{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:32:28Z","timestamp":1740123148314,"version":"3.37.3"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100011051","name":"Council on grants of the President of the Russian Federation","doi-asserted-by":"publisher","award":["MD-7395.2016.7"],"award-info":[{"award-number":["MD-7395.2016.7"]}],"id":[{"id":"10.13039\/501100011051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012189","name":"\u043c\u0435\u0433\u0430\u0433\u0440\u0430\u043d\u0442\u044b","doi-asserted-by":"publisher","award":["075-15-2021-595"],"award-info":[{"award-number":["075-15-2021-595"]}],"id":[{"id":"10.13039\/501100012189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s11033-021-06517-4","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T16:08:19Z","timestamp":1625069299000},"page":"5355-5362","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genetic predictors of sick sinus syndrome"],"prefix":"10.1007","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9918-6962","authenticated-orcid":false,"given":"Yanina","family":"Timasheva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9397-6250","authenticated-orcid":false,"given":"Marat","family":"Badykov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0043-5090","authenticated-orcid":false,"given":"Leysan","family":"Akhmadishina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8823-8678","authenticated-orcid":false,"given":"Timur","family":"Nasibullin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8167-4271","authenticated-orcid":false,"given":"Elena","family":"Badykova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4637-4724","authenticated-orcid":false,"given":"Alfiya","family":"Pushkareva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6716-4048","authenticated-orcid":false,"given":"Vladimir","family":"Plechev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5830-5056","authenticated-orcid":false,"given":"Ildus","family":"Sagitov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2386-6707","authenticated-orcid":false,"given":"Naufal","family":"Zagidullin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"issue":"8","key":"6517_CR1","doi-asserted-by":"publisher","first-page":"e382","DOI":"10.1161\/cir.0000000000000628","volume":"140","author":"FM Kusumoto","year":"2019","unstructured":"Kusumoto FM, Schoenfeld MH, Barrett C, Edgerton JR, Ellenbogen KA, Gold MR, Goldschlager NF, Hamilton RM, Joglar JA, Kim RJ, Lee R, Marine JE, McLeod CJ, Oken KR, Patton KK, Pellegrini CN, Selzman KA, Thompson A, Varosy PD (2019) 2018 ACC\/AHA\/HRS guideline on the evaluation and management of patients with bradycardia and cardiac conduction delay: a report of the American College of Cardiology\/American Heart Association task force on clinical practice guidelines and the heart rhythm society. Circulation 140(8):e382\u2013e482. https:\/\/doi.org\/10.1161\/cir.0000000000000628","journal-title":"Circulation"},{"issue":"4","key":"6517_CR2","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S0022-0736(73)80052-4","volume":"6","author":"HE Kulbertus","year":"1973","unstructured":"Kulbertus HE, Leval-Rutten Fd, Demoulin JC (1973) Sino-atrial disease: a report on 13 cases. J Electrocardiol 6(4):303\u2013312. https:\/\/doi.org\/10.1016\/S0022-0736(73)80052-4","journal-title":"J Electrocardiol"},{"issue":"6","key":"6517_CR3","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.jacc.2014.03.056","volume":"64","author":"PN