{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T07:11:59Z","timestamp":1776323519631,"version":"3.50.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973404, 81503058"],"award-info":[{"award-number":["81973404, 81503058"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007620","name":"Department of Education of Liaoning Province","doi-asserted-by":"publisher","award":["JC2019034"],"award-info":[{"award-number":["JC2019034"]}],"id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2014021065"],"award-info":[{"award-number":["2014021065"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1007\/s11033-020-06065-3","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T11:04:23Z","timestamp":1609758263000},"page":"975-981","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Calcium-sensing receptor in the development and treatment of pulmonary hypertension"],"prefix":"10.1007","volume":"48","author":[{"given":"Ming-Yuan","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Jian","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7146-8290","authenticated-orcid":false,"given":"Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,4]]},"reference":[{"key":"6065_CR1","doi-asserted-by":"publisher","first-page":"21975","DOI":"10.1038\/srep21975","volume":"6","author":"SC Brennan","year":"2016","unstructured":"Brennan SC, Wilkinson WJ, Tseng HE et al (2016) The extracellular calcium-sensing receptor regulates human fetal lung development via CFTR. Sci Rep 6:21975","journal-title":"Sci Rep"},{"issue":"2","key":"6065_CR2","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/hr.2013.129","volume":"37","author":"Q Guo","year":"2014","unstructured":"Guo Q, Huang JA, Yamamura A et al (2014) Inhibition of the Ca(2+)-sensing receptor rescues pulmonary hypertension in rats and mice. Hypertens Res 37(2):116\u2013124","journal-title":"Hypertens Res"},{"issue":"115","key":"6065_CR3","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1183\/09059180.00007109","volume":"19","author":"ML Handoko","year":"2010","unstructured":"Handoko ML, de Man FS, Allaart CP et al (2010) Perspectives on novel therapeutic strategies for right heart failure in pulmonary arterial hypertension: lessons from the left heart. Eur Respir Rev 19(115):72\u201382","journal-title":"Eur Respir Rev"},{"issue":"Suppl 1","key":"6065_CR4","first-page":"55","volume":"42","author":"MM Hoeper","year":"2014","unstructured":"Hoeper MM, Bogaard HJ, Condliffe R et al (2014) Pulmoner hipertansiyon tan\u0131 ve tan\u0131mlar [Definitions and diagnosis of pulmonary hypertension]. Turk Kardiyol Dern Ars 42(Suppl 1):55\u201366","journal-title":"Turk Kardiyol Dern Ars"},{"issue":"1 Suppl","key":"6065_CR5","doi-asserted-by":"publisher","first-page":"S10","DOI":"10.1016\/j.jacc.2009.04.006","volume":"54","author":"PM Hassoun","year":"2009","unstructured":"Hassoun PM, Mouthon L, Barber\u00e0 JA et al (2009) Inflammation, growth factors, and pulmonary vascular remodeling. J Am Coll Cardiol 54(1 Suppl):S10\u2013S19","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"6065_CR6","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1161\/CIRCRESAHA.112.266361","volume":"111","author":"A Yamamura","year":"2012","unstructured":"Yamamura A, Guo Q, Yamamura H et al (2012) Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension. Circ Res 111(4):469\u2013481","journal-title":"Circ Res"},{"issue":"2","key":"6065_CR7","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1097\/FJC.0000000000000328","volume":"67","author":"MX Li","year":"2016","unstructured":"Li MX, Jiang DQ, Wang Y et al (2016) Signal mechanisms of vascular remodeling in the development of pulmonary arterial hypertension. J Cardiovasc Pharmacol 67(2):182\u2013190","journal-title":"J Cardiovasc Pharmacol"},{"issue":"3","key":"6065_CR8","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.beem.2013.02.009","volume":"27","author":"GN Hendy","year":"2013","unstructured":"Hendy GN, Canaff L, Cole DE (2013) The CASR gene: alternative splicing and transcriptional control, and calcium-sensing receptor (CaSR) protein: structure and ligand binding sites. Best Pract Res Clin Endocrinol Metab 