{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T08:24:40Z","timestamp":1779006280089,"version":"3.51.4"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2020,7,11]],"date-time":"2020-07-11T00:00:00Z","timestamp":1594425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,11]],"date-time":"2020-07-11T00:00:00Z","timestamp":1594425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2017\/12244-2"],"award-info":[{"award-number":["2017\/12244-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"name":"CNPQ"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1007\/s11033-020-05644-8","type":"journal-article","created":{"date-parts":[[2020,7,11]],"date-time":"2020-07-11T14:02:55Z","timestamp":1594476175000},"page":"6259-6267","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The relationship among vitamin D, TLR4 pathway and preeclampsia"],"prefix":"10.1007","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5073-4614","authenticated-orcid":false,"given":"Esther Alves","family":"de Souza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6579-6167","authenticated-orcid":false,"given":"Luciana Pellegrini","family":"Pisani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,7,11]]},"reference":[{"key":"5644_CR1","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1097\/01.AOG.0000437382.03963.88","volume":"122","author":"JM Roberts","year":"2013","unstructured":"Roberts JM, August PA, Bakris G et al (2013) Task force on hypertension in pregnancy. Hypertension in pregnancy. Am Coll Obstet Gynecol 122:1122\u20131131","journal-title":"Am Coll Obstet Gynecol"},{"key":"5644_CR2","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.molmed.2014.11.009","volume":"21","author":"S Goulopoulou","year":"2015","unstructured":"Goulopoulou S, Davidge ST (2015) Molecular mechanisms of maternal vascular dysfunction in preeclampsia. Trends Mol Med 21:88\u201397. https:\/\/doi.org\/10.1016\/j.molmed.2014.11.009","journal-title":"Trends Mol Med"},{"key":"5644_CR3","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1016\/j.jacc.2018.05.077","volume":"72","author":"JJ Stuart","year":"2018","unstructured":"Stuart JJ, Tanz LJ, Cook NR et al (2018) Hypertensive disorders of pregnancy and 10-year cardiovascular risk prediction. J Am Coll Cardiol 72:1252\u20131263. https:\/\/doi.org\/10.1016\/j.jacc.2018.05.077","journal-title":"J Am Coll Cardiol"},{"key":"5644_CR4","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.preghy.2018.04.015","volume":"13","author":"LJ Tanz","year":"2018","unstructured":"Tanz LJ, Stuart JJ, Missmer SA et al (2018) Cardiovascular biomarkers in the years following pregnancies complicated by hypertensive disorders or delivered preterm. Pregnancy Hypertens 13:14\u201321. https:\/\/doi.org\/10.1016\/j.preghy.2018.04.015","journal-title":"Pregnancy Hypertens"},{"key":"5644_CR5","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980018002616","author":"KT Kibret","year":"2018","unstructured":"Kibret KT, Chojenta C, Gresham E et al (2018) Maternal dietary patterns and risk of adverse pregnancy (hypertensive disorders of pregnancy and gestational diabetes mellitus) and birth (preterm birth and low birth weight) outcomes: a systematic review and meta-analysis. Public Health Nutr. https:\/\/doi.org\/10.1017\/S1368980018002616","journal-title":"Public Health Nutr"},{"key":"5644_CR6","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s12884-018-1685-5","volume":"18","author":"D Mannaerts","year":"2018","unstructured":"Mannaerts D, Faes E, Gielis J et al (2018) Oxidative stress and endothelial function in normal pregnancy versus pre-eclampsia, a combined longitudinal and case control study. BMC Pregnancy Childbirth 18:60. https:\/\/doi.org\/10.1186\/s12884-018-1685-5","journal-title":"BMC Pregnancy Childbirth"},{"key":"5644_CR7","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.phrs.2017.04.018","volume":"121","author":"D Balasubbramanian","year":"2017","unstructured":"Balasubbramanian D, Gelston CAL, Mitchell BM, Chatterjee P (2017) Toll-like receptor activation, vascular endothelial function, and hypertensive disorders