{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:28:35Z","timestamp":1764174515150},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T00:00:00Z","timestamp":1527724800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s11033-018-4201-0","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T06:24:42Z","timestamp":1527747882000},"page":"621-624","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prevalence of factor V leiden, MTHFR C677T and MTHFR A1298C polymorphisms in patients with deep vein thrombosis in Central Iran"],"prefix":"10.1007","volume":"45","author":[{"given":"Majid","family":"Ehsani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Imani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Moravveji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,5,31]]},"reference":[{"issue":"1","key":"4201_CR1","first-page":"153","volume":"55","author":"TR Pop","year":"2014","unstructured":"Pop TR, Vesa \u015eC, Trifa AP, Cri\u015fan S, Buzoianu AD (2014) PAI-1 4G\/5G and MTHFR C677T polymorphisms increased the accuracy of two prediction scores for the risk of acute lower extremity deep vein thrombosis. Rom J Morphol Embryol 55(1):153\u2013157","journal-title":"Rom J Morphol Embryol"},{"issue":"6","key":"4201_CR2","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1001\/archinte.158.6.585","volume":"158","author":"MD Silverstein","year":"1998","unstructured":"Silverstein MD, Heit JA, Mohr DN, Petterson TM, O\u2019fallon WM, Melton LJ (1998) Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern Med 158(6):585\u2013593","journal-title":"Arch Intern Med"},{"issue":"1","key":"4201_CR3","first-page":"27","volume":"14","author":"B Sharif-Kashani","year":"2015","unstructured":"Sharif-Kashani B, Mohebi-Nejad A, Abooturabi SM (2015) Estimated prevalence of venous thromboembolism in Iran: prophylaxis still an unmet challenge. Tanaffos 14(1):27","journal-title":"Tanaffos"},{"issue":"8","key":"4201_CR4","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1038\/nrcardio.2015.83","volume":"12","author":"JA Heit","year":"2015","unstructured":"Heit JA (2015) Epidemiology of venous thromboembolism. Nat Rev Cardiol 12(8):464\u2013474","journal-title":"Nat Rev Cardiol"},{"issue":"2","key":"4201_CR5","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1160\/TH09-01-0013","volume":"102","author":"R Gohil","year":"2009","unstructured":"Gohil R, Peck G, Sharma P (2009) The genetics of venous thromboembolism A meta-analysis involving ~ 120,000 cases and 180,000 controls. Thrombosis haemostasis 102(2):360\u2013370","journal-title":"Thrombosis haemostasis"},{"issue":"9","key":"4201_CR6","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1093\/oxfordjournals.aje.a010290","volume":"151","author":"LD Botto","year":"2000","unstructured":"Botto LD, Yang Q (2000) 5, 10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol 151(9):862\u2013877","journal-title":"Am J Epidemiol"},{"issue":"1","key":"4201_CR7","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1089\/gte.2007.0064","volume":"12","author":"AS Sabbagh","year":"2008","unstructured":"Sabbagh AS, Mahfoud Z, Taher A, Zaatari G, Daher R, Mahfouz RA (2008) High prevalence of MTHFR gene A1298C polymorphism in Lebanon. Genet Test 12(1):75\u201380","journal-title":"Genet Test"},{"issue":"4","key":"4201_CR8","doi-asserted-by":"publisher","first-page":"5025","DOI":"10.1007\/s11033-011-1299-8","volume":"39","author":"KN Saraswathy","year":"2012","unstructured":"Saraswathy KN, Asghar M, Samtani R, Murry B, Mondal PR, Ghosh PK, Sachdeva MP (2012) Spectrum of MTHFR gene SNPs C677T and A1298C: a study among 23 population groups of India. Mol Biol Rep 39(4):5025\u20135031","journal-title":"Mol Biol Rep"},{"issue":"5","key":"4201_CR9","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1097\/MBC.0b013e328330e69a","volume":"21","author":"Z Rahimi","year":"2010","unstructured":"Rahimi Z, Mozafari H, Shahriari-Ahmadi A, Alimogaddam K, Ghavamzadeh A, Aznab M, Mansouri K, Rezaei M, Parsian A (2010) Deep venous thrombosis and thrombophilic mutations in western Iran: association with factor V Leiden. Blood Coagul Fibrinolysis 21(5):385\u2013388","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"23","key":"4201_CR10","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1056\/NEJM199412083312305","volume":"331","author":"JS