{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:31:16Z","timestamp":1761514276277,"version":"3.37.3"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:00:00Z","timestamp":1538524800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1007\/s11033-018-4407-1","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T10:27:15Z","timestamp":1538562435000},"page":"2411-2419","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["AGXT2 and DDAH-1 genetic variants are highly correlated with serum ADMA and SDMA levels and with incidence of coronary artery disease in Egyptians"],"prefix":"10.1007","volume":"45","author":[{"given":"Mina","family":"Amir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9863-2086","authenticated-orcid":false,"given":"Sally I.","family":"Hassanein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed F.","family":"Abdel Rahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Z.","family":"Gad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,10,3]]},"reference":[{"key":"4407_CR1","doi-asserted-by":"publisher","first-page":"9466","DOI":"10.3748\/wjg.v21.i32.9466","volume":"21","author":"P Lluch","year":"2015","unstructured":"Lluch P, Segarra G, Medina P (2015) Asymmetric dimethylarginine as a mediator of vascular dysfunction in cirrhosis. World J Gastroenterol 21:9466","journal-title":"World J Gastroenterol"},{"key":"4407_CR2","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1152\/physrev.00029.2006","volume":"87","author":"P Pacher","year":"2007","unstructured":"Pacher P, Beckman JS, Liaudet L (2007) Nitric oxide and peroxynitrite in health and disease. Physiol Rev 87:315\u2013424","journal-title":"Physiol Rev"},{"key":"4407_CR3","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1111\/j.1600-079X.2010.00806.x","volume":"49","author":"Y-L Tain","year":"2010","unstructured":"Tain Y-L, Huang L-T, Lin I-C, Lau Y-T, Lin C-Y (2010) Melatonin prevents hypertension and increased asymmetric dimethylarginine in young spontaneous hypertensive rats. J Pineal Res 49:390\u2013398","journal-title":"J Pineal Res"},{"key":"4407_CR4","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1042\/bj1540179","volume":"154","author":"JR McDermott","year":"1976","unstructured":"McDermott JR (1976) Studies on the catabolism of Ng-methylarginine, Ng, Ng-dimethylarginine and Ng, Ng-dimethylarginine in the rabbit. Biochem J 154:179\u2013184","journal-title":"Biochem J"},{"key":"4407_CR5","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1161\/01.RES.87.2.99","volume":"87","author":"RH B\u00f6ger","year":"2000","unstructured":"B\u00f6ger RH, Sydow K, Borlak J, Thum T, Lenzen H, Schubert B, Tsikas D, Bode-B\u00f6ger SM (2000) LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S-adenosylmethionine-dependent methyltransferases. Circ Res 87:99\u2013105","journal-title":"Circ Res"},{"key":"4407_CR6","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1006\/niox.1996.0106","volume":"1","author":"EI Closs","year":"1997","unstructured":"Closs EI, Basha FZ, Habermeier A, F\u00f6rstermann U (1997) Interference of L-arginine analogues with L-arginine transport mediated by the y+ carrier hCAT-2B. Nitric Oxide 1:65\u201373","journal-title":"Nitric Oxide"},{"key":"4407_CR7","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1016\/S0140-6736(01)07184-7","volume":"358","author":"V-P Valkonen","year":"2001","unstructured":"Valkonen V-P, P\u00e4iv\u00e4 H, Salonen JT, Lakka TA, Lehtim\u00e4ki T, Laakso J, Laaksonen R (2001) Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine. Lancet 358:2127\u20132128","journal-title":"Lancet"},{"key":"4407_CR8","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S1567-5688(03)00030-8","volume":"4","author":"RH