{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:04:08Z","timestamp":1790949848205,"version":"4.1.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T00:00:00Z","timestamp":1412640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1007\/s11033-014-3383-3","type":"journal-article","created":{"date-parts":[[2014,10,6]],"date-time":"2014-10-06T15:45:16Z","timestamp":1412610316000},"page":"7073-7088","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Computational analysis of human N-acetylgalactosamine-6-sulfate sulfatase enzyme: an update in genotype\u2013phenotype correlation for Morquio A"],"prefix":"10.1007","volume":"41","author":[{"given":"Sergio","family":"Olarte-Avellaneda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Rodr\u00edguez-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Javier","family":"Alm\u00e9ciga-D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Alejandro","family":"Barrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,10,7]]},"reference":[{"key":"3383_CR1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nmeth0410-248","volume":"7","author":"IA Adzhubei","year":"2010","unstructured":"Adzhubei IA, Schmidt S, Peshkin L, Ramensky VE, Gerasimova A, Bork P, Kondrashov AS, Sunyaev SR (2010) A method and server for predicting damaging missense mutations. Nat Methods 7:248\u2013249","journal-title":"Nat Methods"},{"key":"3383_CR2","doi-asserted-by":"crossref","first-page":"3608","DOI":"10.1111\/j.1742-4658.2010.07769.x","volume":"277","author":"C Alm\u00e9ciga-D\u00edaz","year":"2010","unstructured":"Alm\u00e9ciga-D\u00edaz C, Monta\u00f1o AM, Tomatsu S, Barrera L (2010) Adeno-associated virus gene transfer on Morquio A: effect of promoters and sulfatase-modifying Factor 1. FEBS J 277:3608\u20133619","journal-title":"FEBS J"},{"key":"3383_CR3","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1007\/s11033-008-9392-3","volume":"36","author":"C Alm\u00e9ciga-D\u00edaz","year":"2009","unstructured":"Alm\u00e9ciga-D\u00edaz C, Rueda-Paramo M, Espejo A, Echeverri O, Monta\u00f1o A, Tomatsu S, Barrera L (2009) Effect of Elongation Factor 1\u03b1 promoter and SUMF1 over in vitro expression of N-acetylgalactosamine-6-sulfate sulfatase. Mol Biol Rep 36:1863\u20131870","journal-title":"Mol Biol Rep"},{"key":"3383_CR4","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1107\/S0021889807021875","volume":"40","author":"B Balamurugan","year":"2007","unstructured":"Balamurugan B, Roshan B, Hameed BS, Sumathi K, Senthilkumar R, Udayakumar A, Babu KHV, Kalaivani M, Sowmiya G, Sivasankari P, Saravanan S, Ranjani CV, Gopalakrishnan K, Selvakumar KN, Jaikumar M, Brindha T, Michael D, Sekar K (2007) PSAP: protein structure analysis package. J Appl Crystallogr 40:773\u2013777","journal-title":"J Appl Crystallogr"},{"key":"3383_CR5","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0092-8674(03)00348-9","volume":"113","author":"M Cosma","year":"2003","unstructured":"Cosma M, Pepe P, Annunziata I, Newbold R, Grompe M, Parenti G, Ballabio A (2003) The multiple sulfatase deficiency gene encodes an essential and limiting factor for the activity of sulfatases. Cell 113:445\u2013456","journal-title":"Cell"},{"key":"3383_CR6","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/nrd3929","volume":"12","author":"S Crunkhorn","year":"2013","unstructured":"Crunkhorn S (2013) Trial watch: enzyme replacement success in Phase III trial for rare metabolic disorder. Nat Rev Drug Discov 12:12","journal-title":"Nat Rev Drug Discov"},{"key":"3383_CR7","doi-asserted-by":"crossref","first-page":"W116","DOI":"10.1093\/nar\/gkl282","volume":"34","author":"J Dundas","year":"2006","unstructured":"Dundas J, Ouyang Z, Tseng J, Binkowski A, Turpaz Y, Liang J (2006) CASTp: computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues. Nucleic Acids Res 34:W116\u2013W118","journal-title":"Nucleic Acids