{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T22:04:30Z","timestamp":1755036270677,"version":"3.37.3"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T00:00:00Z","timestamp":1546387200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s11033-018-04573-x","type":"journal-article","created":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T09:45:14Z","timestamp":1546422314000},"page":"1127-1138","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["IL-22 in hepatocyte\u2019s survival of Pakistani patients with end stage liver disease: an insight into IL 22 mediated hepato-regenerative pathway"],"prefix":"10.1007","volume":"46","author":[{"given":"Muhammad","family":"Saalim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saleha","family":"Resham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9273-6880","authenticated-orcid":false,"given":"Sobia","family":"Manzoor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassam","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tariq Ali","family":"Bangash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Latif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahla","family":"Jaleel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,1,2]]},"reference":[{"key":"4573_CR1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ijid.2008.06.019","volume":"13","author":"SA Ali","year":"2009","unstructured":"Ali SA, Donahue RM, Qureshi H, Vermund SH (2009) Hepatitis B and hepatitis C in Pakistan: prevalence and risk factors. Int J Infect Dis 13:9\u201319","journal-title":"Int J Infect Dis"},{"key":"4573_CR2","doi-asserted-by":"publisher","first-page":"S48","DOI":"10.1038\/sj.cdd.4401119","volume":"10","author":"H Bantel","year":"2003","unstructured":"Bantel H, Schulze-Osthoff K (2003) Apoptosis in hepatitis C virus infection. Cell Death Differ 10:S48\u2013S58","journal-title":"Cell Death Differ"},{"key":"4573_CR3","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1002\/hep.510240410","volume":"24","author":"D Byron","year":"1996","unstructured":"Byron D, Minuk GY (1996) Clinical hepatology: profile of an urban, hospital-based practic Hepatology 24:813\u2013815","journal-title":"Hepatology"},{"key":"4573_CR4","unstructured":"Cancer IAfRo (1989) Diesel and gasoline engine exhausts and some nitroarenes\/this publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans which met in Lyon, 1\u20138 March 1988"},{"key":"4573_CR5","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/nature07537","volume":"457","author":"M Cella","year":"2008","unstructured":"Cella M et al (2008) A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity. Nature 457:722\u2013725","journal-title":"Nature"},{"key":"4573_CR6","doi-asserted-by":"publisher","first-page":"2638","DOI":"10.1245\/s10434-011-1779-z","volume":"18","author":"K-M Chan","year":"2011","unstructured":"Chan K-M, Yu M-C, Chou H-S, Wu T-J, Lee C-F, Lee W-C (2011) Significance of tumor necrosis for outcome of patients with hepatocellular carcinoma receiving locoregional therapy prior to liver transplantation. Ann Surg Oncol 18:2638\u20132646","journal-title":"Ann Surg Oncol"},{"key":"4573_CR7","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ajpath.2012.08.043","volume":"182","author":"MA Cobleigh","year":"2013","unstructured":"Cobleigh MA, Robek MD (2013) Protective and pathological properties of IL-22 in liver disease: implications for viral hepatitis. Am J Pathol 182:21\u201328","journal-title":"Am J Pathol"},{"key":"4573_CR8","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.cca.2008.05.010","volume":"395","author":"EN Debruyne","year":"2008","unstructured":"Debruyne EN, Delanghe JR (2008) Diagnosing and monitoring hepatocellular carcinoma with alpha-fetoprotein: new aspects and applications. Clin Chim Acta 395:19\u201326","journal-title":"Clin Chim Acta"},{"key":"4573_CR9","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.canlet.2005.02.012","volume":"232","author":"G-J Du","year":"2006","unstructured":"Du G-J, Lin H-H, Xu Q-T, Wang M-W (2006) Bcl-2 