{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T09:22:28Z","timestamp":1774084948863,"version":"3.50.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T00:00:00Z","timestamp":1537747200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Celal Bayar University Scientific Research Projects Coordination Unit","award":["2016-095"],"award-info":[{"award-number":["2016-095"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1007\/s11033-018-4389-z","type":"journal-article","created":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T05:27:18Z","timestamp":1537766838000},"page":"2275-2282","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Expression profiles of histone modification genes in gastric cancer progression"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1651-1940","authenticated-orcid":false,"given":"Seda","family":"Orenay-Boyacioglu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4335-1156","authenticated-orcid":false,"given":"Elmas","family":"Kasap","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7494-2912","authenticated-orcid":false,"given":"Emre","family":"Gerceker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1545-362X","authenticated-orcid":false,"given":"Hakan","family":"Yuceyar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6923-1470","authenticated-orcid":false,"given":"Ufuk","family":"Demirci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9302-4532","authenticated-orcid":false,"given":"Fahri","family":"Bilgic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2420-3681","authenticated-orcid":false,"given":"Mehmet","family":"Korkmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,9,24]]},"reference":[{"key":"4389_CR1","unstructured":"American Cancer Society. Cancer Facts & Figures (2017) https:\/\/www.cancer.org\/content\/dam\/cancer-org\/research\/cancer-facts-and-statistics\/annual-cancer-facts-and-figures\/2017 . Accessed 25 May 2018"},{"key":"4389_CR2","doi-asserted-by":"publisher","first-page":"354","DOI":"10.3748\/wjg.v12.i3.354","volume":"12","author":"KD Crew","year":"2006","unstructured":"Crew KD, Neugut AI (2006) Epidemiology of gastric cancer. World J Gastroenterol 12:354\u2013362","journal-title":"World J Gastroenterol"},{"key":"4389_CR3","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s10120-007-0420-0","volume":"10","author":"S Tsugane","year":"2007","unstructured":"Tsugane S, Sasazuki S (2007) Diet and the risk of gastric cancer: review of epidemiological evidence. Gastric Cancer 10:75","journal-title":"Gastric Cancer"},{"key":"4389_CR4","volume-title":"Gastrointestinal pathology an atlas and text","author":"CM Fenoglio-Preiser","year":"2008","unstructured":"Fenoglio-Preiser CM (2008) Gastrointestinal pathology an atlas and text. Wolters Kluwer, London"},{"key":"4389_CR5","first-page":"67356740","volume":"52","author":"P Correa","year":"1992","unstructured":"Correa P (1992) Human gastric carcinogenesis: a multistep and multifactorial process\u2014first American Cancer Society Award Lecture on cancer epidemiology and prevention. Cancer Res 52:6735\u20136740","journal-title":"Cancer Res"},{"issue":"21","key":"4389_CR6","doi-asserted-by":"publisher","first-page":"6433","DOI":"10.3748\/wjg.v20.i21.6433","volume":"20","author":"C Kang","year":"2014","unstructured":"Kang C, Song JJ, Lee J, Kim MY (2014) Epigenetics: an emerging player in gastric cancer. World J Gastroenterol 20(21):6433\u20136447","journal-title":"World J Gastroenterol"},{"key":"4389_CR7","doi-asserted-by":"publisher","first-page":"240","DOI":"10.4103\/0973-1482.151450","volume":"10","author":"WY Yang","year":"2014","unstructured":"Yang WY, Gu JL, Zhen TM (2014) Recent advances of histone modification in gastric cancer. J Cancer Res Ther 10:240\u2013245","journal-title":"J Cancer Res Ther"},{"key":"4389_CR8","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1002\/path.1684","volume":"205","author":"Y Mitani","year":"2005","unstructured":"Mitani Y, Oue N, Hamai Y et al (2005) Histone H3 acetylation is associated with reduced p21WAF1\/CIP1 expression by gastric carcinoma. J Pathol 205:65\u201373","journal-title":"J Pathol"},{"key":"4389_CR9","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.bbrc.2008.02.073","volume":"369","author":"G Xia","year":"2008","unstructured":"Xia G, Schneider-Stock R, Diestel A et al (2008) Helicobacter pylori regulates p21 WAF1 by histone H4 acetylation. Biochem Biophys Res Commun 369:526\u2013531","journal-title":"Biochem Biophys Res