Res"},{"key":"3383_CR8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ymgme.2013.06.008","volume":"110","author":"VC Dung","year":"2013","unstructured":"Dung VC, Tomatsu S, Montano AM, Gottesman G, Bober MB, Mackenzie W, Maeda M, Mitchell GA, Suzuki Y, Orii T (2013) Mucopolysaccharidosis IVA: correlation between genotype, phenotype and keratan sulfate levels. Mol Genet Metab 110:129\u2013138","journal-title":"Mol Genet Metab"},{"key":"3383_CR9","doi-asserted-by":"crossref","first-page":"e12194","DOI":"10.1371\/journal.pone.0012194","volume":"5","author":"M Dvorak-Ewell","year":"2010","unstructured":"Dvorak-Ewell M, Wendt D, Hague C, Christianson T, Koppaka V, Crippen D, Kakkis E, Vellard M (2010) Enzyme replacement in a human model of mucopolysaccharidosis IVA in vitro and its biodistribution in the cartilage of wild type mice. PLoS One 5:e12194","journal-title":"PLoS One"},{"key":"3383_CR10","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/1471-2105-5-113","volume":"5","author":"RC Edgar","year":"2004","unstructured":"Edgar RC (2004) MUSCLE: a multiple sequence alignment method with reduced time and space complexity. BMC Bioinform 5:113","journal-title":"BMC Bioinform"},{"key":"3383_CR11","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/15216540214932","volume":"54","author":"J Funderburgh","year":"2002","unstructured":"Funderburgh J (2002) Keratan sulfate biosynthesis. IUBMB Life 54:187\u2013194","journal-title":"IUBMB Life"},{"key":"3383_CR12","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1007\/s00018-007-7175-y","volume":"64","author":"D Ghosh","year":"2007","unstructured":"Ghosh D (2007) Human sulfatases: a structural perspective to catalysis. Cell Mol Life Sci 64:2013\u20132022","journal-title":"Cell Mol Life Sci"},{"key":"3383_CR13","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1002\/elps.1150181505","volume":"18","author":"N Guex","year":"1997","unstructured":"Guex N, Peitsch MC (1997) SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis 18:2714\u20132723","journal-title":"Electrophoresis"},{"key":"3383_CR14","doi-asserted-by":"crossref","first-page":"448","DOI":"10.7705\/biomedica.v28i3.85","volume":"28","author":"M Gutierrez","year":"2008","unstructured":"Gutierrez M, Garcia-Vallejo F, Tomatsu S, Ceron F, Alm\u00e9ciga-D\u00edaz C, Dom\u00ednguez M, Barrera L (2008) Construction of an adenoassociated virus-derived vector for the treatment of Morquio A disease. Biomedica 28:448\u2013459","journal-title":"Biomedica"},{"key":"3383_CR15","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1096\/fasebj.1.6.3315809","volume":"1","author":"S Kornfeld","year":"1987","unstructured":"Kornfeld S (1987) Trafficking of lysosomal enzymes. FASEB J 1:462\u2013468","journal-title":"FASEB J"},{"key":"3383_CR16","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.gene.2012.12.100","volume":"517","author":"F Kubaski","year":"2013","unstructured":"Kubaski F, Brusius-Facchin AC, Palhares HM, Balarin MA, Viapiana-Camelier M, Guidobono R, Burin MG, Giugliani R, Leistner-Segal S (2013) Identification of a novel missense mutation in Brazilian patient with a severe form of mucopolysaccharidosis type IVA. Gene 517:112\u2013115","journal-title":"Gene"},{"key":"3383_CR17","doi-asserted-by":"crossref","first-page":"D266","DOI":"10.1093\/nar\/gki001","volume":"33","author":"RA Laskowski","year":"2005","unstructured":"Laskowski RA, Chistyakov VV, Thornton JM (2005) PDBsum more: new summaries and analyses of the known 3D structures of proteins and nucleic acids. Nucleic Acids Res 33:D266\u2013D268","journal-title":"Nucleic Acids Res"},{"key":"3383_CR18","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/oxfordjournals.jbchem.a123697","volume":"110","author":"M Masue","year":"1991","unstructured":"Masue M, Sukegawa K, Orii T, Hashimoto T (1991) N-Acetylgalactosamine-6-sulfate sulfatase in human placenta: purification and characteristics. J