{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T11:09:48Z","timestamp":1774868988993,"version":"3.50.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100007086","name":"Sel\u00e7uk \u00dcniversitesi","doi-asserted-by":"publisher","award":["19401029"],"award-info":[{"award-number":["19401029"]}],"id":[{"id":"10.13039\/501100007086","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1007\/s11033-021-06579-4","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T09:02:41Z","timestamp":1626944561000},"page":"5579-5586","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Relationship of endoplasmic reticulum stress with the etiopathogenesis of chronic tonsillitis and tonsillar hypertrophy in pediatric patients: a prospective, parallel-group study"],"prefix":"10.1007","volume":"48","clinical-trial-number":[{"clinical-trial-number":"nct04653376","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0591-8411","authenticated-orcid":false,"given":"Merih","family":"Onal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1727-1582","authenticated-orcid":false,"given":"Nadir","family":"Kocak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8130-9792","authenticated-orcid":false,"given":"Fahrettin","family":"Duymus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3153-3294","authenticated-orcid":false,"given":"Mete Kaan","family":"Bozkurt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9804-7023","authenticated-orcid":false,"given":"Cagdas","family":"Elsurer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5596-0100","authenticated-orcid":false,"given":"Omer","family":"Erdur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5574-1901","authenticated-orcid":false,"given":"Ozkan","family":"Onal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,7,22]]},"reference":[{"issue":"5 Suppl","key":"6579_CR1","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1097\/00006454-200005001-00002","volume":"19","author":"PL Ogra","year":"2000","unstructured":"Ogra PL (2000) Mucosal immune response in the ear, nose and throat. Pediatr Infect Dis J 19(5 Suppl):S4-8. https:\/\/doi.org\/10.1097\/00006454-200005001-00002","journal-title":"Pediatr Infect Dis J"},{"issue":"19","key":"6579_CR2","doi-asserted-by":"publisher","first-page":"e15530","DOI":"10.1097\/MD.0000000000015530","volume":"98","author":"Y Yan","year":"2019","unstructured":"Yan Y, Song Y, Liu Y, Su J, Cui L, Wang J, Geng J, Liu X, Shi Y, Quan S, Hang A, Zuo L (2019) Short and long-term impacts of adenoidectomy with\/without tonsillectomy on immune function of young children <3 years of age A cohort study. Medicine (Baltimore) 98(19):e15530. https:\/\/doi.org\/10.1097\/MD.0000000000015530","journal-title":"Medicine (Baltimore)"},{"key":"6579_CR3","first-page":"2129","volume-title":"Otorhinolaryngology","author":"D Alan","year":"1991","unstructured":"Alan D, Kornblut A (1991) Non neoplastic diseases of the tonsils and adenoids. In: Paparella M, Shumrick DA, Gluckman JL, Meyerhof WL (eds) Otorhinolaryngology, vol 3, 3rd edn. W. B. Sounders Company, New York, pp 2129\u201347","edition":"3"},{"key":"6579_CR4","first-page":"84","volume":"523","author":"M Hata","year":"1996","unstructured":"Hata M, Asakura K, Saito H, Morimoto K, Kataura A (1996) Profile of immunoglobulin production in adenoid and tonsil lymphocytes. Acta Otolaryngol Suppl 523:84\u201386","journal-title":"Acta Otolaryngol Suppl"},{"issue":"2","key":"6579_CR5","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.jaci.2011.09.031","volume":"129","author":"O Palomares","year":"2012","unstructured":"Palomares O, R\u00fcckert B, Jartti T, K\u00fcc\u00fcksezer UC, Puhakka T, Gomez E, Fahrner EB, Speiser A, Jung A, Kwok WW, Kalogjera