{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:32:30Z","timestamp":1740123150975,"version":"3.37.3"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:00:00Z","timestamp":1539043200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1007\/s11033-018-4372-8","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T03:26:15Z","timestamp":1539055575000},"page":"2135-2143","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of matrix metalloproteinase 3 and endogenous inhibitors with inflammatory markers in mitral valve disease and calcification"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8714-4634","authenticated-orcid":false,"given":"Sonia","family":"Aloui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0792-3997","authenticated-orcid":false,"given":"Wiem","family":"Zidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sana","family":"Ouali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9477-8937","authenticated-orcid":false,"given":"Imen","family":"Guizani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameh","family":"Hadj-Taieb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Sami","family":"Mourali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moncef","family":"Feki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5325-6347","authenticated-orcid":false,"given":"Monia","family":"Allal-Elasmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,10,9]]},"reference":[{"key":"4372_CR1","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1006\/clin.1995.1140","volume":"77","author":"N Narin","year":"1995","unstructured":"Narin N, K\u00fct\u00fck\u00e7\u00fcler N, Ozy\u00fcrek R, Bakiler AR, Parlar A, Arcasoy M (1995) Lymphocyte subsets and plasma IL-1 alpha, IL-2 and TNF-alpha concentrations in acute rheumatic fever and chronic rheumatic heart disease. Clin Immunol Immunopathol 77:172\u2013176","journal-title":"Clin Immunol Immunopathol"},{"key":"4372_CR2","first-page":"820","volume":"88","author":"Y Ben Ameur","year":"2010","unstructured":"Ben Ameur Y, Zairi I, Kamoun K, Ben sassi M, Longo S, Battikh K, Slimane ML (2010) Tricuspid dysfunction as a result of rheumatic disease. Tunis Med 88:820\u2013828","journal-title":"Tunis Med"},{"key":"4372_CR3","doi-asserted-by":"publisher","first-page":"e3562","DOI":"10.1097\/MD.0000000000003562","volume":"95","author":"MZ Bilik","year":"2016","unstructured":"Bilik MZ, Kaplan \u0130, Polat N, Akil MA, Aky\u00fcz A, Acet H, Y\u00fcksel M, \u0130nci \u00dc, Kayan F, Toprak N (2016) Serum Levels of IL-17 and IL-23 in patients with rheumatic mitral stenosis. Medicine (Baltimore) 95:e3562","journal-title":"Medicine (Baltimore)"},{"key":"4372_CR4","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s11239-008-0245-7","volume":"28","author":"O Alyan","year":"2009","unstructured":"Alyan O, Metin F, Kacmaz F, Ozdemir O, Maden O, Topaloglu S, Demir AD, Karahan Z, Karadede A, Ilkay E (2009) High levels of high sensitivity C-reactive protein predict the progression of chronic rheumatic mitral stenosis. J Thromb Thrombolysis 28:63\u201369","journal-title":"J Thromb Thrombolysis"},{"key":"4372_CR5","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1016\/S0002-9149(03)00131-0","volume":"91","author":"CJ Chang","year":"2003","unstructured":"Chang CJ, Hsu LA, Chiang CW, Ko YS, See LC, Shen YC, Ko YL, Kou CT, Lee YS, Pang JH (2003) Percutaneous transvenous mitral valvulotomy normalizes elevated circulating levels of tumor necrosis factor-alpha and interleukin-6 in mitral stenosis with heart failure. Am J Cardiol 91:1018\u20131020","journal-title":"Am J Cardiol"},{"key":"4372_CR6","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s00380-009-1175-9","volume":"25","author":"KE Cagli","year":"2010","unstructured":"Cagli KE, Aras D, Topaloglu S, Geyik B, Ayaz S, Cagirci G, Kisacik HL, Korkmaz S (2010) Plasma levels of tumor necrosis factor-alpha and its receptors in patients with mitral stenosis and sinus rhythm undergoing percutaneous balloon valvuloplasty. Heart Vessels 25:131\u2013137","journal-title":"Heart Vessels"},{"key":"4372_CR7","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S1054-8807(00)00043-0","volume":"9","author":"ME Edep","year":"2000","unstructured":"Edep ME, Shirani J, Wolf P, Brown DL (2000) Matrix metalloproteinase