{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:58:59Z","timestamp":1790351939188,"version":"4.1.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["Sanction letter No. 2019-0687\/CMB\/ADHOC-BMS, dated 13.11.2019"],"award-info":[{"award-number":["Sanction letter No. 2019-0687\/CMB\/ADHOC-BMS, dated 13.11.2019"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s11033-020-05817-5","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T04:04:57Z","timestamp":1600229097000},"page":"7547-7555","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["DNA methylation in the upstream CpG island of the GPER locus and its relationship with GPER expression in colon cancer cell lines"],"prefix":"10.1007","volume":"47","author":[{"given":"Uttariya","family":"Pal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujasha","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7488-8079","authenticated-orcid":false,"given":"Anil Mukund","family":"Limaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,16]]},"reference":[{"key":"5817_CR1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F, Ferlay J, Soerjomataram I et al (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68:394\u2013424. https:\/\/doi.org\/10.3322\/caac.21492","journal-title":"CA Cancer J Clin"},{"key":"5817_CR2","doi-asserted-by":"publisher","first-page":"3983","DOI":"10.1200\/JCO.2012.42.7732","volume":"30","author":"MS Simon","year":"2012","unstructured":"Simon MS, Chlebowski RT, Wactawski-Wende J et al (2012) Estrogen plus progestin and colorectal cancer incidence and mortality. J Clin Oncol 30:3983\u20133990. https:\/\/doi.org\/10.1200\/JCO.2012.42.7732","journal-title":"J Clin Oncol"},{"key":"5817_CR3","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1002\/ijc.26026","volume":"130","author":"KJ Lin","year":"2012","unstructured":"Lin KJ, Cheung WY, Lai JY-C, Giovannucci EL (2012) The effect of estrogen vs. combined estrogen-progestogen therapy on the risk of colorectal cancer. Int J cancer 130:419\u2013430. https:\/\/doi.org\/10.1002\/ijc.26026","journal-title":"Int J cancer"},{"key":"5817_CR4","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1001\/jama.288.3.321","volume":"288","author":"JE Rossouw","year":"2002","unstructured":"Rossouw JE, Anderson GL, Prentice RL et al (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women\u2019s Health Initiative randomized controlled trial. JAMA 288:321\u2013333. https:\/\/doi.org\/10.1001\/jama.288.3.321","journal-title":"JAMA"},{"key":"5817_CR5","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1016\/S0140-6736(14)61396-9","volume":"385","author":"M Quaresma","year":"2015","unstructured":"Quaresma M, Coleman MP, Rachet B (2015) 40-Year trends in an index of survival for all cancers combined and survival adjusted for age and sex for each cancer in England and Wales, 1971\u20132011: a population-based study. Lancet 385:1206\u20131218. https:\/\/doi.org\/10.1016\/S0140-6736(14)61396-9","journal-title":"Lancet"},{"key":"5817_CR6","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1152\/physrev.2001.81.4.1535","volume":"81","author":"S Nilsson","year":"2001","unstructured":"Nilsson S, M\u00e4kel\u00e4 S, Treuter E et al (2001) Mechanisms of estrogen action. Physiol Rev 81:1535\u20131565. https:\/\/doi.org\/10.1152\/physrev.2001.81.4.1535","journal-title":"Physiol Rev"},{"key":"5817_CR7","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1210\/er.2007-0022","volume":"28","author":"SR Hammes","year":"2007","unstructured":"Hammes SR, Levin ER (2007) Extranuclear steroid receptors: nature and actions. Endocrinol Rev 28:726\u2013741. https:\/\/doi.org\/10.1210\/er.2007-0022","journal-title":"Endocrinol Rev"},{"key":"5817_CR8","doi-asserted-by":"publisher","first-page":"4489","DOI":"10.1210\/en.2011-1470","volume":"152","author":"SR Hammes","year":"2011","unstructured":"Hammes SR, Levin ER (2011) Minireview: recent advances in extranuclear steroid receptor actions. Endocrinology 152:4489\u20134495. https:\/\/doi.org\/10.1210\/en.2011-1470","journal-title":"Endocrinology"},{"key":"5817_CR9","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1146\/annurev.physiol.69.031905.160319","volume":"69","author":"CA Lange","year":"2007","unstructured":"Lange CA, Gioeli D, Hammes SR, Marker PC (2007) Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer. Annu Rev Physiol 69:171\u2013199. https:\/\/doi.org\/10.1146\/annurev.physiol.69.031905.160319","journal-title":"Annu Rev Physiol"},{"key":"5817_CR10","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1152\/physrev.00003.2003","volume":"83","author":"RM Losel","year":"2003","unstructured":"Losel RM, Falkenstein E, Feuring M et al (2003) Nongenomic steroid action: controversies, questions, and answers. Physiol Rev 83:965\u20131016. https:\/\/doi.org\/10.1152\/physrev.00003.2003","journal-title":"Physiol Rev"},{"key":"5817_CR11","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.steroids.2013.10.020","volume":"81","author":"RA Chaudhri","year":"2014","unstructured":"Chaudhri RA, Schwartz N, Elbaradie K et al (2014) Role of ER\u03b136 in membrane-associated signaling by estrogen. Steroids 81:74\u201380. https:\/\/doi.org\/10.1016\/j.steroids.2013.10.020","journal-title":"Steroids"},{"key":"5817_CR12","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.ejcb.2015.10.001","volume":"94","author":"K So\u0142tysik","year":"2015","unstructured":"So\u0142tysik K, Czekaj P (2015) ER\u03b136\u2013another piece of the estrogen puzzle. Eur J Cell Biol 94:611\u2013625. https:\/\/doi.org\/10.1016\/j.ejcb.2015.10.001","journal-title":"Eur J Cell Biol"},{"key":"5817_CR13","doi-asserted-by":"publisher","first-page":"725","DOI":"10.3389\/fendo.2019.00725","volume":"10","author":"S Xu","year":"2019","unstructured":"Xu S, Yu S, Dong D, Lee LTO (2019) G protein-coupled estrogen receptor: a potential therapeutic target in cancer. Front Endocrinol (Lausanne) 10:725. https:\/\/doi.org\/10.3389\/fendo.2019.00725","journal-title":"Front Endocrinol (Lausanne)"},{"key":"5817_CR14","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/S1470-2045(08)70100-1","volume":"9","author":"R Kennelly","year":"2008","unstructured":"Kennelly R, Kavanagh DO, Hogan AM, Winter DC (2008) Oestrogen and the colon: potential mechanisms for cancer prevention. Lancet Oncol 9:385\u2013391. https:\/\/doi.org\/10.1016\/S1470-2045(08)70100-1","journal-title":"Lancet Oncol"},{"key":"5817_CR15","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1097\/MEG.0b013e328335ef50","volume":"22","author":"K Papaxoinis","year":"2010","unstructured":"Papaxoinis K, Triantafyllou K, Sasco AJ et al (2010) Subsite-specific differences of estrogen receptor beta expression in the normal colonic epithelium: implications for carcinogenesis and colorectal cancer epidemiology. Eur J Gastroenterol Hepatol 22:614\u2013619. https:\/\/doi.org\/10.1097\/MEG.0b013e328335ef50","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"5817_CR16","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1016\/s0959-8049(03)00239-9","volume":"39","author":"PA Konstantinopoulos","year":"2003","unstructured":"Konstantinopoulos PA, Kominea A, Vandoros G et al (2003) Oestrogen receptor beta (ERbeta) is abundantly expressed in normal colonic mucosa, but declines in colon adenocarcinoma paralleling the tumour\u2019s dedifferentiation. Eur J Cancer 39:1251\u20131258. https:\/\/doi.org\/10.1016\/s0959-8049(03)00239-9","journal-title":"Eur J Cancer"},{"key":"5817_CR17","first-page":"17","volume":"14","author":"N Jassam","year":"2005","unstructured":"Jassam N, Bell SM, Speirs V, Quirke P (2005) Loss of expression of oestrogen receptor beta in colon cancer and its association with Dukes\u2019 staging. Oncol Rep 14:17\u201321","journal-title":"Oncol Rep"},{"key":"5817_CR18","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/s12029-010-9214-4","volume":"43","author":"HG Elbanna","year":"2012","unstructured":"Elbanna HG, Ebrahim MA, Abbas AM et al (2012) Potential value of estrogen receptor beta expression in colorectal carcinoma: interaction with apoptotic index. J Gastrointest Cancer 43:56\u201362. https:\/\/doi.org\/10.1007\/s12029-010-9214-4","journal-title":"J Gastrointest Cancer"},{"key":"5817_CR19","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1038\/bjc.2012.323","volume":"107","author":"A Rudolph","year":"2012","unstructured":"Rudolph A, Toth C, Hoffmeister M et al (2012) Expression of oestrogen receptor \u03b2 and prognosis of colorectal cancer. Br J Cancer 107:831\u2013839. https:\/\/doi.org\/10.1038\/bjc.2012.323","journal-title":"Br J Cancer"},{"key":"5817_CR20","doi-asserted-by":"publisher","first-page":"2553","DOI":"10.1002\/ijc.27578","volume":"131","author":"D Saleiro","year":"2012","unstructured":"Saleiro D, Murillo G, Benya RV et al (2012) Estrogen receptor-\u03b2 protects against colitis-associated neoplasia in mice. Int J cancer 131:2553\u20132561. https:\/\/doi.org\/10.1002\/ijc.27578","journal-title":"Int J cancer"},{"key":"5817_CR21","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.canlet.2015.12.009","volume":"372","author":"C Williams","year":"2016","unstructured":"Williams C, DiLeo A, Niv Y, Gustafsson J-\u00c5 (2016) Estrogen receptor beta as target for colorectal cancer prevention. Cancer Lett 372:48\u201356. https:\/\/doi.org\/10.1016\/j.canlet.2015.12.009","journal-title":"Cancer Lett"},{"key":"5817_CR22","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.prostaglandins.2009.05.001","volume":"89","author":"ER Prossnitz","year":"2009","unstructured":"Prossnitz ER, Barton M (2009) Signaling, physiological functions and clinical relevance of the G protein-coupled estrogen receptor GPER. Prostaglandins Other Lipid Mediat 89:89\u201397. https:\/\/doi.org\/10.1016\/j.prostaglandins.2009.05.001","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"5817_CR23","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1677\/JOE-09-0242","volume":"204","author":"M Maggiolini","year":"2010","unstructured":"Maggiolini M, Picard D (2010) The unfolding stories of GPR30, a new membrane-bound estrogen receptor. J Endocrinol 204:105\u2013114. https:\/\/doi.org\/10.1677\/JOE-09-0242","journal-title":"J Endocrinol"},{"key":"5817_CR24","doi-asserted-by":"publisher","first-page":"386.e1","DOI":"10.1016\/j.ajog.2007.01.004","volume":"196","author":"HO Smith","year":"2007","unstructured":"Smith HO, Leslie KK, Singh M et al (2007) GPR30: a novel indicator of poor survival for endometrial carcinoma. Am J Obstet Gynecol 196:386.e1-386.e11. https:\/\/doi.org\/10.1016\/j.ajog.2007.01.004","journal-title":"Am J Obstet Gynecol"},{"key":"5817_CR25","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.ygyno.2009.05.015","volume":"114","author":"HO Smith","year":"2009","unstructured":"Smith HO, Arias-Pulido H, Kuo DY et al (2009) GPR30 predicts poor survival for ovarian cancer. Gynecol Oncol 114:465\u2013471. https:\/\/doi.org\/10.1016\/j.ygyno.2009.05.015","journal-title":"Gynecol Oncol"},{"key":"5817_CR26","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.mce.2014.02.002","volume":"389","author":"ER Prossnitz","year":"2014","unstructured":"Prossnitz ER, Barton M (2014) Estrogen biology: new insights into GPER function and clinical opportunities. Mol Cell Endocrinol 389:71\u201383. https:\/\/doi.org\/10.1016\/j.mce.2014.02.002","journal-title":"Mol Cell Endocrinol"},{"key":"5817_CR27","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.mce.2015.07.016","volume":"418 Pt 3","author":"HM Gaudet","year":"2015","unstructured":"Gaudet HM, Cheng SB, Christensen EM, Filardo EJ (2015) The G-protein coupled estrogen receptor, GPER: the inside and inside-out story. Mol