B\u00f6ger","year":"2003","unstructured":"B\u00f6ger RH, Zoccali C (2003) ADMA: a novel risk factor that explains excess cardiovascular event rate in patients with end-stage renal disease. Atheroscler Suppl 4:23\u201328","journal-title":"Atheroscler Suppl"},{"key":"4407_CR9","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1161\/ATVBAHA.107.156596","volume":"28","author":"T Leong","year":"2008","unstructured":"Leong T, Zylberstein D, Graham I, Lissner L, Ward D, Fogarty J, Bengtsson C, Bjorkelund C, Thelle D (2008) Asymmetric dimethylarginine independently predicts fatal and nonfatal myocardial infarction and stroke in women: 24-year follow-up of the population study of women in Gothenburg. Arterioscler Thromb Vasc Biol 28:961\u2013967","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"4407_CR10","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/0003-9861(87)90060-9","volume":"252","author":"T Ogawa","year":"1987","unstructured":"Ogawa T, Kimoto M, Watanabe H, Sasaoka K (1987) Metabolism of NG, NG- and NG, N\u2019G-dimethylarginine in rats. Arch Biochem Biophys 252:526\u2013537","journal-title":"Arch Biochem Biophys"},{"key":"4407_CR11","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.1093\/oxfordjournals.ndt.a027213","volume":"11","author":"RJ MacAllister","year":"1996","unstructured":"MacAllister RJ, Rambausek MH, Vallance P, Williams D, Hoffmann KH, Ritz E (1996) Concentration of dimethyl-L-arginine in the plasma of patients with end-stage renal failure. Nephrol Dial Transplant 11:2449\u20132452","journal-title":"Nephrol Dial Transplant"},{"key":"4407_CR12","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1097\/01.ASN.0000032548.18973.0F","volume":"13","author":"C Zoccali","year":"2002","unstructured":"Zoccali C, Benedetto FA, Maas R, Mallamaci F, Tripepi G, Malatino LS, B\u00f6ger R, CREED Investigators (2002) Asymmetric dimethylarginine, C-reactive protein, and carotid intima-media thickness in end-stage renal disease. J Am Soc Nephrol 13:490\u2013496","journal-title":"J Am Soc Nephrol"},{"key":"4407_CR13","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/j.bbrc.2003.09.097","volume":"310","author":"LC Jones","year":"2003","unstructured":"Jones LC, Tran CTL, Leiper JM, Hingorani AD, Vallance P (2003) Common genetic variation in a basal promoter element alters DDAH2 expression in endothelial cells. Biochem Biophys Res Commun 310:836\u2013843","journal-title":"Biochem Biophys Res Commun"},{"key":"4407_CR14","doi-asserted-by":"publisher","first-page":"S45","DOI":"10.1177\/1358836X0501000107","volume":"10","author":"V-P Valkonen","year":"2005","unstructured":"Valkonen V-P, Tuomainen T-P, Laaksonen R (2005) DDAH gene and cardiovascular risk. Vasc Med 10:S45\u2013S48","journal-title":"Vasc Med"},{"key":"4407_CR15","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/ng.837","volume":"43","author":"K Suhre","year":"2011","unstructured":"Suhre K, Wallaschofski H, Raffler J, Friedrich N, Haring R, Michael K, Wasner C, Krebs A, Kronenberg F, Chang D, Meisinger C, Wichmann H-E, Hoffmann W, V\u00f6lzke H, V\u00f6lker U, Teumer A, Biffar R, Kocher T, Felix SB, Illig T, Kroemer HK, Gieger C, R\u00f6misch-Margl W, Nauck M (2011) A genome-wide association study of metabolic traits in human urine. Nat Genet 43:565\u2013569","journal-title":"Nat Genet"},{"key":"4407_CR16","doi-asserted-by":"publisher","first-page":"e88544","DOI":"10.1371\/journal.pone.0088544","volume":"9","author":"A Kittel","year":"2014","unstructured":"Kittel A, M\u00fcller F, K\u00f6nig J, Mieth M, Sticht H, Zolk O, Kralj A, Heinrich MR, Fromm MF, Maas R (2014) Alanine-glyoxylate