of pregnancy. Pharmacol Res 121:14\u201321. https:\/\/doi.org\/10.1016\/j.phrs.2017.04.018","journal-title":"Pharmacol Res"},{"key":"5644_CR8","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1097\/MCO.0000000000000186","volume":"18","author":"EK Calton","year":"2015","unstructured":"Calton EK, Keane KN, Soares MJ (2015) The potential regulatory role of vitamin D in the bioenergetics of inflammation. Curr Opin Clin Nutr Metab Care 18:367\u2013373. https:\/\/doi.org\/10.1097\/MCO.0000000000000186","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"5644_CR9","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1530\/REP-18-0070","volume":"156","author":"Z Kalem","year":"2018","unstructured":"Kalem Z, Kalem MN, Anado E et al (2018) Maternal nutrition and reproductive functions of female and male offspring. Reproduction 156:353\u2013364. https:\/\/doi.org\/10.1530\/REP-18-0070","journal-title":"Reproduction"},{"key":"5644_CR10","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.preghy.2014.02.001","volume":"4","author":"AL Tranquilli","year":"2014","unstructured":"Tranquilli AL, Dekker G, Magee L et al (2014) The classification, diagnosis and management of the hypertensive disorders of pregnancy: a revised statement from the ISSHP. Pregnancy Hypertens 4:97\u2013104","journal-title":"Pregnancy Hypertens"},{"key":"5644_CR11","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28991","author":"Z Chen","year":"2019","unstructured":"Chen Z, Liu Q, Zhu Z et al (2019) Toll-like receptor 4 contributes to uterine activation by upregulating pro-inflammatory cytokine and CAP expression via the NF-kappaB\/P38MAPK signaling pathway during pregnancy. J Cell Physiol. https:\/\/doi.org\/10.1002\/jcp.28991","journal-title":"J Cell Physiol"},{"key":"5644_CR12","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1515\/med-2017-0057","volume":"12","author":"Z Litang","year":"2017","unstructured":"Litang Z, Hong W, Weimin Z et al (2017) Serum NF-kappaBp65, TLR4 as biomarker for diagnosis of preeclampsia. Open Med (Warsaw Poland) 12:399\u2013402. https:\/\/doi.org\/10.1515\/med-2017-0057","journal-title":"Open Med (Warsaw Poland)"},{"key":"5644_CR13","doi-asserted-by":"publisher","first-page":"316","DOI":"10.3389\/fmicb.2014.00316","volume":"5","author":"M Duriez","year":"2014","unstructured":"Duriez M, Quillay H, Madec Y et al (2014) Human decidual macrophages and NK cells differentially express Toll-like receptors and display distinct cytokine profiles upon TLR stimulation. Front Microbiol 5:316. https:\/\/doi.org\/10.3389\/fmicb.2014.00316","journal-title":"Front Microbiol"},{"key":"5644_CR14","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1093\/humupd\/dms015","volume":"18","author":"AE Wallace","year":"2012","unstructured":"Wallace AE, Fraser R, Cartwright JE (2012) Extravillous trophoblast and decidual natural killer cells: a remodelling partnership. Hum Reprod Update 18:458\u2013471. https:\/\/doi.org\/10.1093\/humupd\/dms015","journal-title":"Hum Reprod Update"},{"key":"5644_CR15","doi-asserted-by":"publisher","DOI":"10.1159\/000491087","author":"J Valencia-Ortega","year":"2018","unstructured":"Valencia-Ortega J, Zarate A, Saucedo R et al (2018) Placental proinflammatory state and maternal endothelial dysfunction in preeclampsia. Gynecol Obstet Invest. https:\/\/doi.org\/10.1159\/000491087","journal-title":"Gynecol Obstet Invest"},{"key":"5644_CR16","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.arcmed.2014.10.003","volume":"45","author":"A Zarate","year":"2014","unstructured":"Zarate A, Saucedo R, Valencia J et al (2014) Early disturbed placental ischemia and hypoxia creates immune alteration and vascular disorder causing preeclampsia. Arch Med Res 45:519\u2013524. https:\/\/doi.org\/10.1016\/j.arcmed.2014.10.003","journal-title":"Arch Med Res"},{"key":"5644_CR17","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1042\/CS20150702","volume":"130","author":"AC Harmon","year":"2016","unstructured":"Harmon AC, Cornelius DC, Amaral LM et al (2016) The role of inflammation in the pathology of preeclampsia. Clin Sci (Lond) 