L, Akdis M, Akdis CA (2012) Induction and maintenance of allergen-specific FOXP3+ Treg cells in human tonsils as potential first-line organs of oral tolerance. J Allergy Clin Immunol 129(2):510\u2013520. https:\/\/doi.org\/10.1016\/j.jaci.2011.09.031","journal-title":"J Allergy Clin Immunol"},{"issue":"8","key":"6579_CR6","doi-asserted-by":"publisher","first-page":"705","DOI":"10.14348\/molcells.2018.0241","volume":"41","author":"JS So","year":"2018","unstructured":"So JS (2018) Roles of endoplasmic reticulum stress in \u0131mmune responses. Mol Cells 41(8):705\u2013716. https:\/\/doi.org\/10.14348\/molcells.2018.0241","journal-title":"Mol Cells"},{"issue":"11","key":"6579_CR7","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/j.tcb.2020.09.002","volume":"30","author":"M Gonz\u00e1lez-Quiroz","year":"2020","unstructured":"Gonz\u00e1lez-Quiroz M, Blondel A, Sagredo A, Hetz C, Chevet E, Pedeux R (2020) When endoplasmic reticulum proteostasis meets the DNA damage response. Trends Cell Biol 30(11):881\u2013891. https:\/\/doi.org\/10.1016\/j.tcb.2020.09.002","journal-title":"Trends Cell Biol"},{"issue":"13","key":"6579_CR8","doi-asserted-by":"publisher","first-page":"673","DOI":"10.3389\/fnins.2019.00673","volume":"27","author":"G Amodio","year":"2019","unstructured":"Amodio G, Moltedo O, Fasano D, Zerillo L, Oliveti M, Di Pietro P, Faraonio R, Barone P, Pellecchia MT, De Rose A (2019) PERK-mediated unfolded protein response activation and oxidative stress in PARK20 fibroblasts. Front Neurosci Switz 27(13):673. https:\/\/doi.org\/10.3389\/fnins.2019.00673","journal-title":"Front Neurosci Switz"},{"issue":"6051","key":"6579_CR9","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1126\/science.1209126","volume":"333","author":"BM Gardner","year":"2011","unstructured":"Gardner BM, Walter P (2011) Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response. Science 333(6051):1891\u20131894. https:\/\/doi.org\/10.1126\/science.1209126","journal-title":"Science"},{"key":"6579_CR10","doi-asserted-by":"publisher","first-page":"3507","DOI":"10.1016\/j.bbamcr.2013.07.024","volume":"12","author":"H Urra","year":"1833","unstructured":"Urra H, Dufey E, Lisbona F, Rojas-Rivera D (1833) Hetz C (2013) When ER stress reaches a dead end. Biochim Biophys Acta 12:3507\u20133517. https:\/\/doi.org\/10.1016\/j.bbamcr.2013.07.024","journal-title":"Biochim Biophys Acta"},{"issue":"7","key":"6579_CR11","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1016\/j.cell.2007.04.027","volume":"129","author":"H Puthalakath","year":"2007","unstructured":"Puthalakath H, Oeilly LA, Gunn P, Lee L, Kelly PN, Huntington ND, Hughes PD, Michalak EM, McKimm-Breschkin J, Motoyama N et al (2007) ER stress triggers apoptosis by activating BH3-only protein Bim. Cell 129(7):1337\u201349. https:\/\/doi.org\/10.1016\/j.cell.2007.04.027","journal-title":"Cell"},{"issue":"7","key":"6579_CR12","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1083\/jcb.201110131","volume":"197","author":"S Wang","year":"2012","unstructured":"Wang S, Kaufman RJ (2012) The impact of the unfolded protein response on human disease. J Cell Biol 197(7):857\u201367. https:\/\/doi.org\/10.1083\/jcb.201110131","journal-title":"J Cell Biol"},{"issue":"12","key":"6579_CR13","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1097\/00005537-199912000-00002","volume":"109","author":"M Friedman","year":"1999","unstructured":"Friedman M, Tanyeri H, Rosa ML, Landsberg R, Vaidyanathan K, Pieri S, Caldarelli D (1999) Clinical predictors of obstructive sleep Apnea. Laryngoscope 109(12):1901\u20131907. https:\/\/doi.org\/10.1097\/00005537-199912000-00002","journal-title":"Laryngoscope"},{"key":"6579_CR14","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.prot5439","author":"DC