aminotransferase 2 (AGXT2) polymorphisms have considerable impact on methylarginine and \u03b2-aminoisobutyrate metabolism in healthy volunteers. PLoS ONE 9:e88544","journal-title":"PLoS ONE"},{"key":"4407_CR17","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1089\/gtmb.2011.0342","volume":"16","author":"MZ Gad","year":"2012","unstructured":"Gad MZ, Abdel Rahman MF, Hashad IM, Abdel-Maksoud SM, Farag NM, Abou-Aisha K (2012) Endothelial nitric oxide synthase (G894T) gene polymorphism in a random sample of the Egyptian population: comparison with myocardial infarction patients. Genet Test Mol Biomark 16:695\u2013700","journal-title":"Genet Test Mol Biomark"},{"key":"4407_CR18","doi-asserted-by":"publisher","first-page":"391","DOI":"10.3109\/10799893.2014.959593","volume":"35","author":"MA Abu el Maaty","year":"2015","unstructured":"Abu el Maaty MA, Hassanein SI, Sleem HM, Gad MZ (2015) Vitamin D receptor gene polymorphisms (TaqI and ApaI) in relation to 25-hydroxyvitamin D levels and coronary artery disease incidence. J Recept Signal Transduct 35:391\u2013395","journal-title":"J Recept Signal Transduct"},{"key":"4407_CR19","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1159\/000360422","volume":"6","author":"MA Abu El Maaty","year":"2013","unstructured":"Abu El Maaty MA, Hassanein SI, Sleem HM, Gad MZ (2013) Effect of polymorphisms in the NADSYN1\/DHCR7 locus (rs12785878 and rs1790349) on plasma 25-hydroxyvitamin D levels and coronary artery disease incidence. J Nutrigenet Nutrigenomics 6:327\u2013335","journal-title":"J Nutrigenet Nutrigenomics"},{"key":"4407_CR20","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3109\/1354750X.2015.1118535","volume":"21","author":"MA Abu el Maaty","year":"2016","unstructured":"Abu el Maaty MA, Hassanein SI, Gad MZ (2016) Genetic variation in vitamin D receptor gene (Fok1:rs2228570) is associated with risk of coronary artery disease. Biomarkers 21:68\u201372","journal-title":"Biomarkers"},{"key":"4407_CR21","doi-asserted-by":"publisher","first-page":"513","DOI":"10.5114\/aoms.2015.52353","volume":"11","author":"MFA Rahman","year":"2015","unstructured":"Rahman MFA, Hashad IM, Abou-Aisha K, Abdel-Maksoud SM, Gad MZ (2015) Addressing the link between paraoxonase-1 gene variants and the incidence of early onset myocardial infarction. Arch Med Sci 11:513\u2013520","journal-title":"Arch Med Sci"},{"key":"4407_CR22","doi-asserted-by":"publisher","first-page":"488","DOI":"10.3109\/1354750X.2014.939226","volume":"19","author":"SI Hassanein","year":"2014","unstructured":"Hassanein SI, Abu el Maaty MA, Sleem HM, Gad MZ (2014) Triangular relationship between single nucleotide polymorphisms in the CYP2R1 gene (rs10741657 and rs12794714), 25-hydroxyvitamin d levels, and coronary artery disease incidence. Biomarkers 19:488\u2013492","journal-title":"Biomarkers"},{"key":"4407_CR23","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1007\/s11033-014-3081-1","volume":"41","author":"IM Hashad","year":"2014","unstructured":"Hashad IM, Abdel Rahman MF, Abdel-Maksoud SM, Amr KS, Effat LK, Shaban GM, Gad MZ (2014) C242T polymorphism of NADPH oxidase p22phox gene reduces the risk of coronary artery disease in a random sample of Egyptian population. Mol Biol Rep 41:2281\u20132286","journal-title":"Mol Biol Rep"},{"key":"4407_CR24","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1186\/1471-2105-8-428","volume":"8","author":"TR Gaunt","year":"2007","unstructured":"Gaunt TR, Rodr\u00edguez S, Day IN (2007) Cubic exact solutions for the estimation of pairwise haplotype frequencies: implications for linkage disequilibrium analyses and a web tool \u201cCubeX\u201d. BMC Bioinform 