Jensen","year":"2014","unstructured":"Jensen PN, Gronroos NN, Chen LY, Folsom AR, deFilippi C, Heckbert SR, Alonso A (2014) Incidence of and risk factors for sick sinus syndrome in the general population. J Am Coll Cardiol 64(6):531\u2013538. https:\/\/doi.org\/10.1016\/j.jacc.2014.03.056","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"6517_CR4","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1161\/CIRCEP.113.001340","volume":"7","author":"K Abe","year":"2014","unstructured":"Abe K, Machida T, Sumitomo N, Yamamoto H, Ohkubo K, Watanabe I, Makiyama T, Fukae S, Kohno M, Harrell Daniel T, Ishikawa T, Tsuji Y, Nogami A, Watabe T, Oginosawa Y, Abe H, Maemura K, Motomura H, Makita N (2014) Sodium channelopathy underlying familial sick sinus syndrome with early onset and predominantly male characteristics. Circulation 7(3):511\u2013517. https:\/\/doi.org\/10.1161\/CIRCEP.113.001340","journal-title":"Circulation"},{"issue":"6","key":"6517_CR5","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.hrcr.2020.03.003","volume":"6","author":"A Wacker-Gussmann","year":"2020","unstructured":"Wacker-Gussmann A, Oberhoffer-Fritz R, Westphal DS, Hessling G, Wakai RT, Strasburger JF (2020) The missense variant p.(Gly482Arg) in HCN4 is responsible for fetal tachy-bradycardia syndrome. HeartRhythm Case Rep 6(6):352\u2013356","journal-title":"HeartRhythm Case Rep"},{"issue":"5","key":"6517_CR6","first-page":"7073","volume":"17","author":"YB Zhu","year":"2018","unstructured":"Zhu YB, Luo JW, Jiang F, Liu G (2018) Genetic analysis of sick sinus syndrome in a family harboring compound CACNA1C and TTN mutations. Mol Med Rep 17(5):7073\u20137080","journal-title":"Mol Med Rep"},{"issue":"5","key":"6517_CR7","doi-asserted-by":"publisher","first-page":"e0155421","DOI":"10.1371\/journal.pone.0155421","volume":"11","author":"MV Zaragoza","year":"2016","unstructured":"Zaragoza MV, Fung L, Jensen E, Oh F, Cung K, McCarthy LA, Tran CK, Hoang V, Hakim SA, Grosberg A (2016) Exome sequencing identifies a novel LMNA splice-site mutation and multigenic heterozygosity of potential modifiers in a family with sick sinus syndrome, dilated cardiomyopathy, and sudden cardiac death. PLoS ONE 11(5):e0155421","journal-title":"PLoS ONE"},{"issue":"3","key":"6517_CR8","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.hrcr.2015.01.022","volume":"1","author":"L Lam","year":"2015","unstructured":"Lam L, Ingles J, Turner C, Kilborn M, Bagnall RD, Semsarian C (2015) Exome sequencing identifies a novel mutation in the MYH6 gene in a family with early-onset sinus node dysfunction, ventricular arrhythmias, and cardiac arrest. HeartRhythm Case Rep 1(3):141\u2013145","journal-title":"HeartRhythm Case Rep"},{"issue":"2","key":"6517_CR9","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/ng.511","volume":"42","author":"H Holm","year":"2010","unstructured":"Holm H, Gudbjartsson DF, Arnar DO, Thorleifsson G, Thorgeirsson G, Stefansdottir H, Gudjonsson SA, Jonasdottir A, Mathiesen EB, Nj\u00f8lstad I, Nyrnes A, Wilsgaard T, Hald EM, Hveem K, Stoltenberg C, L\u00f8chen M-L, Kong A, Thorsteinsdottir U, Stefansson K (2010) Several common variants modulate heart rate, PR interval and QRS duration. Nat Genet 42(2):117\u2013122. https:\/\/doi.org\/10.1038\/ng.511","journal-title":"Nat