Rio","year":"2010","unstructured":"Rio DC, Ares MJ, Hannon GJ, Nilsen TW (2010) Purification of RNA using TRIzol (TRI reagent). Cold Spring Harb Protoc. https:\/\/doi.org\/10.1101\/pdb.prot5439","journal-title":"Cold Spring Harb Protoc"},{"issue":"2","key":"6579_CR15","doi-asserted-by":"publisher","first-page":"105","DOI":"10.15171\/bi.2016.16","volume":"6","author":"B Nami","year":"2016","unstructured":"Nami B, Ghasemi-Dizgah A, Vaseghi A (2016) Overexpression of molecular chaperons GRP78 and GRP94 in CD44hi\/CD24lo breast cancer stem cells. Bioimpacts 6(2):105\u2013110. https:\/\/doi.org\/10.15171\/bi.2016.16","journal-title":"Bioimpacts"},{"issue":"2","key":"6579_CR16","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.ijporl.2014.12.005","volume":"79","author":"M Onal","year":"2015","unstructured":"Onal M, Y\u0131lmaz T, Bilgic E, M\u00fcft\u00fco\u011flu SF, Ku\u015f\u00e7u O, G\u00fcnayd\u0131n RO (2015) Apoptosis in chronic tonsillitis and tonsillar hypertrophy. Int J Pediatr Otorhinolaryngol 79(2):191\u2013195. https:\/\/doi.org\/10.1016\/j.ijporl.2014.12.005","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"1","key":"6579_CR17","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1080\/21691401.2019.1709862","volume":"48","author":"X Liu","year":"2020","unstructured":"Liu X, Liu JK (2020) Tanshinone I induces cell apoptosis by reactive oxygen species-mediated endoplasmic reticulum stress and by suppressing p53\/DRAM-mediated autophagy in human hepatocellular carcinoma. Artif Cells Nanomed Biotechnol 48(1):488\u2013497. https:\/\/doi.org\/10.1080\/21691401.2019.1709862","journal-title":"Artif Cells Nanomed Biotechnol"},{"issue":"6","key":"6579_CR18","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.anl.2015.04.012","volume":"42","author":"M Onal","year":"2015","unstructured":"Onal M, Y\u0131lmaz T, Bilgi\u00e7 E, M\u00fcft\u00fco\u011flu S, S\u00f6zen T, Bajin MD (2015) Possible role of apoptosis in pathogenesis of adenoid hypertrophy and chronic adenoiditis: prospective case-control study. Auris Nasus Larynx 42(6):449\u2013452. https:\/\/doi.org\/10.1016\/j.anl.2015.04.012","journal-title":"Auris Nasus Larynx"},{"issue":"1","key":"6579_CR19","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1080\/00016489.2020.1814965","volume":"141","author":"M Onal","year":"2021","unstructured":"Onal M, Onal O, Turan A (2021) Can secondary lymphoid organs exert a favorable effect on the mild course of COVID-19 in children? Acta Otolaryngol 141(1):83\u201384. https:\/\/doi.org\/10.1080\/00016489.2020.1814965","journal-title":"Acta Otolaryngol"},{"key":"6579_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2020.110503","volume":"140","author":"U Funakoshi","year":"2021","unstructured":"Funakoshi U, Yonekura S, Iinuma T, Arimoto Y, Nakano A, Yamaide A, Tomiita M, Hoshioka A, Sakurai D, Okamoto Y (2021) The influence of tonsillectomy on allergic diseases in pediatric patients. Int J Pediatr Otorhinolaryngol 140:110503. https:\/\/doi.org\/10.1016\/j.ijporl.2020.110503","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"27","key":"6579_CR21","doi-asserted-by":"publisher","first-page":"6915","DOI":"10.7150\/jca.31319","volume":"10","author":"EH Ji","year":"2019","unstructured":"Ji EH, Elzakra N, Chen W, Cui L, Lee ES, Sun B, Messadi D, Xia T, Zhu Y, Hu S (2019) E-cigarette aerosols induce unfolded protein response in normal human oral keratinocytes. J Cancer 10(27):6915\u20136924. https:\/\/doi.org\/10.7150\/jca.31319","journal-title":"J Cancer"},{"issue":"6","key":"6579_CR22","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1111\/apm.12679","volume":"125","author":"G