8:428","journal-title":"BMC Bioinform"},{"key":"4407_CR25","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1093\/eurheartj\/eht447","volume":"35","author":"I Seppala","year":"2014","unstructured":"Seppala I, Kleber ME, Lyytikainen L-P, Hernesniemi JA, Makela K-M, Oksala N, Laaksonen R, Pilz S, Tomaschitz A, Silbernagel G, Boehm BO, Grammer TB, Koskinen T, Juonala M, Hutri-Kahonen N, Alfthan G, Viikari JSA, Kahonen M, Raitakari OT, Marz W, Meinitzer A, Lehtimaki T (2014) Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality. Eur Heart J 35:524\u2013531","journal-title":"Eur Heart J"},{"key":"4407_CR26","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.1373\/clinchem.2005.056788","volume":"51","author":"J Martens-Lobenhoffer","year":"2005","unstructured":"Martens-Lobenhoffer J, Westphal S, Awiszus F, Bode-B\u00f6ger SM, Luley C (2005) Determination of asymmetric dimethylarginine: liquid chromatography-mass spectrometry or ELISA? Clin Chem 51:2188\u20132189","journal-title":"Clin Chem"},{"key":"4407_CR27","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1111\/j.1365-2362.2005.01561.x","volume":"35","author":"F Schulze","year":"2005","unstructured":"Schulze F, Maas R, Freese R, Schwedhelm E, Silberhorn E, Boger RH (2005) Determination of a reference value for NG, NG-dimethyl-L-arginine in 500 subjects. Eur J Clin Invest 35:622\u2013626","journal-title":"Eur J Clin Invest"},{"key":"4407_CR28","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1515\/cclm-2014-0314","volume":"52","author":"D Atzler","year":"2014","unstructured":"Atzler D, Schwedhelm E, Nauck M, Ittermann T, B\u00f6ger RH, Friedrich N (2014) Serum reference intervals of homoarginine, ADMA, and SDMA in the Study of Health in Pomerania. Clin Chem Lab Med 52:1835\u20131842","journal-title":"Clin Chem Lab Med"},{"key":"4407_CR29","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.atherosclerosis.2008.12.039","volume":"205","author":"A Sobczak","year":"2009","unstructured":"Sobczak A, Goniewicz ML, Szoltysek-Boldys I (2009) ADMA and SDMA levels in healthy men exposed to tobacco smoke. Atherosclerosis 205:357\u2013359","journal-title":"Atherosclerosis"},{"key":"4407_CR30","doi-asserted-by":"publisher","first-page":"746","DOI":"10.3109\/1354750X.2010.519784","volume":"15","author":"MZ Gad","year":"2010","unstructured":"Gad MZ, Hassanein SI, Abdel-Maksoud SM, Shaban GM, Abou-Aisha K, Elgabarty HA (2010) Assessment of serum levels of asymmetric dimethylarginine, symmetric dimethylarginine and L-arginine in coronary artery disease. Biomarkers 15:746\u2013752","journal-title":"Biomarkers"},{"key":"4407_CR31","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3390\/toxins8050149","volume":"8","author":"J Boelaert","year":"2016","unstructured":"Boelaert J, Schepers E, Glorieux G, Eloot S, Vanholder R, Lynen F (2016) Determination of asymmetric and symmetric dimethylarginine in serum from patients with chronic kidney disease: UPLC-MS\/MS versus ELISA. Toxins (Basel) 8:149","journal-title":"Toxins (Basel)"},{"key":"4407_CR32","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/j.autrev.2010.07.016","volume":"9","author":"S Sitia","year":"2010","unstructured":"Sitia S, Tomasoni L, Atzeni F, Ambrosio G, Cordiano C, Catapano A, Tramontana S, Perticone F, Naccarato P, Camici P, Picano E, Cortigiani L, Bevilacqua M, Milazzo L, Cusi D, Barlassina C, Sarzi-Puttini P, Turiel M (2010) From endothelial dysfunction to atherosclerosis. Autoimmun Rev 9:830\u2013834","journal-title":"Autoimmun Rev"},{"key":"4407_CR33","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1016\/j.ehj.2003.08.013","volume":"24","author":"T Lu","year":"2003","unstructured":"Lu