{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T13:17:43Z","timestamp":1789219063327,"version":"build-2803163510"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["2014\/13295-1, 2016\/03753-8, 2016\/18313-3, 2018\/26367-1, 2016\/08070-6"],"award-info":[{"award-number":["2014\/13295-1, 2016\/03753-8, 2016\/18313-3, 2018\/26367-1, 2016\/08070-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["445336\/2014-5 , 304570\/2017-6."],"award-info":[{"award-number":["445336\/2014-5 , 304570\/2017-6."]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1007\/s11033-021-06172-9","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T02:40:40Z","timestamp":1612924840000},"page":"1103-1114","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Polymorphisms and haplotypes in the Interleukin 17 Alfa gene: potential effect of smoking habits in the association with periodontitis and type 2 diabetes mellitus"],"prefix":"10.1007","volume":"48","author":[{"given":"Marco A.","family":"Rimachi Hidalgo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thamiris","family":"Cirelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara Roque","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingra Gagno","family":"Nicchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Nepomuceno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana R. P.","family":"Orrico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joni A.","family":"Cirelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Let\u00edcia Helena","family":"Theodoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana P.","family":"Barros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5068-0268","authenticated-orcid":false,"given":"Raquel M.","family":"Scarel-Caminaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,9]]},"reference":[{"issue":"Suppl 18","key":"6172_CR1","doi-asserted-by":"publisher","first-page":"S39","DOI":"10.1111\/jcpe.12685","volume":"44","author":"IL Chapple","year":"2017","unstructured":"Chapple IL, Bouchard P, Cagetti MG, Campus G, Carra MC, Cocco F, Nibali L, Hujoel P, Laine ML, Lingstrom P, Manton DJ, Montero E, Pitts N, Range H, Schlueter N, Teughels W, Twetman S, Van Loveren C, Van der Weijden F, Vieira AR, Schulte AG (2017) Interaction of lifestyle, behaviour or systemic diseases with dental caries and periodontal diseases: consensus report of group 2 of the joint EFP\/ORCA workshop on the boundaries between caries and periodontal diseases. J Clin Periodontol 44(Suppl 18):S39\u2013S51. https:\/\/doi.org\/10.1111\/jcpe.12685","journal-title":"J Clin Periodontol"},{"key":"6172_CR2","doi-asserted-by":"publisher","unstructured":"Vieira Colombo AP, Magalhaes CB, Hartenbach FA, Martins do Souto R, Maciel da Silva-Boghossian C (2016) Periodontal-disease-associated biofilm: a reservoir for pathogens of medical importance. Microb Pathog 94:27\u201334. doi:https:\/\/doi.org\/10.1016\/j.micpath.2015.09.009","DOI":"10.1016\/j.micpath.2015.09.009"},{"issue":"3","key":"6172_CR3","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1111\/j.1399-302X.2007.00411.x","volume":"23","author":"AD Haffajee","year":"2008","unstructured":"Haffajee AD, Socransky SS, Patel MR, Song X (2008) Microbial complexes in supragingival plaque. Oral Microbiol Immunol 23(3):196\u2013205. https:\/\/doi.org\/10.1111\/j.1399-302X.2007.00411.x","journal-title":"Oral Microbiol Immunol"},{"issue":"1","key":"6172_CR4","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/j.1600-0757.1997.tb00189.x","volume":"14","author":"RC Page","year":"2000","unstructured":"Page RC (2000) Kornman KS (1997) the pathogenesis of human periodontitis: an introduction. Periodontology 14(1):9\u201311","journal-title":"Periodontology"},{"issue":"7","key":"6172_CR5","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1902\/jop.2004.75.7.1033","volume":"75","author":"C Susin","year":"2004","unstructured":"Susin C, Dalla Vecchia CF, Oppermann