{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:33:42Z","timestamp":1788345222468,"version":"build-2803163510"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"MIUR-PRIN 2015"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1007\/s11033-020-05552-x","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T18:05:25Z","timestamp":1591121125000},"page":"4373-4382","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Seminal plasma miRNAs in Klinefelter syndrome and in obstructive and non-obstructive azoospermia"],"prefix":"10.1007","volume":"47","author":[{"given":"Federica","family":"Finocchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Pelloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Balercia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Pallotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio F.","family":"Radicioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Lenzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Lombardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9699-8703","authenticated-orcid":false,"given":"Donatella","family":"Paoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,1]]},"reference":[{"key":"5552_CR1","first-page":"669","volume-title":"WHO laboratory manual for the examination and processing of human semen","author":"World Health Organization","year":"2010","unstructured":"World Health Organization (2010) WHO laboratory manual for the examination and processing of human semen, 5th edn. World Health Organization, Geneva, pp 669\u2013676","edition":"5"},{"key":"5552_CR2","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1016\/j.juro.2006.11.039","volume":"177","author":"R Ramasamy","year":"2007","unstructured":"Ramasamy R, Schlegel PN (2007) microdissection testicular sperm extraction: effect of prior biopsy on success of sperm retrieval. J Urol 177:1447\u20131449","journal-title":"J Urol"},{"key":"5552_CR3","doi-asserted-by":"publisher","first-page":"e28218","DOI":"10.4161\/spmg.28218","volume":"4","author":"M Wosnitzer","year":"2014","unstructured":"Wosnitzer M, Goldstein M, Hardy MP (2014) Review of Azoospermia Spermatogenesis 4:e28218","journal-title":"Review of Azoospermia Spermatogenesis"},{"key":"5552_CR4","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1093\/hmg\/5.7.933","volume":"5","author":"PH Vogt","year":"1996","unstructured":"Vogt PH, Edelmann A, Kirsch S, Henegariu O, Hirschmann P et al (1996) Human Y chromosome azoospermia factors (AZF) mapped to different subregions in Yq11. Hum Mol Genet 5:933\u2013943","journal-title":"Hum Mol Genet"},{"key":"5552_CR5","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/s12020-018-1604-6","volume":"61","author":"N Tahani","year":"2018","unstructured":"Tahani N, Nieddu L, Prossomariti G, Spaziani M, Granato S et al (2018) Long-term effect of testosterone replacement therapy on bone in hypogonadal men with Klinefelter Syndrome. Endocrine 61:327\u2013335","journal-title":"Endocrine"},{"key":"5552_CR6","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1002\/j.1939-4640.2003.tb03129.x","volume":"24","author":"A Kamischke","year":"2003","unstructured":"Kamischke A, Baumgardt A, Horst J, Nieschlag E (2003) Clinical and diagnostic features of patients with suspected Klinefelter syndrome. J Androl 24:41\u201348","journal-title":"J Androl"},{"key":"5552_CR7","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1093\/humupd\/dmi039","volume":"12","author":"L Aksglaede","year":"2006","unstructured":"Aksglaede L, Wikstr\u00f6m AM, Rajpert-De Meyts E, Dunkel L, Skakkebaek NE et al (2006) Natural history of seminiferous tubule degeneration in Klinefelter syndrome. Hum Reprod Update 12:39\u201348","journal-title":"Hum Reprod Update"},{"key":"5552_CR8","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/nature02871","volume":"431","author":"V Ambros","year":"2004","unstructured":"Ambros V (2004) The functions of animal microRNAs. Nature 431:350\u2013355","journal-title":"Nature"},{"key":"5552_CR9","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.fertnstert.2013.09.009","volume":"101","author":"M