130:409\u2013419. https:\/\/doi.org\/10.1042\/CS20150702","journal-title":"Clin Sci (Lond)"},{"key":"5644_CR18","doi-asserted-by":"publisher","first-page":"2789","DOI":"10.1080\/14767058.2016.1263295","volume":"30","author":"JJA van Esch","year":"2017","unstructured":"van Esch JJA, van Heijst AF, de Haan AFJ, van der Heijden OWH (2017) Early-onset preeclampsia is associated with perinatal mortality and severe neonatal morbidity. J Matern Fetal Neonatal Med 30:2789\u20132794. https:\/\/doi.org\/10.1080\/14767058.2016.1263295","journal-title":"J Matern Fetal Neonatal Med"},{"key":"5644_CR19","doi-asserted-by":"publisher","DOI":"10.1177\/1093526618803759","author":"J Stanek","year":"2018","unstructured":"Stanek J (2018) Histological features of shallow placental implantation unify early-onset and late-onset preeclampsia. Pediatr Dev Pathol. https:\/\/doi.org\/10.1177\/1093526618803759","journal-title":"Pediatr Dev Pathol"},{"key":"5644_CR20","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1111\/jmwh.12469","volume":"61","author":"MS Leslie","year":"2016","unstructured":"Leslie MS, Briggs LA (2016) Preeclampsia and the risk of future vascular disease and mortality: a review. J Midwifery Womens Health 61:315\u2013324. https:\/\/doi.org\/10.1111\/jmwh.12469","journal-title":"J Midwifery Womens Health"},{"key":"5644_CR21","doi-asserted-by":"publisher","first-page":"107.e1","DOI":"10.1016\/j.ajog.2018.04.002","volume":"219","author":"LH Theilen","year":"2018","unstructured":"Theilen LH, Meeks H, Fraser A et al (2018) Long-term mortality risk and life expectancy following recurrent hypertensive disease of pregnancy. Am J Obstet Gynecol 219:107.e1-107.e6. https:\/\/doi.org\/10.1016\/j.ajog.2018.04.002","journal-title":"Am J Obstet Gynecol"},{"key":"5644_CR22","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.preghy.2018.06.013","volume":"13","author":"K Nahum Sacks","year":"2018","unstructured":"Nahum Sacks K, Friger M, Shoham-Vardi I et al (2018) Prenatal exposure to preeclampsia as an independent risk factor for long-term cardiovascular morbidity of the offspring. Pregnancy Hypertens 13:181\u2013186. https:\/\/doi.org\/10.1016\/j.preghy.2018.06.013","journal-title":"Pregnancy Hypertens"},{"key":"5644_CR23","doi-asserted-by":"publisher","DOI":"10.1177\/1933719118808916","author":"X Huang","year":"2018","unstructured":"Huang X, Wu L, Zhang G et al (2018) Elevated MicroRNA-181a-5p contributes to trophoblast dysfunction and preeclampsia. Reprod Sci. https:\/\/doi.org\/10.1177\/1933719118808916","journal-title":"Reprod Sci"},{"key":"5644_CR24","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.placenta.2017.02.019","volume":"52","author":"T Gunel","year":"2017","unstructured":"Gunel T, Hosseini MK, Gumusoglu E et al (2017) Expression profiling of maternal plasma and placenta microRNAs in preeclamptic pregnancies by microarray technology. Placenta 52:77\u201385. https:\/\/doi.org\/10.1016\/j.placenta.2017.02.019","journal-title":"Placenta"},{"key":"5644_CR25","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/s13224-017-0982-7","volume":"67","author":"SNPK Yusrawati","year":"2017","unstructured":"Yusrawati SNPK, Lipoeto NI, Machmud R (2017) Analyses of nutrients and body mass index as risk factor for preeclampsia. J Obstet Gynaecol India 67:409\u2013413. https:\/\/doi.org\/10.1007\/s13224-017-0982-7","journal-title":"J Obstet Gynaecol India"},{"key":"5644_CR26","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1080\/14767058.2017.1297411","volume":"31","author":"YS Khader","year":"2018","unstructured":"Khader YS, Batieha A, Al-Njadat RA, Hijazi SS (2018) Preeclampsia in Jordan: incidence, risk factors, and its associated maternal and neonatal outcomes. J Matern Fetal Neonatal Med 31:770\u2013776. https:\/\/doi.org\/10.1080\/14767058.2017.1297411","journal-title":"J Matern Fetal Neonatal Med"},{"key":"5644_CR27","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1111\/1471-0528.14163","volume":"124","author":"D Jaskolka","year":"2017","unstructured":"Jaskolka D, Retnakaran R, Zinman B, Kramer CK (2017) Fetal sex and maternal risk of