RV, Haugejorden O, Albandar JM (2004) Periodontal attachment loss in an urban population of Brazilian adults: effect of demographic, behavioral, and environmental risk indicators. J Periodontol 75(7):1033\u20131041. https:\/\/doi.org\/10.1902\/jop.2004.75.7.1033","journal-title":"J Periodontol"},{"issue":"11","key":"6172_CR6","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1902\/jop.2000.71.11.1699","volume":"71","author":"BS Michalowicz","year":"2000","unstructured":"Michalowicz BS, Diehl SR, Gunsolley JC, Sparks BS, Brooks CN, Koertge TE, Califano JV, Burmeister JA, Schenkein HA (2000) Evidence of a substantial genetic basis for risk of adult periodontitis. J Periodontol 71(11):1699\u20131707. https:\/\/doi.org\/10.1902\/jop.2000.71.11.1699","journal-title":"J Periodontol"},{"key":"6172_CR7","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S","volume":"15","author":"K Alberti","year":"1998","unstructured":"Alberti K, Zimmet P (1998) For the World Health Organization consultation: definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Report of a WHO consultation. Diabetic Med J British Diabetic Assoc 15:539\u2013553","journal-title":"Diabetic Med J British Diabetic Assoc"},{"issue":"8","key":"6172_CR8","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1902\/jop.2006.050459","volume":"77","author":"BL Mealey","year":"2006","unstructured":"Mealey BL, Oates TW (2006) Diabetes mellitus and periodontal diseases. J Periodontol 77(8):1289\u20131303","journal-title":"J Periodontol"},{"issue":"1","key":"6172_CR9","first-page":"71","volume":"24","author":"HK Lu","year":"2004","unstructured":"Lu HK, Yang PC (2004) Cross-sectional analysis of different variables of patients with non-insulin dependent diabetes and their periodontal status. Int J Periodontics Restorative Dent 24(1):71\u201379","journal-title":"Int J Periodontics Restorative Dent"},{"issue":"1","key":"6172_CR10","doi-asserted-by":"publisher","first-page":"329","DOI":"10.2337\/diacare.16.1.329","volume":"16","author":"H L\u00f6e","year":"1993","unstructured":"L\u00f6e H (1993) Periodontal disease: the sixth complication of diabetes mellitus. Diabetes Care 16(1):329\u2013334","journal-title":"Diabetes Care"},{"issue":"1","key":"6172_CR11","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1902\/annals.2001.6.1.99","volume":"6","author":"GW Taylor","year":"2001","unstructured":"Taylor GW (2001) Bidirectional interrelationships between diabetes and periodontal diseases: an epidemiologic perspective. Ann Periodontol 6(1):99\u2013112. https:\/\/doi.org\/10.1902\/annals.2001.6.1.99","journal-title":"Ann Periodontol"},{"issue":"1","key":"6172_CR12","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s00125-011-2342-y","volume":"55","author":"PM Preshaw","year":"2012","unstructured":"Preshaw PM, Alba AL, Herrera D, Jepsen S, Konstantinidis A, Makrilakis K, Taylor R (2012) Periodontitis and diabetes: a two-way relationship. Diabetologia 55(1):21\u201331. https:\/\/doi.org\/10.1007\/s00125-011-2342-y","journal-title":"Diabetologia"},{"issue":"7","key":"6172_CR13","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1111\/odi.12598","volume":"23","author":"L Abusleme","year":"2017","unstructured":"Abusleme L, Moutsopoulos NM (2017) IL-17: overview and role in oral immunity and microbiome. Oral Dis 23(7):854\u2013865","journal-title":"Oral Dis"},{"issue":"4","key":"6172_CR14","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1038\/cmi.2015.105","volume":"13","author":"X Song","year":"2016","unstructured":"Song X, He X, Li X, Qian Y (2016) The roles and functional mechanisms of interleukin-17 family cytokines in mucosal immunity. Cell Mol Immunol 13(4):418\u2013431. https:\/\/doi.org\/10.1038\/cmi.2015.105","journal-title":"Cell Mol Immunol"},{"issue":"9","key":"6172_CR15","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/nri3707","volume":"14","author":"SL Gaffen","year":"2014","unstructured":"Gaffen