switches the type of demise from apoptosis to necrosis via cyclooxygenase-2 upregulation in HeLa cell induced by hydrogen peroxide. Cancer Lett 232:179\u2013188","journal-title":"Cancer Lett"},{"key":"4573_CR10","doi-asserted-by":"publisher","first-page":"26377","DOI":"10.1074\/jbc.M109.007955","volume":"284","author":"L Dumoutier","year":"2009","unstructured":"Dumoutier L, de Meester C, Tavernier J, Renauld J-C (2009) New activation modus of STAT3 A tyrosine-less region of the interleukin-22 receptor recruits STAT3 by interacting with its coiled-coil domain. J Biol Chem 284:26377\u201326384","journal-title":"J Biol Chem"},{"key":"4573_CR11","doi-asserted-by":"publisher","first-page":"1814","DOI":"10.4049\/jimmunol.164.4.1814","volume":"164","author":"L Dumoutier","year":"2000","unstructured":"Dumoutier L, Louahed J, Renauld J-C (2000) Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9. J Immunol 164:1814\u20131819","journal-title":"J Immunol"},{"key":"4573_CR12","doi-asserted-by":"publisher","first-page":"817","DOI":"10.7326\/0003-4819-139-10-200311180-00009","volume":"139","author":"HB El-Serag","year":"2003","unstructured":"El-Serag HB, Davila JA, Petersen NJ, McGlynn KA (2003) The continuing increase in the incidence of hepatocellular carcinoma in the United States: an update. Ann Intern Med 139:817\u2013823","journal-title":"Ann Intern Med"},{"key":"4573_CR13","doi-asserted-by":"publisher","first-page":"2557","DOI":"10.1053\/j.gastro.2007.04.061","volume":"132","author":"HB El-Serag","year":"2007","unstructured":"El-Serag HB, Rudolph KL (2007) Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 132:2557\u20132576","journal-title":"Gastroenterology"},{"key":"4573_CR14","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1046\/j.1440-1746.2003.02989.x","volume":"18","author":"GC Farrell","year":"2003","unstructured":"Farrell GC (2003) Non-alcoholic steatohepatitis: what is it, and why is it important in the Asia\u2013Pacific region? J Gastroenterol Hepatol 18:124\u2013138","journal-title":"J Gastroenterol Hepatol"},{"key":"4573_CR15","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1053\/j.gastro.2012.03.044","volume":"143","author":"D Feng","year":"2012","unstructured":"Feng D et al (2012) Interleukin-22 promotes proliferation of liver stem\/progenitor cells in mice and patients with chronic hepatitis B virus infection. Gastroenterology 143:188\u2013198.e187","journal-title":"Gastroenterology"},{"key":"4573_CR16","doi-asserted-by":"publisher","first-page":"E359","DOI":"10.1002\/ijc.29210","volume":"136","author":"J Ferlay","year":"2015","unstructured":"Ferlay J et al (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136:E359\u2013E386","journal-title":"Int J Cancer"},{"key":"4573_CR17","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/s10620-011-1997-z","volume":"57","author":"RG Foster","year":"2012","unstructured":"Foster RG, Golden-Mason L, Rutebemberwa A, Rosen HR (2012) Interleukin (IL)-17\/IL-22-producing T cells enriched within the liver of patients with chronic hepatitis C viral (HCV) infection. Dig Dis Sci 57:381\u2013389","journal-title":"Dig Dis Sci"},{"key":"4573_CR18","doi-asserted-by":"publisher","first-page":"21795","DOI":"10.1073\/pnas.0911472106","volume":"106","author":"H Fujita","year":"2009","unstructured":"Fujita H, Nograles KE, Kikuchi T, Gonzalez J, Carucci JA, Krueger JG (2009) Human Langerhans cells induce distinct IL-22-producing CD4\u2009+\u2009T cells lacking IL-17 production. Proc Natl Acad Sci 106:21795\u201321800","journal-title":"Proc Natl Acad Sci"},{"key":"4573_CR19","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1111\/j.1478-3231.2007.01518.x","volume":"27","author":"BJ Hennig","year":"2007","unstructured":"Hennig BJ et al (2007) Influence of IL-10RA and IL-22 polymorphisms on outcome of hepatitis C virus infection. Liver Int 27:1134\u20131143","journal-title":"Liver Int"},{"key":"4573_CR20","doi-asserted-by":"publisher","first-page":"4628","DOI":"10.1093\/emboj\/16.15.4628","volume":"16","author":"DC