Genet"},{"issue":"6","key":"6517_CR10","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/ng.2610","volume":"45","author":"M den Hoed","year":"2013","unstructured":"den Hoed M, Eijgelsheim M, Esko T, Brundel BJ, Peal DS, Evans DM, Nolte IM, Segre AV, Holm H, Handsaker RE, Westra HJ, Johnson T, Isaacs A, Yang J, Lundby A, Zhao JH, Kim YJ, Go MJ, Almgren P, Bochud M, Boucher G, Cornelis MC, Gudbjartsson D, Hadley D, van der Harst P, Hayward C, den Heijer M, Igl W, Jackson AU, Kutalik Z, Luan J, Kemp JP, Kristiansson K, Ladenvall C, Lorentzon M, Montasser ME, Njajou OT, O\u2019Reilly PF, Padmanabhan S, St Pourcain B, Rankinen T, Salo P, Tanaka T, Timpson NJ, Vitart V, Waite L, Wheeler W, Zhang W, Draisma HH, Feitosa MF, Kerr KF, Lind PA, Mihailov E, Onland-Moret NC, Song C, Weedon MN, Xie W, Yengo L, Absher D, Albert CM, Alonso A, Arking DE, de Bakker PI, Balkau B, Barlassina C, Benaglio P, Bis JC, Bouatia-Naji N, Brage S, Chanock SJ, Chines PS, Chung M, Darbar D, Dina C, Dorr M, Elliott P, Felix SB, Fischer K, Fuchsberger C, de Geus EJ, Goyette P, Gudnason V, Harris TB, Hartikainen AL, Havulinna AS, Heckbert SR, Hicks AA, Hofman A, Holewijn S, Hoogstra-Berends F, Hottenga JJ, Jensen MK, Johansson A, Junttila J, Kaab S, Kanon B, Ketkar S, Khaw KT, Knowles JW, Kooner AS, Kors JA, Kumari M, Milani L, Laiho P, Lakatta EG, Langenberg C, Leusink M, Liu Y, Luben RN, Lunetta KL, Lynch SN, Markus MR, Marques-Vidal P, Mateo Leach I, McArdle WL, McCarroll SA, Medland SE, Miller KA, Montgomery GW, Morrison AC, Muller-Nurasyid M, Navarro P, Nelis M, O\u2019Connell JR, O\u2019Donnell CJ, Ong KK, Newman AB, Peters A, Polasek O, Pouta A, Pramstaller PP, Psaty BM, Rao DC, Ring SM, Rossin EJ, Rudan D, Sanna S, Scott RA, Sehmi JS, Sharp S, Shin JT, Singleton AB, Smith AV, Soranzo N, Spector TD, Stewart C, Stringham HM, Tarasov KV, Uitterlinden AG, Vandenput L, Hwang SJ, Whitfield JB, Wijmenga C, Wild SH, Willemsen G, Wilson JF, Witteman JC, Wong A, Wong Q, Jamshidi Y, Zitting P, Boer JM, Boomsma DI, Borecki IB, van Duijn CM, Ekelund U, Forouhi NG, Froguel P, Hingorani A, Ingelsson E, Kivimaki M, Kronmal RA, Kuh D, Lind L, Martin NG, Oostra BA, Pedersen NL, Quertermous T, Rotter JI, van der Schouw YT, Verschuren WM, Walker M, Albanes D, Arnar DO, Assimes TL, Bandinelli S, Boehnke M, de Boer RA, Bouchard C, Caulfield WL, Chambers JC, Curhan G, Cusi D, Eriksson J, Ferrucci L, van Gilst WH, Glorioso N, de Graaf J, Groop L, Gyllensten U, Hsueh WC, Hu FB, Huikuri HV, Hunter DJ, Iribarren C, Isomaa B, Jarvelin MR, Jula A, Kahonen M, Kiemeney LA, van der Klauw MM, Kooner JS, Kraft P, Iacoviello L, Lehtimaki T, Lokki ML, Mitchell BD, Navis G, Nieminen MS, Ohlsson C, Poulter NR, Qi L, Raitakari OT, Rimm EB, Rioux JD, Rizzi F, Rudan I, Salomaa V, Sever PS, Shields DC, Shuldiner AR, Sinisalo J, Stanton AV, Stolk RP, Strachan DP, Tardif JC, Thorsteinsdottir U, Tuomilehto J, van Veldhuisen DJ, Virtamo J, Viikari J, Vollenweider P, Waeber G, Widen E, Cho YS, Olsen JV, Visscher PM, Willer C, Franke L, Erdmann J, Thompson JR, Pfeufer A, Sotoodehnia N, Newton-Cheh C, Ellinor PT, Stricker BH, Metspalu A, Perola M, Beckmann JS, Smith GD, Stefansson K, Wareham NJ, Munroe PB, Sibon OC, Milan DJ, Snieder H, Samani NJ, Loos RJ (2013) Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet 45(6):621\u2013631. https:\/\/doi.org\/10.1038\/ng.2610","journal-title":"Nat Genet"},{"issue":"D1","key":"6517_CR11","doi-asserted-by":"publisher","first-page":"D682","DOI":"10.1093\/nar\/gkz966","volume":"48","author":"AD