pre-eclampsia\/eclampsia: a systematic review and meta-analysis. BJOG 124:553\u2013560. https:\/\/doi.org\/10.1111\/1471-0528.14163","journal-title":"BJOG"},{"key":"5644_CR28","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.preghy.2018.10.006","volume":"14","author":"D Nzelu","year":"2018","unstructured":"Nzelu D, Dumitrascu-Biris D, Kay P et al (2018) Severe hypertension, preeclampsia and small for gestational age in women with chronic hypertension diagnosed before and during pregnancy. Pregnancy Hypertens 14:200\u2013204. https:\/\/doi.org\/10.1016\/j.preghy.2018.10.006","journal-title":"Pregnancy Hypertens"},{"key":"5644_CR29","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.imlet.2009.05.006","volume":"125","author":"K-M Lee","year":"2009","unstructured":"Lee K-M, Seong S-Y (2009) Partial role of TLR4 as a receptor responding to damage-associated molecular pattern. Immunol Lett 125:31\u201339. https:\/\/doi.org\/10.1016\/j.imlet.2009.05.006","journal-title":"Immunol Lett"},{"key":"5644_CR30","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.freeradbiomed.2017.01.010","volume":"104","author":"J Kim","year":"2017","unstructured":"Kim J, Lee K-S, Kim J-H et al (2017) Aspirin prevents TNF-alpha-induced endothelial cell dysfunction by regulating the NF-kappaB-dependent miR-155\/eNOS pathway: role of a miR-155\/eNOS axis in preeclampsia. Free Radic Biol Med 104:185\u2013198. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2017.01.010","journal-title":"Free Radic Biol Med"},{"key":"5644_CR31","doi-asserted-by":"publisher","first-page":"461","DOI":"10.3389\/fimmu.2014.00461","volume":"5","author":"T Kawasaki","year":"2014","unstructured":"Kawasaki T, Kawai T (2014) Toll-like receptor signaling pathways. Front Immunol 5:461. https:\/\/doi.org\/10.3389\/fimmu.2014.00461","journal-title":"Front Immunol"},{"key":"5644_CR32","doi-asserted-by":"publisher","first-page":"5389","DOI":"10.21873\/anticanres.11965","volume":"37","author":"LP Pisani","year":"2017","unstructured":"Pisani LP, Estadella D, Ribeiro DA (2017) The role of toll like receptors (TLRs) in oral carcinogenesis. Anticancer Res 37:5389\u20135394. https:\/\/doi.org\/10.21873\/anticanres.11965","journal-title":"Anticancer Res"},{"key":"5644_CR33","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s10517-019-04383-6","volume":"166","author":"NV Nizyaeva","year":"2019","unstructured":"Nizyaeva NV, Kulikova GV, Nagovitsyna MN, Shchegolev AI (2019) Peculiarities of the expression of TLR4 and inhibitor of TLR-cascade tollip in the placenta in earlyand late-onset preeclampsia. Bull Exp Biol Med 166:507\u2013511. https:\/\/doi.org\/10.1007\/s10517-019-04383-6","journal-title":"Bull Exp Biol Med"},{"key":"5644_CR34","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.placenta.2004.12.012","volume":"27","author":"ECE Beijar","year":"2006","unstructured":"Beijar ECE, Mallard C, Powell TL (2006) Expression and subcellular localization of TLR-4 in term and first trimester human placenta. Placenta 27:322\u2013326. https:\/\/doi.org\/10.1016\/j.placenta.2004.12.012","journal-title":"Placenta"},{"key":"5644_CR35","doi-asserted-by":"publisher","first-page":"e0124001","DOI":"10.1371\/journal.pone.0124001","volume":"10","author":"P Xue","year":"2015","unstructured":"Xue P, Zheng M, Gong P et al (2015) Single administration of ultra-low-dose lipopolysaccharide in rat early pregnancy induces TLR4 activation in the placenta contributing to preeclampsia. PLoS One 10:e0124001. https:\/\/doi.org\/10.1371\/journal.pone.0124001","journal-title":"PLoS One"},{"key":"5644_CR36","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1095\/biolreprod.115.134627","volume":"94","author":"L Li","year":"2016","unstructured":"Li L, Tu J, Jiang Y et al (2016) Effects of lipopolysaccharide on human first trimester villous cytotrophoblast cell function in vitro. Biol Reprod 94:33. https:\/\/doi.org\/10.1095\/biolreprod.115.134627","journal-title":"Biol Reprod"},{"key":"5644_CR37","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1161\/HYPERTENSIONAHA.115.06455","volume":"67","author":"BB van Rijn","year":"2016","unstructured":"van Rijn BB, Bruinse HW, Veerbeek JH et al (2016) Postpartum circulating markers of inflammation and the systemic acute-phase response after early-onset preeclampsia. Hypertens (Dallas, Tex,1979 ) 67:404\u2013414. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.115.06455","journal-title":"Hypertens (Dallas, Tex,1979 )"},{"key":"5644_CR38","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1007\/s10517-016-3259-8","volume":"160","author":"GV Kulikova","year":"2016","unstructured":"Kulikova GV, Nizyaeva NV, Nagovitsina MN et al (2016) Specific features of TLR4 expression in structural elements of placenta in patients with preeclampsia. Bull Exp Biol Med 160:718\u2013721. https:\/\/doi.org\/10.1007\/s10517-016-3259-8","journal-title":"Bull Exp Biol Med"},{"key":"5644_CR39","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.2215\/CJN.12081115","volume":"11","author":"E Phipps","year":"2016","unstructured":"Phipps E, Prasanna D, Brima W, Jim B (2016) Preeclampsia: updates in pathogenesis, definitions, and guidelines. Clin J Am Soc Nephrol 11:1102\u20131113. https:\/\/doi.org\/10.2215\/CJN.12081115","journal-title":"Clin J Am Soc Nephrol"},{"key":"5644_CR40","doi-asserted-by":"publisher","first-page":"e0187082","DOI":"10.1371\/journal.pone.0187082","volume":"13","author":"NJ Hannan","year":"2018","unstructured":"Hannan NJ, Binder NK, Beard S et al (2018) Melatonin enhances antioxidant molecules in the placenta, reduces secretion of soluble fms-like tyrosine kinase 1 (sFLT) from primary trophoblast but does not rescue endothelial dysfunction: an evaluation of its potential to treat preeclampsia. PLoS One 13:e0187082. https:\/\/doi.org\/10.1371\/journal.pone.0187082","journal-title":"PLoS One"},{"key":"5644_CR41","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.cellimm.2013.06.012","volume":"283","author":"A Kumar","year":"2013","unstructured":"Kumar A, Begum N, Prasad S et al (2013) IL-10, TNF-alpha & IFN-gamma: potential early biomarkers for preeclampsia. Cell Immunol 283:70\u201374. https:\/\/doi.org\/10.1016\/j.cellimm.2013.06.012","journal-title":"Cell Immunol"},{"key":"5644_CR42","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.jri.2015.09.003","volume":"112","author":"L Guillemette","year":"2015","unstructured":"Guillemette L, Lacroix M, Allard C et al (2015) Preeclampsia is associated with an increased pro-inflammatory profile in newborns. J Reprod Immunol 112:111\u2013114. https:\/\/doi.org\/10.1016\/j.jri.2015.09.003","journal-title":"J Reprod Immunol"},{"key":"5644_CR43","doi-asserted-by":"publisher","first-page":"269.e1","DOI":"10.1016\/j.ajog.2009.06.060","volume":"201","author":"CS Wu","year":"2009","unstructured":"Wu CS, Nohr EA, Bech BH et al (2009) Health of children born to mothers who had preeclampsia: a population-based cohort study. Am J Obstet Gynecol 201:269.e1-269.e10. https:\/\/doi.org\/10.1016\/j.ajog.2009.06.060","journal-title":"Am J Obstet Gynecol"},{"key":"5644_CR44","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s12978-018-0534-3","volume":"15","author":"KM Hambidge","year":"2018","unstructured":"Hambidge KM, Krebs NF (2018) Strategies for optimizing maternal nutrition to promote infant development. Reprod Health 15:87. https:\/\/doi.org\/10.1186\/s12978-018-0534-3","journal-title":"Reprod Health"},{"key":"5644_CR45","doi-asserted-by":"publisher","DOI":"10.1530\/REP-18-0130","author":"BC Baker","year":"2018","unstructured":"Baker BC, Hayes D, Jones RL (2018) Effects of micronutrients on placental function: evidence from clinical studies to animal models. Reproduction. https:\/\/doi.org\/10.1530\/REP-18-0130","journal-title":"Reproduction"},{"key":"5644_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11033-019-04731-9","volume":"46","author":"EA de Souza","year":"2019","unstructured":"de Souza EA, Momentti AC, de Assis Neves R et al (2019) Calcium intake in high-risk pregnant women assisted in a high-complexity hospital. Mol Biol Rep 46:1\u20136. https:\/\/doi.org\/10.1007\/s11033-019-04731-9","journal-title":"Mol Biol