{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T14:41:57Z","timestamp":1793457717024,"version":"4.5.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T00:00:00Z","timestamp":1549238400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"crossref","award":["449485\/2014-5"],"award-info":[{"award-number":["449485\/2014-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","award":["CAPES\/PROEX ? Process numbers: 23038.005848\/2018-31 and 88882.182142\/2018-01"],"award-info":[{"award-number":["CAPES\/PROEX ? Process numbers: 23038.005848\/2018-31 and 88882.182142\/2018-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1007\/s11033-019-04658-1","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T14:01:47Z","timestamp":1549288907000},"page":"2085-2092","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":104,"title":["Antiproliferative and apoptotic effects of caffeic acid on SK-Mel-28 human melanoma cancer cells"],"prefix":"10.1007","volume":"46","author":[{"given":"Luana Paula","family":"Pelinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles Elias","family":"Assmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ta\u00eds Vidal","family":"Palma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana Beatrice M\u00e2nica","family":"da Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micheli Mainardi","family":"Pillat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"M\u00e2nica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naiara","family":"Stefanello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazielle Castagna Cezimbra","family":"Weis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrei","family":"de Oliveira Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinthia Melazzo","family":"de Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Ulrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera Maria Melchiors","family":"Morsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosa Chitolina","family":"Schetinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9263-4980","authenticated-orcid":false,"given":"Margarete Dulce","family":"Bagatini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,2,4]]},"reference":[{"key":"4658_CR1","volume-title":"Human skin cancers\u2014pathways, mechanisms, targets and treatments","author":"J O\u2019Sullivan","year":"2018","unstructured":"O\u2019Sullivan J, O\u2019Connor D (2018) The modern approach to targeting melanoma. In: Human skin cancers\u2014pathways, mechanisms, targets and treatments. InTechOpen, London"},{"key":"4658_CR2","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1016\/j.cell.2015.05.044","volume":"161","author":"R Akbani","year":"2015","unstructured":"Akbani R, Akdemir KC, Aksoy BA et al (2015) Genomic classification of cutaneous melanoma. Cell 161:1681\u20131696","journal-title":"Cell"},{"key":"4658_CR3","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1634\/theoncologist.2010-0190","volume":"16","author":"C Garbe","year":"2011","unstructured":"Garbe C, Eigentler TK, Keilholz U, Hauschild A, Kirkwood JM (2011) Systematic review of medical treatment in melanoma: current status and future prospects. Oncologist 16:5\u201324","journal-title":"Oncologist"},{"key":"4658_CR4","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/cncr.22427","volume":"109","author":"HJ Gogas","year":"2007","unstructured":"Gogas HJ, Kirkwood JM, Sondak VK (2007) Chemotherapy for metastatic melanoma: time for a change? Cancer 109:455\u2013464","journal-title":"Cancer"},{"key":"4658_CR5","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1200\/JCO.2000.18.1.158","volume":"18","author":"MR Middleton","year":"2000","unstructured":"Middleton MR, Grob JJ, Aaronson N, Fierlbeck G, Tilgen W, Seiter S, Gore M, Aamdal S, Cebon J, Coates