Commun"},{"key":"4389_CR10","first-page":"377","volume":"21","author":"S Ono","year":"2002","unstructured":"Ono S, Oue N, Kuniyasu H et al (2002) Acetylated histone H4 is reduced in human gastric adenomas and carcinomas. J Exp Clin Cancer Res 21:377\u2013382","journal-title":"J Exp Clin Cancer Res"},{"key":"4389_CR11","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1097\/00129039-200609000-00007","volume":"14","author":"H Takahashi","year":"2006","unstructured":"Takahashi H, Murai Y, Tsuneyama K et al (2006) Overexpression of phosphorylated histone H3 is an indicator of poor prognosis in gastric adenocarcinoma patients. Appl Immunohistochem Mol Morphol 14:296\u2013302","journal-title":"Appl Immunohistochem Mol Morphol"},{"issue":"38","key":"4389_CR12","doi-asserted-by":"publisher","first-page":"13804","DOI":"10.3748\/wjg.v20.i38.13804","volume":"20","author":"J Shi","year":"2014","unstructured":"Shi J, Qu YP, Hou P (2014) Pathogenetic mechanisms in gastric cancer. World J Gastroenterol 20(38):13804","journal-title":"World J Gastroenterol"},{"key":"4389_CR13","doi-asserted-by":"publisher","first-page":"577","DOI":"10.4161\/epi.4.8.10217","volume":"4","author":"LF Fehri","year":"2009","unstructured":"Fehri LF, Rechner C, Janssen S et al (2009) Helicobacter pylori-induced modification of the histone H3 phosphorylation status in gastric epithelial cells reflects its impact on cell cycle regulation. Epigenetics 4:577\u2013586","journal-title":"Epigenetics"},{"issue":"1","key":"4389_CR14","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.bbrc.2015.11.063","volume":"469","author":"SR Kim","year":"2016","unstructured":"Kim SR, Kim KB, Chae YC et al (2016) H3S10 phosphorylation-mediated transcriptional regulation by Aurora kinase A. Biochem Biophys Res Commun 469(1):22\u201328","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"4389_CR15","doi-asserted-by":"publisher","first-page":"3071","DOI":"10.1007\/s13277-015-4131-6","volume":"37","author":"E Kasap","year":"2015","unstructured":"Kasap E, Gerceker E, Orenay-Boyacioglu S et al (2015) The potential role of the NEK6, AURKA, AURKB and PAK1 genes in adenomatous colorectal polyps and colorectal adenocarcinoma. Tumor Biol 37(3):3071\u20133080","journal-title":"Tumor Biol"},{"issue":"4","key":"4389_CR16","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.3892\/or.2015.4187","volume":"34","author":"E Gerceker","year":"2015","unstructured":"Gerceker E, Orenay-Boyacioglu S, Kasap E et al (2015) Never in mitosis gene A-related kinase 6 (NEK6) and aurora kinase A (AURKA): new gene biomarkers in the conversion from ulcerative colitis to colorectal cancer. Oncol Rep 34(4):1905\u20131914","journal-title":"Oncol Rep"},{"key":"4389_CR17","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.3748\/wjg.v20.i7.1635","volume":"20","author":"M Orditura","year":"2014","unstructured":"Orditura M, Galizia G, Sforza V et al (2014) Treatment of gastric cancer. World J Gastroenterol 20:1635\u20131649","journal-title":"World J Gastroenterol"},{"key":"4389_CR18","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1158\/1541-7786.MCR-13-0044","volume":"11","author":"Z Xia","year":"2013","unstructured":"Xia Z, Wei P, Zhang H, Ding Z, Yang L, Huang Z et al (2013) AURKA governs self-renewal capacity in glioma-initiating cells via stabilization\/activation of beta-catenin\/Wnt signaling. Mol Cancer Res 11:1101\u20131111","journal-title":"Mol Cancer Res"},{"key":"4389_CR19","doi-asserted-by":"publisher","first-page":"2699","DOI":"10.1182\/blood-2008-12-194290","volume":"114","author":"J Dutta-Simmons","year":"2009","unstructured":"Dutta-Simmons J, Zhang Y, Gorgun G et al (2009) Aurora kinase A is a target of Wnt\/beta-catenin involved in multiple myeloma disease progression. Blood 114:2699\u20132708","journal-title":"Blood"},{"key":"4389_CR20","first-page":"23","volume":"26","author":"J Wang","year":"2011","unstructured":"Wang J, Yang S, Zhang H et al (2011) Aurora-A as an independent molecular prognostic marker in gastric cancer. Oncol Rep 26:23\u201332","journal-title":"Oncol Rep"},{"key":"4389_CR21","doi-asserted-by":"publisher","first-page":"13121322","DOI":"10.1053\/j.gastro.2013.08.050","volume":"145","author":"A Katsha","year":"2013","unstructured":"Katsha A, Soutto M, Sehdev V et al (2013) Aurora kinase A promotes inflammation and tumorigenesis in mice and human gastric neoplasia. Gastroenterology 145:1312\u20131322","journal-title":"Gastroenterology"},{"key":"4389_CR22","first-page":"593","volume":"12","author":"K