Yates","year":"2019","unstructured":"Yates AD, Achuthan P, Akanni W, Allen J, Allen J, Alvarez-Jarreta J, Amode MR, Armean IM, Azov AG, Bennett R, Bhai J, Billis K, Boddu S, Marug\u00e1n JC, Cummins C, Davidson C, Dodiya K, Fatima R, Gall A, Giron CG, Gil L, Grego T, Haggerty L, Haskell E, Hourlier T, Izuogu OG, Janacek SH, Juettemann T, Kay M, Lavidas I, Le T, Lemos D, Martinez JG, Maurel T, McDowall M, McMahon A, Mohanan S, Moore B, Nuhn M, Oheh DN, Parker A, Parton A, Patricio M, Sakthivel MP, Abdul Salam AI, Schmitt BM, Schuilenburg H, Sheppard D, Sycheva M, Szuba M, Taylor K, Thormann A, Threadgold G, Vullo A, Walts B, Winterbottom A, Zadissa A, Chakiachvili M, Flint B, Frankish A, Hunt SE, Iisley G, Kostadima M, Langridge N, Loveland JE, Martin FJ, Morales J, Mudge JM, Muffato M, Perry E, Ruffier M, Trevanion SJ, Cunningham F, Howe KL, Zerbino DR, Flicek P (2019) Ensembl 2020. Nucleic Acids Res 48(D1):D682\u2013D688. https:\/\/doi.org\/10.1093\/nar\/gkz966","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"6517_CR12","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1086\/519795","volume":"81","author":"S Purcell","year":"2007","unstructured":"Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira Manuel AR, Bender D, Maller J, Sklar P, de Bakker PIW, Daly Mark J, Sham Pak C (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81(3):559\u2013575. https:\/\/doi.org\/10.1086\/519795","journal-title":"Am J Hum Genet"},{"key":"6517_CR13","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Royal Stat Soc Ser B 57:289\u2013300. https:\/\/doi.org\/10.1111\/j.2517-6161.1995.tb02031.x","journal-title":"J Royal Stat Soc Ser B"},{"issue":"4","key":"6517_CR14","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1534\/genetics.105.048090","volume":"171","author":"AV Favorov","year":"2005","unstructured":"Favorov AV, Andreewski TV, Sudomoina MA, Favorova OO, Parmigiani G, Ochs MF (2005) A Markov chain Monte Carlo technique for identification of combinations of allelic variants underlying complex diseases in humans. Genetics 171(4):2113\u20132121. https:\/\/doi.org\/10.1534\/genetics.105.048090","journal-title":"Genetics"},{"issue":"6","key":"6517_CR15","first-page":"6009","volume":"11","author":"N Tounsi","year":"2018","unstructured":"Tounsi N, Labro AJ, Kerkeni E, Grissa MH, Trabelsi I, Gannoun I, Van Tilborg A, Bzeouich N, Monastiri K, Snyders DJ (2018) Relevance of KCNE1, SCN5A and eNOS gene polymorphisms in Tunisian atrial fibrillation patients. Int J Clin Exp Med 11(6):6009\u20136018","journal-title":"Int J Clin Exp Med"},{"issue":"6","key":"6517_CR16","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1046\/j.1529-8817.2005.00182.x","volume":"69","author":"Y Friedlander","year":"2005","unstructured":"Friedlander Y, Vatta M, Sotoodehnia N, Sinnreich R, Li H, Manor O, Towbin JA, Siscovick DS, Kark JD (2005) Possible association of the human KCNE1 (minK) gene and QT interval in healthy subjects: evidence from association and linkage analyses in Israeli families. Ann Hum Genet 69(6):645\u2013656. https:\/\/doi.org\/10.1046\/j.1529-8817.2005.00182.x","journal-title":"Ann Hum Genet"},{"issue":"9","key":"6517_CR17","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1038\/sj.ejhg.5201866","volume":"15","author":"L Gouas","year":"2007","unstructured":"Gouas L, Nicaud V, Chaouch S, Berthet M, Forhan