Abu-Halima","year":"2014","unstructured":"Abu-Halima M, Backes C, Leidinger P, Keller A, Lubbad AM et al (2014) MicroRNA expression profiles in human testicular tissues of infertile men with different histopathologic patterns. Fertil Steril 101:78\u201386","journal-title":"Fertil Steril"},{"key":"5552_CR10","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1007\/s12020-016-1150-z","volume":"57","author":"M Pelloni","year":"2016","unstructured":"Pelloni M, Coltrinari G, Paoli D, Pallotti F, Lombardo F et al (2016) Differential expression of miRNAs in the seminal plasma and serum of testicular cancer patients. Endocrine 57:518\u2013527","journal-title":"Endocrine"},{"key":"5552_CR11","doi-asserted-by":"publisher","first-page":"16635","DOI":"10.1074\/jbc.M412247200","volume":"280","author":"YS Lee","year":"2005","unstructured":"Lee YS, Kim HK, Chung S, Kim KS, Dutta A (2005) Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down-regulation of putative targets during differentiation. J Biol Chem 280:16635\u201316641","journal-title":"J Biol Chem"},{"key":"5552_CR12","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1126\/science.1091903","volume":"303","author":"CZ Chen","year":"2004","unstructured":"Chen CZ, Li L, Lodish HF, Bartel DP (2004) MicroRNAs modulate hematopoietic lineage differentiation. Science 303:83\u201386","journal-title":"Science"},{"key":"5552_CR13","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/S0092-8674(03)00428-8","volume":"113","author":"V Ambros","year":"2003","unstructured":"Ambros V (2003) MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing. Cell 113:673\u2013676","journal-title":"Cell"},{"key":"5552_CR14","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/nrc1840","volume":"6","author":"A Esquela-Kerscher","year":"2006","unstructured":"Esquela-Kerscher A, Slack FJ (2006) Oncomirs\u2014microRNAs with a role in cancer. Nat Rev Cancer 6:259\u2013269","journal-title":"Nat Rev Cancer"},{"key":"5552_CR15","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1373\/clinchem.2010.147405","volume":"56","author":"JA Weber","year":"2010","unstructured":"Weber JA, Baxter DH, Zhang S, Huang DY, Huang KH et al (2010) The microRNA spectrum in 12 body fluids. Clin Chem 56:1733\u20131741","journal-title":"Clin Chem"},{"key":"5552_CR16","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1373\/clinchem.2011.169714","volume":"57","author":"C Wang","year":"2011","unstructured":"Wang C, Yang C, Chen X, Yao B, Yang C et al (2011) Altered profile of seminal plasma microRNAs in the molecular diagnosis of male infertility. Clin Chem 57:1722\u20131731","journal-title":"Clin Chem"},{"key":"5552_CR17","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1016\/j.fertnstert.2014.04.025","volume":"101","author":"N Kotaja","year":"2014","unstructured":"Kotaja N (2014) MicroRNAs and spermatogenesis. Fertil Steril 101:1552\u20131562","journal-title":"Fertil Steril"},{"key":"5552_CR18","doi-asserted-by":"publisher","first-page":"e1738","DOI":"10.1371\/journal.pone.0001738","volume":"3","author":"K Hayashi","year":"2008","unstructured":"Hayashi K, de Sousa C, Lopes SM, Kaneda M, Tang F, Hajkova P et al (2008) MicroRNA biogenesis is required for mouse primordial germ cell development and spermatogenesis. PLoS ONE 3:e1738","journal-title":"PLoS ONE"},{"key":"5552_CR19","doi-asserted-by":"publisher","first-page":"26","DOI":"10.2164\/jandrol.109.008128","volume":"31","author":"MD Papaioannou","year":"2010","unstructured":"Papaioannou MD, Nef S (2010) microRNAs in the testis: building up male fertility. J Androl 31:26\u201333","journal-title":"J Androl"},{"key":"5552_CR20","doi-asserted-by":"publisher","first-page":"2486","DOI":"10.1101\/gr.2845604","volume":"14","author":"O Barad","year":"2004","unstructured":"Barad O, Meiri E, Avniel A, Aharonov R, Barzilai A et al (2004) MicroRNA expression detected by oligonucleotide microarrays: system establishment and expression profiling in human tissues. Genome Res 14:2486\u20132494","journal-title":"Genome