27(3):285\u2013301","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"6065_CR9","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1007\/978-3-030-12457-1_41","volume":"1131","author":"S Chavez-Abiega","year":"2020","unstructured":"Chavez-Abiega S, Mos I, Centeno PP et al (2020) Sensing extracellular calcium - an insight into the structure and function of the calcium-sensing receptor (CaSR). Adv Exp Med Biol 1131:1031\u20131063","journal-title":"Adv Exp Med Biol"},{"issue":"3","key":"6065_CR10","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1124\/pr.119.018531","volume":"72","author":"K Leach","year":"2020","unstructured":"Leach K, Hannan FM, Josephs TM et al (2020) International Union of Basic and Clinical Pharmacology. CVIII. Calcium-sensing receptor nomenclature, pharmacology, and function. Pharmacol Rev 72(3):558\u2013604","journal-title":"Pharmacol Rev"},{"issue":"3","key":"6065_CR11","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.beem.2013.05.010","volume":"27","author":"AD Conigrave","year":"2013","unstructured":"Conigrave AD, Ward DT (2013) Calcium-sensing receptor (CaSR): pharmacological properties and signaling pathways. Best Pract Res Clin Endocrinol Metab 27(3):315\u2013331","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"1","key":"6065_CR12","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13023-017-0570-z","volume":"12","author":"C Vahe","year":"2017","unstructured":"Vahe C, Benomar K, Espiard S et al (2017) Diseases associated with calcium-sensing receptor. Orphanet J Rare Dis 12(1):19","journal-title":"Orphanet J Rare Dis"},{"issue":"7","key":"6065_CR13","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1016\/j.bbamcr.2012.12.011","volume":"1833","author":"SC Brennan","year":"2013","unstructured":"Brennan SC, Thiem U, Roth S et al (2013) Calcium sensing receptor signalling in physiology and cancer. Biochim Biophys Acta 1833(7):1732\u20131744","journal-title":"Biochim Biophys Acta"},{"issue":"9","key":"6065_CR14","doi-asserted-by":"publisher","first-page":"L846","DOI":"10.1152\/ajplung.00050.2016","volume":"310","author":"H Tang","year":"2016","unstructured":"Tang H, Yamamura A, Yamamura H et al (2016) Pathogenic role of calcium-sensing receptors in the development and progression of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 310(9):L846\u2013L859","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"6065_CR15","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.lfs.2018.08.016","volume":"209","author":"Y Guo","year":"2018","unstructured":"Guo Y, Yang X, He J et al (2018) Important roles of the Ca2+-sensing receptor in vascular health and disease. Life Sci 209:217\u2013227","journal-title":"Life Sci"},{"issue":"17","key":"6065_CR16","first-page":"30323","volume":"S1537-1891","author":"R Schreckenberg","year":"2018","unstructured":"Schreckenberg R, Schl\u00fcter KD (2018) Calcium sensing receptor expression and signalling in cardiovascular physiology and disease [published online ahead of print, 2018 Mar 4]. Vascul Pharmacol S1537-1891(17):30323\u201330323","journal-title":"Vascul Pharmacol"},{"issue":"1","key":"6065_CR17","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1423-0127-18-16","volume":"18","author":"GW Li","year":"2011","unstructured":"Li GW, Wang QS, Hao JH et al (2011) The functional expression of extracellular calcium-sensing receptor in rat pulmonary artery smooth muscle cells. J Biomed Sci 18(1):16","journal-title":"J Biomed Sci"},{"key":"6065_CR18","doi-asserted-by":"publisher","first-page":"517","DOI":"10.3389\/fphys.2016.00517","volume":"7","author":"KA Smith","year":"2016","unstructured":"Smith KA, Ayon RJ, Tang H et al (2016) Calcium-sensing receptor regulates cytosolic [Ca2+] and plays a major role in the development of pulmonary hypertension. Front Physiol 7:517","journal-title":"Front Physiol"},{"issue":"3","key":"6065_CR19","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1089\/ars.2011.4168","volume":"17","author":"J Zhang","year":"2012","unstructured":"Zhang J, Zhou J, Cai L et al (2012) Extracellular calcium-sensing receptor is critical in hypoxic pulmonary vasoconstriction. Antioxid Redox Signal 