Kamada","year":"2004","unstructured":"Kamada K, Yamada Y, Hirao T et al (2004) Amplification\/overexpression of Aurora-A in human gastric carcinoma: potential role in differentiated type gastric carcinogenesis. Oncol Rep 12:593\u2013599","journal-title":"Oncol Rep"},{"key":"4389_CR23","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1002\/cncr.23371","volume":"112","author":"AA Dar","year":"2008","unstructured":"Dar AA, Zaika A, Piazuelo MB et al (2008) Frequent overexpression of Aurora Kinase A in upper gastrointestinal adenocarcinomas correlates with potent antiapoptotic functions. Cancer 112:1688\u20131698","journal-title":"Cancer"},{"issue":"2","key":"4389_CR24","doi-asserted-by":"publisher","first-page":"e298","DOI":"10.1038\/oncsis.2016.80","volume":"6","author":"M Kamran","year":"2017","unstructured":"Kamran M, Long ZJ, Xu D et al (2017) Aurora kinase A regulates survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis. Oncogenesis 6(2):e298","journal-title":"Oncogenesis"},{"key":"4389_CR25","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3329\/jsr.v6i2.14505","volume":"6","author":"X Xu","year":"2014","unstructured":"Xu X, Xiao J, Wei S et al (2014) Relationship between expression of Aurka and clinicopathological characteristics in gastric cancer patients. Sci Res 6:243\u2013249","journal-title":"Sci Res"},{"key":"4389_CR26","doi-asserted-by":"publisher","first-page":"10436","DOI":"10.1158\/0008-5472.CAN-07-1379","volume":"67","author":"Z Guan","year":"2007","unstructured":"Guan Z, Wang XR, Zhu XF et al (2007) Aurora-A, a negative prognostic marker, increases migration and decreases radiosensitivity in cancer cells. Cancer Res 67:10436\u201310444","journal-title":"Cancer Res"},{"issue":"1","key":"4389_CR27","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3892\/etm.2012.561","volume":"4","author":"E Kasap","year":"2012","unstructured":"Kasap E, Orenay-Boyacioglu S, Korkmaz M et al (2012) Aurora kinase A (AURKA) and never in mitosis gene A-related Kinase 6 (NEK6) up-regulated gene using cDNA microarray and real-time reverse transcription-PCR in erosive esophagitis and esophageal adenocarcinoma. Exp Ther Med 4(1):33\u201342","journal-title":"Exp Ther Med"},{"key":"4389_CR28","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.tips.2009.09.007","volume":"30","author":"OH Kramer","year":"2009","unstructured":"Kramer OH (2009) HDAC2: a critical factor in health and disease. Trends Pharmacol Sci 30:647\u2013655","journal-title":"Trends Pharmacol Sci"},{"key":"4389_CR29","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1111\/j.1600-0463.2005.apm_04.x","volume":"113","author":"J Song","year":"2005","unstructured":"Song J, Noh JH, Lee JH et al (2005) Increased expression of histone deacetylase 2 is found in human gastric cancer. APMIS 113:264\u2013268","journal-title":"APMIS"},{"key":"4389_CR30","first-page":"166","volume":"2","author":"JH Noh","year":"2006","unstructured":"Noh JH, Eun JW, Ryu SY,et al (2006) Increased expression of histone deacetylase 2 is found in human hepatocellular carcinoma. Mol Cell Toxicol 2:166\u2013169","journal-title":"Mol Cell Toxicol"},{"key":"4389_CR31","doi-asserted-by":"publisher","first-page":"3336","DOI":"10.1245\/s10434-010-1182-1","volume":"17","author":"K Mutze","year":"2010","unstructured":"Mutze K, Langer R, Becker K et al (2010) Histone deacetylase (HDAC) 1 and 2 expression and chemotherapy in gastric cancer. Ann Surg Oncol 17:3336\u20133343","journal-title":"Ann Surg Oncol"},{"issue":"2","key":"4389_CR32","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/S1470-2045(08)70004-4","volume":"9","author":"W Weichert","year":"2008","unstructured":"Weichert W, R\u00f6ske A, Gekeler V et al (2008) Association of patterns of class I histone deacetylase expression with patient prognosis in gastric cancer: a retrospective analysis. Lancet Oncol 9(2):139\u2013148","journal-title":"Lancet Oncol"},{"issue":"12","key":"4389_CR33","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1111\/j.1349-7006.2001.tb02153.x","volume":"92","author":"JH Choi","year":"2001","unstructured":"Choi JH, Kwon HJ, Yoon BI et al (2001) Expression profile of histone deacetylase 1 in gastric cancer tissues. Jpn J Cancer Res 92(12):1300\u20131304","journal-title":"Jpn J Cancer Res"},{"key":"4389_CR34","first-page":"4916","volume":"62","author":"R Furumai","year":"2002","unstructured":"Furumai R, Matsuyama A, Kobashi N et al (2002) FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases. Cancer