T, Ding Y-A, Lin S-J, Lee W-S, Tai H-C (2003) Plasma levels of asymmetrical dimethylarginine and adverse cardiovascular events after percutaneous coronary intervention. Eur Heart J 24:1912\u20131919","journal-title":"Eur Heart J"},{"key":"4407_CR34","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1161\/ATVBAHA.107.156596","volume":"28","author":"T Leong","year":"2008","unstructured":"Leong T, Zylberstein D, Graham I, Lissner L, Ward D, Fogarty J, Bengtsson C, Bjorkelund C, Thelle D, Swedish-Irish-Norwegian Collaboration (2008) Asymmetric dimethylarginine independently predicts fatal and nonfatal myocardial infarction and stroke in women: 24-year follow-up of the population study of women in Gothenburg. Arterioscler Thromb Vasc Biol 28:961\u2013967","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"4407_CR35","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.yjmcc.2017.09.010","volume":"113","author":"XL Hu","year":"2017","unstructured":"Hu XL, Li MP, Song PY, Tang J, Chen XP (2017) AGXT2: An unnegligible aminotransferase in cardiovascular and urinary systems. J Mol Cell Cardiol 113:33\u201338","journal-title":"J Mol Cell Cardiol"},{"key":"4407_CR36","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.atherosclerosis.2014.12.030","volume":"239","author":"Y Notsu","year":"2015","unstructured":"Notsu Y, Yano S, Shibata H, Nagai A, Nabika T (2015) Plasma arginine\/ADMA ratio as a sensitive risk marker for atherosclerosis: Shimane CoHRE study. Atherosclerosis 239:61\u201366","journal-title":"Atherosclerosis"},{"key":"4407_CR37","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.1016\/S0024-3205(98)00225-2","volume":"62","author":"M Usui","year":"1998","unstructured":"Usui M, Matsuoka H, Miyazaki H, Ueda S, Okuda S, Imaizumi T (1998) Increased endogenous nitric oxide synthase inhibitor in patients with congestive heart failure. Life Sci 62:2425\u20132430","journal-title":"Life Sci"},{"key":"4407_CR38","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.atherosclerosis.2012.09.040","volume":"225","author":"C-P Hsu","year":"2012","unstructured":"Hsu C-P, Lin S-J, Chung M-Y, Lu T-M (2012) Asymmetric dimethylarginine predicts clinical outcomes in ischemic chronic heart failure. Atherosclerosis 225:504\u2013510","journal-title":"Atherosclerosis"},{"key":"4407_CR39","doi-asserted-by":"publisher","first-page":"855","DOI":"10.3892\/mmr.2012.985","volume":"6","author":"NM Khalifa","year":"2012","unstructured":"Khalifa NM, Gad MZ, Hataba AA, Mahran LG (2012) Changes in ADMA and TAFI levels after stenting in coronary artery disease patients. Mol Med Rep 6:855\u2013859","journal-title":"Mol Med Rep"},{"key":"4407_CR40","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1681\/ASN.2005101119","volume":"17","author":"SM Bode-B\u00f6ger","year":"2006","unstructured":"Bode-B\u00f6ger SM, Scalera F, Kielstein JT, Martens-Lobenhoffer J, Breithardt G, Fobker M, Reinecke H (2006) Symmetrical dimethylarginine: a new combined parameter for renal function and extent of coronary artery disease. J Am Soc Nephrol 17:1128\u20131134","journal-title":"J Am Soc Nephrol"},{"key":"4407_CR41","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s00392-012-0515-4","volume":"102","author":"B Siegerink","year":"2013","unstructured":"Siegerink B, Maas R, Vossen CY, Schwedhelm E, Koenig W, B\u00f6ger R, Rothenbacher D, Brenner H, Breitling LP (2013) Asymmetric and symmetric dimethylarginine and risk of secondary cardiovascular disease events and mortality in patients with stable coronary heart disease: The KAROLA follow-up study. Clin Res Cardiol 102:193\u2013202","journal-title":"Clin Res