{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:32:26Z","timestamp":1740123146682,"version":"3.37.3"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["\u03a41\u0395\u0394\u039a-02787"],"award-info":[{"award-number":["\u03a41\u0395\u0394\u039a-02787"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1007\/s11033-021-06470-2","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T07:04:57Z","timestamp":1623049497000},"page":"4967-4972","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Replicating a GWAS: two novel candidate markers for oligospermia in Greek population"],"prefix":"10.1007","volume":"48","author":[{"given":"Maria","family":"Markantoni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theologia","family":"Sarafidou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria-Anna","family":"Kyrgiafini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexia","family":"Chatziparasidou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Christoforidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Dafopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zissis","family":"Mamuris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,6,7]]},"reference":[{"key":"6470_CR1","first-page":"336","volume":"50","author":"J Poongothai","year":"2009","unstructured":"Poongothai J, Gopenath TS, Manonayaki S, Poongothai S (2009) Genetics of human male infertility. Singap Med J 50:336\u2013347","journal-title":"Singap Med J"},{"key":"6470_CR2","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/S1472-6483(10)60677-3","volume":"14","author":"A Ferlin","year":"2007","unstructured":"Ferlin A, Raicu F, Gatta V, Zuccarello D, Palka G, Foresta C (2007) Male infertility: role of genetic background. Reprod BioMed Online 14:734\u2013745. https:\/\/doi.org\/10.1016\/S1472-6483(10)60677-3","journal-title":"Reprod BioMed Online"},{"key":"6470_CR3","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1002\/(SICI)1098-2795(199905)53:1<27::AID-MRD4>3.0.CO;2-W","volume":"53","author":"M Kent-First","year":"1999","unstructured":"Kent-First M, Muallem A, Shultz J, Pryor J, Roberts K, Nolten W et al (1999) Defining regions of the Y-chromosome responsible for male infertility and identification of a fourth AZF region (AZFd) by Y-chromosome microdeletion detection. Mol Reprod Dev 53:27\u201341. https:\/\/doi.org\/10.1002\/(SICI)1098-2795(199905)53:1%3c27::AID-MRD4%3e3.0.CO;2-W","journal-title":"Mol Reprod Dev"},{"key":"6470_CR4","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12704","author":"T Fenz Araujo","year":"2019","unstructured":"Fenz Araujo T, Friedrich C, Paiva Grangeiro CH, Martelli LR, Emich J, Wyrwoll MJ et al (2019) Sequence analysis of 37 candidate genes for male infertility: challenges in variant assessment and validating genes. Andrology. https:\/\/doi.org\/10.1111\/andr.12704","journal-title":"Andrology"},{"key":"6470_CR5","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-020-01937-w","author":"MA Kyrgiafini","year":"2020","unstructured":"Kyrgiafini MA, Markantoni M, Sarafidou T, Chatziparasidou A, Christoforidis N, Mamuris Z (2020) Genome-wide association study identifies candidate markers related to lincRNAs associated with male infertility in the Greek population. J Assist Reprod Genet. https:\/\/doi.org\/10.1007\/s10815-020-01937-w","journal-title":"J Assist Reprod Genet"},{"key":"6470_CR6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0307306101","author":"C Chang","year":"2004","unstructured":"Chang C, Chen YT, Der YS, Xu Q, Wang RS, Guillou F et al (2004) Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells. Proc Natl Acad Sci U S A. https:\/\/doi.org\/10.1073\/pnas.0307306101","journal-title":"Proc Natl Acad Sci U S A"},{"key":"6470_CR7","first-page":"307","volume":"18","author":"SY