{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:04:35Z","timestamp":1772751875314,"version":"3.50.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T00:00:00Z","timestamp":1489017600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1007\/s11033-017-4098-z","type":"journal-article","created":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T21:29:58Z","timestamp":1489094998000},"page":"219-226","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Ghrelin protected neonatal rat cardiomyocyte against hypoxia\/reoxygenation injury by inhibiting apoptosis through Akt-mTOR signal"],"prefix":"10.1007","volume":"44","author":[{"given":"Lifeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingjie","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,3,9]]},"reference":[{"issue":"16","key":"4098_CR1","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1016\/j.jacc.2013.12.034","volume":"63","author":"RG O\u2019Malley","year":"2014","unstructured":"O\u2019Malley RG, Bonaca MP, Scirica BM, Murphy SA, Jarolim P et al (2014) Prognostic performance of multiple biomarkers in patients with non-ST-segment elevation acute coronary syndrome: analysis from the MERLIN-TIMI 36 trial (metabolic efficiency with ranolazine for less ischemia in non-ST-elevation acute coronary syndromes-thrombolysis in myocardial infarction 36). J Am Coll Cardiol 63(16):1644\u20131653. doi:\n10.1016\/j.jacc.2013.12.034","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"4098_CR2","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1172\/JCI62874","volume":"123","author":"DJ Hausenloy","year":"2013","unstructured":"Hausenloy DJ, Yellon DM (2013) Myocardial ischemia-reperfusion injury: a neglected therapeutic target. J Clin Investig 123(1):92\u2013100. doi:\n10.1172\/JCI62874","journal-title":"J Clin Investig"},{"issue":"3\u20134","key":"4098_CR3","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s10741-007-9030-5","volume":"12","author":"DV Cokkinos","year":"2007","unstructured":"Cokkinos DV, Pantos C (2007) Myocardial protection in man\u2014from research concept to clinical practice. Heart Fail Rev 12(3\u20134):345\u2013362. doi:\n10.1007\/s10741-007-9030-5","journal-title":"Heart Fail Rev"},{"issue":"8","key":"4098_CR4","doi-asserted-by":"publisher","first-page":"e70956","DOI":"10.1371\/journal.pone.0070956","volume":"8","author":"Y Wang","year":"2013","unstructured":"Wang Y, Li X, Wang X, Lau W, Xing Y et al (2013) Ginsenoside Rd attenuates myocardial ischemia\/reperfusion injury via Akt\/GSK-3beta signaling and inhibition of the mitochondria-dependent apoptotic pathway. PLoS One 8(8):e70956. doi:\n10.1371\/journal.pone.0070956","journal-title":"PLoS One"},{"issue":"6","key":"4098_CR5","doi-asserted-by":"publisher","first-page":"e001852","DOI":"10.1161\/JAHA.115.001852","volume":"4","author":"H Han","year":"2015","unstructured":"Han H, Zhu J, Zhu Z, Ni J, Du R et al (2015) p-Cresyl sulfate aggravates cardiac dysfunction associated with chronic kidney disease by enhancing apoptosis of cardiomyocytes. J Am Heart Assoc 4(6):e001852. doi:\n10.1161\/JAHA.115.001852","journal-title":"J Am Heart Assoc"},{"issue":"11","key":"4098_CR6","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1111\/j.1440-1681.2009.05243.x","volume":"36","author":"XM Li","year":"2009","unstructured":"Li XM, Ma YT, Yang YN, Liu F, Chen BD et al (2009) Downregulation of survival signalling pathways and increased apoptosis in the transition of pressure overload-induced cardiac hypertrophy to heart failure. Clin Exp Pharmacol Physiol 36(11):1054\u20131061. doi:\n10.1111\/j.1440-1681.2009.05243.x","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"8","key":"4098_CR7","doi-asserted-by":"publisher","first-page":"3731","DOI":"10.1210\/en.2003-1424","volume":"145","author":"J Kamegai","year":"2004","unstructured":"Kamegai J, Tamura H, Shimizu T, Ishii S, Tatsuguchi A et al (2004) The role of pituitary ghrelin in growth hormone (GH) secretion: GH-releasing hormone-dependent regulation of pituitary ghrelin gene expression and peptide content. Endocrinology 145(8):3731\u20133738. doi:\n10.1210\/en.2003-1424","journal-title":"Endocrinology"},{"issue":"6","key":"4098_CR8","doi-asserted-by":"publisher","first-page":"2724","DOI":"10.1016\/j.ijcard.2012.06.106","volume":"167","author":"M Gao","year":"2013","unstructured":"Gao M, Yang J, Wei R, Liu G, Zhang L et al (2013) Ghrelin induces cardiac lineage differentiation of human embryonic stem cells through ERK1\/2 pathway. Int J Cardiol 167(6):2724\u20132733. doi:\n10.1016\/j.ijcard.2012.06.106","journal-title":"Int J Cardiol"},{"issue":"1","key":"4098_CR9","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.cardiores.2005.09.001","volume":"69","author":"MJ Kleinz","year":"2006","unstructured":"Kleinz MJ, Maguire JJ, Skepper JN, Davenport AP (2006) Functional and immunocytochemical evidence for a role of ghrelin and des-octanoyl ghrelin in the regulation of vascular tone in man. Cardiovasc Res 69(1):227\u2013235. doi:\n10.1016\/j.cardiores.2005.09.001","journal-title":"Cardiovasc Res"},{"key":"4098_CR10","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.appet.2014.01.011","volume":"76","author":"J Buss","year":"2014","unstructured":"Buss J, Havel PJ, Epel E, Lin J, Blackburn E et al (2014) Associations of ghrelin with eating behaviors, stress, metabolic factors, and telomere length among overweight and obese women: preliminary evidence of attenuated ghrelin effects in obesity? Appetite 76:84\u201394. doi:\n10.1016\/j.appet.2014.01.011","journal-title":"Appetite"},{"issue":"4","key":"4098_CR11","doi-asserted-by":"publisher","first-page":"e0122211","DOI":"10.1371\/journal.pone.0122211","volume":"10","author":"D Siegl","year":"2015","unstructured":"Siegl D, Midura EF, Annecke T, Conzen P, Caldwell CC et al (2015) The effect of ghrelin upon the early immune response in lean and obese mice during sepsis. PLoS One 10(4):e0122211. doi:\n10.1371\/journal.pone.0122211","journal-title":"PLoS One"},{"key":"4098_CR12","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.peptides.2013.11.021","volume":"52","author":"T Waseem","year":"2014","unstructured":"Waseem T, Duxbury M, Ashley SW, Robinson MK (2014) Ghrelin promotes intestinal epithelial cell proliferation through PI3K\/Akt pathway and EGFR trans-activation both converging to ERK 1\/2 phosphorylation. Peptides 52:113\u2013121. doi:\n10.1016\/j.peptides.2013.11.021","journal-title":"Peptides"},{"issue":"4","key":"4098_CR13","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1007\/s11695-013-1135-4","volume":"24","author":"J Yang","year":"2014","unstructured":"Yang J, Feng X, Zhong S, Wang Y, Liu J (2014) Gastric bypass surgery may improve beta cell apoptosis with ghrelin overexpression in patients with BMI\u2009\u2265\u200932.5\u00a0kg\/m2. Obes Surg 24(4):561\u2013571. doi:\n10.1007\/s11695-013-1135-4","journal-title":"Obes Surg"},{"issue":"1","key":"4098_CR14","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1210\/en.2014-1539","volume":"156","author":"B Li","year":"2015","unstructured":"Li B, Zeng M, He W, Huang X, Luo L et al (2015) Ghrelin protects alveolar macrophages against lipopolysaccharide-induced apoptosis through growth hormone secretagogue receptor 1a-dependent c-Jun N-terminal kinase and Wnt\/beta-catenin signaling and suppresses lung inflammation. Endocrinology 156(1):203\u2013217. doi:\n10.1210\/en.2014-1539","journal-title":"Endocrinology"},{"issue":"2","key":"4098_CR15","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1093\/jb\/mvr134","volume":"151","author":"T Sato","year":"2012","unstructured":"Sato T, Nakamura Y, Shiimura Y, Ohgusu H, Kangawa K et al (2012) Structure, regulation and function of ghrelin. J Biochem 151(2):119\u2013128. doi:\n10.1093\/jb\/mvr134","journal-title":"J Biochem"},{"issue":"17","key":"4098_CR16","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1161\/hc4201.097836","volume":"104","author":"N Nagaya","year":"2001","unstructured":"Nagaya N, Uematsu M, Kojima M, Date Y, Nakazato M et al (2001) Elevated circulating level of ghrelin in cachexia associated with chronic heart failure: relationships between ghrelin and anabolic\/catabolic factors. Circulation 104(17):2034\u20132038","journal-title":"Circulation"},{"issue":"1","key":"4098_CR17","doi-asserted-by":"publisher","first-page":"e85785","DOI":"10.1371\/journal.pone.0085785","volume":"9","author":"C Yang","year":"2014","unstructured":"Yang C, Liu Z, Liu K, Yang P (2014) Mechanisms of Ghrelin anti-heart failure: inhibition of Ang II-induced cardiomyocyte apoptosis by down-regulating AT1R expression. PLoS One 9(1):e85785. doi:\n10.1371\/journal.pone.0085785","journal-title":"PLoS One"},{"issue":"4","key":"4098_CR18","doi-asserted-by":"publisher","first-page":"e19143","DOI":"10.1371\/journal.pone.0019143","volume":"6","author":"M Park","year":"2011","unstructured":"Park M, Youn B, Zheng XL, Wu D, Xu A et al (2011) Globular adiponectin, acting via AdipoR1\/APPL1, protects H9c2 cells from hypoxia\/reoxygenation-induced apoptosis. PLoS One 6(4):e19143. doi:\n10.1371\/journal.pone.0019143","journal-title":"PLoS One"},{"issue":"1\u20133","key":"4098_CR19","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.ejphar.2009.04.038","volume":"614","author":"YC Jin","year":"2009","unstructured":"Jin YC, Kim CW, Kim YM, Nizamutdinova IT, Ha YM et al (2009) Cryptotanshinone, a lipophilic compound of Salvia miltiorrriza root, inhibits TNF-\u03b1-induced expression of adhesion molecules in HUVEC and attenuates rat myocardial ischemia\/reperfusion injury in vivo. Eur J Pharmacol 614(1\u20133):91\u201397. doi:\n10.1016\/j.ejphar.2009.04.038","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"4098_CR20","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.jacc.2011.10.863","volume":"59","author":"YH Liao","year":"2012","unstructured":"Liao YH, Xia N, Zhou SF, Tang TT, Yan XX et al (2012) Interleukin-17A contributes to myocardial ischemia\/reperfusion injury by regulating cardiomyocyte apoptosis and neutrophil infiltration. J Am Coll Cardiol 59(4):420\u2013429. doi:\n10.1016\/j.jacc.2011.10.863","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"4098_CR21","doi-asserted-by":"publisher","first-page":"4580","DOI":"10.3390\/ijms11114580","volume":"11","author":"Q Li","year":"2010","unstructured":"Li Q, Li Z, Xu XY, Guo YL, Du F (2010) Neuroprotective properties of picroside II in a rat model of focal cerebral ischemia. Int J Mol Sci 11(11):4580\u20134590. doi:\n10.3390\/ijms11114580","journal-title":"Int J Mol Sci"},{"issue":"10","key":"4098_CR22","doi-asserted-by":"publisher","first-page":"3803","DOI":"10.1210\/jcem.85.10.6846","volume":"85","author":"M Papotti","year":"2000","unstructured":"Papotti M, Ghe C, Cassoni P, Catapano F, Deghenghi R et al (2000) Growth hormone secretagogue binding sites in peripheral human tissues. J Clin Endocrinol Metab 85(10):3803\u20133807. doi:\n10.1210\/jcem.85.10.6846","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"4098_CR23","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1161\/hc3601.095575","volume":"104","author":"N Nagaya","year":"2001","unstructured":"Nagaya N, Uematsu M, Kojima M, Ikeda Y, Yoshihara F et al (2001) Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure. Circulation 104(12):1430\u20131435","journal-title":"Circulation"},{"issue":"1\u20133","key":"4098_CR24","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.regpep.2009.03.003","volume":"155","author":"L Kui","year":"2009","unstructured":"Kui L, Weiwei Z, Ling L, Daikun H, Guoming Z et al (2009) Ghrelin inhibits apoptosis induced by high glucose and sodium palmitate in adult rat cardiomyocytes through the PI3K-Akt signaling pathway. Regul Pept 155(1\u20133):62\u201369. doi:\n10.1016\/j.regpep.2009.03.003","journal-title":"Regul Pept"},{"issue":"19","key":"4098_CR25","doi-asserted-by":"publisher","first-page":"14071","DOI":"10.1074\/jbc.R109.094003","volume":"285","author":"KG Foster","year":"2010","unstructured":"Foster KG, Fingar DC (2010) Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony. J Biol Chem 285(19):14071\u201314077. doi:\n10.1074\/jbc.R109.094003","journal-title":"J Biol Chem"},{"key":"4098_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/srep15881","author":"M Ikeda","year":"2015","unstructured":"Ikeda M, Ide T, Fujino T, Matsuo Y, Arai S et al (2015) The Akt-mTOR axis is a pivotal regulator of eccentric hypertrophy during volume overload. Sci Rep. doi:\n10.1038\/srep15881","journal-title":"Sci Rep"},{"issue":"1","key":"4098_CR27","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1093\/cvr\/cvv252","volume":"109","author":"P Shende","year":"2016","unstructured":"Shende P, Xu L, Morandi C, Pentassuglia L, Heim P et al (2016) Cardiac mTOR complex 2 preserves ventricular function in pressure-overload hypertrophy. Cardiovasc Res 109(1):103\u2013114. doi:\n10.1093\/cvr\/cvv252","journal-title":"Cardiovasc Res"},{"issue":"12","key":"4098_CR28","doi-asserted-by":"publisher","first-page":"H1530","DOI":"10.1152\/ajpheart.00008.2015","volume":"308","author":"T Aoyagi","year":"2015","unstructured":"Aoyagi T, Higa JK, Aoyagi H, Yorichika N, Shimada BK et al (2015) Cardiac mTOR rescues the detrimental effects of diet-induced obesity in the heart after ischemia-reperfusion. Am J Physiol Heart Circ Physiol 308(12):H1530\u2013H1539. doi:\n10.1152\/ajpheart.00008.2015","journal-title":"Am J Physiol Heart Circ Physiol"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11033-017-4098-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-017-4098-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-017-4098-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,9]],"date-time":"2017-05-09T12:14:29Z","timestamp":1494332069000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11033-017-4098-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,9]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["4098"],"URL":"https:\/\/doi.org\/10.1007\/s11033-017-4098-z","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,9]]}}}