A, Dreno B, Henz M, Schadendorf D, Kapp A, Weiss J, Fraass U, Statkevich P, Muller M, Thatcher N (2000) Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma. J Clin Oncol 18:158\u2013166","journal-title":"J Clin Oncol"},{"key":"4658_CR6","doi-asserted-by":"publisher","first-page":"665","DOI":"10.4161\/cbt.28555","volume":"15","author":"M Sanlorenzo","year":"2014","unstructured":"Sanlorenzo M, Vujic I, Posch C, Dajee A, Yen A, Kim S, Ashworth M, Rosenblum MD, Algazi A, Osella-Abate S, Quaglino P, Daud A, Ortiz-Urda S (2014) Melanoma immunotherapy. Cancer Biol Ther 15:665\u2013674","journal-title":"Cancer Biol Ther"},{"key":"4658_CR7","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.ejso.2016.07.145","volume":"43","author":"C Franklin","year":"2017","unstructured":"Franklin C, Livingstone E, Roesch A, Schilling B, Schadendorf D (2017) Immunotherapy in melanoma: recent advances and future directions. Eur J Surg Oncol 43:604\u2013611","journal-title":"Eur J Surg Oncol"},{"key":"4658_CR8","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/S0753-3322(02)00178-6","volume":"56","author":"H Tapiero","year":"2002","unstructured":"Tapiero H, Tew K, Nguyen Ba G, Math\u00e9 G (2002) Polyphenols: do they play a role in the prevention of human pathologies? Biomed Pharmacother 56:200\u2013207","journal-title":"Biomed Pharmacother"},{"key":"4658_CR9","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1089\/109662003772519831","volume":"6","author":"J Shi","year":"2003","unstructured":"Shi J, Yu J, Pohorly JE, Kakuda Y (2003) Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291\u2013299","journal-title":"J Med Food"},{"key":"4658_CR10","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.ctrv.2011.03.001","volume":"38","author":"CJ Weng","year":"2012","unstructured":"Weng CJ, Yen GC (2012) Chemopreventive effects of dietary phytochemicals against cancer invasion and metastasis: phenolic acids, monophenol, polyphenol, and their derivatives. Cancer Treat Rev 38:76\u201387","journal-title":"Cancer Treat Rev"},{"key":"4658_CR11","doi-asserted-by":"publisher","first-page":"372345","DOI":"10.1100\/2012\/372345","volume":"2012","author":"SK Jaganathan","year":"2012","unstructured":"Jaganathan SK (2012) Growth inhibition by caffeic acid, one of the phenolic constituents of honey, in HCT 15 colon cancer cells. Sci World J 2012:372345","journal-title":"Sci World J"},{"key":"4658_CR12","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1016\/j.biopha.2018.04.096","volume":"103","author":"CE Assmann","year":"2018","unstructured":"Assmann CE, Cadon\u00e1 FC, Bonadiman BDSR, Dornelles EB, Trevisan G, Cruz IBMD (2018) Tea tree oil presents in vitro antitumor activity on breast cancer cells without cytotoxic effects on fibroblasts and on peripheral blood mononuclear cells. Biomed Pharmacother 103:1253\u20131261","journal-title":"Biomed Pharmacother"},{"key":"4658_CR13","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"T Mosmann","year":"1983","unstructured":"Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55\u201363","journal-title":"J Immunol Methods"},{"key":"4658_CR14","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/0167-4889(96)00033-X","volume":"1312","author":"K Konopka","year":"1996","unstructured":"Konopka K, Pretzer E, Felgner PL, D\u00fczg\u00fcne\u015f N (1996) Human immunodeficiency virus type-1 (HIV-1) infection increases the sensitivity of macrophages and THP-1 cells to cytotoxicity by cationic liposomes. Biochim Biophys Acta 1312:186\u2013196","journal-title":"Biochim Biophys Acta"},{"key":"4658_CR15","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/0022-1759(95)00072-I","volume":"184","author":"I Vermes","year":"1995","unstructured":"Vermes I, Haanen C, Steffens-Nakken H, Reutellingsperger C (1995) A