Rep"},{"key":"5644_CR47","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.amjms.2017.03.022","volume":"353","author":"P Keshavarz","year":"2017","unstructured":"Keshavarz P, Nobakht M, Gh BF, Mirhafez SR et al (2017) Alterations in lipid profile, zinc and copper levels and superoxide dismutase activities in normal pregnancy and preeclampsia. Am J Med Sci 353:552\u2013558. https:\/\/doi.org\/10.1016\/j.amjms.2017.03.022","journal-title":"Am J Med Sci"},{"key":"5644_CR48","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1002\/jbm.a.36350","volume":"106","author":"C-Y Kuo","year":"2018","unstructured":"Kuo C-Y, Guo T, Cabrera-Luque J et al (2018) Placental basement membrane proteins are required for effective cytotrophoblast invasion in a three-dimensional bioprinted placenta model. J Biomed Mater Res A 106:1476\u20131487. https:\/\/doi.org\/10.1002\/jbm.a.36350","journal-title":"J Biomed Mater Res A"},{"key":"5644_CR49","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jtemb.2015.08.002","volume":"33","author":"MM Haque","year":"2016","unstructured":"Haque MM, Moghal MMR, Sarwar MS et al (2016) Low serum selenium concentration is associated with preeclampsia in pregnant women from Bangladesh. J Trace Elem Med Biol 33:21\u201325. https:\/\/doi.org\/10.1016\/j.jtemb.2015.08.002","journal-title":"J Trace Elem Med Biol"},{"key":"5644_CR50","volume-title":"Dietary reference intakes for calcium and vitamin D","author":"AC Ross","year":"2011","unstructured":"Ross AC, Taylor CL, Yaktine AL, Del Valle HB (2011) Dietary reference intakes for calcium and vitamin D. National Academies Press, Washington (DC)"},{"key":"5644_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/J.JSBMB.2017.11.008","author":"K von Websky","year":"2017","unstructured":"von Websky K, Hasan AA, Reichetzeder C et al (2017) Impact of vitamin D on pregnancy-related disorders and on offspring outcome. J Steroid Biochem Mol Biol. https:\/\/doi.org\/10.1016\/J.JSBMB.2017.11.008","journal-title":"J Steroid Biochem Mol Biol"},{"key":"5644_CR52","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.jfma.2017.08.005","volume":"117","author":"Z-M Fu","year":"2018","unstructured":"Fu Z-M, Ma Z-Z, Liu G-J et al (2018) Vitamins supplementation affects the onset of preeclampsia. J Formos Med Assoc 117:6\u201313. https:\/\/doi.org\/10.1016\/j.jfma.2017.08.005","journal-title":"J Formos Med Assoc"},{"key":"5644_CR53","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/bs.afnr.2015.11.001","volume":"77","author":"PK Pannu","year":"2016","unstructured":"Pannu PK, Calton EK, Soares MJ (2016) Calcium and vitamin D in obesity and related chronic disease. Adv Food Nutr Res 77:57\u2013100. https:\/\/doi.org\/10.1016\/bs.afnr.2015.11.001","journal-title":"Adv Food Nutr Res"},{"key":"5644_CR54","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.jsbmb.2010.02.004","volume":"121","author":"V Lagishetty","year":"2010","unstructured":"Lagishetty V, Chun RF, Liu NQ et al (2010) 1alpha-hydroxylase and innate immune responses to 25-hydroxyvitamin D in colonic cell lines. J Steroid Biochem Mol Biol 121:228\u2013233. https:\/\/doi.org\/10.1016\/j.jsbmb.2010.02.004","journal-title":"J Steroid Biochem Mol Biol"},{"key":"5644_CR55","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1177\/1933719112459225","volume":"20","author":"C Thota","year":"2013","unstructured":"Thota C, Farmer T, Garfield RE et al (2013) Vitamin D elicits anti-inflammatory response, inhibits contractile-associated proteins, and modulates Toll-like receptors in human myometrial cells. Reprod Sci 20:463\u2013475. https:\/\/doi.org\/10.1177\/1933719112459225","journal-title":"Reprod Sci"},{"key":"5644_CR56","doi-asserted-by":"publisher","first-page":"R93","DOI":"10.1530\/JOE-17-0491","volume":"236","author":"A Ganguly","year":"2018","unstructured":"Ganguly A, Tamblyn JA, Finn-Sell S et al (2018) Vitamin D, the placenta and early pregnancy: effects on trophoblast function. J Endocrinol 236:R93\u2013R103. https:\/\/doi.org\/10.1530\/JOE-17-0491","journal-title":"J Endocrinol"},{"key":"5644_CR57","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.jaci.2017.02.039","volume":"141","author":"E