Huang","year":"1997","unstructured":"Huang DC, O\u2019Reilly LA, Strasser A, Cory S (1997) The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry. EMBO J 16:4628\u20134638","journal-title":"EMBO J"},{"key":"4573_CR21","first-page":"359","volume":"41","author":"S Imaoka","year":"1994","unstructured":"Imaoka S et al (1994) Necrosis of hepatocellular carcinoma caused by spontaneously arising arterial thrombus. Hepato-gastroenterology 41:359\u2013362","journal-title":"Hepato-gastroenterology"},{"key":"4573_CR22","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1002\/hep.24486","volume":"54","author":"R Jiang","year":"2011","unstructured":"Jiang R et al (2011) Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3. Hepatology 54:900\u2013909","journal-title":"Hepatology"},{"key":"4573_CR23","doi-asserted-by":"publisher","first-page":"3554","DOI":"10.4161\/cc.10.20.17856","volume":"10","author":"S Knoll","year":"2011","unstructured":"Knoll S, F\u00fcrst K, Thomas S, Villanueva Baselga S, Stoll A, Schaefer S, P\u00fctzer BM (2011) Dissection of cell context-dependent interactions between HBx and p53 family members in regulation of apoptosis: a role for HBV-induced. HCC Cell Cycle 10:3554\u20133565","journal-title":"HCC Cell Cycle"},{"key":"4573_CR24","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1002\/hep.25744","volume":"56","author":"X Kong","year":"2012","unstructured":"Kong X, Feng D, Wang H, Hong F, Bertola A, Wang FS, Gao B (2012) Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice. Hepatology 56:1150\u20131159","journal-title":"Hepatology"},{"key":"4573_CR25","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/1741-7015-10-102","volume":"10","author":"B Kronenberger","year":"2012","unstructured":"Kronenberger B et al (2012) Interleukin-22 predicts severity and death in advanced liver cirrhosis: a prospective cohort study. BMC Med 10:102","journal-title":"BMC Med"},{"key":"4573_CR26","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1084\/jem.20061308","volume":"203","author":"SC Liang","year":"2006","unstructured":"Liang SC, Tan X-Y, Luxenberg DP, Karim R, Dunussi-Joannopoulos K, Collins M, Fouser LA (2006) Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med 203:2271\u20132279","journal-title":"J Exp Med"},{"key":"4573_CR27","first-page":"434","volume":"7","author":"J Ludwig","year":"1980","unstructured":"Ludwig J, Viggiano TR, Mcgill DB, Oh B (1980) Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc 7:434\u2013438","journal-title":"Mayo Clin Proc"},{"key":"4573_CR28","volume-title":"Food, nutrition, physical activity, and the prevention of cancer: a global perspective","author":"M Marmot","year":"2007","unstructured":"Marmot M et al (2007) Food, nutrition, physical activity, and the prevention of cancer: a global perspective. American Institute for Cancer Research, Washington, DC"},{"key":"4573_CR29","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.1084\/jem.183.5.2219","volume":"183","author":"S Mazel","year":"1996","unstructured":"Mazel S, Burtrum D, Petrie HT (1996) Regulation of cell division cycle progression by bcl-2 expression: a potential mechanism for inhibition of programmed cell death. J Exp Med 183:2219\u20132226","journal-title":"J Exp Med"},{"key":"4573_CR30","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/705294<\/bib>","author":"J Michels","year":"2013","unstructured":"Michels J, Kepp O, Senovilla L, Lissa D, Castedo M, Kroemer G, Galluzzi L (2013) Functions of BCL-X L at the interface between cell death and metabolism. Int J Cell Biol. \n                    https:\/\/doi.org\/10.1155\/2013\/705294","journal-title":"Int J Cell Biol"},{"key":"4573_CR31","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/j.1749-6632.2002.tb04090.x","volume":"963","author":"G Montalto","year":"2002","unstructured":"Montalto G, Cervello M, Giannitrapani L, Dantona F, Terranova A, Castagnetta LA (2002) Epidemiology, risk factors, and natural history of hepatocellular carcinoma. Ann N Y Acad Sci 963:13\u201320","journal-title":"Ann N Y Acad