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These microbial interactions have both positive and negative effects on plant. Plant growth promoting bacterial (PGPR) interaction could result in positive growth under normal as well as in stress conditions.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Here, we have screened two PGPR\u2019s and determined their potential in induction of specific gene in host plant to overcome the adverse effect of biotic stress caused by <jats:italic>Magnaporthe grisea<\/jats:italic>, a fungal pathogen that cause blast in rice. We demonstrated the glucanase protein mode of action by performing comparative modeling and molecular docking of guanosine triphosphate (GTP) ligand with the protein. Besides, molecular dynamic simulations have been performed to understand the behavior of the glucanase-GTP complex.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The results clearly showed that selected PGPR was better able to induce modification in host plant at morphological, biochemical, physiological and molecular level by activating the expression of \u03b2-1,3-glucanases gene in infected host plant. The docking results indicated that Tyr75, Arg256, Gly258, and Ser223 of glucanase formed four crucial hydrogen bonds with the GTP, while, only Val220 found to form hydrophobic contact with ligand.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The PGPR able to induce \u03b2-1,3-glucanases gene in host plant upon pathogenic interaction and \u03b2-1,3-glucanases form complex with GTP by hydrophilic interaction for induction of defense cascade for acquiring resistance against <jats:italic>Magnaporthe grisea.<\/jats:italic><\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1007\/s11033-021-07059-5","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T16:03:00Z","timestamp":1639670580000},"page":"2579-2589","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Delineation of molecular interactions of plant growth promoting bacteria induced \u03b2-1,3-glucanases and guanosine triphosphate ligand for antifungal response in rice: a molecular dynamics approach"],"prefix":"10.1007","volume":"49","author":[{"given":"Yachana","family":"Jha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Budheswar","family":"Dehury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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