{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T10:20:03Z","timestamp":1794565203978,"version":"4.9.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2018,7,28]],"date-time":"2018-07-28T00:00:00Z","timestamp":1532736000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s11033-018-4268-7","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T04:09:06Z","timestamp":1559707746000},"page":"1565-1568","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["IL-17 blood levels increase in healthy pregnancy but not in spontaneous abortion"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2731-0653","authenticated-orcid":false,"given":"Val\u00e9ria de Lima","family":"Kaminski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1040-2738","authenticated-orcid":false,"given":"Joel Henrique","family":"Ellwanger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3367-1789","authenticated-orcid":false,"given":"Maria Cristina Cotta","family":"Matte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2779-5443","authenticated-orcid":false,"given":"Ricardo Francalacci","family":"Savaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9306-3291","authenticated-orcid":false,"given":"Priscila","family":"Vianna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7025-0660","authenticated-orcid":false,"given":"Jos\u00e9 Artur Bogo","family":"Chies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,7,28]]},"reference":[{"key":"4268_CR1","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/172603a0","volume":"172","author":"RE Billingham","year":"1953","unstructured":"Billingham RE, Brent L, Medawar PB (1953) \u2018Actively acquired tolerance\u2019 of foreign cells. Nature 172:603\u2013606. \n                    https:\/\/doi.org\/10.1038\/172603a0","journal-title":"Nature"},{"key":"4268_CR2","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1111\/j.1749-6632.2010.05938.x","volume":"1221","author":"G Mor","year":"2011","unstructured":"Mor G, Cardenas I, Abrahams V, Guller S (2011) Inflammation and pregnancy: the role of the immune system at the implantation site. Ann NY Acad Sci 1221:80\u201387. \n                    https:\/\/doi.org\/10.1111\/j.1749-6632.2010.05938.x","journal-title":"Ann NY Acad Sci"},{"issue":"1\u20132","key":"4268_CR3","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/S0165-0378(01)00119-X","volume":"53","author":"G Chaouat","year":"2002","unstructured":"Chaouat G, Zourbas S, Ostojic S, Lappree-Delage G, Dubanchet S, Ledee N, Martal J (2002) A brief review of recent data on some cytokine expressions at the materno-foetal interface which might challenge the classical Th1\/Th2 dichotomy. J Reprod Immunol 53(1\u20132):241\u2013256. \n                    https:\/\/doi.org\/10.1016\/S0165-0378(01)00119-X","journal-title":"J Reprod Immunol"},{"issue":"7","key":"4268_CR4","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/0167-5699(93)90235-D","volume":"14","author":"TG Wegmann","year":"1993","unstructured":"Wegmann TG, Lin H, Guilbert L, Mosmann TR (1993) Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? Immunol Today 14(7):353\u2013356. \n                    https:\/\/doi.org\/10.1016\/0167-5699(93)90235-D","journal-title":"Immunol Today"},{"key":"4268_CR5","doi-asserted-by":"publisher","first-page":"253","DOI":"10.3389\/fimmu.2014.00253","volume":"5","author":"P Chatterjee","year":"2014","unstructured":"Chatterjee P, Chiasson VL, Bounds KR, Mitchell BM (2014) Regulation of the anti-inflammatory cytokines interleukin-4 and interleukin-10 during pregnancy. Front Immunol 5:253. \n                    https:\/\/doi.org\/10.3389\/fimmu.2014.00253","journal-title":"Front Immunol"},{"issue":"5","key":"4268_CR6","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1007\/s00018-003-3228-z","volume":"61","author":"J Witowski","year":"2004","unstructured":"Witowski J, Ksi\u0105\u017cek K, J\u00f6rres A (2004) Interleukin-17: a mediator of inflammatory responses. Cell Mol Life Sci 61(5):567\u2013579. \n                    https:\/\/doi.org\/10.1007\/s00018-003-3228-z","journal-title":"Cell Mol Life Sci"},{"issue":"6","key":"4268_CR7","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1038\/cmi.2014.54","volume":"11","author":"B Fu","year":"2014","unstructured":"Fu B, Tian Z, Wei H (2014) TH17 cells in human recurrent pregnancy loss and pre-eclampsia. Cell Mol Immunol 