Sci"},{"key":"4573_CR32","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.intimp.2004.01.008","volume":"4","author":"ML Nagalakshmi","year":"2004","unstructured":"Nagalakshmi ML, Rascle A, Zurawski S, Menon S, de Waal Malefyt R (2004) Interleukin-22 activates STAT3 and induces IL-10 by colon epithelial cells. Int Immunopharmacol 4:679\u2013691","journal-title":"Int Immunopharmacol"},{"key":"4573_CR33","first-page":"43","volume":"1","author":"H Pan","year":"2004","unstructured":"Pan H, Hong F, Radaeva S, Gao B (2004) Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3. Cell Mol Immunol 1:43\u201349","journal-title":"Cell Mol Immunol"},{"key":"4573_CR34","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1002\/hep.24339","volume":"54","author":"O Park","year":"2011","unstructured":"Park O et al (2011) In vivo consequences of liver-specific interleukin-22 expression in mice: implications for human liver disease progression. Hepatology 54:252\u2013261","journal-title":"Hepatology"},{"key":"4573_CR35","first-page":"74","volume":"55","author":"DM Parkin","year":"2005","unstructured":"Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002. CA: Cancer J Clin 55:74\u2013108","journal-title":"CA: Cancer J Clin"},{"key":"4573_CR36","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1016\/S0002-9440(10)61101-7","volume":"160","author":"RH Pierce","year":"2002","unstructured":"Pierce RH, Vail ME, Ralph L, Campbell JS, Fausto N (2002) Bcl-2 expression inhibits liver carcinogenesis and delays the development of proliferating foci. Am J Pathol 160:1555\u20131560","journal-title":"Am J Pathol"},{"key":"4573_CR37","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/S1470-2045(09)70241-4","volume":"10","author":"D Poon","year":"2009","unstructured":"Poon D et al (2009) Management of hepatocellular carcinoma in Asia: consensus statement from the Asian Oncology Summit 2009. Lancet Oncol 10:1111\u20131118","journal-title":"Lancet Oncol"},{"key":"4573_CR38","first-page":"135","volume":"26","author":"S Qin","year":"2014","unstructured":"Qin S, Ma S, Huang X, Lu D, Zhou Y, Jiang H (2014) Th22 cells are associated with hepatocellular carcinoma development and progression. Chin J Cancer Res 26:135","journal-title":"Chin J Cancer Res"},{"key":"4573_CR39","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1002\/hep.20184","volume":"39","author":"S Radaeva","year":"2004","unstructured":"Radaeva S, Sun R, Pan H, Hong F, Gao B (2004) Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology 39:1332\u20131342","journal-title":"Hepatology"},{"key":"4573_CR40","doi-asserted-by":"publisher","first-page":"G74","DOI":"10.1152\/ajpgi.00075.2009","volume":"298","author":"X Ren","year":"2010","unstructured":"Ren X, Hu B, Colletti LM (2010) IL-22 is involved in liver regeneration after hepatectomy. Am J Physiol-Gastrointest Liver Physiol 298:G74\u2013G80","journal-title":"Am J Physiol-Gastrointest Liver Physiol"},{"key":"4573_CR41","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.coph.2009.04.008","volume":"9","author":"S Sanjabi","year":"2009","unstructured":"Sanjabi S, Zenewicz LA, Kamanaka M, Flavell RA (2009) Anti-inflammatory and pro-inflammatory roles of TGF-\u03b2, IL-10, and IL-22 in immunity and autoimmunity. Curr Opin Pharmacol 9:447\u2013453","journal-title":"Curr Opin Pharmacol"},{"key":"4573_CR42","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1634\/theoncologist.2010-S4-14","volume":"15","author":"AJ Sanyal","year":"2010","unstructured":"Sanyal AJ, Yoon SK, Lencioni R (2010) The etiology of hepatocellular carcinoma and consequences for treatment. Oncologist 15:14\u201322","journal-title":"Oncologist"},{"key":"4573_CR43","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1038\/ncb1192","volume":"6","author":"S Shimizu","year":"2004","unstructured":"Shimizu S, Kanaseki T, Mizushima N, Mizuta T, Arakawa-Kobayashi S, Thompson CB, Tsujimoto Y (2004) Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol 6:1221\u20131228","journal-title":"Nat Cell