novel assay for apoptosis flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin V. J Immunol Methods 184:39\u201351","journal-title":"J Immunol Methods"},{"key":"4658_CR16","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1111\/jphp.12789","volume":"69","author":"LM Silva da","year":"2017","unstructured":"da Silva LM, Fri\u00f3n-Herrera Y, Bartolomeu AR, Gorgulho CM, Sforcin JM (2017) Mechanisms involved in the cytotoxic action of Brazilian propolis and caffeic acid against HEp-2 cells and modulation of P-glycoprotein activity. J Pharm Pharmacol 69:1625\u20131633","journal-title":"J Pharm Pharmacol"},{"key":"4658_CR17","doi-asserted-by":"publisher","first-page":"14782","DOI":"10.1074\/jbc.M113.527978","volume":"289","author":"M Cubillos-Rojas","year":"2014","unstructured":"Cubillos-Rojas M, Amair-Pinedo F, Peir\u00f3-Jord\u00e1n R, Bartrons R, Ventura F, Rosa JL (2014) The E3 ubiquitin protein ligase HERC2 modulates the activity of tumor protein p53 by regulating its oligomerization. J Biol Chem 289:14782\u201314795","journal-title":"J Biol Chem"},{"key":"4658_CR18","doi-asserted-by":"publisher","first-page":"R63","DOI":"10.1186\/bcr752","volume":"6","author":"M Kampa","year":"2004","unstructured":"Kampa M, Alexaki V, Notas G, Nifli AP, Nistikaki A, Hatzoglou A, Bakogeorgou E, Kouimtzoglou E, Blekas G, Boskou D, Gravanis A, Castanas E (2004) Antiproliferative and apoptotic effects of selective phenolic acids on T47D human breast cancer cells: potential mechanisms of action. Breast Cancer Res 6:R63\u2013R74","journal-title":"Breast Cancer Res"},{"key":"4658_CR19","doi-asserted-by":"publisher","first-page":"104","DOI":"10.5582\/ddt.2017.01009","volume":"11","author":"H Takahashi","year":"2017","unstructured":"Takahashi H, Nguyen BCQ, Uto Y, Shahinozzaman M, Tawata S, Maruta H (2017) 1,2,3-Triazolyl esterization of PAK1-blocking propolis ingredients, artepillin C (ARC) and caffeic acid (CA), for boosting their anti-cancer\/anti-PAK1 activities along with cell-permeability. Drug Discov Ther 11:104\u2013109","journal-title":"Drug Discov Ther"},{"key":"4658_CR20","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/S1028-4559(10)60092-7","volume":"49","author":"WC Chang","year":"2010","unstructured":"Chang WC, Hsieh CH, Hsiao MW, Lin WC, Hung YC, Ye JC (2010) Caffeic acid induces apoptosis in human cervical cancer cells through the mitochondrial pathway. Taiwan J Obstet Gynecol 49:419\u2013424","journal-title":"Taiwan J Obstet Gynecol"},{"key":"4658_CR21","doi-asserted-by":"publisher","first-page":"e90397","DOI":"10.1371\/journal.pone.0090397","volume":"9","author":"W Huang","year":"2014","unstructured":"Huang W, Seo J, Willingham SB, Czyzewski AM, Gonzalgo ML, Weissman IL, Barron AE (2014) Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity. PLoS ONE 9:e90397","journal-title":"PLoS ONE"},{"key":"4658_CR22","doi-asserted-by":"publisher","first-page":"321","DOI":"10.3389\/fmicb.2013.00321","volume":"4","author":"KC Mulder","year":"2013","unstructured":"Mulder KC, Lima LA, Miranda VJ, Dias SC, Franco OL (2013) Current scenario of peptide-based drugs: the key roles of cationic antitumor and antiviral peptides. Front Microbiol 4:321","journal-title":"Front Microbiol"},{"key":"4658_CR23","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1111\/jphp.12364","volume":"67","author":"MC B\u00fafalo","year":"2015","unstructured":"B\u00fafalo MC, Sforcin JM (2015) The modulatory effects of caffeic acid on human monocytes and its involvement in propolis action. J Pharm Pharmacol 67:740\u2013745","journal-title":"J Pharm Pharmacol"},{"key":"4658_CR24","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1080\/01480545.2016.1252919","volume":"40","author":"S Kilani-Jaziri","year":"2017","unstructured":"Kilani-Jaziri S, Mokdad-Bzeouich