Cardiol"},{"key":"4407_CR42","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.atherosclerosis.2009.06.039","volume":"208","author":"F Schulze","year":"2010","unstructured":"Schulze F, Carter AM, Schwedhelm E, Ajjan R, Maas R, von Holten R-A, Atzler D, Grant PJ, B\u00f6ger RH (2010) Symmetric dimethylarginine predicts all-cause mortality following ischemic stroke. Atherosclerosis 208:518\u2013523","journal-title":"Atherosclerosis"},{"key":"4407_CR43","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1016\/j.jvs.2015.01.002","volume":"61","author":"A Staniszewska","year":"2015","unstructured":"Staniszewska A, Rajagopalan S, Al-Shaheen A, Thies F, Brittenden J (2015) Increased levels of symmetric dimethyl-arginine are associated with all-cause mortality in patients with symptomatic peripheral arterial disease. J Vasc Surg 61:1292\u20131298","journal-title":"J Vasc Surg"},{"key":"4407_CR44","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/j.atherosclerosis.2007.07.034","volume":"197","author":"J Wang","year":"2008","unstructured":"Wang J, Sim AS, Wang XL, Salonikas C, Moriatis M, Naidoo D, Wilcken DEL (2008) Relations between markers of renal function, coronary risk factors and the occurrence and severity of coronary artery disease. Atherosclerosis 197:853\u2013859","journal-title":"Atherosclerosis"},{"key":"4407_CR45","first-page":"605","volume":"28","author":"Y Yoshino","year":"2014","unstructured":"Yoshino Y, Kohara K, Abe M, Ochi S, Mori Y, Yamashita K, Igase M, Tabara Y, Mori T, Miki T, Ueno S (2014) Missense variants of the alanine: glyoxylate aminotransferase 2 gene correlated with carotid atherosclerosis in the Japanese population. J Biol Regul Homeost Agents 28:605\u2013614","journal-title":"J Biol Regul Homeost Agents"},{"key":"4407_CR46","doi-asserted-by":"publisher","first-page":"23207","DOI":"10.1038\/srep23207","volume":"6","author":"I Sepp\u00e4l\u00e4","year":"2016","unstructured":"Sepp\u00e4l\u00e4 I, Kleber ME, Bevan S, Lyytik\u00e4inen L-P, Oksala N, Hernesniemi JA, M\u00e4kel\u00e4 K-M, Rothwell PM, Sudlow C, Dichgans M, Mononen N, Vlachopoulou E, Sinisalo J, Delgado GE, Laaksonen R, Koskinen T, Scharnagl H, K\u00e4h\u00f6nen M, Markus HS, M\u00e4rz W, Lehtim\u00e4ki T (2016) Associations of functional alanine-glyoxylate aminotransferase 2 gene variants with atrial fibrillation and ischemic stroke. Sci Rep 6:23207","journal-title":"Sci Rep"},{"key":"4407_CR47","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.5551\/jat.23077","volume":"21","author":"J-P Zhou","year":"2014","unstructured":"Zhou J-P, Bai Y-P, Hu X-L, Kuang D-B, Shi R-Z, Xiong Y, Zhang W, Xia J, Chen B-L, Yang T-L, Chen X-P (2014) Association of the AGXT2 V140I polymorphism with risk for coronary heart disease in a Chinese population. J Atheroscler Thromb 21:1022\u20131030","journal-title":"J Atheroscler Thromb"},{"key":"4407_CR48","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.atherosclerosis.2016.07.006","volume":"251","author":"X-L Hu","year":"2016","unstructured":"Hu X-L, Zhou J-P, Kuang D-B, Qi H, Peng L-M, Yang T-L, Li X, Zhang W, Zhou H-H, Chen X-P (2016) Considerable impacts of AGXT2 V140I polymorphism on chronic heart failure in the Chinese population. Atherosclerosis 251:255\u2013262","journal-title":"Atherosclerosis"},{"key":"4407_CR49","doi-asserted-by":"publisher","DOI":"10.1038\/srep23207","author":"I Sepp\u00e4l\u00e4","year":"2016","unstructured":"Sepp\u00e4l\u00e4 I, Kleber ME, Bevan S, Lyytik\u00e4inen L-P, Oksala N, Hernesniemi JA, M\u00e4kel\u00e4 K-M, Rothwell PM, Sudlow C, Dichgans M, Mononen N, Vlachopoulou E, Sinisalo J, Delgado GE, Laaksonen R, Koskinen T, Scharnagl H, K\u00e4h\u00f6nen M, Markus HS (2016) Associations of functional alanine-glyoxylate aminotransferase 2 gene variants with atrial fibrillation and ischemic stroke. Sci Rep. \n                    https:\/\/doi.org\/10.1038\/srep23207","journal-title":"Sci Rep"},{"key":"4407_CR50","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1161\/CIRCGENETICS.113.000264","volume":"7","author":"N Luneburg","year":"2014","unstructured":"Luneburg N, Lieb W, Zeller T, Chen M-H, Maas R, Carter AM, Xanthakis V, Glazer NL, Schwedhelm E, Seshadri S, Ikram MA, Longstreth WT, Fornage M, Konig IR, Loley C, Ojeda FM, Schillert A, Wang TJ, Sticht H, Kittel A, Konig J, Benjamin EJ, Sullivan LM, Bernges I, Anderssohn M, Ziegler A, Gieger C, Illig T, Meisinger C, Wichmann H-E, Wild PS, Schunkert H, Psaty BM, Wiggins KL, Heckbert SR, Smith N, Lackner K, Lunetta KL, Blankenberg S, Erdmann J, Munzel T, Grant PJ, Vasan RS, Boger RH (2014) Genome-Wide Association Study of L-arginine and dimethylarginines reveals novel metabolic pathway for symmetric dimethylarginine. Circ Cardiovasc Genet 7:864\u2013872","journal-title":"Circ Cardiovasc Genet"},{"key":"4407_CR51","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1161\/CIRCRESAHA.109.215616","volume":"106","author":"H Ding","year":"2010","unstructured":"Ding H, Wu B, Wang H, Lu Z, Yan J, Wang X, Shaffer JR, Hui R, Wang DW (2010) A novel loss-of-function DDAH1 promoter polymorphism is associated with increased susceptibility to thrombosis stroke and coronary heart disease. Circ Res 106:1145\u20131152","journal-title":"Circ Res"},{"key":"4407_CR52","doi-asserted-by":"publisher","first-page":"846","DOI":"10.2337\/dc13-0546","volume":"37","author":"M Anderssohn","year":"2014","unstructured":"Anderssohn M, McLachlan S, L\u00fcneburg N, Robertson C, Schwedhelm E, Williamson RM, Strachan MWJ, Ajjan R, Grant PJ, B\u00f6ger RH, Price JF (2014) Genetic and environmental determinants of dimethylarginines and association with cardiovascular disease in patients with type 2 diabetes. Diabetes Care 37:846\u2013854","journal-title":"Diabetes Care"},{"key":"4407_CR53","doi-asserted-by":"publisher","first-page":"e9462","DOI":"10.1371\/journal.pone.0009462","volume":"5","author":"S Abhary","year":"2010","unstructured":"Abhary S, Burdon KP, Kuot A, Javadiyan S, Whiting MJ, Kasmeridis N, Petrovsky N, Craig JE (2010) Sequence variation in DDAH1 and DDAH2 genes is strongly and additively associated with serum ADMA concentrations in individuals with type 2 diabetes. PLoS ONE 5:e9462","journal-title":"PLoS ONE"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11033-018-4407-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-018-4407-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-018-4407-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T19:18:36Z","timestamp":1570043916000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11033-018-4407-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,3]]},"references-count":53,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["4407"],"URL":"https:\/\/doi.org\/10.1007\/s11033-018-4407-1","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"type":"print","value":"0301-4851"},{"type":"electronic","value":"1573-4978"}],"subject":[],"published":{"date-parts":[[2018,10,3]]},"assertion":[{"value":"10 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"German University Cairo ethics committee [Chair of Committee Prof. Dr. Hans-Georg Breitinger, Hans-Georg Breitinger (hans.breitinger@guc.edu.eg)], approved the study protocols.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Consent by all participants (patients and healthy controls).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}