Biol"},{"key":"4573_CR44","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/ng0802-339","volume":"31","author":"SS Thorgeirsson","year":"2002","unstructured":"Thorgeirsson SS, Grisham JW (2002) Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet 31:339\u2013346","journal-title":"Nat Genet"},{"key":"4573_CR45","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1097\/01.MP.0000097367.56816.5E","volume":"16","author":"AC Tsamandas","year":"2003","unstructured":"Tsamandas AC et al (2003) Potential role of bcl-2 and bax mRNA and protein expression in chronic hepatitis type B and C: a clinicopathologic study. Mod Pathol 16:1273\u20131288","journal-title":"Mod Pathol"},{"key":"4573_CR46","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1007\/s00535-008-2251-0","volume":"44","author":"T Umemura","year":"2009","unstructured":"Umemura T, Ichijo T, Yoshizawa K, Tanaka E, Kiyosawa K (2009) Epidemiology of hepatocellular carcinoma in Japan. J Gastroenterol 44:102\u2013107","journal-title":"J Gastroenterol"},{"key":"4573_CR47","first-page":"594","volume":"61","author":"ME Vail","year":"2001","unstructured":"Vail ME, Pierce RH, Fausto N (2001) Bcl-2 delays and alters hepatic carcinogenesis induced by transforming growth factor \u03b1. Cancer Res 61:594\u2013601","journal-title":"Cancer Res"},{"key":"4573_CR48","first-page":"515","volume":"21","author":"J Watanabe","year":"2002","unstructured":"Watanabe J, Kushihata F, Honda K, Mominoki K, Matsuda S, Kobayashi N (2002) Bcl-xL overexpression in human hepatocellular carcinoma. Int J Oncol 21:515\u2013519","journal-title":"Int J Oncol"},{"key":"4573_CR49","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.amjmed.2008.03.005","volume":"121","author":"R Wong","year":"2008","unstructured":"Wong R, Corley DA (2008) Racial and ethnic variations in hepatocellular carcinoma incidence within the United States The American. J Med 121:525\u2013531","journal-title":"J Med"},{"key":"4573_CR50","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1038\/icb.2011.79","volume":"90","author":"X Xiang","year":"2012","unstructured":"Xiang X, Gui H, King NJ, Cole L, Wang H, Xie Q, Bao S (2012) IL-22 and non-ELR-CXC chemokine expression in chronic hepatitis B virus-infected liver. Immunol Cell Biol 90:611\u2013619","journal-title":"Immunol Cell Biol"},{"key":"4573_CR51","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/nrgastro.2010.100","volume":"7","author":"JD Yang","year":"2010","unstructured":"Yang JD, Roberts LR (2010) Hepatocellular carcinoma: a global view. Nat Rev Gastroenterol Hepatol 7:448\u2013458","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"4573_CR52","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1038\/nri2093","volume":"7","author":"A Yoshimura","year":"2007","unstructured":"Yoshimura A, Naka T, Kubo M (2007) SOCS proteins, cytokine signalling and immune regulation. Nat Rev Immunol 7:454\u2013465","journal-title":"Nat Rev Immunol"},{"key":"4573_CR53","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1111\/j.1440-1746.2009.05784.x","volume":"24","author":"MF Yuen","year":"2009","unstructured":"Yuen MF, Hou JL, Chutaputti A (2009) Hepatocellular carcinoma in the Asia pacific region. J Gastroenterol Hepatol 24:346\u2013353","journal-title":"J Gastroenterol Hepatol"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-018-04573-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11033-018-04573-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-018-04573-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T19:40:45Z","timestamp":1577907645000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11033-018-04573-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,2]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["4573"],"URL":"https:\/\/doi.org\/10.1007\/s11033-018-04573-x","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"type":"print","value":"0301-4851"},{"type":"electronic","value":"1573-4978"}],"subject":[],"published":{"date-parts":[[2019,1,2]]},"assertion":[{"value":"11 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}