Cell Endocrinol 418 Pt 3:207\u2013219. https:\/\/doi.org\/10.1016\/j.mce.2015.07.016","journal-title":"Mol Cell Endocrinol"},{"key":"5817_CR28","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.steroids.2016.02.016","volume":"111","author":"M Barton","year":"2016","unstructured":"Barton M (2016) Not lost in translation: Emerging clinical importance of the G protein-coupled estrogen receptor GPER. Steroids 111:37\u201345. https:\/\/doi.org\/10.1016\/j.steroids.2016.02.016","journal-title":"Steroids"},{"key":"5817_CR29","doi-asserted-by":"publisher","first-page":"4092","DOI":"10.3748\/wjg.v25.i30.4092","volume":"25","author":"D Jacenik","year":"2019","unstructured":"Jacenik D, Beswick EJ, Krajewska WM, Prossnitz ER (2019) G protein-coupled estrogen receptor in colon function, immune regulation and carcinogenesis. World J Gastroenterol 25:4092\u20134104. https:\/\/doi.org\/10.3748\/wjg.v25.i30.4092","journal-title":"World J Gastroenterol"},{"key":"5817_CR30","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s12943-017-0654-3","volume":"16","author":"Q Liu","year":"2017","unstructured":"Liu Q, Chen Z, Jiang G et al (2017) Epigenetic down regulation of G protein-coupled estrogen receptor (GPER) functions as a tumor suppressor in colorectal cancer. Mol Cancer 16:87. https:\/\/doi.org\/10.1186\/s12943-017-0654-3","journal-title":"Mol Cancer"},{"key":"5817_CR31","doi-asserted-by":"publisher","first-page":"84258","DOI":"10.18632\/oncotarget.20653","volume":"8","author":"V Bustos","year":"2017","unstructured":"Bustos V, Nolan \u00c1M, Nijhuis A et al (2017) GPER mediates differential effects of estrogen on colon cancer cell proliferation and migration under normoxic and hypoxic conditions. Oncotarget 8:84258\u201384275. https:\/\/doi.org\/10.18632\/oncotarget.20653","journal-title":"Oncotarget"},{"key":"5817_CR32","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s00432-014-1598-2","volume":"140","author":"C Wei\u00dfenborn","year":"2014","unstructured":"Wei\u00dfenborn C, Ignatov T, Poehlmann A et al (2014) GPER functions as a tumor suppressor in MCF-7 and SK-BR-3 breast cancer cells. J Cancer Res Clin Oncol 140:663\u2013671. https:\/\/doi.org\/10.1007\/s00432-014-1598-2","journal-title":"J Cancer Res Clin Oncol"},{"key":"5817_CR33","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1080\/07357907.2016.1271886","volume":"35","author":"C Weissenborn","year":"2017","unstructured":"Weissenborn C, Ignatov T, Nass N et al (2017) GPER promoter methylation controls GPER expression in breast cancer patients. Cancer Invest 35:100\u2013107. https:\/\/doi.org\/10.1080\/07357907.2016.1271886","journal-title":"Cancer Invest"},{"key":"5817_CR34","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.gene.2017.03.006","volume":"614","author":"MC Manjegowda","year":"2017","unstructured":"Manjegowda MC, Gupta PS, Limaye AM (2017) Hyper-methylation of the upstream CpG island shore is a likely mechanism of GPER1 silencing in breast cancer cells. Gene 614:65\u201373. https:\/\/doi.org\/10.1016\/j.gene.2017.03.006","journal-title":"Gene"},{"key":"5817_CR35","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/j.dib.2016.03.054","volume":"7","author":"MC Manjegowda","year":"2016","unstructured":"Manjegowda MC, Gupta PS, Limaye AM (2016) Validation data of a rabbit antiserum and affinity purified polyclonal antibody against the N-terminus of human GPR30. Data Br 7:1015\u20131020. https:\/\/doi.org\/10.1016\/j.dib.2016.03.054","journal-title":"Data Br"},{"key":"5817_CR36","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"NJ LOWRY OH, ROSEBROUGH","year":"1951","unstructured":"LOWRY OH, ROSEBROUGH NJ, RANDALL FARRAL RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265\u2013275","journal-title":"J Biol Chem"},{"key":"5817_CR37","first-page":"312","volume":"52","author":"MC Manjegowda","year":"2014","unstructured":"Manjegowda MC, Deb