Res"},{"key":"5552_CR21","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.ydbio.2007.09.009","volume":"311","author":"S Ro","year":"2007","unstructured":"Ro S, Park C, Sanders KM, McCarrey JR, Yan W (2007) Cloning and expression profiling of testis-expressed microRNAs. Dev Biol 311:592\u2013602","journal-title":"Dev Biol"},{"key":"5552_CR22","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/1471-2164-10-97","volume":"10","author":"X Guo","year":"2009","unstructured":"Guo X, Su B, Zhou Z, Sha J (2009) Rapid evolution of mammalian X-linked testis microRNAs. BMC Genomics 10:97","journal-title":"BMC Genomics"},{"key":"5552_CR23","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1095\/biolreprod.105.040998","volume":"73","author":"Z Yu","year":"2005","unstructured":"Yu Z, Raabe T, Hecht NB (2005) MicroRNA Mirn122a reduces expression of the posttranscriptionally regulated germ cell transition protein 2 (Tnp2) messenger RNA (mRNA) by mRNA cleavage. Biol Reprod 73:427\u2013433","journal-title":"Biol Reprod"},{"key":"5552_CR24","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1089\/scd.2012.0653","volume":"22","author":"T Liu","year":"2013","unstructured":"Liu T, Huang Y, Liu J, Zhao Y, Jiang L et al (2013) MicroRNA-122 influences the development of sperm abnormalities from human induced pluripotent stem cells by regulating TNP2 expression. Stem Cells Dev 22:1839\u20131850","journal-title":"Stem Cells Dev"},{"key":"5552_CR25","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.bbrc.2008.07.154","volume":"375","author":"CJF Lin","year":"2008","unstructured":"Lin CJF, Gong HY, Tseng HC, Wang WL, Wu JL (2008) miR-122 targets an anti-apoptotic gene, Bcl-w, in human hepatocellular carcinoma cell lines. Biochem Biophys Res Commun 375:315\u2013320","journal-title":"Biochem Biophys Res Commun"},{"key":"5552_CR26","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/cdd.2009.56","volume":"17","author":"H Hermeking","year":"2009","unstructured":"Hermeking H (2009) The miR-34 family in cancer and apoptosis. Cell Death Differ 17:193\u2013199","journal-title":"Cell Death Differ"},{"key":"5552_CR27","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1038\/nature05939","volume":"447","author":"L He","year":"2007","unstructured":"He L, He X, Lim LP, de Stanchina E, Xuan Z et al (2007) A microRNA component of the p53 tumour suppressor network. Nature 447:1130\u20131134","journal-title":"Nature"},{"key":"5552_CR28","doi-asserted-by":"publisher","first-page":"8866","DOI":"10.1073\/pnas.0800650105","volume":"105","author":"YW Kong","year":"2008","unstructured":"Kong YW, Cannell IG, de Moor CH, Hill K, Garside PG et al (2008) The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene. Proc Natl Acad Sci USA 105:8866\u20138871","journal-title":"Proc Natl Acad Sci USA"},{"key":"5552_CR29","doi-asserted-by":"publisher","first-page":"5204","DOI":"10.1038\/onc.2008.154","volume":"27","author":"JS Wei","year":"2008","unstructured":"Wei JS, Song YK, Durinck S, Chen QR, Cheuk AT et al (2008) The MYCN oncogene is a direct target of miR-34a. Oncogene 27:5204\u20135213","journal-title":"Oncogene"},{"key":"5552_CR30","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1038\/cdd.2009.109","volume":"17","author":"NR Christoffersen","year":"2010","unstructured":"Christoffersen NR, Shalgi R, Frankel LB, Leucci E, Lees M et al (2010) p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC. Cell Death Differ 17:236\u2013245","journal-title":"Cell Death Differ"},{"key":"5552_CR31","doi-asserted-by":"publisher","first-page":"5638","DOI":"10.1182\/blood-2010-04-281600","volume":"116","author":"JA Pulikkan","year":"2010","unstructured":"Pulikkan JA, Peramangalam PS, Dengler V, Ho PA, Preudhomme C et al (2010) C\/EBPa regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutations. Blood 116:5638\u20135649","journal-title":"Blood"},{"key":"5552_CR32","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1093\/jmcb\/mju003","volume":"6","author":"M Rokavec","year":"2014","unstructured":"Rokavec M, Li H, Jiang L, Hm H (2014) The p53\/miR-34 axis in development and disease. J Mol Cell