17(3):471\u2013484","journal-title":"Antioxid Redox Signal"},{"issue":"1\u20132","key":"6065_CR20","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s11010-014-2145-9","volume":"396","author":"X Peng","year":"2014","unstructured":"Peng X, Li HX, Shao HJ et al (2014) Involvement of calcium-sensing receptors in hypoxia-induced vascular remodeling and pulmonary hypertension by promoting phenotypic modulation of small pulmonary arteries. Mol Cell Biochem 396(1\u20132):87\u201398","journal-title":"Mol Cell Biochem"},{"issue":"3","key":"6065_CR21","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1161\/ATVBAHA.118.312280","volume":"39","author":"L Zhu","year":"2019","unstructured":"Zhu L, Xiao R, Zhang X et al (2019) Spermine on endothelial extracellular vesicles mediates smoking-induced pulmonary hypertension partially through calcium-sensing receptor. Arterioscler Thromb Vasc Biol 39(3):482\u2013495","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"7","key":"6065_CR22","doi-asserted-by":"publisher","first-page":"L576","DOI":"10.1152\/ajplung.00162.2014","volume":"307","author":"KC Penumatsa","year":"2014","unstructured":"Penumatsa KC, Toksoz D, Warburton RR et al (2014) Role of hypoxia-induced transglutaminase 2 in pulmonary artery smooth muscle cell proliferation. Am J Physiol Lung Cell Mol Physiol 307(7):L576\u2013L585","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"2","key":"6065_CR23","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s00383-017-4191-3","volume":"34","author":"H Nakamura","year":"2018","unstructured":"Nakamura H, Zimmer J, Lim T et al (2018) Increased CaSR and TRPC6 pulmonary vascular expression in the nitrofen-induced model of congenital diaphragmatic hernia. Pediatr Surg Int 34(2):211\u2013215","journal-title":"Pediatr Surg Int"},{"issue":"5","key":"6065_CR24","first-page":"73","volume":"114","author":"MM Hoeper","year":"2017","unstructured":"Hoeper MM, Ghofrani HA, Gr\u00fcnig E et al (2017) Pulmonary hypertension. Dtsch Arztebl Int 114(5):73\u201384","journal-title":"Dtsch Arztebl Int"},{"issue":"6","key":"6065_CR25","doi-asserted-by":"publisher","first-page":"7363","DOI":"10.1096\/fj.201802620R","volume":"33","author":"A Yamamura","year":"2019","unstructured":"Yamamura A, Nayeem MJ, Al Mamun A et al (2019) Platelet-derived growth factor up-regulates Ca2+-sensing receptors in idiopathic pulmonary arterial hypertension. FASEB J 33(6):7363\u20137374","journal-title":"FASEB J"},{"issue":"1","key":"6065_CR26","doi-asserted-by":"publisher","first-page":"C111","DOI":"10.1152\/ajpcell.00219.2018","volume":"316","author":"C AgarLi","year":"2019","unstructured":"AgarLi C, Qin F, Xue M et al (2019) miR-429 and miR-424-5p inhibit cell proliferation and Ca2+ influx by downregulating CaSR in pulmonary artery smooth muscle cells. Am J Physiol Cell Physiol 316(1):C111\u2013C120","journal-title":"Am J Physiol Cell Physiol"},{"key":"6065_CR27","doi-asserted-by":"publisher","first-page":"e05005","DOI":"10.7554\/eLife.05005","volume":"4","author":"V Agarwal","year":"2015","unstructured":"Agarwal V, Bell GW, Nam JW et al (2015) Predicting effective microRNA target sites in mammalian mRNAs. Elife 4:e05005 Published 2015 Aug 12","journal-title":"Elife"},{"key":"6065_CR28","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/j.biopha.2018.07.017","volume":"106","author":"L Luo","year":"2018","unstructured":"Luo L, Hong X, Diao B et al (2018) Sulfur dioxide attenuates hypoxia-induced pulmonary arteriolar remodeling via Dkk1\/Wnt signaling pathway. Biomed Pharmacother 106:692\u2013698","journal-title":"Biomed Pharmacother"},{"issue":"24","key":"6065_CR29","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1042\/CS20190835","volume":"133","author":"HE Morris","year":"2019","unstructured":"Morris HE, Neves KB, Montezano AC et al (2019) Notch3 signalling and vascular remodelling in pulmonary arterial hypertension. Clin Sci (Lond) 133(24):2481\u20132498","journal-title":"Clin Sci (Lond)"},{"issue":"2","key":"6065_CR30","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/hr.2016.118","volume":"40","author":"Q Guo","year":"2017","unstructured":"Guo Q, Xu H, Yang X et al (2017) Notch