Hornsby","year":"2018","unstructured":"Hornsby E, Pfeffer PE, Laranjo N et al (2018) Vitamin D supplementation during pregnancy: effect on the neonatal immune system in a randomized controlled trial. J Allergy Clin Immunol 141:269-278.e1. https:\/\/doi.org\/10.1016\/j.jaci.2017.02.039","journal-title":"J Allergy Clin Immunol"},{"key":"5644_CR58","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/sji.12403","volume":"83","author":"I Szymczak","year":"2016","unstructured":"Szymczak I, Pawliczak R (2016) The active metabolite of vitamin D3 as a potential immunomodulator. Scand J Immunol 83:83\u201391. https:\/\/doi.org\/10.1111\/sji.12403","journal-title":"Scand J Immunol"},{"key":"5644_CR59","doi-asserted-by":"publisher","first-page":"3188","DOI":"10.1002\/eji.201545541","volume":"45","author":"K Ota","year":"2015","unstructured":"Ota K, Dambaeva S, Kim MW-I et al (2015) 1,25-Dihydroxy-vitamin D3 regulates NK-cell cytotoxicity, cytokine secretion, and degranulation in women with recurrent pregnancy losses. Eur J Immunol 45:3188\u20133199. https:\/\/doi.org\/10.1002\/eji.201545541","journal-title":"Eur J Immunol"},{"key":"5644_CR60","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1126\/science.1123933","volume":"311","author":"PT Liu","year":"2006","unstructured":"Liu PT, Stenger S, Li H et al (2006) Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 311:1770\u20131773. https:\/\/doi.org\/10.1126\/science.1123933","journal-title":"Science"},{"key":"5644_CR61","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.steroids.2018.07.009","volume":"137","author":"AC Momentti","year":"2018","unstructured":"Momentti AC, Estadella D, Pellegrini Pisani L (2018) Role of vitamin D in pregnancy and Toll-like receptor pathway. Steroids 137:22\u201329. https:\/\/doi.org\/10.1016\/j.steroids.2018.07.009","journal-title":"Steroids"},{"key":"5644_CR62","doi-asserted-by":"publisher","first-page":"222","DOI":"10.3177\/jnsv.63.222","volume":"63","author":"L Feng","year":"2017","unstructured":"Feng L, Hu Z, Wang Q (2017) Dietary calcium and serum 25OHD protect Chinese women from type 2 diabetes. J Nutr Sci Vitaminol (Tokyo) 63:222\u2013227. https:\/\/doi.org\/10.3177\/jnsv.63.222","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"key":"5644_CR63","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1111\/1753-0407.12611","volume":"10","author":"W Bao","year":"2018","unstructured":"Bao W, Song Y, Bertrand KA et al (2018) Prepregnancy habitual intake of vitamin D from diet and supplements in relation to risk of gestational diabetes mellitus: a prospective cohort study. J Diabetes 10:373\u2013379. https:\/\/doi.org\/10.1111\/1753-0407.12611","journal-title":"J Diabetes"},{"key":"5644_CR64","doi-asserted-by":"publisher","first-page":"511.e1","DOI":"10.1016\/j.ajog.2014.11.009","volume":"212","author":"M Achkar","year":"2015","unstructured":"Achkar M, Dodds L, Giguere Y et al (2015) Vitamin D status in early pregnancy and risk of preeclampsia. Am J Obstet Gynecol 212:511.e1-511.e7. https:\/\/doi.org\/10.1016\/j.ajog.2014.11.009","journal-title":"Am J Obstet Gynecol"},{"key":"5644_CR65","doi-asserted-by":"publisher","DOI":"10.1080\/10641955.2019.1597108","author":"SZ Nassar","year":"2019","unstructured":"Nassar SZ, Badae NM (2019) Protective effect of vitamin D supplementation in a rat modal of preeclampsia: a possible implication of chemerin. Hypertens Pregnancy. https:\/\/doi.org\/10.1080\/10641955.2019.1597108","journal-title":"Hypertens Pregnancy"},{"key":"5644_CR66","doi-asserted-by":"publisher","first-page":"R346","DOI":"10.1152\/ajpregu.00388.2015","volume":"310","author":"JL Faulkner","year":"2016","unstructured":"Faulkner JL, Cornelius DC, Amaral LM et al (2016) Vitamin D supplementation improves pathophysiology in a rat model of preeclampsia. Am J Physiol Regul Integr Comp Physiol 310:R346\u2013R354. https:\/\/doi.org\/10.1152\/ajpregu.00388.2015","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"5644_CR67","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1172\/JCI15219","volume":"110","author":"YC Li","year":"2002","unstructured":"Li