G, Limaye AM (2014) Epigallocatechin gallate induces the steady state mRNA levels of pS2 and PR genes in MCF-7 breast cancer cell. Indian J Exp Biol 52:312\u2013316","journal-title":"Indian J Exp Biol"},{"key":"5817_CR38","doi-asserted-by":"publisher","first-page":"110701","DOI":"10.1016\/j.mce.2020.110701","volume":"504","author":"DJS John Mary","year":"2020","unstructured":"John Mary DJS, Sikarwar G, Kumar A, Limaye AM (2020) Interplay of ER\u03b1 binding and DNA methylation in the intron-2 determines the expression and estrogen regulation of cystatin A in breast cancer cells. Mol Cell Endocrinol 504:110701. https:\/\/doi.org\/10.1016\/j.mce.2020.110701","journal-title":"Mol Cell Endocrinol"},{"key":"5817_CR39","doi-asserted-by":"publisher","first-page":"43234","DOI":"10.1074\/jbc.M112.417303","volume":"287","author":"MF Santolla","year":"2012","unstructured":"Santolla MF, Lappano R, De Marco P et al (2012) G protein-coupled estrogen receptor mediates the up-regulation of fatty acid synthase induced by 17\u03b2-estradiol in cancer cells and cancer-associated fibroblasts. J Biol Chem 287:43234\u201343245. https:\/\/doi.org\/10.1074\/jbc.M112.417303","journal-title":"J Biol Chem"},{"key":"5817_CR40","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3389\/fphar.2017.00103","volume":"8","author":"LC Gilligan","year":"2017","unstructured":"Gilligan LC, Gondal A, Tang V et al (2017) Estrone sulfate transport and steroid sulfatase activity in colorectal cancer: implications for hormone replacement therapy. Front Pharmacol 8:103. https:\/\/doi.org\/10.3389\/fphar.2017.00103","journal-title":"Front Pharmacol"},{"key":"5817_CR41","doi-asserted-by":"publisher","first-page":"4435","DOI":"10.1210\/jc.2016-3716","volume":"102","author":"LC Gilligan","year":"2017","unstructured":"Gilligan LC, Rahman HP, Hewitt A-M et al (2017) Estrogen activation by steroid sulfatase increases colorectal cancer proliferation via GPER. J Clin Endocrinol Metab 102:4435\u20134447. https:\/\/doi.org\/10.1210\/jc.2016-3716","journal-title":"J Clin Endocrinol Metab"},{"key":"5817_CR42","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1007\/s00432-014-1620-8","volume":"140","author":"C Wei\u00dfenborn","year":"2014","unstructured":"Wei\u00dfenborn C, Ignatov T, Ochel H-J et al (2014) GPER functions as a tumor suppressor in triple-negative breast cancer cells. J Cancer Res Clin Oncol 140:713\u2013723. https:\/\/doi.org\/10.1007\/s00432-014-1620-8","journal-title":"J Cancer Res Clin Oncol"},{"key":"5817_CR43","doi-asserted-by":"publisher","first-page":"894","DOI":"10.7150\/jca.17064","volume":"8","author":"Q-Y Lv","year":"2017","unstructured":"Lv Q-Y, Xie B-Y, Yang B-Y et al (2017) Increased TET1 expression in inflammatory microenvironment of hyperinsulinemia enhances the response of endometrial cancer to estrogen by epigenetic modulation of GPER. J Cancer 8:894\u2013902. https:\/\/doi.org\/10.7150\/jca.17064","journal-title":"J Cancer"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-020-05817-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-020-05817-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-020-05817-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T20:48:20Z","timestamp":1631738900000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-020-05817-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,16]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["5817"],"URL":"https:\/\/doi.org\/10.1007\/s11033-020-05817-5","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.07.03.187351","asserted-by":"object"}]},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,16]]},"assertion":[{"value":"21 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The work involves cell line models. No human participants and animals are involved in this work.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human and animal rights"}}]}}