SL, Jain R, Garg AV, Cua DJ (2014) The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing. Nat Rev Immunol 14(9):585\u2013600. https:\/\/doi.org\/10.1038\/nri3707","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"6172_CR16","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1111\/prd.12083","volume":"69","author":"C Zenobia","year":"2015","unstructured":"Zenobia C, Hajishengallis G (2015) Basic biology and role of interleukin-17 in immunity and inflammation. Periodontology 2000 69(1):142\u2013159. https:\/\/doi.org\/10.1111\/prd.12083","journal-title":"Periodontology 2000"},{"issue":"1","key":"6172_CR17","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1902\/jop.2004.75.1.37","volume":"75","author":"RB Johnson","year":"2004","unstructured":"Johnson RB, Wood N, Serio FG (2004) Interleukin-11 and IL-17 and the pathogenesis of periodontal disease. J Periodontol 75(1):37\u201343. https:\/\/doi.org\/10.1902\/jop.2004.75.1.37","journal-title":"J Periodontol"},{"issue":"8","key":"6172_CR18","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1902\/jop.2007.060458","volume":"78","author":"SR Lester","year":"2007","unstructured":"Lester SR, Bain JL, Johnson RB, Serio FG (2007) Gingival concentrations of interleukin-23 and -17 at healthy sites and at sites of clinical attachment loss. J Periodontol 78(8):1545\u20131550. https:\/\/doi.org\/10.1902\/jop.2007.060458","journal-title":"J Periodontol"},{"issue":"1","key":"6172_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1399-302X.2008.00463.x","volume":"24","author":"CR Cardoso","year":"2009","unstructured":"Cardoso CR, Garlet GP, Crippa GE, Rosa AL, Junior WM, Rossi MA, Silva JS (2009) Evidence of the presence of T helper type 17 cells in chronic lesions of human periodontal disease. Oral Microbiol Immunol 24(1):1\u20136. https:\/\/doi.org\/10.1111\/j.1399-302X.2008.00463.x","journal-title":"Oral Microbiol Immunol"},{"issue":"5","key":"6172_CR20","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1038\/mi.2015.136","volume":"9","author":"N Dutzan","year":"2016","unstructured":"Dutzan N, Konkel JE, Greenwell-Wild T, Moutsopoulos NM (2016) Characterization of the human immune cell network at the gingival barrier. Mucosal Immunol 9(5):1163\u20131172","journal-title":"Mucosal Immunol"},{"key":"6172_CR21","doi-asserted-by":"publisher","first-page":"2979846","DOI":"10.1155\/2016\/2979846","volume":"2016","author":"P Borilova Linhartova","year":"2016","unstructured":"Borilova Linhartova P, Kastovsky J, Lucanova S, Bartova J, Poskerova H, Vokurka J, Fassmann A, Kankova K, Izakovicova Holla L (2016) Interleukin-17A gene variability in patients with type 1 Diabetes mellitus and chronic periodontitis: its correlation with IL-17 levels and the occurrence of Periodontopathic Bacteria. Mediat Inflamm 2016:2979846. https:\/\/doi.org\/10.1155\/2016\/2979846","journal-title":"Mediat Inflamm"},{"key":"6172_CR22","doi-asserted-by":"crossref","unstructured":"Wang J, Shete S (2017) Testing departure from Hardy-Weinberg proportions. In: Statistical Human Genetics. Springer, pp. 83\u2013115","DOI":"10.1007\/978-1-4939-7274-6_6"},{"key":"6172_CR23","doi-asserted-by":"publisher","unstructured":"Cirelli T, Nepomuceno R, Rios ACS, Orrico SRP, Cirelli JA, Theodoro LH, Barros SP, Scarel-Caminaga RM (2020) Genetic polymorphisms in the interleukins IL1B, IL4, and IL6 are associated with concomitant periodontitis and type 2 diabetes mellitus in Brazilian patients. J Periodontal Res. https:\/\/doi.org\/10.1111\/jre.12784","DOI":"10.1111\/jre.12784"},{"issue":"Suppl 1","key":"6172_CR24","doi-asserted-by":"publisher","first-page":"S61","DOI":"10.2337\/dc19-S006","volume":"42","author":"American Diabetes A","year":"2019","unstructured":"American Diabetes A (2019) 6. Glycemic targets: standards of medical care in Diabetes-2019. Diabetes Care 42(Suppl 1):S61\u2013S70. https:\/\/doi.org\/10.2337\/dc19-S006","journal-title":"Diabetes