I, Krifa M, Nasr N, Ghedira K, Chekir-Ghedira L (2017) Immunomodulatory and cellular anti-oxidant activities of caffeic, ferulic, and p-coumaric phenolic acids: a structure-activity relationship study. Drug Chem Toxicol 40:416\u2013424","journal-title":"Drug Chem Toxicol"},{"key":"4658_CR25","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1080\/01635581.2015.1004736","volume":"67","author":"LD Murad","year":"2015","unstructured":"Murad LD, Soares Nda C, Brand C, Monteiro MC, Teodoro AJ (2015) Effects of caffeic and 5-caffeoylquinic acids on cell viability and cellular uptake in human colon adenocarcinoma cells. Nutr Cancer 67:532\u2013542","journal-title":"Nutr Cancer"},{"key":"4658_CR26","first-page":"1191","volume":"21","author":"YN Chen","year":"2017","unstructured":"Chen YN (2017) Dacarbazine inhibits proliferation of melanoma FEMX-1 cells by up-regulating expression of miRNA-200. Eur Rev Med Pharmacol Sci 21:1191\u20131197","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"4658_CR27","first-page":"112","volume":"8","author":"J Baharara","year":"2016","unstructured":"Baharara J, Amini E, Nikdel N, Salek-Abdollahi F (2016) The cytotoxicity of dacarbazine potentiated by sea cucumber saponin in resistant B16F10 melanoma cells through apoptosis induction. Avicenna J Med Biotechnol 8:112\u2013119","journal-title":"Avicenna J Med Biotechnol"},{"key":"4658_CR28","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1038\/embor.2012.162","volume":"13","author":"J He","year":"2012","unstructured":"He J, Xu Q, Jing Y, Agani F, Qian X, Carpenter R, Li Q, Wang XR, Peiper SS, Lu Z, Liu LZ, Jiang BH (2012) Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR-199a\/125b and DNA methylation. EMBO Rep 13:1116\u20131122","journal-title":"EMBO Rep"},{"key":"4658_CR29","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1002\/path.1324","volume":"200","author":"H Grabsch","year":"2003","unstructured":"Grabsch H, Takeno S, Parsons WJ, Pomjanski N, Boecking A, Gabbert HE, Mueller W (2003) Overexpression of the mitotic checkpoint genes BUB1, BUBR1, and BUB3 in gastric cancer-association with tumour cell proliferation. J Pathol 200:16\u201322","journal-title":"J Pathol"},{"key":"4658_CR30","first-page":"389","volume":"30","author":"M Pinto","year":"2008","unstructured":"Pinto M, Vieira J, Ribeiro FR, Soares MJ, Henrique R, Oliveira J, Jer\u00f3nimo C, Teixeira MR (2008) Overexpression of the mitotic checkpoint genes BUB1 and BUBR1 is associated with genomic complexity in clear cell kidney carcinomas. Cell Oncol 30:389\u2013395","journal-title":"Cell Oncol"},{"key":"4658_CR31","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1111\/j.1365-2184.2008.00539.x","volume":"41","author":"E Burum-Auensen","year":"2008","unstructured":"Burum-Auensen E, DeAngelis PM, Schj\u00f8lberg AR, R\u00f8islien J, Mj\u00e5land O, Clausen OP (2008) Reduced level of the spindle checkpoint protein BUB1B is associated with aneuploidy in colorectal cancers. Cell Prolif 41:645\u2013659","journal-title":"Cell Prolif"},{"key":"4658_CR32","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.lungcan.2011.01.025","volume":"74","author":"T Kato","year":"2011","unstructured":"Kato T, Daigo Y, Aragaki M, Ishikawa K, Sato M, Kondo S, Kaji M (2011) Overexpression of MAD2 predicts clinical outcome in primary lung cancer patients. Lung Cancer 74:124\u2013131","journal-title":"Lung Cancer"},{"key":"4658_CR33","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1159\/000492253","volume":"48","author":"J Min","year":"2018","unstructured":"Min J, Shen H, Xi W, Wang Q, Yin L, Zhang Y, Yu Y, Yang Q, Wang ZN (2018) Synergistic anticancer activity of combined use of caffeic acid with paclitaxel enhances apoptosis of non-small-cell lung cancer H1299 cells in vivo