{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:06:31Z","timestamp":1790960791907,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T00:00:00Z","timestamp":1630972800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T00:00:00Z","timestamp":1630972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100015364","name":"Prothena","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015364","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>CD146 (MCAM-melanoma cell adhesion molecule) is a cell surface adhesion molecule for Laminin 411. T cells expressing MCAM are mainly responsible for IL-17 production. IL-17 secreting T helper cells (Th17 cells) are critical for the pathogenesis of psoriatic arthritis (PsA). Here we hypothesized enrichment of CD146<jats:sup>+<\/jats:sup>IL-17<jats:sup>+<\/jats:sup>memory T cells in PsA synovium and studied the association of CD146 expression and CD4<jats:sup>+<\/jats:sup>IL-17<jats:sup>+<\/jats:sup>activated memory (CD11a<jats:sup>+<\/jats:sup>CD45RO<jats:sup>+<\/jats:sup>) T cells in synovial fluid and blood of PSA, rheumatoid arthritis (RA, a positive control) and osteoarthritis (OA) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Hi-D FACS studies were done to identify IL-17 in CD4<jats:sup>+<\/jats:sup>CD146<jats:sup>+<\/jats:sup>CD45RO<jats:sup>+<\/jats:sup>and CD8<jats:sup>+<\/jats:sup>CD146<jats:sup>+<\/jats:sup>CD45RO<jats:sup>+<\/jats:sup>T cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed that effector CD146<jats:sup>+<\/jats:sup>(MCAM<jats:sup>+<\/jats:sup>) T cells are enriched at the synovial inflammation site in PsA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>As CD146<jats:sup>+<\/jats:sup>T cells are a key resource for IL-17 it is likely that the enrichment of these MCAM<jats:sup>+<\/jats:sup>pathologic cells are critical for the disease process of PsA.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s11033-021-06678-2","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T11:02:47Z","timestamp":1631012567000},"page":"6787-6796","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Phenotype and pathological significance of MCAM+ (CD146+) T cell subset in psoriatic arthritis"],"prefix":"10.1007","volume":"48","author":[{"given":"Smriti K.","family":"Raychaudhuri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Abria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7594-6528","authenticated-orcid":false,"given":"Siba P.","family":"Raychaudhuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,7]]},"reference":[{"key":"6678_CR1","doi-asserted-by":"crossref","unstructured":"Raychaudhuri SK, Abria C, Raychaudhuri SP (2019) Polyfunctional TEM cells in psoriatic arthritis synovium skewed towards Th17 cells. 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