Biol 6:214\u2013230","journal-title":"J Mol Cell Biol"},{"key":"5552_CR33","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1530\/REP-07-0056","volume":"134","author":"N Yan","year":"2007","unstructured":"Yan N, Lu Y, Sun H, Tao D, Zhang S et al (2007) A microarray for microRNA profiling in mouse testis tissues. Reproduction 134:73\u201379","journal-title":"Reproduction"},{"key":"5552_CR34","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s10815-009-9305-y","volume":"26","author":"N Yan","year":"2009","unstructured":"Yan N, Lu Y, Sun H, Qui W, Tao D et al (2009) Microarray profiling of microRNAs expressed in testis tissues of developing primates. J Assist Reprod Genet 26:179\u2013186","journal-title":"J Assist Reprod Genet"},{"key":"5552_CR35","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1261\/rna.1963810","volume":"16","author":"F Bouhallier","year":"2010","unstructured":"Bouhallier F, Allioli N, Lavial F, Chalmel F, Perrard MH et al (2010) Role of miR-34c microRNA in the late steps of spermatogenesis. RNA 16:720\u2013731","journal-title":"RNA"},{"key":"5552_CR36","doi-asserted-by":"publisher","first-page":"e33861","DOI":"10.1371\/journal.pone.0033861","volume":"7","author":"X Liang","year":"2012","unstructured":"Liang X, Zhou D, Wei C, Luo H, Liu J et al (2012) MicroRNA-34c enhances murine male germ cell apoptosis through targeting ATF1. PLoS ONE 7:e33861","journal-title":"PLoS ONE"},{"key":"5552_CR37","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1002\/cbf.2922","volume":"30","author":"S Zhang","year":"2012","unstructured":"Zhang S, Yu M, Liu C, Wang L, Hu Y et al (2012) MiR-34c regulates mouse embryonic stem cells differentiation into male germ-like cells through RARg. Cell biochem and function 30:623\u2013632","journal-title":"Cell biochem and function"},{"key":"5552_CR38","doi-asserted-by":"publisher","first-page":"e66809","DOI":"10.1371\/journal.pone.0066809","volume":"8","author":"Q Yang","year":"2013","unstructured":"Yang Q, Hua J, Wang L, Xu B, Zhang H et al (2013) MicroRNA and piRNA profiles in normal human testis detected by next generation sequencing. PLoS ONE 8:e66809","journal-title":"PLoS ONE"},{"key":"5552_CR39","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1073\/pnas.1110368109","volume":"109","author":"WM Liu","year":"2012","unstructured":"Liu WM, Pang RT, Chiu PC, Wong BP, Lao K et al (2012) Sperm-borne microRNA-34c is required for the first cleavage division in mouse. Proc Natl Acad Sci U S A 109:490\u2013494","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5552_CR40","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1002\/jcb.24655","volume":"115","author":"M Yu","year":"2014","unstructured":"Yu M, Mu H, Niu Z, Chu Z, Zhu H et al (2014) miR-34c enhances muose spermatogonial stem cells differentiation by targeting Nanos2. J Cell Biochem 115:232\u2013242","journal-title":"J Cell Biochem"},{"key":"5552_CR41","first-page":"3617","volume":"21","author":"YH Song","year":"2017","unstructured":"Song YH, Wang J, Nie G, Chen YJ, Li X et al (2017) MicroRNA-509-5p functions as an anti-oncogene in breast cancer via targeting SOD2. Eur Rev Med Pharmacol Sci 21:3617\u20133625","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"5552_CR42","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/j.clinbiochem.2013.11.009","volume":"47","author":"L Hu","year":"2014","unstructured":"Hu L, Wu C, Guo C, Li H, Xiong C (2014) Identification of microRNAs predominately derived from testis and epididymis in human seminal plasma. Clin Biochem 47:967\u2013972","journal-title":"Clin Biochem"},{"key":"5552_CR43","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1016\/j.fertnstert.2012.11.054","volume":"99","author":"M Abu-Halima","year":"2013","unstructured":"Abu-Halima M, Hammadeh M, Schmitt J, Leidinger P, Keller A et al (2013) Altered microRNA expression profiles of human spermatozoa in patients with different spermatogenic impairments. Fertil Steril 99:1249\u20131255","journal-title":"Fertil Steril"},{"key":"5552_CR44","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1093\/humrep\/dey072","volume":"33","author":"M