activation of Ca2+-sensing receptor mediates hypoxia-induced pulmonary hypertension. Hypertens Res 40(2):117\u2013129","journal-title":"Hypertens Res"},{"issue":"5","key":"6065_CR31","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1161\/HYPERTENSIONAHA.116.08743","volume":"69","author":"X Zeng","year":"2017","unstructured":"Zeng X, Zhu L, Xiao R et al (2017) Hypoxia-induced mitogenic factor acts as a nonclassical ligand of calcium-sensing receptor, therapeutically exploitable for intermittent hypoxia-induced pulmonary hypertension. Hypertension 69(5):844\u2013854","journal-title":"Hypertension"},{"key":"6065_CR32","doi-asserted-by":"publisher","first-page":"109931","DOI":"10.1016\/j.biopha.2020.109931","volume":"125","author":"J Li","year":"2020","unstructured":"Li J, Jia M, Liu M et al (2020) The effect of activated \u03ba-opioid receptor (\u03ba-OR) on the role of calcium sensing receptor (CaSR) in preventing hypoxic pulmonary hypertension development. Biomed Pharmacother 125:109931","journal-title":"Biomed Pharmacother"},{"key":"6065_CR33","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/1750-1172-8-97","volume":"8","author":"D Montani","year":"2013","unstructured":"Montani D, G\u00fcnther S, Dorfm\u00fcller P et al (2013) Pulmonary arterial hypertension. Orphanet J Rare Dis 8:97 Published 2013 Jul 6","journal-title":"Orphanet J Rare Dis"},{"issue":"5","key":"6065_CR34","doi-asserted-by":"publisher","first-page":"696","DOI":"10.5858\/arpa.2016-0035-RA","volume":"141","author":"M Foshat","year":"2017","unstructured":"Foshat M, Boroumand N (2017) The evolving classification of pulmonary hypertension. Arch Pathol Lab Med 141(5):696\u2013703","journal-title":"Arch Pathol Lab Med"},{"issue":"10","key":"6065_CR35","doi-asserted-by":"publisher","first-page":"3162","DOI":"10.3390\/ijms19103162","volume":"19","author":"M Lambert","year":"2018","unstructured":"Lambert M, Capuano V, Olschewski A et al (2018 Oct 14) Ion channels in pulmonary hypertension: a therapeutic interest? Int J Mol Sci 19(10):3162","journal-title":"Int J Mol Sci"},{"issue":"6","key":"6065_CR36","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/ncpcardio0890","volume":"4","author":"A Puri","year":"2007","unstructured":"Puri A, McGoon MD, Kushwaha SS (2007) Pulmonary arterial hypertension: current therapeutic strategies. Nat Clin Pract Cardiovasc Med 4(6):319\u2013329","journal-title":"Nat Clin Pract Cardiovasc Med"},{"issue":"10","key":"6065_CR37","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1248\/yakushi.16-00086","volume":"136","author":"A Yamamura","year":"2016","unstructured":"Yamamura A (2016) Molecular mechanism of dihydropyridine Ca2+ channel blockers in pulmonary hypertension. Yakugaku Zasshi 136(10):1373\u20131377","journal-title":"Yakugaku Zasshi"},{"issue":"4","key":"6065_CR38","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1161\/CIRCRESAHA.113.300897","volume":"112","author":"A Yamamura","year":"2013","unstructured":"Yamamura A, Yamamura H, Guo Q et al (2013) Dihydropyridine Ca(2+) channel blockers increase cytosolic [Ca(2+)] by activating Ca(2+)-sensing receptors in pulmonary arterial smooth muscle cells. Circ Res 112(4):640\u2013650","journal-title":"Circ Res"},{"issue":"4","key":"6065_CR39","doi-asserted-by":"publisher","first-page":"e004865","DOI":"10.1161\/JAHA.116.004865","volume":"6","author":"R Xiao","year":"2017","unstructured":"Xiao R, Su Y, Feng T et al (2017) Monocrotaline Induces Endothelial Injury and Pulmonary Hypertension by Targeting the Extracellular Calcium-Sensing Receptor. J Am Heart Assoc 6(4):e004865 Published 2017 Mar 22","journal-title":"J Am Heart Assoc"},{"key":"6065_CR40","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.ejphar.2016.04.059","volume":"784","author":"A Yamamura","year":"2016","unstructured":"Yamamura A, Yagi S, Ohara N et al (2016) Calcilytics enhance sildenafil-induced antiproliferation in idiopathic pulmonary arterial hypertension. Eur J Pharmacol 784:15\u201321","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"6065_CR41","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","volume":"147","author":"N Mizushima","year":"2011","unstructured":"Mizushima