and in vitro. Cell Physiol Biochem 48:1433\u20131442","journal-title":"Cell Physiol Biochem"},{"key":"4658_CR34","doi-asserted-by":"publisher","first-page":"6793456","DOI":"10.1155\/2017\/6793456","volume":"2017","author":"A Dziedzic","year":"2017","unstructured":"Dziedzic A, Kubina R, Kaba\u0142a-Dzik A, Tanasiewicz M (2017) Induction of cell cycle arrest and apoptotic response of head and neck squamous carcinoma cells (Detroit 562) by caffeic acid and caffeic acid phenethyl ester derivative. Evid Based Complement Altern Med 2017:6793456","journal-title":"Evid Based Complement Altern Med"},{"key":"4658_CR35","doi-asserted-by":"publisher","first-page":"E1554","DOI":"10.3390\/molecules22091554","volume":"22","author":"A Kaba\u0142a-Dzik","year":"2017","unstructured":"Kaba\u0142a-Dzik A, Rzepecka-Stojko A, Kubina R, Jastrz\u0119bska-Stojko \u017b, Stojko R, Wojtyczka RD, Stojko J (2017) Comparison of two components of propolis: caffeic acid (CA) and caffeic acid phenethyl ester (CAPE) induce apoptosis and cell cycle arrest of breast cancer cells MDA-MB-231. Molecules 22:E1554","journal-title":"Molecules"},{"key":"4658_CR36","doi-asserted-by":"publisher","first-page":"E723","DOI":"10.3390\/ijms19030723","volume":"19","author":"S Sadeghi Ekbatan","year":"2018","unstructured":"Sadeghi Ekbatan S, Li XQ, Ghorbani M, Azadi B, Kubow S (2018) Chlorogenic acid and its microbial metabolites exert anti-proliferative effects, S-phase cell-cycle arrest and apoptosis in human colon cancer caco-2 cells. Int J Mol Sci 19:E723","journal-title":"Int J Mol Sci"},{"key":"4658_CR37","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1179\/1607845412Y.0000000042","volume":"18","author":"AA Gokbulut","year":"2013","unstructured":"Gokbulut AA, Apohan E, Baran Y (2013) Resveratrol and quercetin-induced apoptosis of human 232B4 chronic lymphocytic leukemia cells by activation of caspase-3 and cell cycle arrest. Hematology 18:144\u2013150","journal-title":"Hematology"},{"key":"4658_CR38","first-page":"21","volume":"110","author":"A Munshi","year":"2005","unstructured":"Munshi A, Hobbs M, Meyn RE (2005) Clonogenic cell survival assay. Methods Mol Med 110:21\u201328","journal-title":"Methods Mol Med"},{"key":"4658_CR39","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1007\/s10637-009-9334-5","volume":"29","author":"SK Kudugunti","year":"2011","unstructured":"Kudugunti SK, Vad NM, Ekogbo E, Moridani MY (2011) Efficacy of caffeic acid phenethyl ester (CAPE) in skin B16-F0 melanoma tumor bearing C57BL\/6 mice. Investig N Drugs 29:52\u201362","journal-title":"Investig N Drugs"},{"key":"4658_CR40","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1093\/carcin\/bgt154","volume":"34","author":"KC Pramanik","year":"2013","unstructured":"Pramanik KC, Kudugunti SK, Fofaria NM, Moridani MY, Srivastava SK (2013) Caffeic acid phenethyl ester suppresses melanoma tumor growth by inhibiting PI3K\/AKT\/XIAP pathway. Carcinogenesis 34:2061\u20132070","journal-title":"Carcinogenesis"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11033-019-04658-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-019-04658-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-019-04658-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T19:21:20Z","timestamp":1580757680000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11033-019-04658-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,4]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["4658"],"URL":"https:\/\/doi.org\/10.1007\/s11033-019-04658-1","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,4]]},"assertion":[{"value":"29 October 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Infromed consent was obtained from all individual participants in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}