expression in nonrheumatic aortic stenosis. Cardiovasc Pathol 9:281\u2013286","journal-title":"Cardiovasc Pathol"},{"key":"4372_CR8","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1002\/path.850","volume":"194","author":"Y Soini","year":"2001","unstructured":"Soini Y, Satta J, Maatta M, Autio-Harmainen H (2001) Expression of MMP-2, MMP-9, MTI-MMP, TIMP-1, and TIMP-2 mRNA in valvular lesions of the heart. J Pathol 194:225\u2013231","journal-title":"J Pathol"},{"key":"4372_CR9","doi-asserted-by":"publisher","first-page":"21491","DOI":"10.1074\/jbc.274.31.21491","volume":"274","author":"H Nagase","year":"1999","unstructured":"Nagase H, Woessner JF (1999) Matrix metalloproteinases. J Biol Chem 274:21491\u201321494","journal-title":"J Biol Chem"},{"key":"4372_CR10","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1093\/eurheartj\/ehi248","volume":"26","author":"O Fondard","year":"2005","unstructured":"Fondard O, Detaint D, Iung B, Choqueux C, Adle-Biassette H, Jarraya M, Hvass U, Couetil JP, Henin D, Michel JB, Vahanian A, Jacob MP (2005) Extracellular matrix remodelling in human aortic valve disease: the role of matrix metalloproteinases and their tissue inhibitors. Eur Heart J 26:1333\u20131341","journal-title":"Eur Heart J"},{"key":"4372_CR11","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1136\/hrt.60.4.299","volume":"60","author":"GT Wilkins","year":"1988","unstructured":"Wilkins GT, Weyman AE, Abascal VM, Block PC, Palacios IF (1988) Percutaneous balloon dilatation of the mitral valve: an analysis of echocardiographic variables related to outcome and the mechanism of dilatation. Br Heart J 60:299\u2013308","journal-title":"Br Heart J"},{"key":"4372_CR12","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1016\/S0002-9149(01)02067-7","volume":"88","author":"E Yetkin","year":"2001","unstructured":"Yetkin E, Erbay AR, Ileri M, Turhan H, Balci M, Cehreli S, Yetkin G, Demirkan D (2001) Levels of circulating adhesion molecules in rheumatic mitral stenosis. Am J Cardiol 88:1209\u20131211","journal-title":"Am J Cardiol"},{"key":"4372_CR13","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1016\/S0002-8703(03)00506-4","volume":"146","author":"RA Krasuski","year":"2003","unstructured":"Krasuski RA, Bush A, Kay JE, Mayes CE Jr, Wang A, Fleming J, Pierce C, Kisslo KB, Harrison JK, Bashore TM (2003) C-reactive protein elevation independently influences the procedural success of percutaneous balloon mitral valve commissurotomy. Am Heart J 146:1099\u20131104","journal-title":"Am Heart J"},{"key":"4372_CR14","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/0002-9149(86)90067-6","volume":"58","author":"MJ Thubrikar","year":"1986","unstructured":"Thubrikar MJ, Aouad J, Nolan SP (1986) Patterns of calcific deposits in operatively excised stenotic or purely regurgitant aortic valves and their relationship to mechanical stress. Am J Cardiol 58:304\u2013308","journal-title":"Am J Cardiol"},{"key":"4372_CR15","doi-asserted-by":"publisher","first-page":"754","DOI":"10.2353\/ajpath.2010.090422","volume":"76","author":"TG Loof","year":"2010","unstructured":"Loof TG, Goldmann O, Gessner A, Herwald H, Medina E (2010) Aberrant inflammatory response to Streptococcus pyogenes in mice lacking myeloid differentiation factor 88. Am J Pathol 76:754\u2013763","journal-title":"Am J Pathol"},{"key":"4372_CR16","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1161\/01.CIR.99.11.1492","volume":"99","author":"MW Irwin","year":"1999","unstructured":"Irwin MW, Mak S, Mann DL, Qu R, Penninger JM, Yan A, Dawood F, Wen WH, Shou Z, Liu P (1999) Tissue expression and immunolocalization of tumor necrosis factor-alpha in postinfarction dysfunctional myocardium. Circulation 99:1492\u20131498","journal-title":"Circulation"},{"key":"4372_CR17","doi-asserted-by":"publisher","first-page":"151","DOI":"10.2147\/JBM.S82423","volume":"6","author":"E Baysal","year":"2015","unstructured":"Baysal E, Burak C, Cay S, Aksu T, Alt\u0131nta\u015f B, Yaylak B, Sev\u00fck U, Bilge \u00d6 (2015) The neutrophil to lymphocyte ratio is associated with severity of rheumatic mitral valve stenosis. J Blood Med 6:151\u2013156","journal-title":"J Blood Med"},{"key":"4372_CR18","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1097\/00005344-199702000-00011","volume":"29","author":"Y