Barcel\u00f3","year":"2018","unstructured":"Barcel\u00f3 M, Mata A, Bassas L, Larriba S (2018) Exosomal microRNAs in seminal plasma are markers of the origin of azoospermia and can predict the presence of sperm in testicular tissue. Hum Reprod 33:1087\u20131098","journal-title":"Hum Reprod"},{"key":"5552_CR45","doi-asserted-by":"publisher","first-page":"825","DOI":"10.3892\/etm.2012.682","volume":"4","author":"W Sui","year":"2012","unstructured":"Sui W, Ou M, Chen J, Li H, Lin H et al (2012) microRNA expression profile in peripheral blood mononuclear cells of Klinefelter syndrome. Exp Ther Med 4:825\u2013831","journal-title":"Exp Ther Med"},{"key":"5552_CR46","doi-asserted-by":"publisher","first-page":"16672","DOI":"10.1038\/s41598-017-16892-3","volume":"30","author":"L Cimino","year":"2017","unstructured":"Cimino L, Salemi M, Cannarella R, Condorelli RA, Giurato G et al (2017) Decreased miRNA expression in Klinefelter syndrome. Sci Rep 30:16672","journal-title":"Sci Rep"},{"key":"5552_CR47","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s00441-017-2667-z","volume":"370","author":"MS Proc\u00f3pio","year":"2017","unstructured":"Proc\u00f3pio MS, de Avelar GF, Costa GMJ, Lacerda SMSN, Resende RR et al (2017) MicroRNAs in Sertoli cells: implications for spermatogenesis and fertility. Cell Tissue Res 370:335\u2013346","journal-title":"Cell Tissue Res"},{"key":"5552_CR48","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1210\/en.2010-1341","volume":"152","author":"PK Nicholls","year":"2011","unstructured":"Nicholls PK, Harrison CA, Walton KL, McLachlan RI, O'Donnell L et al (2011) Hormonal regulation of sertoli cell micro-RNAs at spermiation. Endocrinology 152:1670\u20131683","journal-title":"Endocrinology"},{"key":"5552_CR49","doi-asserted-by":"publisher","first-page":"2","DOI":"10.2174\/2211536605666161208154633","volume":"6","author":"M Williams","year":"2017","unstructured":"Williams M, Cheng YY, Blenkiron C, Reid G (2017) Exploring Mechanisms of MicroRNA Downregulation in Cancer. Microrna 6:2\u201316","journal-title":"Microrna"},{"issue":"5","key":"5552_CR50","first-page":"4726","volume":"17","author":"HH Jun","year":"2019","unstructured":"Jun HH, Kwack K, Lee KH, Kim JO, Park HS, Ryu CS, Lee JY, Ko D, Kim J, Kim NK (2019) Association between TP53 genetic polymorphisms and the methylation and expression of miR-34a, 34b\/c in colorectal cancer tissues. Oncol Lett. 17(5):4726\u20134734","journal-title":"Oncol Lett."},{"key":"5552_CR51","doi-asserted-by":"publisher","first-page":"490","DOI":"10.4161\/cbt.11.5.14550","volume":"11","author":"Z Wang","year":"2011","unstructured":"Wang Z, Chen Z, Gao Y, Li N, Li B, Tan F, Tan X, Lu N, Sun Y, Sun J et al (2011) DNA hypermethylation of microRNA-34b\/c has prognostic value for stage I non-small cell lung cancer. Cancer Biol Ther 11:490\u2013496","journal-title":"Cancer Biol Ther"},{"key":"5552_CR52","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.lungcan.2011.10.002","volume":"76","author":"N Tanaka","year":"2012","unstructured":"Tanaka N, Toyooka S, Soh J, Kubo T, Yamamoto H, Maki Y, Muraoka T, Shien K, Furukawa M, Ueno T et al (2012) Frequent methylation and oncogenic role of microRNA-34b\/c in small-cell lung cancer. Lung Cancer 76:32\u201338","journal-title":"Lung Cancer"},{"key":"5552_CR53","doi-asserted-by":"crossref","unstructured":"Xie K, Liu J, Chen J, Dong J, Ma H, Liu Y, Hu Z. Methylation-associated silencing of microRNA-34b in hepatocellular carcinoma cancer. Gene. 2014;543(1):101\u2013107.","DOI":"10.1016\/j.gene.2014.03.059"},{"key":"5552_CR54","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1093\/carcin\/bgq203","volume":"31","author":"H Suzuki","year":"2010","unstructured":"Suzuki H, Yamamoto E, Nojima M, Kai M, Yamano HO, Yoshikawa K, Kimura T, Kudo T, Harada E, Sugai T et al (2010) Methylation-associated silencing of microRNA-34b\/c in gastric cancer and its involvement in an epigenetic field defect. Carcinogenesis 