Care"},{"issue":"Suppl 1","key":"6172_CR25","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.2337\/dc19-S002","volume":"42","author":"American Diabetes A","year":"2019","unstructured":"American Diabetes A (2019) 2. Classification and diagnosis of Diabetes: standards of medical Care in Diabetes-2019. Diabetes Care 42(Suppl 1):S13\u2013S28. https:\/\/doi.org\/10.2337\/dc19-S002","journal-title":"Diabetes Care"},{"issue":"Supplement 1","key":"6172_CR26","doi-asserted-by":"publisher","first-page":"S61","DOI":"10.2337\/dc19-S006","volume":"42","author":"D Care","year":"2019","unstructured":"Care D (2019) 6. Glycemic targets: standards of medical care in diabetes\u20142019. Diabetes Care 42(Supplement 1):S61\u2013S70","journal-title":"Diabetes Care"},{"issue":"Suppl 7S","key":"6172_CR27","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1902\/jop.2007.060264","volume":"78","author":"RC Page","year":"2007","unstructured":"Page RC, Eke PI (2007) Case definitions for use in population-based surveillance of periodontitis. J Periodontol 78(Suppl 7S):1387\u20131399. https:\/\/doi.org\/10.1902\/jop.2007.060264","journal-title":"J Periodontol"},{"issue":"11","key":"6172_CR28","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1093\/hmg\/ddt065","volume":"22","author":"K Divaris","year":"2013","unstructured":"Divaris K, Monda KL, North KE, Olshan AF, Reynolds LM, Hsueh WC, Lange EM, Moss K, Barros SP, Weyant RJ, Liu Y, Newman AB, Beck JD, Offenbacher S (2013) Exploring the genetic basis of chronic periodontitis: a genome-wide association study. Hum Mol Genet 22(11):2312\u20132324. https:\/\/doi.org\/10.1093\/hmg\/ddt065","journal-title":"Hum Mol Genet"},{"issue":"11","key":"6172_CR29","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1111\/jcpe.12154","volume":"40","author":"A Teumer","year":"2013","unstructured":"Teumer A, Holtfreter B, Volker U, Petersmann A, Nauck M, Biffar R, Volzke H, Kroemer HK, Meisel P, Homuth G, Kocher T (2013) Genome-wide association study of chronic periodontitis in a general German population. J Clin Periodontol 40(11):977\u2013985. https:\/\/doi.org\/10.1111\/jcpe.12154","journal-title":"J Clin Periodontol"},{"issue":"6","key":"6172_CR30","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1111\/sji.12171","volume":"79","author":"Y Miyake","year":"2014","unstructured":"Miyake Y, Tanaka K, Arakawa M (2014) IL3 rs40401 polymorphism and interaction with smoking in risk of asthma in Japanese women: the Kyushu Okinawa maternal and child health study. Scand J Immunol 79(6):410\u2013414. https:\/\/doi.org\/10.1111\/sji.12171","journal-title":"Scand J Immunol"},{"issue":"2","key":"6172_CR31","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1590\/S0103-64402007000200012","volume":"18","author":"M Aidar","year":"2007","unstructured":"Aidar M, Line SR (2007) A simple and cost-effective protocol for DNA isolation from buccal epithelial cells. Braz Dent J 18(2):148\u2013152","journal-title":"Braz Dent J"},{"issue":"3","key":"6172_CR32","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1086\/519795","volume":"81","author":"S Purcell","year":"2007","unstructured":"Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, Sham PC (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81(3):559\u2013575. https:\/\/doi.org\/10.1086\/519795","journal-title":"Am J Hum Genet"},{"issue":"3","key":"6172_CR33","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1111\/j.1600-051X.1994.tb00297.x","volume":"21","author":"B Sepp\u00e4l\u00e4","year":"1994","unstructured":"Sepp\u00e4l\u00e4 B, Ainamo J (1994) A site-by-site follow-up study on the effect of controlled versus poorly controlled insulin-dependent diabetes mellitus. J Clin Periodontol 21(3):161\u2013165","journal-title":"J Clin Periodontol"},{"issue":"1","key":"6172_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1902\/annals.1996.1.1.1","volume":"1","author":"PN