Kim","year":"2017","unstructured":"Kim SY, Kim HJ, Lee BY, Park SY, Lee HS, Seo JT (2017) Y chromosome microdeletions in infertile men with non-obstructive azoospermia and severe oligozoospermia. J Reprod Infertil 18:307\u2013315","journal-title":"J Reprod Infertil"},{"issue":"4","key":"6470_CR8","first-page":"253","volume":"7","author":"R Suganthi","year":"2014","unstructured":"Suganthi R, Vijesh VV, Vandana N, Benazir JAFY (2014) Choromosomal microdeletion screening in the workup of male infertility and its current status in India. Int J Fertil Sterility 7(4):253","journal-title":"Int J Fertil Sterility"},{"issue":"1","key":"6470_CR9","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1007\/s11825-018-0181-7","volume":"30","author":"F T\u00fcttelmann","year":"2018","unstructured":"T\u00fcttelmann F, Ruckert C, R\u00f6pke A (2018) Disorders of spermatogenesis perspectives for novel genetic diagnostics after 20 years of unchanged routine. Med Genet 30(1):12\u201320. https:\/\/doi.org\/10.1007\/s11825-018-0181-7","journal-title":"Med Genet"},{"key":"6470_CR10","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4857","author":"Z Hu","year":"2014","unstructured":"Hu Z, Li Z, Yu J, Tong C, Lin Y, Guo X et al (2014) Association analysis identifies new risk loci for non-obstructive azoospermia in Chinese men. Nat Commun. https:\/\/doi.org\/10.1038\/ncomms4857","journal-title":"Nat Commun"},{"key":"6470_CR11","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1136\/jmedgenet-2011-100174","volume":"49","author":"MD Dalgaard","year":"2012","unstructured":"Dalgaard MD, Weinhold N, Edsg\u00e4rd D, Silver JD, Pers TH, Nielsen JE et al (2012) A genome-wide association study of men with symptoms of testicular dysgenesis syndrome and its network biology interpretation. J Med Genet 49:58\u201365. https:\/\/doi.org\/10.1136\/jmedgenet-2011-100174","journal-title":"J Med Genet"},{"key":"6470_CR12","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1016\/j.ajhg.2012.04.016","volume":"90","author":"G Kosova","year":"2012","unstructured":"Kosova G, Scott NM, Niederberger C, Prins GS, Ober C (2012) Genome-wide association study identifies candidate genes for male fertility traits in humans. Am J Hum Genet 90:950\u2013961. https:\/\/doi.org\/10.1016\/j.ajhg.2012.04.016","journal-title":"Am J Hum Genet"},{"key":"6470_CR13","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1093\/humrep\/deq081","volume":"25","author":"KI Aston","year":"2010","unstructured":"Aston KI, Krausz C, Laface I, Ruiz-Castan\u00e9 E, Carrell DT (2010) Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. Hum Reprod 25:1383\u20131397. https:\/\/doi.org\/10.1093\/humrep\/deq081","journal-title":"Hum Reprod"},{"key":"6470_CR14","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/ng.1040","volume":"44","author":"Z Hu","year":"2012","unstructured":"Hu Z, Xia Y, Guo X, Dai J, Li H, Hu H et al (2012) A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia. Nat Genet 44:183\u2013186. https:\/\/doi.org\/10.1038\/ng.1040","journal-title":"Nat Genet"},{"key":"6470_CR15","doi-asserted-by":"publisher","first-page":"3857","DOI":"10.1038\/ncomms4857","volume":"5","author":"Z Hu","year":"2014","unstructured":"Hu Z, Li Z, Yu J, Tong C, Lin Y, Guo X et al (2014) Association analysis identifies new risk loci for non-obstructive azoospermia in Chinese men. Nat Commun 5:3857. https:\/\/doi.org\/10.1038\/ncomms4857","journal-title":"Nat Commun"},{"key":"6470_CR16","doi-asserted-by":"publisher","first-page":"e80374","DOI":"10.1371\/journal.pone.0080374","volume":"8","author":"M Xu","year":"2013","unstructured":"Xu M, Qin Y, Qu J, Lu C, Wang Y, Wu W et al (2013) Evaluation of five candidate genes from GWAS for association with oligozoospermia in a han