YC, Kong J, Wei M et al (2002) 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 110:229\u2013238. https:\/\/doi.org\/10.1172\/JCI15219","journal-title":"J Clin Invest"},{"key":"5644_CR68","doi-asserted-by":"publisher","first-page":"4702","DOI":"10.1172\/JCI89031","volume":"126","author":"H Mirzakhani","year":"2016","unstructured":"Mirzakhani H, Litonjua AA, McElrath TF et al (2016) Early pregnancy vitamin D status and risk of preeclampsia. J Clin Invest 126:4702\u20134715. https:\/\/doi.org\/10.1172\/JCI89031","journal-title":"J Clin Invest"},{"key":"5644_CR69","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2019.02.015","author":"A Benachi","year":"2019","unstructured":"Benachi A, Baptiste A, Taieb J et al (2019) Relationship between vitamin D status in pregnancy and the risk for preeclampsia: A nested case-control study. Clin Nutr. https:\/\/doi.org\/10.1016\/j.clnu.2019.02.015","journal-title":"Clin Nutr"},{"key":"5644_CR70","doi-asserted-by":"publisher","first-page":"2936","DOI":"10.1210\/jc.2018-00109","volume":"103","author":"M Rostami","year":"2018","unstructured":"Rostami M, Tehrani FR, Simbar M et al (2018) Effectiveness of prenatal vitamin D deficiency screening and treatment program: a stratified randomized field trial. J Clin Endocrinol Metab 103:2936\u20132948. https:\/\/doi.org\/10.1210\/jc.2018-00109","journal-title":"J Clin Endocrinol Metab"},{"key":"5644_CR71","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1111\/cen.12751","volume":"83","author":"A Sablok","year":"2015","unstructured":"Sablok A, Batra A, Thariani K et al (2015) Supplementation of vitamin D in pregnancy and its correlation with feto-maternal outcome. Clin Endocrinol (Oxf) 83:536\u2013541. https:\/\/doi.org\/10.1111\/cen.12751","journal-title":"Clin Endocrinol (Oxf)"},{"key":"5644_CR72","doi-asserted-by":"publisher","DOI":"10.3390\/nu10030294","author":"K O\u2019Callaghan","year":"2018","unstructured":"O\u2019Callaghan K, Kiely M (2018) Systematic review of vitamin D and hypertensive disorders of pregnancy. Nutrients. https:\/\/doi.org\/10.3390\/nu10030294","journal-title":"Nutrients"},{"key":"5644_CR73","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.jsbmb.2016.02.008","volume":"164","author":"C Palacios","year":"2016","unstructured":"Palacios C, De-Regil LM, Lombardo LK, Pena-Rosas JP (2016) Vitamin D supplementation during pregnancy: updated meta-analysis on maternal outcomes. J Steroid Biochem Mol Biol 164:148\u2013155. https:\/\/doi.org\/10.1016\/j.jsbmb.2016.02.008","journal-title":"J Steroid Biochem Mol Biol"},{"key":"5644_CR74","doi-asserted-by":"publisher","first-page":"CD001059","DOI":"10.1002\/14651858.CD001059.pub5","volume":"10","author":"GJ Hofmeyr","year":"2018","unstructured":"Hofmeyr GJ, Lawrie TA, Atallah AN, Torloni MR (2018) Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane database Syst Rev 10:CD001059. https:\/\/doi.org\/10.1002\/14651858.CD001059.pub5","journal-title":"Cochrane database Syst Rev"},{"key":"5644_CR75","doi-asserted-by":"publisher","DOI":"10.3390\/nu9101141","author":"W Khaing","year":"2017","unstructured":"Khaing W, Vallibhakara SA-O, Tantrakul V et al (2017) Calcium and vitamin D supplementation for prevention of preeclampsia: a systematic review and network meta-analysis. Nutrients. https:\/\/doi.org\/10.3390\/nu9101141","journal-title":"Nutrients"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-020-05644-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-020-05644-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-020-05644-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T23:21:24Z","timestamp":1625959284000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-020-05644-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,11]]},"references-count":75,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["5644"],"URL":"https:\/\/doi.org\/10.1007\/s11033-020-05644-8","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,11]]},"assertion":[{"value":"18 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Research involving human participants and\/or animals"}}]}}