11(6):564\u2013570. \n                    https:\/\/doi.org\/10.1038\/cmi.2014.54","journal-title":"Cell Mol Immunol"},{"key":"4268_CR8","doi-asserted-by":"publisher","first-page":"4137","DOI":"10.4049\/jimmunol.167.8.4137","volume":"167","author":"T Starnes","year":"2001","unstructured":"Starnes T, Robertson MJ, Sledge G, Kelich S, Nakshatri H, Broxmeyer HE, Hromas R (2001) Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production. J Immunol 167:4137\u20134140. \n                    https:\/\/doi.org\/10.4049\/jimmunol.167.8.4137","journal-title":"J Immunol"},{"key":"4268_CR9","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.4049\/jimmunol.170.4.2106","volume":"170","author":"S Ferretti","year":"2003","unstructured":"Ferretti S, Bonneau O, Dubois GR, Jones CE, Trifilieff A (2003) IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger. J Immunol 170:2106\u20132112. \n                    https:\/\/doi.org\/10.4049\/jimmunol.170.4.2106","journal-title":"J Immunol"},{"issue":"7","key":"4268_CR10","doi-asserted-by":"publisher","first-page":"2620","DOI":"10.1182\/blood-2002-05-1461","volume":"101","author":"M Numasaki","year":"2003","unstructured":"Numasaki M, Fukushi J, Ono M, Narula SK, Zavodny PJ, Kudo T, Robbins PD, Tahara H, Lotze MT (2003) Interleukin-17 promotes angiogenesis and tumor growth. Blood 101(7):2620\u20132627. \n                    https:\/\/doi.org\/10.1182\/blood-2002-05-1461","journal-title":"Blood"},{"issue":"3","key":"4268_CR11","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1038\/cmi.2013.67","volume":"11","author":"HX Wu","year":"2014","unstructured":"Wu HX, Jin LP, Xu B, Liang SS, Li DJ (2014) Decidual stromal cells recruit Th17 cells into decidua to promote proliferation and invasion of human trophoblast cells by secreting IL-17. Cell Mol Immunol 11(3):253\u2013262. \n                    https:\/\/doi.org\/10.1038\/cmi.2013.67","journal-title":"Cell Mol Immunol"},{"issue":"9","key":"4268_CR12","doi-asserted-by":"publisher","first-page":"e0163252","DOI":"10.1371\/journal.pone.0163252","volume":"11","author":"J Cai","year":"2016","unstructured":"Cai J, Li M, Huang Q, Fu X, Wu H (2016) Differences in cytokine expression and STAT3 activation between healthy controls and patients of unexplained recurrent spontaneous abortion (URSA) during early pregnancy. PLoS ONE 11(9):e0163252. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0163252","journal-title":"PLoS ONE"},{"key":"4268_CR13","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.jri.2016.03.001","volume":"116","author":"S Hosseini","year":"2016","unstructured":"Hosseini S, Shokri F, Ansari Pour S, Jeddi-Tehrani M, Nikoo S, Yousefi M, Zarnani AH (2016) A shift in the balance of T17 and Treg cells in menstrual blood of women with unexplained recurrent spontaneous abortion. J Reprod Immunol 116:13\u201322. \n                    https:\/\/doi.org\/10.1016\/j.jri.2016.03.001","journal-title":"J Reprod Immunol"},{"issue":"4","key":"4268_CR14","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1097\/MOT.0b013e32833b9bfb","volume":"15","author":"S Heidt","year":"2010","unstructured":"Heidt S, Segundo DS, Chadha R, Wood KJ (2010) The impact of Th17 cells on transplant rejection and the induction of tolerance. Curr Opin Organ Transplant 15(4):456\u2013461. \n                    https:\/\/doi.org\/10.1097\/MOT.0b013e32833b9bfb","journal-title":"Curr Opin Organ Transplant"},{"issue":"3","key":"4268_CR15","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1093\/humrep\/15.3.713","volume":"15","author":"R Raghupathy","year":"2000","unstructured":"Raghupathy R, Makhseed M, Azizieh F, Omu A, Gupta M, Farhat R (2000) Cytokine production by maternal lymphocytes during normal human pregnancy and in unexplained recurrent spontaneous abortion. Hum Reprod 15(3):713\u2013718","journal-title":"Hum Reprod"},{"issue":"3","key":"4268_CR16","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1111\/j.1600-0897.2011.00987.x","volume":"66","author":"G Toldi","year":"2011","unstructured":"Toldi G, Rig\u00f3 J Jr, Stenczer B, V\u00e1s\u00e1rhelyi B, Molvarec A (2011) Increased prevalence of IL-17-producing peripheral blood lymphocytes in pre-eclampsia. Am J Reprod Immunol 66(3):223\u2013229. \n                    https:\/\/doi.org\/10.1111\/j.1600-0897.2011.00987.x","journal-title":"Am J Reprod