Biochem 110:965\u2013970","journal-title":"J Biochem"},{"key":"3383_CR19","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1007\/s10545-007-0702-z","volume":"30","author":"AM Monta\u00f1o","year":"2007","unstructured":"Monta\u00f1o AM, Sukegawa K, Kato Z, Carrozzo R, Di Natale P, Christensen E, Orii KO, Orii T, Kondo N, Tomatsu S (2007) Effect of \u2018attenuated\u2019 mutations in mucopolysaccharidosis IVA on molecular phenotypes of N-acetylgalactosamine-6-sulfate sulfatase. J Inherit Metab Dis 30:758\u2013767","journal-title":"J Inherit Metab Dis"},{"key":"3383_CR20","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10545-007-0529-7","volume":"30","author":"AM Monta\u00f1o","year":"2007","unstructured":"Monta\u00f1o AM, Tomatsu S, Gottesman G, Smith M, Orii T (2007) International Morquio A registry: clinical manifestation and natural course of Morquio A disease. J Inherit Metab Dis 30:165\u2013174","journal-title":"J Inherit Metab Dis"},{"key":"3383_CR21","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1016\/j.procbio.2012.07.028","volume":"47","author":"A Mosquera","year":"2012","unstructured":"Mosquera A, Rodr\u00edguez A, Vargas C, Leonardi F, Espejo A, S\u00e1nchez O, Alm\u00e9ciga-D\u00edaz C, Barrera L (2012) Characterization of a recombinant N-acetylgalactosamine-6-sulfate sulfatase produced in E. coli for enzyme replacement therapy of Morquio A disease. Process Biochem 47:2097\u20132102","journal-title":"Process Biochem"},{"key":"3383_CR22","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/978-3-319-01568-2_21","volume-title":"Advances in computational biology","author":"S Olarte-Avellaneda","year":"2014","unstructured":"Olarte-Avellaneda S, Rodr\u00edguez-L\u00f3pez A, Alm\u00e9ciga-D\u00edaz CJ (2014) In-silico analysis of the active cavity of N-acetylgalactosamine-6-sulfate sulfatase in eight species. In: Castillo LF, Cristancho M, Isaza G, Pinz\u00f3n A, Corchado JM (eds) Advances in computational biology. Springer, Las Vegas, pp 141\u2013146"},{"key":"3383_CR23","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","volume":"25","author":"EF Pettersen","year":"2004","unstructured":"Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE (2004) UCSF Chimera: a visualization system for exploratory research and analysis. J Comput Chem 25:1605\u20131612","journal-title":"J Comput Chem"},{"key":"3383_CR24","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/bioinformatics\/btt055","volume":"29","author":"S Pronk","year":"2013","unstructured":"Pronk S, Pall S, Schulz R, Larsson P, Bjelkmar P, Apostolov R, Shirts MR, Smith JC, Kasson PM, van der Spoel D, Hess B, Lindahl E (2013) GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit. Bioinformatics 29:845\u2013854","journal-title":"Bioinformatics"},{"key":"3383_CR25","doi-asserted-by":"crossref","first-page":"28359","DOI":"10.1074\/jbc.271.45.28359","volume":"271","author":"AV Pshezhetsky","year":"1996","unstructured":"Pshezhetsky AV, Potier M (1996) Association of N-acetylgalactosamine-6-sulfate sulfatase with the multienzyme lysosomal complex of beta-galactosidase, cathepsin A, and neuraminidase. Possible implication for intralysosomal catabolism of keratan sulfate. J Biol Chem 271:28359\u201328365","journal-title":"J Biol Chem"},{"key":"3383_CR26","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.jmb.2012.08.020","volume":"423","author":"Y Rivera-Colon","year":"2012","unstructured":"Rivera-Colon Y, Schutsky EK, Kita AZ, Garman SC (2012) The structure of human GALNS reveals the molecular basis for mucopolysaccharidosis IV A. J Mol Biol 423:736\u2013751","journal-title":"J Mol Biol"},{"key":"3383_CR27","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s10295-010-0766-x","volume":"37","author":"A Rodriguez","year":"2010","unstructured":"Rodriguez A, Espejo AJ, Hernandez A, Velasquez OL, Lizaraso LM, Cordoba HA, Sanchez OF, Almeciga-Diaz