Greengard","year":"1994","unstructured":"Greengard JS, Eichinger S, Griffin JH, Bauer KA (1994) Variability of thrombosis among homozygous siblings with resistance to activated protein C due to an Arg-to-Gln mutation in the gene for factor V. N Engl J Med 331(23):1559\u20131562","journal-title":"N Engl J Med"},{"issue":"5","key":"4201_CR11","first-page":"1219","volume":"31","author":"A Saeed","year":"2015","unstructured":"Saeed A, Sumreen M, Kashif MA (2015) To determine the frequency of Factor V Leiden in cases of Deep Vein Thrombosis and Healthy controls. Pak J Med Sci 31(5):1219","journal-title":"Pak J Med Sci"},{"issue":"4","key":"4201_CR12","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1177\/1076029607303341","volume":"13","author":"B D\u00f6lek","year":"2007","unstructured":"D\u00f6lek B, Eraslan S, Ero\u011flu S, Kesim BE, Ulutin T, Yal\u00e7\u0131ner A, Laleli YR, G\u00f6z\u00fckirm\u0131z\u0131 N (2007) Molecular analysis of factor V Leiden, factor V Hong Kong, factor II G20210A, methylenetetrahydrofolate reductase C677T, and A1298C mutations related to Turkish thrombosis patients. Clin Appl Thromb\/Hemost 13(4):435\u2013438","journal-title":"Clin Appl Thromb\/Hemost"},{"issue":"8","key":"4201_CR13","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1007\/s10654-013-9825-8","volume":"28","author":"B Simone","year":"2013","unstructured":"Simone B, De Stefano V, Leoncini E, Zacho J, Martinelli I, Emmerich J, Rossi E, Folsom AR, Almawi WY, Scarabin PY, Den Heijer M (2013) Risk of venous thromboembolism associated with single and combined effects of Factor V Leiden, Prothrombin 20210A and Methylenetethraydrofolate reductase C677T: a meta-analysis involving over 11,000 cases and 21,000 controls. Eur J Epidemiol 28(8):621\u2013647","journal-title":"Eur J Epidemiol"},{"issue":"4","key":"4201_CR14","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/S0049-3848(03)00179-8","volume":"109","author":"E Ramacciotti","year":"2003","unstructured":"Ramacciotti E, Wolosker N, Puech-Leao P, Zeratti EA, Gusson PR, del Giglio A, Franco RF (2003) Prevalence of factor V Leiden, FII G20210A, FXIII Val34Leu and MTHFR C677T polymorphisms in cancer patients with and without venous thrombosis. Thromb Res 109(4):171\u2013174","journal-title":"Thromb Res"},{"issue":"1","key":"4201_CR15","doi-asserted-by":"publisher","first-page":"17","DOI":"10.2169\/internalmedicine.50.4144","volume":"50","author":"E Tug","year":"2011","unstructured":"Tug E, Aydin H, Kaplan E, Dogruer D (2011) Frequency of genetic mutations associated with thromboembolism in the Western Black Sea Region. Intern Med 50(1):17\u201321","journal-title":"Intern Med"},{"issue":"2","key":"4201_CR16","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1097\/MBC.0b013e3280108e01","volume":"18","author":"SM Naushad","year":"2007","unstructured":"Naushad SM, Jamal MN, Angalena R, Prasad CK, Devi AR (2007) Hyperhomocysteinemia and the compound heterozygous state for methylene tetrahydrofolate reductase are independent risk factors for deep vein thrombosis among South Indians. Blood Coagul Fibrinolysis 18(2):113\u2013117","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"6","key":"4201_CR17","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1089\/gtmb.2009.0063","volume":"13","author":"R Mukhopadhyay","year":"2009","unstructured":"Mukhopadhyay R, Saraswathy KN, Ghosh PK (2009) MTHFR C677T and factor V Leiden in recurrent pregnancy loss: a study among an endogamous group in North India. Genetic Test Mol Biomark 13(6):861\u2013865","journal-title":"Genetic Test Mol Biomark"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11033-018-4201-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-018-4201-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-018-4201-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T21:44:23Z","timestamp":1559252663000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11033-018-4201-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,31]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["4201"],"URL":"https:\/\/doi.org\/10.1007\/s11033-018-4201-0","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,31]]},"assertion":[{"value":"18 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}