{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T12:00:29Z","timestamp":1792843229348,"version":"4.5.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T00:00:00Z","timestamp":1641686400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T00:00:00Z","timestamp":1641686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873741"],"award-info":[{"award-number":["81873741"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071297"],"award-info":[{"award-number":["82071297"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1007\/s11033-021-07028-y","type":"journal-article","created":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T00:02:32Z","timestamp":1641686552000},"page":"2107-2118","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Apelin-13 attenuates early brain injury through inhibiting inflammation and apoptosis in rats after experimental subarachnoid hemorrhage"],"prefix":"10.1007","volume":"49","author":[{"given":"Xiaoyan","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiqiang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demao","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9296-3725","authenticated-orcid":false,"given":"Haitao","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,9]]},"reference":[{"key":"7028_CR1","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/S0140-6736(16)30668-7","volume":"389","author":"RL Macdonald","year":"2017","unstructured":"Macdonald RL, Schweizer TA (2017) Spontaneous subarachnoid haemorrhage. Lancet 389:655\u2013666. https:\/\/doi.org\/10.1016\/S0140-6736(16)30668-7","journal-title":"Lancet"},{"key":"7028_CR2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X19863021","author":"M Balbi","year":"2019","unstructured":"Balbi M, Vega MJ, Lourbopoulos A et al (2019) Long-term impairment of neurovascular coupling following experimental subarachnoid hemorrhage. J Cereb Blood Flow Metab. https:\/\/doi.org\/10.1177\/0271678X19863021","journal-title":"J Cereb Blood Flow Metab"},{"key":"7028_CR3","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1007\/s12975-019-00713-y","volume":"10","author":"H Suzuki","year":"2019","unstructured":"Suzuki H (2019) Inflammation: a good research target to improve outcomes of poor-grade subarachnoid hemorrhage. Transl Stroke Res 10:597\u2013600. https:\/\/doi.org\/10.1007\/s12975-019-00713-y","journal-title":"Transl Stroke Res"},{"key":"7028_CR4","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1161\/STROKEAHA.117.017436","volume":"49","author":"M Mejdoubi","year":"2018","unstructured":"Mejdoubi M, Schertz M, Zanolla S et al (2018) Transoceanic management and treatment of aneurysmal subarachnoid hemorrhage: a 10-year experience. Stroke 49:127\u2013132. https:\/\/doi.org\/10.1161\/STROKEAHA.117.017436","journal-title":"Stroke"},{"key":"7028_CR5","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.4103\/1673-5374.257529","volume":"14","author":"YK Xie","year":"2019","unstructured":"Xie YK, Zhou X, Yuan HT et al (2019) Resveratrol reduces brain injury after subarachnoid hemorrhage by inhibiting oxidative stress and endoplasmic reticulum stress. Neural Regen Res 14:1734\u20131742. https:\/\/doi.org\/10.4103\/1673-5374.257529","journal-title":"Neural Regen Res"},{"key":"7028_CR6","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1007\/s12975-018-0674-3","volume":"10","author":"C Conzen","year":"2019","unstructured":"Conzen C, Becker K, Albanna W et al (2019) The acute phase of experimental subarachnoid hemorrhage: intracranial pressure dynamics and their effect on cerebral blood flow and autoregulation. Transl Stroke Res 10:566\u2013582. https:\/\/doi.org\/10.1007\/s12975-018-0674-3","journal-title":"Transl Stroke Res"},{"key":"7028_CR7","doi-asserted-by":"publisher","first-page":"e63","DOI":"10.1016\/j.wneu.2019.05.009","volume":"129","author":"M Naraoka","year":"2019","unstructured":"Naraoka M, Fumoto T, Li Y et al (2019) The role of intracranial pressure and subarachnoid blood clots in early brain injury after experimental subarachnoid hemorrhage in rats. World Neurosurg 129:e63\u2013e72. https:\/\/doi.org\/10.1016\/j.wneu.2019.05.009","journal-title":"World