Fukumoto","year":"1997","unstructured":"Fukumoto Y, Shimokawa H, Ito A, Kadokami T, Yonemitsu Y, Aikawa M, Owada MK, Egashira K, Sueishi K, Nagai R, Yazaki Y, Takeshita A (1997) Inflammatory cytokines cause coronary arteriosclerosis like changes and alterations in the smooth-muscle phenotypes in pigs. J Cardiovasc Pharmacol 29:222\u2013231","journal-title":"J Cardiovasc Pharmacol"},{"key":"4372_CR19","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1146\/annurev.immunol.021908.132620","volume":"27","author":"E Galkina","year":"2009","unstructured":"Galkina E, Ley K (2009) Immune and inflammatory mechanisms of atherosclerosis. Annu Rev Immunol 27:165\u2013197","journal-title":"Annu Rev Immunol"},{"key":"4372_CR20","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1161\/01.CIR.0000109642.27985.FA","volume":"109","author":"A Diwan","year":"2004","unstructured":"Diwan A, Dibbs Z, Nemoto S, DeFreitas G, Carabello BA, Sivasubramanian N, Wilson EM, Spinale FG, Mann DL (2004) Targeted overexpression of noncleavable and secreted forms of tumor necrosis factor provokes disparate cardiac phenotypes. Circulation 109:262\u2013268","journal-title":"Circulation"},{"key":"4372_CR21","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1042\/bj3150335","volume":"315","author":"RP Fabunmi","year":"1996","unstructured":"Fabunmi RP, Baker AH, Murray EJ, Booth RF, Newby AC (1996) Divergent regulation by growth factors and cytokines of 95 kDa and 72 kDa gelatinases and tissue inhibitors or metalloproteinases-1,-2, and-3 in rabbit aortic smooth muscle cells. Biochem J 315:335\u2013342","journal-title":"Biochem J"},{"key":"4372_CR22","first-page":"875","volume":"11","author":"SA Dreger","year":"2002","unstructured":"Dreger SA, Taylor PM, Allen SP, Yacoub MH (2002) Profile and localization of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in human heart valves. J Heart Valve Dis 11: 875\u2013880","journal-title":"J Heart Valve Dis"},{"key":"4372_CR23","doi-asserted-by":"publisher","first-page":"13453","DOI":"10.1074\/jbc.270.22.13453","volume":"270","author":"ML Corcoran","year":"1995","unstructured":"Corcoran ML, Stetler-Stevenson WG (1995) Tissue inhibitor of metalloproteinase-2 stimulates fibroblast proliferation via a CAMP-dependent mechanism. J Biol Chem 270:13453\u201313459","journal-title":"J Biol Chem"},{"key":"4372_CR24","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3346\/jkms.2008.23.1.41","volume":"23","author":"L Kim","year":"2008","unstructured":"Kim L, Kim DK, Yang WI, Shin DH, Jung IM, Park HK, Chang BC (2008) Overexpression of transforming growth factor-1 in the valvular fibrosis of chronic rheumatic heart disease. J Korean Med Sci 23:41\u201348","journal-title":"J Korean Med Sci"},{"key":"4372_CR25","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1158\/1541-7786.MCR-05-0140","volume":"4","author":"HJ Kwak","year":"2006","unstructured":"Kwak HJ, Park MJ, Cho H, Park CM, Moon SI, Lee HC, Park IC, Kim MS, Rhee CH, Hong SI (2006) Transforming growth factor-beta1 induces tissue inhibitor of metalloproteinase-1 expression via activation of extracellular signal-regulated kinase and Sp1 in human fibrosarcoma cells. Mol Cancer Res 4:209\u2013220","journal-title":"Mol Cancer Res"},{"key":"4372_CR26","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1161\/01.ATV.0000227513.13697.ac","volume":"26","author":"KD O\u2019Brien","year":"2006","unstructured":"O\u2019Brien KD (2006) Pathogenesis of calcific aortic valve disease: a disease process comes of age (and a good deal more). Arterioscler Thromb Vasc Biol 26:1721\u20131728","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"4372_CR27","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1161\/01.RES.0000171451.88616.c2","volume":"96","author":"I Nadra","year":"2005","unstructured":"Nadra I, Mason JC, Philippidis P, Florey O, Smythe CD, McCarthy GM, Landis RC, Haskard DO (2005) Proinflammatory activation of macrophages by basic calcium phosphate crystals via protein kinase C and MAP kinase pathways: a vicious cycle of inflammation and arterial calcification? Circ Res 96:1248\u20131256","journal-title":"Circ Res"},{"key":"4372_CR28","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/978-3-642-59349-9_3","volume":"162","author":"K