Chinese population. PLoS ONE 8:e80374. https:\/\/doi.org\/10.1371\/journal.pone.0080374","journal-title":"PLoS ONE"},{"key":"6470_CR17","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1093\/humrep\/dev088","volume":"30","author":"Y Sato","year":"2015","unstructured":"Sato Y, Tajima A, Tsunematsu K, Nozawa S, Yoshiike M, Koh E et al (2015) An association study of four candidate loci for human male fertility traits with male infertility. Hum Reprod 30:1510\u20131514. https:\/\/doi.org\/10.1093\/humrep\/dev088","journal-title":"Hum Reprod"},{"key":"6470_CR18","doi-asserted-by":"publisher","first-page":"711","DOI":"10.2164\/jandrol.109.007971","volume":"30","author":"KI Aston","year":"2009","unstructured":"Aston KI, Carrell DT (2009) Genome-wide study of single-nucleotide polymorphisms associated with azoospermia and severe oligozoospermia. J Androl 30:711\u2013725. https:\/\/doi.org\/10.2164\/jandrol.109.007971","journal-title":"J Androl"},{"key":"6470_CR19","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1016\/j.ajhg.2012.04.001","volume":"90","author":"H Zhao","year":"2012","unstructured":"Zhao H, Xu J, Zhang H, Sun J, Sun Y, Wang Z et al (2012) A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia. Am J Hum Genet 90:900\u2013906. https:\/\/doi.org\/10.1016\/j.ajhg.2012.04.001","journal-title":"Am J Hum Genet"},{"key":"6470_CR20","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.fertnstert.2019.03.036","volume":"111","author":"N Thirumavalavan","year":"2019","unstructured":"Thirumavalavan N, Gabrielsen JS, Lamb DJ (2019) Where are we going with gene screening for male infertility? Fertil Steril 111:842\u2013850. https:\/\/doi.org\/10.1016\/j.fertnstert.2019.03.036","journal-title":"Fertil Steril"},{"key":"6470_CR21","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.fertnstert.2006.12.041","volume":"88","author":"A Merisalu","year":"2007","unstructured":"Merisalu A, Punab M, Altm\u00e4e S, Haller K, Tiido T, Peters M et al (2007) The contribution of genetic variations of aryl hydrocarbon receptor pathway genes to male factor infertility. Fertil Steril 88:854\u2013859. https:\/\/doi.org\/10.1016\/j.fertnstert.2006.12.041","journal-title":"Fertil Steril"},{"key":"6470_CR22","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.ejogrb.2005.09.001","volume":"124","author":"A Zhoucun","year":"2006","unstructured":"Zhoucun A, Zhang S, Yang Y, Ma Y, Zhang W, Lin L (2006) The common variant N372H in BRCA2 gene may be associated with idiopathic male infertility with azoospermia or severe oligozoospermia. Eur J Obstet Gynecol Reprod Biol 124:61\u201364. https:\/\/doi.org\/10.1016\/j.ejogrb.2005.09.001","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"6470_CR23","doi-asserted-by":"publisher","first-page":"3185","DOI":"10.1093\/humrep\/del313","volume":"21","author":"JJ Galan","year":"2006","unstructured":"Galan JJ, De Felici M, Buch B, Rivero MC, Segura A, Royo JL et al (2006) Association of genetic markers within the KIT and KITLG genes with human male infertility. Hum Reprod 21:3185\u20133192. https:\/\/doi.org\/10.1093\/humrep\/del313","journal-title":"Hum Reprod"},{"key":"6470_CR24","doi-asserted-by":"publisher","first-page":"564","DOI":"10.2164\/jandrol.107.004580","volume":"29","author":"V Suryavathi","year":"2008","unstructured":"Suryavathi V, Khattri A, Gopal K, Rani DS, Panneerdoss S, Gupta NJ et al (2008) Novel variants in UBE2B gene and idiopathic male infertility. J Androl 29:564\u2013571. https:\/\/doi.org\/10.2164\/jandrol.107.004580","journal-title":"J Androl"},{"key":"6470_CR25","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1016\/j.fertnstert.2008.01.009","volume":"91","author":"S Hammoud","year":"2009","unstructured":"Hammoud S, Emery BR, Dunn D, Weiss RB, Carrell DT (2009) Sequence alterations in the YBX2 gene are associated with male factor infertility. Fertil Steril 91:1090\u20131095. https:\/\/doi.org\/10.1016\/j.fertnstert.2008.01.009","journal-title":"Fertil Steril"},{"key":"6470_CR26","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1038\/aja.2010.58","volume":"12","author":"R Giuliani","year":"2010","unstructured":"Giuliani R, Antonucci I, Torrente I, Grammatico P, Palka G, Stuppia L (2010) Identification of the second CFTR mutation in patients with congenital bilateral absence of vas deferens undergoing ART protocols. Asian J Androl 12:819\u2013826. https:\/\/doi.org\/10.1038\/aja.2010.58","journal-title":"Asian J Androl"},{"key":"6470_CR27","doi-asserted-by":"publisher","first-page":"5343","DOI":"10.1210\/jc.2005-0263","volume":"90","author":"EL Aschim","year":"2005","unstructured":"Aschim EL, Giwercman A, St\u00e5hl O, Eberhard J, Cwikiel M, Nordenskj\u00f6ld A et al (2005) The RsaI polymorphism in the estrogen receptor-\u03b2 gene is associated with male infertility. J Clin Endocrinol Metab 90:5343\u20135348. https:\/\/doi.org\/10.1210\/jc.2005-0263","journal-title":"J Clin Endocrinol Metab"},{"key":"6470_CR28","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/S1472-6483(10)60290-8","volume":"17","author":"G Ji","year":"2008","unstructured":"Ji G, Gu A, Xia Y, Lu C, Liang J, Wang S et al (2008) ERCC1 and ERCC2 polymorphisms and risk of idiopathic azoospermia in a Chinese population. Reprod Biomed Online 17:36\u201341. https:\/\/doi.org\/10.1016\/S1472-6483(10)60290-8","journal-title":"Reprod Biomed Online"},{"key":"6470_CR29","unstructured":"Suzuki Y, Sasagawa I, Itoh K, Ashida J, \u2026 KM-F and, 2002 undefined. Estrogen receptor alpha gene polymorphism is associated with idiopathic azoospermia. fertstert.org. [cited 21 May 2021]. Available: https:\/\/www.fertstert.org\/article\/S0015-0282(02)04267-X\/abstract"},{"key":"6470_CR30","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1016\/j.fertnstert.2005.03.070","volume":"84","author":"JJ Galan","year":"2005","unstructured":"Galan JJ, Buch B, Cruz N, Segura A, Moron FJ, Bassas L et al (2005) Multilocus analyses of estrogen-related genes reveal involvement of the ESR1 gene in male infertility and the polygenic nature of the pathology. Fertil Steril 84:910\u2013918. https:\/\/doi.org\/10.1016\/j.fertnstert.2005.03.070","journal-title":"Fertil Steril"},{"key":"6470_CR31","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S1472-6483(10)60436-1","volume":"18","author":"W Wang","year":"2009","unstructured":"Wang W, Lu N, Xia Y, Gu A, Wu B, Liang J et al (2009) FAS and FASLG polymorphisms and susceptibility to idiopathic azoospermia or severe oligozoospermia. Reprod Biomed Online 18:141\u2013147. https:\/\/doi.org\/10.1016\/S1472-6483(10)60436-1","journal-title":"Reprod Biomed Online"},{"key":"6470_CR32","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1093\/molehr\/gal006","volume":"12","author":"GL Christensen","year":"2006","unstructured":"Christensen GL, Wooding SP, Ivanov IP, Atkins JF, Carrell DT (2006) Sequencing and haplotype analysis of the activator of CREM in the testis (ACT) gene in populations of fertile and infertile males. Mol Hum Reprod 12:257\u2013262. https:\/\/doi.org\/10.1093\/molehr\/gal006","journal-title":"Mol Hum Reprod"},{"key":"6470_CR33","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1530\/REP-06-0125","volume":"133","author":"W Zhang","year":"2007","unstructured":"Zhang W, Zhang S, Xiao C, Yang Y, Zhoucun A (2007) Mutation screening of the FKBP6 gene and its association study with spermatogenic impairment in idiopathic infertile men. Reproduction 133:511\u2013516. https:\/\/doi.org\/10.1530\/REP-06-0125","journal-title":"Reproduction"},{"key":"6470_CR34","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.fertnstert.2006.11.174","volume":"88","author":"EK