Neurosurg"},{"key":"7028_CR8","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.pharmthera.2005.04.001","volume":"107","author":"MJ Kleinz","year":"2005","unstructured":"Kleinz MJ, Davenport AP (2005) Emerging roles of apelin in biology and medicine. Pharmacol Ther 107:198\u2013211. https:\/\/doi.org\/10.1016\/j.pharmthera.2005.04.001","journal-title":"Pharmacol Ther"},{"key":"7028_CR9","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.neulet.2016.06.046","volume":"628","author":"H Bao","year":"2016","unstructured":"Bao H, Yang X, Huang Y et al (2016) The neuroprotective effect of apelin-13 in a mouse model of intracerebral hemorrhage. Neurosci Lett 628:219\u2013224. https:\/\/doi.org\/10.1016\/j.neulet.2016.06.046","journal-title":"Neurosci Lett"},{"key":"7028_CR10","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12974-019-1406-7","volume":"16","author":"J Duan","year":"2019","unstructured":"Duan J, Cui J, Yang Z et al (2019) Neuroprotective effect of Apelin 13 on ischemic stroke by activating AMPK\/GSK-3beta\/Nrf2 signaling. J Neuroinflamm 16:24. https:\/\/doi.org\/10.1186\/s12974-019-1406-7","journal-title":"J Neuroinflamm"},{"key":"7028_CR11","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.brainres.2017.06.001","volume":"1670","author":"X Tian","year":"2017","unstructured":"Tian X, Sun L, Feng D et al (2017) HMGB1 promotes neurovascular remodeling via rage in the late phase of subarachnoid hemorrhage. Brain Res 1670:135\u2013145. https:\/\/doi.org\/10.1016\/j.brainres.2017.06.001","journal-title":"Brain Res"},{"key":"7028_CR12","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.neulet.2014.03.037","volume":"568","author":"Y Yang","year":"2014","unstructured":"Yang Y, Zhang X, Cui H et al (2014) Apelin-13 protects the brain against ischemia\/reperfusion injury through activating PI3K\/Akt and ERK1\/2 signaling pathways. Neurosci Lett 568:44\u201349. https:\/\/doi.org\/10.1016\/j.neulet.2014.03.037","journal-title":"Neurosci Lett"},{"key":"7028_CR13","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.3892\/mmr.2017.6734","volume":"16","author":"Q Xiong","year":"2017","unstructured":"Xiong Q, He W, Wang H et al (2017) Effect of the spinal apelinAPJ system on the pathogenesis of chronic constriction injuryinduced neuropathic pain in rats. Mol Med Rep 16:1223\u20131231. https:\/\/doi.org\/10.3892\/mmr.2017.6734","journal-title":"Mol Med Rep"},{"key":"7028_CR14","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.brainres.2018.09.012","volume":"1701","author":"Z Zhang","year":"2018","unstructured":"Zhang Z, Wu Y, Yuan S et al (2018) Glutathione peroxidase 4 participates in secondary brain injury through mediating ferroptosis in a rat model of intracerebral hemorrhage. Brain Res 1701:112\u2013125. https:\/\/doi.org\/10.1016\/j.brainres.2018.09.012","journal-title":"Brain Res"},{"key":"7028_CR15","doi-asserted-by":"publisher","first-page":"694","DOI":"10.18632\/aging.202178","volume":"13","author":"P Li","year":"2020","unstructured":"Li P, Li X, Deng P et al (2020) Activation of adenosine A3 receptor reduces early brain injury by alleviating neuroinflammation after subarachnoid hemorrhage in elderly rats. Aging 13:694\u2013713. https:\/\/doi.org\/10.18632\/aging.202178","journal-title":"Aging"},{"key":"7028_CR16","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24895","author":"E Angelopoulou","year":"2021","unstructured":"Angelopoulou E, Paudel YN, Bougea A et al (2021) Impact of the apelin\/APJ axis in the pathogenesis of Parkinson\u2019s disease with therapeutic potential. J Neurosci Res. https:\/\/doi.org\/10.1002\/jnr.24895","journal-title":"J Neurosci Res"},{"key":"7028_CR17","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1111\/j.1471-4159.2007.04645.x","volume":"102","author":"LA O'Donnell","year":"2007","unstructured":"O\u2019Donnell LA, Agrawal A, Sabnekar P et al (2007) Apelin, an endogenous neuronal peptide, protects hippocampal neurons against excitotoxic injury. J Neurochem 102:1905\u20131917. https:\/\/doi.org\/10.1111\/j.1471-4159.2007.04645.x","journal-title":"J