Papapanou","year":"1996","unstructured":"Papapanou PN (1996) Periodontal diseases: epidemiology. Ann Periodontol 1(1):1\u201336","journal-title":"Ann Periodontol"},{"issue":"1","key":"6172_CR35","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1046\/j.0906-6713.2002.03206.x","volume":"32","author":"BL Mealey","year":"2003","unstructured":"Mealey BL, Moritz AJ (2003) Hormonal influences: effects of diabetes mellitus and endogenous female sex steroid hormones on the periodontium. Periodontology 2000 32(1):59\u201381","journal-title":"Periodontology 2000"},{"key":"6172_CR36","unstructured":"Lu HK, Yang PC (2004) Cross-sectional analysis of different variables of patients with non-insulin dependent diabetes and their periodontal status. Int J Periodontics Restorative Dentistry 24(1)"},{"issue":"3","key":"6172_CR37","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1902\/jop.2008.070203","volume":"79","author":"F Struch","year":"2008","unstructured":"Struch F, Dau M, Schwahn C, Biffar R, Kocher T, Meisel P (2008) Interleukin-1 gene polymorphism, diabetes, and periodontitis: results from the study of health in Pomerania (SHIP). J Periodontol 79(3):501\u2013507","journal-title":"J Periodontol"},{"issue":"3","key":"6172_CR38","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1902\/jop.1985.56.3.154","volume":"56","author":"T Ervasti","year":"1985","unstructured":"Ervasti T, Knuuttila M, Pohjamo L, Haukipuro K (1985) Relation between control of diabetes and gingival bleeding. J Periodontol 56(3):154\u2013157. https:\/\/doi.org\/10.1902\/jop.1985.56.3.154","journal-title":"J Periodontol"},{"key":"6172_CR39","doi-asserted-by":"publisher","first-page":"147056","DOI":"10.1155\/2015\/147056","volume":"2015","author":"JM Zacarias","year":"2015","unstructured":"Zacarias JM, Sippert EA, Tsuneto PY, Visentainer JE, de Oliveira e Silva C, Sell AM (2015) The influence of interleukin 17A and IL17F polymorphisms on chronic periodontitis disease in Brazilian patients. Mediat Inflamm 2015:147056. https:\/\/doi.org\/10.1155\/2015\/147056","journal-title":"Mediat Inflamm"},{"key":"6172_CR40","doi-asserted-by":"publisher","first-page":"846052","DOI":"10.1155\/2012\/846052","volume":"2012","author":"JD Correa","year":"2012","unstructured":"Correa JD, Madeira MF, Resende RG, Correia-Silva Jde F, Gomez RS, de Souza DG, Teixeira MM, Queiroz-Junior CM, da Silva TA (2012) Association between polymorphisms in interleukin-17A and -17F genes and chronic periodontal disease. Mediat Inflamm 2012:846052. https:\/\/doi.org\/10.1155\/2012\/846052","journal-title":"Mediat Inflamm"},{"issue":"2","key":"6172_CR41","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.humimm.2012.10.026","volume":"74","author":"AM Saraiva","year":"2013","unstructured":"Saraiva AM, Alves e Silva MR, de Correia Silva JF, da Costa JE, Gollob KJ, Dutra WO, Moreira PR (2013) Evaluation of IL17A expression and of IL17A, IL17F and IL23R gene polymorphisms in Brazilian individuals with periodontitis. Hum Immunol 74(2):207\u2013214. https:\/\/doi.org\/10.1016\/j.humimm.2012.10.026","journal-title":"Hum Immunol"},{"key":"6172_CR42","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.fsigen.2018.02.003","volume":"34","author":"F Sim\u00e3o","year":"2018","unstructured":"Sim\u00e3o F, Ferreira AP, de Carvalho EF, Parson W, Gusm\u00e3o L (2018) Defining mtDNA origins and population stratification in Rio de Janeiro. Forensic Sci Int Genet 34:97\u2013104","journal-title":"Forensic Sci Int Genet"},{"issue":"4","key":"6172_CR43","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1007\/s00439-002-0896-y","volume":"112","author":"MD Shriver","year":"2003","unstructured":"Shriver MD, Parra EJ, Dios S, Bonilla C, Norton H, Jovel C, Pfaff C, Jones C, Massac A, Cameron N (2003) Skin pigmentation, biogeographical ancestry and admixture mapping. Hum Genet 112(4):387\u2013399","journal-title":"Hum Genet"},{"key":"6172_CR44","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1476-7961-4-2","volume":"4","author":"B