Res 62:4916\u20134921","journal-title":"Cancer Res"},{"key":"4389_CR35","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1073\/pnas.98.1.87","volume":"98","author":"R Furumai","year":"2001","unstructured":"Furumai R, Komatsu Y, Nishino N, Khochbin S, Yoshida M, Horinouchi S (2001) Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin. Proc Natl Acad Sci USA 98:87\u201392","journal-title":"Proc Natl Acad Sci USA"},{"key":"4389_CR36","doi-asserted-by":"publisher","first-page":"5271","DOI":"10.1158\/1078-0432.CCR-03-0709","volume":"10","author":"JH Park","year":"2004","unstructured":"Park JH, Jung Y, Kim TY et al (2004) Class I histone deacetylase-selective novel synthetic inhibitors potently inhibit human tumor proliferation. Clin Cancer Res 10:5271\u20135281","journal-title":"Clin Cancer Res"},{"issue":"16","key":"4389_CR37","doi-asserted-by":"crossref","first-page":"22285","DOI":"10.18632\/oncotarget.8077","volume":"7","author":"M Zhang","year":"2016","unstructured":"Zhang M, Pan Y, Dorfman RG et al (2016) AR-42 induces apoptosis in human hepatocellular carcinoma cells via HDAC5 inhibition. Oncotarget 7(16):22285\u201322294","journal-title":"Oncotarget"},{"key":"4389_CR38","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/1747-1028-2-25","volume":"2","author":"L O\u2019Regan","year":"2007","unstructured":"O\u2019Regan L, Blot J, Fry AM (2007) Mitotic regulation by NIMA-related kinases. Cell Div 2:25","journal-title":"Cell Div"},{"key":"4389_CR39","doi-asserted-by":"publisher","first-page":"52454","DOI":"10.1074\/jbc.M308080200","volume":"278","author":"MJ Yin","year":"2003","unstructured":"Yin MJ, Shao L, Voehringer D, Smeal T, Jallal B (2003) The serine\/threonine kinase Nek6 is required for cell cycle progression through mitosis. J Biol Chem 278:52454\u201355260","journal-title":"J Biol Chem"},{"key":"4389_CR40","doi-asserted-by":"publisher","first-page":"34897","DOI":"10.1074\/jbc.M303663200","volume":"278","author":"C Belham","year":"2003","unstructured":"Belham C, Roig J, Caldwell JA et al (2003) A mitotic cascade of NIMA family kinases Nercc1\/Nek9 activates the Nek6 and Nek7 kinases. J Biol Chem 278:34897\u201334909","journal-title":"J Biol Chem"},{"issue":"8","key":"4389_CR41","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1038\/sj.bjc.6604682","volume":"99","author":"A Takeno","year":"2008","unstructured":"Takeno A, Takemasa I, Doki Y et al (2008) Integrative approach for differentially overexpressed genes in gastric cancer by combining large-scale gene expression profiling and network analysis. Br J Cancer 99(8):1307\u20131315","journal-title":"Br J Cancer"},{"key":"4389_CR42","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1158\/1541-7786.MCR-09-0291","volume":"8","author":"R Nassirpour","year":"2011","unstructured":"Nassirpour R, Shao L, Flanagan P et al (2011) Nek6 mediates human cancer cell transformation and is a potential cancer therapeutic target. Mol Cancer Res 8:717\u2013728","journal-title":"Mol Cancer Res"},{"key":"4389_CR43","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1159\/000478961","volume":"42","author":"Q He","year":"2017","unstructured":"He Q, Li G, Wang X et al (2017) Decrease of histone deacetylase 6 expression caused by Helicobacter pylori infection is associated with oncogenic transformation in gastric cancer. Cell Physiol Biochem 42:1326\u20131335","journal-title":"Cell Physiol Biochem"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11033-018-4389-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-018-4389-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-018-4389-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T20:12:30Z","timestamp":1605039150000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11033-018-4389-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,24]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["4389"],"URL":"https:\/\/doi.org\/10.1007\/s11033-018-4389-z","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,24]]},"assertion":[{"value":"27 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors have not declared any conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The ethical approval for the study was received from the Institutional Ethical Review Board of the Celal Bayar University Medical Center in January 2016.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent forms were obtained from each subject prior to any study related procedure.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}