Liu","year":"2017","unstructured":"Liu G, Guo T, Zhang Y, Liu N, Chen J, Chen J, Zhang J, Zhao J (2017) Apoptotic pathways of macrophages within osteolytic interface membrane in periprosthestic osteolysis after total hip replacement. APMIS 125(6):565\u2013578. https:\/\/doi.org\/10.1111\/apm.12679","journal-title":"APMIS"},{"issue":"10","key":"6579_CR23","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1038\/labinvest.2015.91","volume":"95","author":"HS Shin","year":"2015","unstructured":"Shin HS, Ryu ES, Oh ES, Kang DH (2015) Endoplasmic reticulum stress as a novel target to ameliorate epithelial-to-mesenchymal transition and apoptosis of human peritoneal mesothelial cells. Lab Invest 95(10):1157\u20131173. https:\/\/doi.org\/10.1038\/labinvest.2015.91","journal-title":"Lab Invest"},{"issue":"5","key":"6579_CR24","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1080\/19768354.2020.1813805","volume":"24","author":"S Bae","year":"2020","unstructured":"Bae S, Kim M-K, Kim HS, Moon Y-A (2020) Arachidonic acid induces ER stress and apoptosis in HT-29 human colon cancer cells. Anim Cells Syst (Seoul) 24(5):260\u2013266. https:\/\/doi.org\/10.1080\/19768354.2020.1813805","journal-title":"Anim Cells Syst (Seoul)"},{"issue":"6","key":"6579_CR25","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.3390\/cancers12061702","volume":"12","author":"Y-Y Wang","year":"2020","unstructured":"Wang Y-Y, Lee K-T, Lim MC, Choi JH (2020) TRPV1 antagonist DWP05195 \u0131nduces ER stress-dependent apoptosis through the ROS-p38-CHOP pathway in human ovarian cancer cells. Cancers 12(6):1702. https:\/\/doi.org\/10.3390\/cancers12061702","journal-title":"Cancers"},{"issue":"1","key":"6579_CR26","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1111\/jcmm.14732","volume":"24","author":"C Liu","year":"2020","unstructured":"Liu C, Yan D-Y, Wang C, Ma Z, Deng Y, Liu W, Xu B (2020) Manganese activates autophagy to alleviate endoplasmic reticulum stress-induced apoptosis via PERK pathway. J Cell Mol Med 24(1):328\u2013341. https:\/\/doi.org\/10.1111\/jcmm.14732","journal-title":"J Cell Mol Med"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-021-06579-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-021-06579-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-021-06579-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T12:18:31Z","timestamp":1628597911000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-021-06579-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["6579"],"URL":"https:\/\/doi.org\/10.1007\/s11033-021-06579-4","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-434079\/v1","asserted-by":"object"}]},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"17 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee (Selcuk University Faculty of Medicine Clinical Researches Ethics Committee) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Ethics approval for the study was obtained from the Clinical Research Ethics Committee of Selcuk University Medical Faculty (Ref No:\u00a02018\/329). Our study was supported by the Selcuk University Scientific Research Projects Coordination Unit (Project Number: 19401029). After obtaining informed consent from the parents of the patients to be included in the study, we conducted our study by the ethical standards stated in the 1964 Helsinki Declaration. Human tonsil samples used in this study were obtained from tonsillectomy patients in Selcuk University, Faculty of Medicine\u00a0Hospital, Department of Otolaryngology between the dates of November 2018 and August 2019.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all patients\u2019 parents.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}