Puthothu","year":"2006","unstructured":"Puthothu B, Krueger M, Heinze J, Forster J, Heinzmann A (2006) Impact of IL8 and IL8-receptor alpha polymorphisms on the genetics of bronchial asthma and severe RSV infections. Clin Mol Allergy: CMA 4:2. https:\/\/doi.org\/10.1186\/1476-7961-4-2","journal-title":"Clin Mol Allergy: CMA"},{"key":"6172_CR45","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/S0065-2660(07)00414-2","volume":"60","author":"N Liu","year":"2008","unstructured":"Liu N, Zhang K, Zhao H (2008) Haplotype-association analysis. Adv Genet 60:335\u2013405","journal-title":"Adv Genet"},{"issue":"7","key":"6172_CR46","doi-asserted-by":"publisher","first-page":"674","DOI":"10.7150\/ijms.6962","volume":"11","author":"S Cantore","year":"2014","unstructured":"Cantore S, Mirgaldi R, Ballini A, Coscia MF, Scacco S, Papa F, Inchingolo F, Dipalma G, De Vito D (2014) Cytokine gene polymorphisms associate with microbiogical agents in periodontal disease: our experience. Int J Med Sci 11(7):674\u2013679. https:\/\/doi.org\/10.7150\/ijms.6962","journal-title":"Int J Med Sci"},{"issue":"1","key":"6172_CR47","doi-asserted-by":"publisher","first-page":"71","DOI":"10.4103\/1735-3327.223614","volume":"15","author":"B Moudi","year":"2018","unstructured":"Moudi B, Heidari Z, Mahmoudzadeh-Sagheb H, Moudi M (2018) Analysis of interleukin-10 gene polymorphisms in patients with chronic periodontitis and healthy controls. Dent Res J (Isfahan) 15(1):71\u201379. https:\/\/doi.org\/10.4103\/1735-3327.223614","journal-title":"Dent Res J (Isfahan)"},{"key":"6172_CR48","doi-asserted-by":"publisher","unstructured":"Ballini A, Dipalma G, Isacco CG, Boccellino M, Di Domenico M, Santacroce L, Nguyen KCD, Scacco S, Calvani M, Boddi A, Corcioli F, Quagliuolo L, Cantore S, Martelli FS, Inchingolo F (2020) Oral microbiota and immune system crosstalk: a translational research. Biology (Basel) 9(6). https:\/\/doi.org\/10.3390\/biology9060131","DOI":"10.3390\/biology9060131"},{"key":"6172_CR49","doi-asserted-by":"publisher","unstructured":"Inchingolo F, Martelli FS, Gargiulo Isacco C, Borsani E, Cantore S, Corcioli F, Boddi A, Nguyen KCD, De Vito D, Aityan SK, Pham VH, Dipalma G, Ballini A (2020) Chronic periodontitis and immunity, towards the implementation of a personalized medicine: a translational research on gene single nucleotide polymorphisms (SNPs) linked to chronic Oral Dysbiosis in 96 Caucasian patients. Biomedicines 8(5). https:\/\/doi.org\/10.3390\/biomedicines8050115","DOI":"10.3390\/biomedicines8050115"},{"issue":"4","key":"6172_CR50","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1007\/s40496-014-0037-4","volume":"1","author":"ML Laine","year":"2014","unstructured":"Laine ML, Jepsen S, Loos BG (2014) Progress in the identification of genetic factors in periodontitis. Curr Oral Health Rep 1(4):272\u2013278","journal-title":"Curr Oral Health Rep"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-021-06172-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11033-021-06172-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-021-06172-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T16:22:13Z","timestamp":1614702133000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11033-021-06172-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["6172"],"URL":"https:\/\/doi.org\/10.1007\/s11033-021-06172-9","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"5 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors have stated explicitly that there are no conflicts of interest in connection with this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This research has been approved by Research Ethic Committee, FOAr-UNESP, protocol number 50\/2006.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Parent(s)\/guardian(s) consent obtained.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent for publication"}}]}}