Neurochem"},{"key":"7028_CR18","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.neuroscience.2018.07.023","volume":"388","author":"W Xu","year":"2018","unstructured":"Xu W, Gao L, Li T et al (2018) Apelin-13 alleviates early brain injury after subarachnoid hemorrhage via suppression of endoplasmic reticulum stress-mediated apoptosis and blood-brain barrier disruption: possible involvement of ATF6\/CHOP pathway. Neuroscience 388:284\u2013296. https:\/\/doi.org\/10.1016\/j.neuroscience.2018.07.023","journal-title":"Neuroscience"},{"key":"7028_CR19","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.bbrc.2019.03.151","volume":"513","author":"Y Liu","year":"2019","unstructured":"Liu Y, Zhang T, Wang Y et al (2019) Apelin-13 attenuates early brain injury following subarachnoid hemorrhage via suppressing neuronal apoptosis through the GLP-1R\/PI3K\/Akt signaling. Biochem Biophys Res Commun 513:105\u2013111. https:\/\/doi.org\/10.1016\/j.bbrc.2019.03.151","journal-title":"Biochem Biophys Res Commun"},{"key":"7028_CR20","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1186\/s12974-019-1620-3","volume":"16","author":"W Xu","year":"2019","unstructured":"Xu W, Li T, Gao L et al (2019) Apelin-13\/APJ system attenuates early brain injury via suppression of endoplasmic reticulum stress-associated TXNIP\/NLRP3 inflammasome activation and oxidative stress in a AMPK-dependent manner after subarachnoid hemorrhage in rats. J Neuroinflamm 16:247. https:\/\/doi.org\/10.1186\/s12974-019-1620-3","journal-title":"J Neuroinflamm"},{"key":"7028_CR21","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1530\/REP-16-0677","volume":"153","author":"J Roche","year":"2017","unstructured":"Roche J, Rame C, Reverchon M et al (2017) Apelin (APLN) regulates progesterone secretion and oocyte maturation in bovine ovarian cells. Reproduction 153:589\u2013603. https:\/\/doi.org\/10.1530\/REP-16-0677","journal-title":"Reproduction"},{"key":"7028_CR22","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-020-00806-z","author":"A Datta","year":"2020","unstructured":"Datta A, Sarmah D, Mounica L et al (2020) Cell death pathways in ischemic stroke and targeted pharmacotherapy. Transl Stroke Res. https:\/\/doi.org\/10.1007\/s12975-020-00806-z","journal-title":"Transl Stroke Res"},{"key":"7028_CR23","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.pnpbp.2018.10.005","volume":"89","author":"S Aminyavari","year":"2019","unstructured":"Aminyavari S, Zahmatkesh M, Farahmandfar M et al (2019) Protective role of Apelin-13 on amyloid beta25-35-induced memory deficit; involvement of autophagy and apoptosis process. Prog Neuropsychopharmacol Biol Psychiatry 89:322\u2013334. https:\/\/doi.org\/10.1016\/j.pnpbp.2018.10.005","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"7028_CR24","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1007\/s11064-016-1878-0","volume":"41","author":"Y Zou","year":"2016","unstructured":"Zou Y, Wang B, Fu W et al (2016) Apelin-13 protects PC12 cells from corticosterone-induced apoptosis through PI3K and ERKs activation. Neurochem Res 41:1635\u20131644. https:\/\/doi.org\/10.1007\/s11064-016-1878-0","journal-title":"Neurochem Res"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-021-07028-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-021-07028-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-021-07028-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T02:39:42Z","timestamp":1645497582000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-021-07028-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,9]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["7028"],"URL":"https:\/\/doi.org\/10.1007\/s11033-021-07028-y","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-302819\/v1","asserted-by":"object"}]},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,9]]},"assertion":[{"value":"30 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"All animal experiments were approved by the Institutional Animal Care Committee of Soochow University and were performed in accordance with the guidelines of the National Institutes of Health.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}