Immunol"},{"issue":"2","key":"4268_CR17","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/j.1600-0897.2010.00893.x","volume":"65","author":"EA Mart\u00ednez-Garc\u00eda","year":"2011","unstructured":"Mart\u00ednez-Garc\u00eda EA, Ch\u00e1vez-Robles B, S\u00e1nchez-Hern\u00e1ndez PE, N\u00fa\u00f1ez-Atahualpa L, Mart\u00edn-M\u00e1quez BT, Mu\u00f1oz-G\u00f3mez A, Gonz\u00e1lez-L\u00f3pez L, G\u00e1mez-Nava JI, Salazar-P\u00e1ramo M, D\u00e1valos-Rodr\u00edguez I, Petri MH, Z\u00fa\u00f1iga-Tamayo D, Vargas-Ram\u00edrez R, V\u00e1zquez-Del Mercado M (2011) IL-17 increased in the third trimester in healthy women with term labor. Am J Reprod Immunol 65(2):99\u2013103. \n                    https:\/\/doi.org\/10.1111\/j.1600-0897.2010.00893.x","journal-title":"Am J Reprod Immunol"},{"issue":"5","key":"4268_CR18","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1089\/jir.2013.0062","volume":"34","author":"HY Liu","year":"2014","unstructured":"Liu HY, Liu ZK, Chao H, Li Z, Song Z, Yang Y, Peng JP (2014) High-dose interferon-\u03b3 promotes abortion in mice by suppressing Treg and Th17 polarization. J Interferon Cytokine Res 34(5):394\u2013403. \n                    https:\/\/doi.org\/10.1089\/jir.2013.0062","journal-title":"J Interferon Cytokine Res"},{"issue":"1","key":"4268_CR19","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/nm.3432","volume":"20","author":"N Komatsu","year":"2014","unstructured":"Komatsu N, Okamoto K, Sawa S, Nakashima T, Oh-hora M, Kodama T, Tanaka S, Bluestone JA, Takayanagi H (2014) Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis. Nat Med 20(1):62\u201368. \n                    https:\/\/doi.org\/10.1038\/nm.3432","journal-title":"Nat Med"},{"issue":"1","key":"4268_CR20","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/imm.12595","volume":"148","author":"AS Figueiredo","year":"2016","unstructured":"Figueiredo AS, Schumacher A (2016) The T helper type 17\/regulatory T cell paradigm in pregnancy. Immunology 148(1):13\u201321. \n                    https:\/\/doi.org\/10.1111\/imm.12595","journal-title":"Immunology"},{"issue":"3","key":"4268_CR21","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1111\/cei.12691","volume":"182","author":"SM Bellemore","year":"2015","unstructured":"Bellemore SM, Nikoopour E, Schwartz JA, Krougly O, Lee-Chan E, Singh B (2015) Preventative role of interleukin-17 producing regulatory T helper type 17 (Treg 17) cells in type 1 diabetes in non-obese diabetic mice. Clin Exp Immunol 182(3):261\u2013269. \n                    https:\/\/doi.org\/10.1111\/cei.12691","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"4268_CR22","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.placenta.2006.01.016","volume":"28","author":"S Pongcharoen","year":"2007","unstructured":"Pongcharoen S, Somran J, Sritippayawan S, Niumsup P, Chanchan P, Butkhamchot P, Tatiwat P, Kunngurn S, Searle RF (2007) Interleukin-17 expression in the human placenta. Placenta 28(1):59\u201363. \n                    https:\/\/doi.org\/10.1016\/j.placenta.2006.01.016","journal-title":"Placenta"},{"key":"4268_CR23","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.gde.2017.08.004","volume":"47","author":"AR Chavan","year":"2017","unstructured":"Chavan AR, Griffith OW, Wagner GP (2017) The inflammation paradox in the evolution of mammalian pregnancy: turning a foe into a friend. Curr Opin Genet Dev 47:24\u201332. \n                    https:\/\/doi.org\/10.1016\/j.gde.2017.08.004","journal-title":"Curr Opin Genet Dev"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-018-4268-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11033-018-4268-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-018-4268-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T05:33:18Z","timestamp":1569389598000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11033-018-4268-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,28]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["4268"],"URL":"https:\/\/doi.org\/10.1007\/s11033-018-4268-7","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,28]]},"assertion":[{"value":"21 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the research ethics committees of HCPA and Universidade Federal do Rio Grande do Sul under the register CAAE: 11390313.7.0000.5347 and all participants signed an informed consent form.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}