31:2066\u20132073","journal-title":"Carcinogenesis"},{"key":"5552_CR55","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.1158\/0008-5472.CAN-07-5194","volume":"68","author":"K Kozaki","year":"2008","unstructured":"Kozaki K, Imoto I, Mogi S, Omura K, Inazawa J (2008) Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer. Cancer Res 68:2094\u20132105","journal-title":"Cancer Res"},{"issue":"1","key":"5552_CR56","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s43032-019-00025-4","volume":"27","author":"A Momeni","year":"2020","unstructured":"Momeni A, Najafipour R, Hamta A, Jahani S, Moghbelinejad S (2020) Expression and Methylation Pattern of hsa-miR-34 Family in Sperm Samples of Infertile Men. Reprod Sci 27(1):301\u2013308","journal-title":"Reprod Sci"},{"issue":"1","key":"5552_CR57","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s40360-018-0201-x","volume":"19","author":"Y Li","year":"2018","unstructured":"Li Y, Ren Q, Zhu L, Li Y, Li J, Zhang Y, Zheng G, Han T, Sun S, Feng F (2018) Involvement of methylation of MicroRNA-122, -125b and -106b in regulation of Cyclin G1, CAT-1 and STAT3 target genes in isoniazid-induced liver injury. BMC Pharmacol Toxicol 19(1):11","journal-title":"BMC Pharmacol Toxicol"},{"key":"5552_CR58","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/978-981-10-6955-0_21","volume":"1042","author":"W Feng","year":"2017","unstructured":"Feng W, Chakraborty A (2017) Fragility extraordinaire: unsolved mysteries of chromosome fragile sites. Adv Exp Med Biol 1042:489\u2013526","journal-title":"Adv Exp Med Biol"},{"issue":"4","key":"5552_CR59","doi-asserted-by":"publisher","first-page":"876","DOI":"10.3390\/cancers12040876","volume":"12","author":"S Marquardt","year":"2020","unstructured":"Marquardt S, Richter C, P\u00fctzer BM, Logotheti S (2020) MiRNAs targeting double strand DNA repair pathways lurk in genomically unstable rare fragile sites and determine cancer outcomes. Cancers (Basel). 12(4):876","journal-title":"Cancers (Basel)."},{"key":"5552_CR60","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1101\/gr.6146507","volume":"17","author":"R Zhang","year":"2007","unstructured":"Zhang R, Peng Y, Wang W, Su B (2007) Rapid evolution of an X-linked microRNA cluster in primates. Genome Res 17:612\u2013617","journal-title":"Genome Res"},{"key":"5552_CR61","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1093\/molbev\/msp284","volume":"27","author":"J Li","year":"2010","unstructured":"Li J, Liu Y, Dong D, Zhang Z (2010) Evolution of an X-linked primate-specific micro RNA cluster. Mol Biol Evol 27:671\u2013683","journal-title":"Mol Biol Evol"},{"key":"5552_CR62","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1186\/1471-2148-13-255","volume":"13","author":"Z Sun","year":"2013","unstructured":"Sun Z, Zhang Y, Zhang R, Qi X, Su B (2013) Functional divergence of the rapidly evolving miR-513 subfamily in primates. BMC Evol Biol 13:255","journal-title":"BMC Evol Biol"},{"key":"5552_CR63","doi-asserted-by":"publisher","first-page":"326","DOI":"10.2174\/138920210791616699","volume":"11","author":"LW Dillon","year":"2010","unstructured":"Dillon LW, Burrow AA, Wang Y-H (2010) DNA instability at chromosomal fragile sites in cancer. Curr Genomics 11:326\u2013337","journal-title":"Curr Genomics"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-020-05552-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-020-05552-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-020-05552-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T05:29:12Z","timestamp":1622525352000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-020-05552-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":63,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["5552"],"URL":"https:\/\/doi.org\/10.1007\/s11033-020-05552-x","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"3 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that there are no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This retrospective study was approved by our University Hospital\u2019s institutional review board (Protocol 835\/18).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}