CJ, Barrera LA (2010) Enzyme replacement therapy for Morquio A: an active recombinant N-acetylgalactosamine-6-sulfate sulfatase produced in Escherichia coli BL21. J Ind Microbiol Biotechnol 37:1193\u20131201","journal-title":"J Ind Microbiol Biotechnol"},{"key":"3383_CR28","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.ymgme.2007.11.017","volume":"93","author":"S Saito","year":"2008","unstructured":"Saito S, Ohno K, Sugawara K, Sakuraba H (2008) Structural and clinical implications of amino acid substitutions in N-acetylgalactosamine-4-sulfatase: insight into mucopolysaccharidosis type VI. Mol Genet Metab 93:419\u2013425","journal-title":"Mol Genet Metab"},{"key":"3383_CR29","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1093\/hmg\/ddi351","volume":"14","author":"M Sardiello","year":"2005","unstructured":"Sardiello M, Annunziata I, Roma G, Ballabio A (2005) Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. Hum Mol Genet 14:3203\u20133217","journal-title":"Hum Mol Genet"},{"key":"3383_CR30","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s10719-008-9222-9","volume":"26","author":"M Schenk","year":"2009","unstructured":"Schenk M, Koppisetty CA, Santos DC, Carmona E, Bhatia S, Nyholm PG, Tanphaichitr N (2009) Interaction of arylsulfatase-A (ASA) with its natural sulfoglycolipid substrates: a computational and site-directed mutagenesis study. Glycoconj J 26:1029\u20131045","journal-title":"Glycoconj J"},{"key":"3383_CR31","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1107\/S0907444904011679","volume":"60","author":"AW Schuttelkopf","year":"2004","unstructured":"Schuttelkopf AW, van Aalten DM (2004) PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. Acta Crystallogr Sect D 60:1355\u20131363","journal-title":"Acta Crystallogr Sect D"},{"key":"3383_CR32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00439-013-1358-4","volume":"133","author":"PD Stenson","year":"2014","unstructured":"Stenson PD, Mort M, Ball EV, Shaw K, Phillips A, Cooper DN (2014) The Human Gene Mutation Database: building a comprehensive mutation repository for clinical and molecular genetics, diagnostic testing and personalized genomic medicine. Hum Genet 133:1\u20139","journal-title":"Hum Genet"},{"key":"3383_CR33","first-page":"3958","volume":"4","author":"SC Sudhakar","year":"2011","unstructured":"Sudhakar SC, Mahalingam K (2011) Structural and functional analysis of N-acetylgalactosamine-6-sulfate sulfatase using bioinformatics tools: insight into Mucopolysaccharidosis IVA. J Pharm Res 4:3958\u20133962","journal-title":"J Pharm Res"},{"key":"3383_CR34","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1093\/hmg\/9.9.1283","volume":"9","author":"K Sukegawa","year":"2000","unstructured":"Sukegawa K, Nakamura H, Kato Z, Tomatsu S, Monta\u00f1o AM, Fukao T, Toietta G, Tortora P, Orii T, Kondo N (2000) Biochemical and structural analysis of missense mutations in N-acetylgalactosamine-6-sulfate sulfatase causing mucopolysaccharidosis IVA phenotypes. Hum Mol Genet 9:1283\u20131290","journal-title":"Hum Mol Genet"},{"key":"3383_CR35","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1093\/molbev\/msr121","volume":"28","author":"K Tamura","year":"2011","unstructured":"Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S (2011) MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol 28:2731\u20132739","journal-title":"Mol Biol Evol"},{"key":"3383_CR36","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/0006-291X(91)91244-7","volume":"181","author":"S Tomatsu","year":"1991","unstructured":"Tomatsu S, Fukuda M, Masue K, Sukegawa T, Fukao A, Yamagishi T, Hori H, Iwati T, Ogawa Y (1991) Morquio disease: isolation, characterization and expression of full-length cDNA for human N-acetylgalactosamine-6-sulfate sulfatase. Biochem Biophys Res Commun 181:677\u2013683","journal-title":"Biochem Biophys Res