N, Komatsu M (2011) Autophagy: renovation of cells and tissues. Cell 147(4):728\u2013741","journal-title":"Cell"},{"issue":"5","key":"6065_CR42","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1096\/fj.12-222224","volume":"27","author":"EA Goncharova","year":"2013","unstructured":"Goncharova EA (2013) mTOR and vascular remodeling in lung diseases: current challenges and therapeutic prospects. FASEB J 27(5):1796\u20131807","journal-title":"FASEB J"},{"issue":"1","key":"6065_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15548627.2015.1100356","volume":"12","author":"DJ Klionsky","year":"2016","unstructured":"Klionsky DJ, Abdelmohsen K, Abe A et al (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) [Published correction appears in autophagy]. Autophagy 12(1):1\u2013222","journal-title":"Autophagy"},{"issue":"5","key":"6065_CR44","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1164\/rccm.201005-0746OC","volume":"183","author":"SJ Lee","year":"2011","unstructured":"Lee SJ, Smith A, Guo L et al (2011) Autophagic protein LC3B confers resistance against hypoxia-induced pulmonary hypertension. Am J Respir Crit Care Med 183(5):649\u2013658","journal-title":"Am J Respir Crit Care Med"},{"issue":"9\u201310","key":"6065_CR45","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s10495-018-1477-4","volume":"23","author":"R Chen","year":"2018","unstructured":"Chen R, Jiang M, Li B et al (2018) The role of autophagy in pulmonary hypertension: a double-edge sword. Apoptosis 23(9\u201310):459\u2013469","journal-title":"Apoptosis"},{"issue":"8","key":"6065_CR46","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1161\/CIRCRESAHA.111.300483","volume":"112","author":"L Long","year":"2013","unstructured":"Long L, Yang X, Southwood M et al (2013) Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation. Circ Res 112(8):1159\u20131170","journal-title":"Circ Res"},{"issue":"2","key":"6065_CR47","doi-asserted-by":"publisher","first-page":"59","DOI":"10.2478\/jtim-2019-0013","volume":"7","author":"X Peng","year":"2019","unstructured":"Peng X, Wei C, Li HZ et al (2019) NPS2390, a Selective Calcium-sensing Receptor Antagonist Controls the Phenotypic Modulation of Hypoxic Human Pulmonary Arterial Smooth Muscle Cells by Regulating Autophagy. J Transl Int Med 7(2):59\u201368 Published 2019 Jul 11","journal-title":"J Transl Int Med"},{"issue":"1","key":"6065_CR48","doi-asserted-by":"publisher","first-page":"111","DOI":"10.3892\/mmr.2016.5279","volume":"14","author":"L Liu","year":"2016","unstructured":"Liu L, Wang C, Lin Y et al (2016) Suppression of calcium-sensing receptor ameliorates cardiac hypertrophy through inhibition of autophagy. Mol Med Rep 14(1):111\u2013120","journal-title":"Mol Med Rep"},{"issue":"11","key":"6065_CR49","doi-asserted-by":"publisher","first-page":"3585","DOI":"10.1016\/j.bbadis.2018.08.020","volume":"1864","author":"P Mattar","year":"2018","unstructured":"Mattar P, Bravo-Sagua R, Tobar N et al (2018) Autophagy mediates calcium-sensing receptor-induced TNF\u03b1 production in human preadipocytes. Biochim Biophys Acta Mol basis Dis 1864(11):3585\u20133594","journal-title":"Biochim Biophys Acta Mol basis Dis"},{"issue":"139","key":"6065_CR50","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1183\/16000617.0096-2015","volume":"25","author":"A Vonk Noordegraaf","year":"2016","unstructured":"Vonk Noordegraaf A, Groeneveldt JA, Bogaard HJ (2016 Mar) Pulmonary hypertension. Eur Respir Rev 25(139):4\u201311","journal-title":"Eur Respir Rev"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-020-06065-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-020-06065-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-020-06065-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T11:14:49Z","timestamp":1674818089000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-020-06065-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["6065"],"URL":"https:\/\/doi.org\/10.1007\/s11033-020-06065-3","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"12 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that there are no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}