{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T20:27:52Z","timestamp":1783628872268,"version":"3.55.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100010221","name":"Higher Education Commision, Pakistan","doi-asserted-by":"publisher","award":["4332"],"award-info":[{"award-number":["4332"]}],"id":[{"id":"10.13039\/501100010221","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1007\/s11033-021-06463-1","type":"journal-article","created":{"date-parts":[[2021,6,6]],"date-time":"2021-06-06T14:02:52Z","timestamp":1622988172000},"page":"4431-4439","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Role of Vitamin D deficiency and mRNA expression of VDR and RXR in haematological cancers"],"prefix":"10.1007","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1649-4757","authenticated-orcid":false,"given":"Syeda","family":"Sana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9886-180X","authenticated-orcid":false,"given":"Mahmood Akhtar","family":"Kayani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,6]]},"reference":[{"issue":"Special issue 4","key":"6463_CR1","doi-asserted-by":"publisher","first-page":"486","DOI":"10.14486\/IJSCS417","volume":"3","author":"Onur ORAL","year":"2015","unstructured":"Onur O, Anna Z, Hasdemir SP, Nomikos G, Varol SR (2015) Vitamin D and Its Metabolic Functions. Int J S C S 3(Special Issue 4): 486\u2013493","journal-title":"International journal of sport culture and science"},{"issue":"2","key":"6463_CR2","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s00394-012-0430-5","volume":"52","author":"S Battault","year":"2013","unstructured":"Battault S, Whiting SJ, Peltier SL, Sadrin S, Gerber G, Maixent JM (2013) Vitamin D metabolism, functions and needs: from science to health claims. Eur J Nutr 52(2):429\u2013441","journal-title":"Eur J Nutr"},{"issue":"176","key":"6463_CR3","first-page":"2376","volume":"4","author":"P Tiwari","year":"2017","unstructured":"Tiwari P, Sharma N (2017) Role of Vitamin D in various illnesses: a review. J Pharma Care Health Sys 4(176):2376","journal-title":"J Pharma Care Health Sys"},{"issue":"5","key":"6463_CR4","first-page":"00201","volume":"6","author":"LF Almeida","year":"2017","unstructured":"Almeida LF, Coimbra TM (2017) Vitamin D actions on cell differentiation, proliferation and inflammation. Int J Complement Alt Med 6(5):00201","journal-title":"Int J Complement Alt Med"},{"issue":"2","key":"6463_CR5","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s12016-013-8361-3","volume":"45","author":"CY Yang","year":"2013","unstructured":"Yang CY, Leung PS, Adamopoulos IE, Gershwin ME (2013) The implication of vitamin D and autoimmunity: a comprehensive review. Clin Rev Allerg Immu 45(2):217\u2013226","journal-title":"Clin Rev Allerg Immu"},{"issue":"2","key":"6463_CR6","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.annepidem.2007.12.002","volume":"19","author":"E Giovannucci","year":"2009","unstructured":"Giovannucci E (2009) Vitamin D and cancer incidence in the Harvard cohorts. Ann Epidemiol 19(2):84\u201388","journal-title":"Ann Epidemiol"},{"issue":"9","key":"6463_CR7","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1111\/nure.12047","volume":"71","author":"L Teleni","year":"2013","unstructured":"Teleni L, Baker J, Koczwara B, Kimlin MG, Walpole E, Tsai K, Isenring EA (2013) Clinical outcomes of vitamin D deficiency and supplementation in cancer patients. Nutr Rev 71(9):611\u2013621","journal-title":"Nutr Rev"},{"issue":"41","key":"6463_CR8","doi-asserted-by":"publisher","first-page":"29847","DOI":"10.1074\/jbc.M703641200","volume":"282","author":"R Kommagani","year":"2007","unstructured":"Kommagani R, Payal V, Kadakia MP (2007) Differential regulation of Vitamin D Receptor (VDR) by the p53 Family p73-dependent induction of VDR upon DNA damage. J Biol Chem 282(41):29847\u201329854","journal-title":"J Biol Chem"},{"issue":"1","key":"6463_CR9","first-page":"35","volume":"50","author":"VP Dave","year":"2012","unstructured":"Dave VP, Kaul D, Sharma M (2012) Crosstalk between RXR, LXR and VDR within blood mononuclear cellular model. Indian J Experimental Biol 50(1):35\u201340","journal-title":"Indian J Experimental Biol"},{"issue":"21","key":"6463_CR10","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1093\/jnci\/djm204","volume":"99","author":"DM Freedman","year":"2007","unstructured":"Freedman DM, Looker AC, Chang SC, Graubard BI (2007) Prospective study of serum vitamin D and cancer mortality in the United States. J Natl Cancer I 99(21):1594\u20131602","journal-title":"J Natl Cancer I"},{"issue":"8","key":"6463_CR11","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1002\/ijc.23311","volume":"122","author":"EL Ding","year":"2008","unstructured":"Ding EL, Mehta S, Fawzi WW, Giovannucci EL (2008) Interaction of estrogen therapy with calcium and vitamin D supplementation on colorectal cancer risk: reanalysis of Women\u2019s Health Initiative randomized trial. Int J Cancer 122(8):1690\u20131694","journal-title":"Int J Cancer"},{"issue":"1","key":"6463_CR12","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1136\/jech.2006.052571","volume":"62","author":"SB Mohr","year":"2008","unstructured":"Mohr SB, Garland CF, Gorham ED, Grant WB, Garland FC (2008) Could ultraviolet B irradiance and vitamin D be associated with lower incidence rates of lung cancer? J Epidemiol Commun H 62(1):69\u201374","journal-title":"J Epidemiol Commun H"},{"issue":"3","key":"6463_CR13","doi-asserted-by":"publisher","first-page":"e103","DOI":"10.1371\/journal.pmed.0040103","volume":"4","author":"H Li","year":"2007","unstructured":"Li H, Stampfe MJ, Hollis JBW, Mucci LA, Gaziano JM, Hunter D, Ma J (2007) A prospective study of plasma vitamin D metabolites, vitamin D receptor polymorphisms, and prostate cancer. PLoS Med 4(3):e103","journal-title":"PLoS Med"},{"issue":"1","key":"6463_CR14","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.yfrne.2012.07.001","volume":"34","author":"DW Eyles","year":"2013","unstructured":"Eyles DW, Burne TH, McGrath JJ (2013) Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. Front Neuroendocrin 34(1):47\u201364","journal-title":"Front Neuroendocrin"},{"issue":"11","key":"6463_CR15","doi-asserted-by":"publisher","first-page":"2520","DOI":"10.1002\/ijc.27946","volume":"132","author":"AK Azad","year":"2013","unstructured":"Azad AK, Bairati I, Qiu X, Huang H, Cheng D, Liu G, Xu W (2013) Genetic sequence variants in vitamin D metabolism pathway genes, serum vitamin D level and outcome in head and neck cancer patients. Int Journal Cancer 132(11):2520\u20132527","journal-title":"Int Journal Cancer"},{"issue":"5","key":"6463_CR16","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1158\/0008-5472.CAN-11-2950","volume":"72","author":"SJ Weinstein","year":"2012","unstructured":"Weinstein SJ, Stolzenberg-Solomon RZ, Kopp W, Rager H, Virtamo J, Albanes D (2012) Impact of circulating vitamin D binding protein levels on the association between 25-hydroxyvitamin D and pancreatic cancer risk: a nested case\u2013control study. Cancer Res 72(5):1190\u20131198","journal-title":"Cancer Res"},{"issue":"2","key":"6463_CR17","doi-asserted-by":"publisher","first-page":"332","DOI":"10.11613\/BM.2017.036","volume":"27","author":"\u00d6\u00c7 Madenci","year":"2017","unstructured":"Madenci \u00d6\u00c7, Or\u00e7un A, Yildiz Z, Sirmali R, Tun\u00e7bilek N, Y\u00fccel N, B\u00f6l\u00fck A (2017) Evaluation of new Beckman Coulter 25 (OH) Vitamin D assay and potential improvement of clinical interpretation. Biochem Med 27(2):332\u2013341","journal-title":"Biochem Med"},{"issue":"1","key":"6463_CR18","doi-asserted-by":"publisher","first-page":"1288773","DOI":"10.1080\/2331205X.2017.1288773","volume":"4","author":"MR Sarwar","year":"2017","unstructured":"Sarwar MR, Saqib A (2017) Cancer prevalence, incidence and mortality rates in Pakistan in 2012. Cogent Med 4(1):1288773","journal-title":"Cogent Med"},{"issue":"6","key":"6463_CR19","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68(6):394\u2013424","journal-title":"CA Cancer J Clin"},{"issue":"11","key":"6463_CR20","doi-asserted-by":"publisher","first-page":"3794S","DOI":"10.1093\/jn\/133.11.3794S","volume":"133","author":"HA Norman","year":"2003","unstructured":"Norman