Commun"},{"key":"3383_CR37","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ymgme.2006.05.012","volume":"89","author":"S Tomatsu","year":"2006","unstructured":"Tomatsu S, Monta\u00f1o A, Lopez P, Trandafirescu G, Gutierrez M, Oikawa H, Nishioka T, Vieira M, Orii T, Noguchi A (2006) Determinant factors of spectrum of missense variants in mucopolysaccharidosis IVA gene. Mol Genet Metab 89:139\u2013149","journal-title":"Mol Genet Metab"},{"key":"3383_CR38","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/humu.20257","volume":"26","author":"S Tomatsu","year":"2005","unstructured":"Tomatsu S, Monta\u00f1o A, Nishioka T, Gutierrez M, Pe\u00f1a O, Trandafirescu G, Lopez P, Yamaguchi S, Noguchi A, Orri T (2005) Mutation and polymorphism spectrum of the GALNS gene in mucopolysaccharidosis IVA (Morquio A). Hum Mutat 26:500\u2013512","journal-title":"Hum Mutat"},{"key":"3383_CR39","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1093\/hmg\/ddm353","volume":"17","author":"S Tomatsu","year":"2008","unstructured":"Tomatsu S, Monta\u00f1o A, Ohashi A, Oikawa H, Oguma T, Dung V, Nishioka T, Orii T, Sly W (2008) Enzyme replacement therapy in a murine model of Morquio A syndrome. Hum Mol Genet 17:815\u2013824","journal-title":"Hum Mol Genet"},{"key":"3383_CR40","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/mt.2010.32","volume":"18","author":"S Tomatsu","year":"2010","unstructured":"Tomatsu S, Monta\u00f1o AM, Dung V, Ohashi A, Oikawa H, Oguma T, Orii T, Barrera L, Sly W (2010) Enhacement of drug delivery: enzyme-replacement therapy for murine Morquio A syndrome. Mol Ther 18:1094\u20131102","journal-title":"Mol Ther"},{"key":"3383_CR41","doi-asserted-by":"crossref","first-page":"931","DOI":"10.2174\/138920111795542615","volume":"12","author":"S Tomatsu","year":"2011","unstructured":"Tomatsu S, Monta\u00f1o AM, Oikawa H, Smith M, Barrera L, Chinen Y, Thacker MM, Mackenzie WG, Suzuki Y, Orii T (2011) Mucopolysaccharidosis type IVA (Morquio A disease): clinical review and current treatment. Curr Pharm Biotechnol 12:931\u2013945","journal-title":"Curr Pharm Biotechnol"},{"key":"3383_CR42","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0009-8981(90)90339-T","volume":"187","author":"O Diggelen van","year":"1990","unstructured":"van Diggelen O, Zhao H, Kleijer W, Janse H, Poorthuis B, Pelt JV, Kamerling J, Galjaard H (1990) A fluorometric enzyme assay for the diagnosis of Morquio disease type A (MPS IVA). Clin Chem Acta 187:131\u2013140","journal-title":"Clin Chem Acta"},{"key":"3383_CR43","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/(SICI)1098-1004(1998)11:3<202::AID-HUMU4>3.0.CO;2-J","volume":"11","author":"N Yamada","year":"1998","unstructured":"Yamada N, Fukuda S, Tomatsu S, Muller V, Hopwood JJ, Nelson J, Kato Z, Yamagishi A, Sukegawa K, Kondo N, Orii T (1998) Molecular heterogeneity in mucopolysaccharidosis IVA in Australia and Northern Ireland: nine novel mutations including T312S, a common allele that confers a mild phenotype. Hum Mutat 11:202\u2013208","journal-title":"Hum Mutat"},{"key":"3383_CR44","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1471-2105-9-40","volume":"9","author":"Y Zhang","year":"2008","unstructured":"Zhang Y (2008) I-TASSER server for protein 3D structure prediction. BMC Bioinform 9:40","journal-title":"BMC Bioinform"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-014-3383-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11033-014-3383-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-014-3383-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T22:14:51Z","timestamp":1565907291000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11033-014-3383-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,7]]},"references-count":44,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["3383"],"URL":"https:\/\/doi.org\/10.1007\/s11033-014-3383-3","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,7]]}}}