Bentz","year":"2007","unstructured":"Bentz EK, Hefler LA, Denschlag D, Pietrowski D, Buerkle B, Tempfer CB (2007) A polymorphism of the interleukin-1 beta gene is associated with sperm pathology in humans. Fertil Steril 88:751\u2013753. https:\/\/doi.org\/10.1016\/j.fertnstert.2006.11.174","journal-title":"Fertil Steril"},{"key":"6470_CR35","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.urology.2011.08.003","volume":"79","author":"SC Esteves","year":"2012","unstructured":"Esteves SC, Zini A, Aziz N, Alvarez JG, Sabanegh ES, Agarwal A (2012) Critical appraisal of world health organization\u2019s new reference values for human semen characteristics and effect on diagnosis and treatment of subfertile men. Urology 79:16\u201322. https:\/\/doi.org\/10.1016\/j.urology.2011.08.003","journal-title":"Urology"},{"key":"6470_CR36","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1083\/jcb.200408113","volume":"161","author":"CJ Lawrence","year":"2004","unstructured":"Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA et al (2004) A standardized kinesin nomenclature. J Cell Biol 161:19\u201322. https:\/\/doi.org\/10.1083\/jcb.200408113","journal-title":"J Cell Biol"},{"key":"6470_CR37","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1515\/bmc-2011-0064","volume":"3","author":"MTT Wong-Riley","year":"2012","unstructured":"Wong-Riley MTT, Besharse JC (2012) The kinesin superfamily protein KIF17: one protein with many functions. Biomol Concepts 3:267\u2013282. https:\/\/doi.org\/10.1515\/bmc-2011-0064","journal-title":"Biomol Concepts"},{"key":"6470_CR38","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1080\/14647270500463400","volume":"9","author":"KN Hogeveen","year":"2006","unstructured":"Hogeveen KN, Sassone-Corsi P (2006) Regulation of gene expression in post-meiotic male germ cells: CREM-signalling pathways and male fertility. Hum Fertil 9:73\u201379. https:\/\/doi.org\/10.1080\/14647270500463400","journal-title":"Hum Fertil"},{"key":"6470_CR39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2010.4142.x","author":"A Gerdin","year":"2010","unstructured":"Gerdin A (2010) The sanger mouse genetics programme: high throughput characterisation of knockout mice. Acta Ophthalmol. https:\/\/doi.org\/10.1111\/j.1755-3768.2010.4142.x","journal-title":"Acta Ophthalmol"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-021-06470-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-021-06470-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-021-06470-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T10:19:03Z","timestamp":1625566743000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-021-06470-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["6470"],"URL":"https:\/\/doi.org\/10.1007\/s11033-021-06470-2","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"type":"print","value":"0301-4851"},{"type":"electronic","value":"1573-4978"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"13 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to declare that are relevant to the content of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All the participants were informed about the study and they gave their consent in order to participate by filling out a questionnaire along with the consent form. Both the study and the consent procedure were approved by the ethics committee of the Medical Faculty of the University of Thessaly.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All individuals have signed consent forms before sample acquisition. Information on potential publications is included in consent forms signed by all individuals.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}