HA, Butrum RR, Feldman E, Heber D, Nixon D, Picciano MF, Zeisel SH (2003) The role of dietary supplements during cancer therapy. Journal Nutr 133(11):3794S-3799S","journal-title":"Journal Nutr"},{"issue":"6","key":"6463_CR21","doi-asserted-by":"publisher","first-page":"1678S","DOI":"10.1093\/ajcn\/80.6.1678S","volume":"80","author":"MF Holick","year":"2004","unstructured":"Holick MF (2004) Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 80(6):1678S-1688S","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"6463_CR22","first-page":"1","volume":"50","author":"SM Jeon","year":"2018","unstructured":"Jeon SM, Shin EA (2018) Exploring vitamin D metabolism and function in cancer. Ex Mol Med 50(4):1\u201314","journal-title":"Ex Mol Med"},{"issue":"21","key":"6463_CR23","doi-asserted-by":"publisher","first-page":"5026","DOI":"10.1182\/blood.V122.21.5026.5026","volume":"122","author":"CG Frangou","year":"2013","unstructured":"Frangou CG, Den HJ, Nowak N, Johnson CS, Trump D, Wetzler M (2013) 25 (OH) Vitamin D3 affects acute myeloid leukemia cell proliferation. Blood 122(21):5026","journal-title":"Blood"},{"issue":"1","key":"6463_CR24","first-page":"10","volume":"29","author":"A Naz","year":"2013","unstructured":"Naz A, Qureshi RN, Shamsi TS, Mahboob T (2013) Vitamin D levels in patients of acute leukemia before and after remission-induction therapy. Pak J Med Sci 29(1):10","journal-title":"Pak J Med Sci"},{"issue":"3","key":"6463_CR25","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/ejh.12818","volume":"98","author":"PM Kulling","year":"2017","unstructured":"Kulling PM, Olson KC, Olson TL, Feith DJ, Loughran TP (2017) Vitamin D in hematological disorders and malignancies. Eur J Hematol 98(3):187\u2013197","journal-title":"Eur J Hematol"},{"key":"6463_CR26","doi-asserted-by":"publisher","first-page":"534","DOI":"10.5604\/17322693.1202482","volume":"70","author":"M Kubeczko","year":"2016","unstructured":"Kubeczko M, Nowara E, Spycha\u0142owicz W, Wdowiak K, Bednarek A, Karwasiecka D, Wojnar J (2016) Efficacy and safety of vitamin D supplementation in patients with chronic lymphocytic leukemia. Postepy Hig Med Dosw 70:534","journal-title":"Postepy Hig Med Dosw"},{"issue":"1","key":"6463_CR27","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1002\/cam4.1166","volume":"7","author":"S Hohaus","year":"2018","unstructured":"Hohaus S, Tisi MC, Bellesi S, Maiolo E, Alma E, Tartaglia G, De Stefano V (2018) Vitamin D deficiency and supplementation in patients with aggressive B-cell lymphomas treated with immunochemotherapy. Cancer Med 7(1):270\u2013281","journal-title":"Cancer Med"},{"issue":"7","key":"6463_CR28","doi-asserted-by":"publisher","first-page":"030006052094342","DOI":"10.1177\/0300060520943421","volume":"48","author":"V Graklanov","year":"2020","unstructured":"Graklanov V, Popov V (2020) Vitamin D levels in patients with non-Hodgkin lymphoma\/diffuse large B-cell lymphoma, chronic lymphocytic leukemia and multiple myeloma. J Int Med Res 48(7):0300060520943421","journal-title":"J Int Med Res"},{"issue":"2","key":"6463_CR29","doi-asserted-by":"publisher","first-page":"77","DOI":"10.4103\/ejh.ejh_15_19","volume":"44","author":"A Bedewy","year":"2019","unstructured":"Bedewy A, Kandil N (2019) Vitamin D supplementation does not affect survival in patients with Hodgkin\u2019s lymphoma. Egyptian J Haematol 44(2):77","journal-title":"Egyptian J Haematol"},{"issue":"1\u20132","key":"6463_CR30","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1023\/A:1021343825552","volume":"34","author":"M Friedrich","year":"2002","unstructured":"Friedrich M, Axt-Fliedner R, Villena-Heinsen C, Tilgen W, Schmidt W, Reichrath J (2002) Analysis of vitamin D-receptor (VDR) and retinoid X-receptor \u03b1 in breast cancer. Histochem J 34(1\u20132):35\u201340","journal-title":"Histochem J"},{"issue":"17","key":"6463_CR31","doi-asserted-by":"publisher","first-page":"2378","DOI":"10.1200\/JCO.2010.30.9880","volume":"29","author":"WK Hendrickson","year":"2011","unstructured":"Hendrickson WK, Flavin R, Kasperzyk JL, Fiorentino M, Fang F, Lis R, Stampfer MJ (2011) Vitamin D receptor protein expression in tumor tissue and prostate cancer progression. J Clin Oncol 29(17):2378","journal-title":"J Clin Oncol"},{"issue":"1\u20132","key":"6463_CR32","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.jsbmb.2010.10.002","volume":"123","author":"M Srinivasan","year":"2011","unstructured":"Srinivasan M, Parwani AV, Hershberger PA, Lenzner DE, Weissfeld JL (2011) Nuclear vitamin D receptor expression is associated with improved survival in non-small cell lung cancer. J Steroid Biochem 123(1\u20132):30\u201336","journal-title":"J Steroid Biochem"},{"issue":"10","key":"6463_CR33","doi-asserted-by":"publisher","first-page":"24369","DOI":"10.3390\/ijms161024369","volume":"16","author":"W J\u00f3\u017awicki","year":"2015","unstructured":"J\u00f3\u017awicki W, Bro\u017cyna AA, Siekiera J, Slominski AT (2015) Expression of vitamin D receptor (VDR) positively correlates with survival of urothelial bladder cancer patients. Int J Mol Sci 16(10):24369\u201324386","journal-title":"Int J Mol Sci"},{"issue":"50","key":"6463_CR34","doi-asserted-by":"publisher","first-page":"83767","DOI":"10.18632\/oncotarget.11765","volume":"7","author":"Y Wang","year":"2016","unstructured":"Wang Y, Huang J, Rong L, Wu P, Kang M, Zhang X, Fang Y (2016) Impact of age on the survival of pediatric leukemia: an analysis of 15083 children in the SEER database. Oncotarget 7(50):83767","journal-title":"Oncotarget"},{"issue":"18","key":"6463_CR35","doi-asserted-by":"publisher","first-page":"4179","DOI":"10.1182\/blood-2008-07-172007","volume":"113","author":"G Juliusson","year":"2009","unstructured":"Juliusson G, Antunovic P, Derolf \u00c5, Lehmann S, M\u00f6llg\u00e5rd L, Stockelberg D, H\u00f6glund M (2009) Age and acute myeloid leukemia: real world data on decision to treat and outcomes from the Swedish Acute Leukemia Registry. Blood 113(18):4179\u20134187","journal-title":"Blood"},{"issue":"1","key":"6463_CR36","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.canep.2013.11.005","volume":"38","author":"EL Marcotte","year":"2014","unstructured":"Marcotte EL, Ritz B, Cockburn M, Clarke CA, Heck JE (2014) Birth characteristics and risk of lymphoma in young children. Cancer Epidemiol 38(1):48\u201355","journal-title":"Cancer Epidemiol"},{"issue":"8","key":"6463_CR37","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1158\/1055-9965.EPI-11-0246","volume":"20","author":"MB Cook","year":"2011","unstructured":"Cook MB, McGlynn KA, Devesa SS, Freedman ND, Anderson WF (2011) Sex disparities in cancer mortality and survival. Cancer Epidemiol Biomarkers Prev 20(8):1629\u20131637","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"9","key":"6463_CR38","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1038\/bjc.2015.94","volume":"112","author":"A Smith","year":"2015","unstructured":"Smith A, Crouch S, Lax S, Li J, Painter D, Howell D, Roman E (2015) Lymphoma incidence, survival and prevalence 2004\u20132014: sub-type analyses from the UK\u2019s Haematological Malignancy Research Network. Br J Cancer 112(9):1575\u20131584","journal-title":"Br J Cancer"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-021-06463-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-021-06463-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-021-06463-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T09:03:26Z","timestamp":1625562206000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-021-06463-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["6463"],"URL":"https:\/\/doi.org\/10.1007\/s11033-021-06463-1","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"13 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by Ethical review board of COMSATS University Islamabad under notification # CIIT\/Bio\/ERB\/17\/23A.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"An Informed consent had been taken from all participants of the study on a specifically designed proforma.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The participants were informed about publishing the results and they all agreed.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}