journal-title":"Cancer"},{"key":"2691_CR36","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/1097-0142(19880715)62:2<355::AID-CNCR2820620221>3.0.CO;2-E","volume":"62","author":"AB Naini","year":"1998","unstructured":"Naini AB, Dickerson JW, Brown MM (1998) Preoperative and postoperative levels of plasma protein and amino acid in esophageal and lung cancer patients. Cancer 62:355\u2013360","journal-title":"Cancer"},{"issue":"23","key":"2691_CR37","doi-asserted-by":"crossref","first-page":"8983","DOI":"10.1073\/pnas.1203244109","volume":"109","author":"W Liu","year":"2012","unstructured":"Liu W, Le A, Hancock C, Lane AN, Dang CV, Fan TW, Phang JM (2012) Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC. Proc Natl Acad Sci USA 109(23):8983\u20138988","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"2691_CR38","first-page":"1159","volume":"31","author":"D Rudman","year":"1971","unstructured":"Rudman D, Vogler WR, Howard CH, Gerron GG (1971) Observations on the plasma amino acids of patients with acute leukemia. Cancer Res 31(8):1159\u20131165","journal-title":"Cancer Res"},{"issue":"3","key":"2691_CR39","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1042\/CS20020198","volume":"104","author":"UB Fl\u00e4ring","year":"2003","unstructured":"Fl\u00e4ring UB, Rooyackers OE, Wernerman J, Hammarqvist F (2003) Glutamine attenuates post-traumatic glutathione depletion in human muscle. Clin Sci (Lond) 104(3):275\u2013282","journal-title":"Clin Sci (Lond)"},{"issue":"1","key":"2691_CR40","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cmet.2011.12.009","volume":"15","author":"A Le","year":"2012","unstructured":"Le A, Lane AN, Hamaker M, Bose S, Gouw A, Barbi J, Tsukamoto T, Rojas CJ, Slusher BS, Zhang H, Zimmerman LJ, Liebler DC, Slebos RJ, Lorkiewicz PK, Higashi RM, Fan TW, Dang CV (2012) Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab 15(1):110\u2013121","journal-title":"Cell Metab"},{"issue":"9","key":"2691_CR41","doi-asserted-by":"crossref","first-page":"8955","DOI":"10.1007\/s11033-012-1764-z","volume":"39","author":"A Hasim","year":"2012","unstructured":"Hasim A, Ma H, Mamtimin B, Abudula A, Niyaz M, Zhang LW, Anwer J, Sheyhidin I (2012) Revealing the metabonomic variation of EC using \u00b9H-NMR spectroscopy and its association with the clinicopathological characteristics. Mol Biol Rep 39(9):8955\u20138964","journal-title":"Mol Biol Rep"},{"key":"2691_CR42","doi-asserted-by":"crossref","first-page":"513S","DOI":"10.1093\/ajcn\/83.2.513S","volume":"83","author":"N Yasushi","year":"2006","unstructured":"Yasushi N, Qing-Wei Zh, Tetsuya S, Yasufumi F, Ryosei S, Mori Masato, Mitsuo T, Takeshi K (2006) Network analysis of plasma and tissue amino acids and the generation of an amino index for potential diagnostic use. Am J Clin Nutr 83:513S\u2013519S","journal-title":"Am J Clin Nutr"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-013-2691-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11033-013-2691-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-013-2691-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T12:03:54Z","timestamp":1564056234000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11033-013-2691-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,26]]},"references-count":42,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["2691"],"URL":"https:\/\/doi.org\/10.1007\/s11033-013-2691-3","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,26]]}}}