A, Tichet J, Tiret L, Balkau B, Guicheney P, The DESIRSG (2007) Confirmation of associations between ion channel gene SNPs and QTc interval duration in healthy subjects. Eur J Hum Genet 15(9):974\u2013979. https:\/\/doi.org\/10.1038\/sj.ejhg.5201866","journal-title":"Eur J Hum Genet"},{"issue":"4","key":"6517_CR18","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1080\/15513815.2019.1585500","volume":"38","author":"S Vojdani","year":"2019","unstructured":"Vojdani S, Amirsalari S, Milanizadeh S, Molaei F, Ajalloueyane M, Khosravi A, Hamzehzadeh L, Ghasemi MM, Talee MR, Abbaszadegan MR (2019) Mutation screening of KCNQ1 and KCNE1 genes in Iranian patients with jervell and lange-nielsen syndrome. Fetal Pediatr Pathol 38(4):273\u2013281. https:\/\/doi.org\/10.1080\/15513815.2019.1585500","journal-title":"Fetal Pediatr Pathol"},{"issue":"3","key":"6517_CR19","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1253\/circj.CJ-13-1126","volume":"78","author":"Y Yamaguchi","year":"2014","unstructured":"Yamaguchi Y, Nishide K, Kato M, Hata Y, Mizumaki K, Kinoshita K, Nonobe Y, Tabata T, Sakamoto T, Kataoka N, Nakatani Y, Ichida F, Mori H, Fukurotani K, Inoue H, Nishida N (2014) Glycine\/serine polymorphism at position 38 influences KCNE1 subunit&rsquo;s modulatory actions on rapid and slow delayed rectifier K<sup>+<\/sup> currents. Circ J 78(3):610\u2013618. https:\/\/doi.org\/10.1253\/circj.CJ-13-1126","journal-title":"Circ J"},{"issue":"2","key":"6517_CR20","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1152\/physrev.00022.2013","volume":"94","author":"N Schmitt","year":"2014","unstructured":"Schmitt N, Grunnet M, Olesen S-P (2014) Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia. Physiol Rev 94(2):609\u2013653. https:\/\/doi.org\/10.1152\/physrev.00022.2013","journal-title":"Physiol Rev"},{"key":"6517_CR21","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.forsciint.2019.05.042","volume":"301","author":"I Gando","year":"2019","unstructured":"Gando I, Williams N, Fishman GI, Sampson BA, Tang Y, Coetzee WA (2019) Functional characterization of SCN10A variants in several cases of sudden unexplained death. Forensic Sci Int 301:289\u2013298. https:\/\/doi.org\/10.1016\/j.forsciint.2019.05.042","journal-title":"Forensic Sci Int"},{"issue":"4","key":"6517_CR22","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1172\/JCI73140","volume":"124","author":"M van den Boogaard","year":"2014","unstructured":"van den Boogaard M, Smemo S, Burnicka-Turek O, Arnolds DE, van de Werken HJG, Klous P, McKean D, Muehlschlegel JD, Moosmann J, Toka O, Yang XH, Koopmann TT, Adriaens ME, Bezzina CR, de Laat W, Seidman C, Seidman JG, Christoffels VM, Nobrega MA, Barnett P, Moskowitz IP (2014) A common genetic variant within SCN10A modulates cardiac SCN5A expression. J Clin Investig 124(4):1844\u20131852. https:\/\/doi.org\/10.1172\/JCI73140","journal-title":"J Clin Investig"},{"key":"6517_CR23","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.envres.2016.04.014","volume":"148","author":"Q Deng","year":"2016","unstructured":"Deng Q, Guo H, Deng N, Zhang W, Li X, Deng H, Xiao Y (2016) Polycyclic aromatic hydrocarbon exposure, miR-146a rs2910164 polymorphism, and heart rate variability in coke oven workers. Environ Res 148:277\u2013284. https:\/\/doi.org\/10.1016\/j.envres.2016.04.014","journal-title":"Environ Res"},{"issue":"1","key":"6517_CR24","doi-asserted-by":"publisher","first-page":"3259","DOI":"10.1038\/s41467-018-05768-3","volume":"9","author":"A Zehender","year":"2018","unstructured":"Zehender A, Huang J, Gy\u00f6rfi A-H, Matei A-E, Trinh-Minh T, Xu X, Li Y-N, Chen C-W, Lin J, Dees C, Beyer C, Gelse K, Zhang Z-Y, Bergmann C, Ramming A, Birchmeier W, Distler O, Schett G, Distler JHW (2018) The tyrosine phosphatase SHP2 controls TGF\u03b2-induced STAT3 signaling to regulate fibroblast activation and fibrosis. Nat Commun 9(1):3259. https:\/\/doi.org\/10.1038\/s41467-018-05768-3","journal-title":"Nat Commun"},{"key":"6517_CR25","doi-asserted-by":"publisher","DOI":"10.1101\/385500","author":"B von der Heyde","year":"2018","unstructured":"von der Heyde B, Emmanouilidou A, Klingstr\u00f6m T, Mazzaferro E, Vicenzi S, Jumaa S, Dethlefsen O, Snieder H, de Geus E, Ingelsson E (2018) In vivo characterization of candidate genes for heart rate variability identifies culprits for sinoatrial pauses and arrests. bioRxiv. https:\/\/doi.org\/10.1101\/385500","journal-title":"bioRxiv"},{"issue":"6","key":"6517_CR26","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1073\/pnas.1017494108","volume":"108","author":"TP Cappola","year":"2011","unstructured":"Cappola TP, Matkovich SJ, Wang W, van Booven D, Li M, Wang X, Qu L, Sweitzer NK, Fang JC, Reilly MP, Hakonarson H, Nerbonne JM, Dorn GW (2011) Loss-of-function DNA sequence variant in the <em>CLCNKA<\/em> chloride channel implicates the cardio-renal axis in interindividual heart failure risk variation. Proc Natl Acad Sci USA 108(6):2456. https:\/\/doi.org\/10.1073\/pnas.1017494108","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"6517_CR27","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.gene.2013.06.055","volume":"527","author":"B Tavira","year":"2013","unstructured":"Tavira B, G\u00f3mez J, Ortega F, Tranche S, D\u00edaz-Corte C, Alvarez F, Ortiz A, Santos F, S\u00e1nchez-Ni\u00f1o MD, Coto E (2013) A CLCNKA polymorphism (rs10927887; p.Arg83Gly) previously linked to heart failure is associated with the estimated glomerular filtration rate in the RENASTUR cohort. Gene 527(2):670\u2013672. https:\/\/doi.org\/10.1016\/j.gene.2013.06.055","journal-title":"Gene"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-021-06517-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-021-06517-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-021-06517-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T13:12:05Z","timestamp":1627477925000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-021-06517-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["6517"],"URL":"https:\/\/doi.org\/10.1007\/s11033-021-06517-4","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"type":"print","value":"0301-4851"},{"type":"electronic","value":"1573-4978"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"18 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the ethics committee of the Institute of Biochemistry and Genetics of Ufa Federal Research Centre of Russian Academy of Sciences (IBG UFRC RAS).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent to take part in the study was obtained from each participant in accordance with Helsinki declaration (2000) outlining the principles for medical research involving human subjects.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors read and approved the final manuscript.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}