Almholt","year":"2003","unstructured":"Almholt K, Johnsen M (2003) Stromal cell involvement in cancer. Recent Results Cancer Res 162:31\u201342 24","journal-title":"Recent Results Cancer Res"},{"key":"4372_CR29","first-page":"237","volume":"1","author":"H Nagase","year":"1992","unstructured":"Nagase H, Suzuki K, Morodomi T, Enghild JJ, Salvesen G (1992) Activation mechanisms of the precursors of matrix metalloproteinases 1, 2 and 3. Matrix Suppl 1:237\u2013244","journal-title":"Matrix Suppl"},{"key":"4372_CR30","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.atherosclerosis.2005.11.034","volume":"189","author":"HA Eriksen","year":"2006","unstructured":"Eriksen HA, Satta J, Risteli J, Veijola M, Vare P, Soini Y (2006) Type I and type III collagen synthesis and composition in the valve matrix in aortic valve stenosis. Atherosclerosis 189:91\u201398","journal-title":"Atherosclerosis"},{"key":"4372_CR31","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1016\/S0741-5214(94)70169-5","volume":"20","author":"KM Newman","year":"1994","unstructured":"Newman KM, Jean-Claude J, Li H, Scholes JV, Ogata Y, Nagase H, Tilson MD (1994) Cellular localization of matrix metalloproteinases in the abdominal aortic aneurysm will. J Vaso Surg 20:814\u2013820","journal-title":"J Vaso Surg"},{"key":"4372_CR32","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1056\/NEJMe0807001","volume":"359","author":"CM Otto","year":"2008","unstructured":"Otto CM (2008) Calcific aortic stenosis\u2014time to look more closely at the valve. N Engl J Med 359:1395\u20131398","journal-title":"N Engl J Med"},{"key":"4372_CR33","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/1471-2202-6-68","volume":"29","author":"C Ogier","year":"2005","unstructured":"Ogier C, Creidy R, Boucraut J, Soloway PD, Khrestchatisky M, Rivera S (2005) Astrocyte reactivity to Fas activation is attenuated in TIMP-1 deficient mice, an in vitro study. BMC Neurosci 29:68","journal-title":"BMC Neurosci"},{"key":"4372_CR34","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.1097\/01.ASN.0000141960.01035.28","volume":"15","author":"JL Reynolds","year":"2004","unstructured":"Reynolds JL, Joannides AJ, Skepper JN, McNair R, Schurgers LJ, Proudfoot D, Jahnen-Dechent W, Weissberg PL, Shanahan CM (2004) Human vascular smooth muscle cells undergo vesicle- mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD. J Am Soc Nephrol 15:2857\u20132867","journal-title":"J Am Soc Nephrol"},{"key":"4372_CR35","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1161\/CIRCRESAHA.110.234914","volume":"109","author":"CM Shanahan","year":"2011","unstructured":"Shanahan CM, Crouthamel MH, Kapustin A, Giachelli CM (2011) Arterial calcification in chronic kidney disease: key roles for calcium and phosphate. Circ Res 109:697\u2013711","journal-title":"Circ Res"},{"issue":"2","key":"4372_CR36","first-page":"171","volume":"41","author":"CC Canver","year":"2000","unstructured":"Canver CC, Gregory RD, Cooler SD, Voytovich MC (2000) Association of osteopontin with calcification in human mitral valves. J Cardiovasc Surg (Torino) 41(2):171\u2013174","journal-title":"J Cardiovasc Surg (Torino)"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11033-018-4372-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-018-4372-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-018-4372-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T19:19:17Z","timestamp":1570562357000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11033-018-4372-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,9]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["4372"],"URL":"https:\/\/doi.org\/10.1007\/s11033-018-4372-8","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"type":"print","value":"0301-4851"},{"type":"electronic","value":"1573-4978"}],"subject":[],"published":{"date-parts":[[2018,10,9]]},"assertion":[{"value":"4 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the Ethics Committee of Rabta Hospital and informed consent was obtained from all participants to this study. This work was carried out in accordance with the Code of Ethics of the World Medical Association (Declaration of Helsinki) for experiments involving humans.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}