{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:19:12Z","timestamp":1792783152274,"version":"4.5.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["81800792"],"award-info":[{"award-number":["81800792"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["81771226"],"award-info":[{"award-number":["81771226"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["U1804186"],"award-info":[{"award-number":["U1804186"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Henan Province Foundation","award":["19IRTSTHN003"],"award-info":[{"award-number":["19IRTSTHN003"]}]},{"name":"the project of science and technology of Henan province","award":["212102310893"],"award-info":[{"award-number":["212102310893"]}]},{"name":"Key Project of Science and Technology Research of Henan Provincial Education Department","award":["19A180027"],"award-info":[{"award-number":["19A180027"]}]},{"name":"Key Project of Science and Technology Research of Henan Provincial Education Department","award":["19B180009"],"award-info":[{"award-number":["19B180009"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s11033-022-07142-5","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T11:06:34Z","timestamp":1643799994000},"page":"3113-3122","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Alternate-day fasting alleviates high fat diet induced non-alcoholic fatty liver disease through controlling PPAR\u03b1\/Fgf21 signaling"],"prefix":"10.1007","volume":"49","author":[{"given":"Xinlei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunya","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8041-1405","authenticated-orcid":false,"given":"Jiang","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,2]]},"reference":[{"issue":"2","key":"7142_CR1","doi-asserted-by":"publisher","first-page":"298","DOI":"10.3390\/ijms20020298","volume":"20","author":"HW Chao","year":"2019","unstructured":"Chao HW, Chao SW, Lin H, Ku HC, Cheng CF (2019) Homeostasis of glucose and lipid in non-alcoholic fatty liver disease. Int J Mol Sci 20(2):298. https:\/\/doi.org\/10.3390\/ijms20020298","journal-title":"Int J Mol Sci"},{"issue":"6","key":"7142_CR2","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1007\/s00125-016-3940-5","volume":"59","author":"JG Jones","year":"2016","unstructured":"Jones JG (2016) Hepatic glucose and lipid metabolism. Diabetologia 59(6):1098\u20131103. https:\/\/doi.org\/10.1007\/s00125-016-3940-5","journal-title":"Diabetologia"},{"issue":"2","key":"7142_CR3","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/liv.14311","volume":"40","author":"J Du","year":"2020","unstructured":"Du J, Ji Y, Qiao L, Liu Y, Lin J (2020) Cellular endo-lysosomal dysfunction in the pathogenesis of non-alcoholic fatty liver disease. Liver Int 40(2):271\u2013280. https:\/\/doi.org\/10.1111\/liv.14311","journal-title":"Liver Int"},{"key":"7142_CR4","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s00018-018-2947-0","volume":"76","author":"F Bessone","year":"2019","unstructured":"Bessone F, Razori MV, Roma MG (2019) Molecular pathways of nonalcoholic fatty liver disease development and progression. Cell Mol Life Sci 76:99\u2013128. https:\/\/doi.org\/10.1007\/s00018-018-2947-0","journal-title":"Cell Mol Life Sci"},{"issue":"6","key":"7142_CR5","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1002\/hep.28392","volume":"63","author":"G Marchesini","year":"2016","unstructured":"Marchesini G, Petta S, Dalle Grave R (2016) Diet, weight loss, and liver health in nonalcoholic fatty liver disease: pathophysiology, evidence, and practice. Hepatology 63(6):2032\u20132043. https:\/\/doi.org\/10.1002\/hep.28392","journal-title":"Hepatology"},{"issue":"10","key":"7142_CR6","doi-asserted-by":"publisher","first-page":"3215","DOI":"10.3390\/nu12103215","volume":"12","author":"ML Nasaruddin","year":"2020","unstructured":"Nasaruddin ML, Syed Abd Halim SA, Kamaruzzaman MA (2020) Studying the relationship of intermittent fasting and \u03b2-amyloid in animal model of Alzheimer\u2019s disease: a scoping review. Nutrients 12(10):3215. https:\/\/doi.org\/10.3390\/nu12103215","journal-title":"Nutrients"},{"issue":"5","key":"7142_CR7","doi-asserted-by":"publisher","first-page":"597","DOI":"10.21037\/hbsn-20-317","volume":"9","author":"D Hu","year":"2020","unstructured":"Hu D, Xie Z, Ye Y, Bahijri S, Chen M (2020) The beneficial effects of intermittent fasting: an update on mechanism, and the role of circadian rhythm and gut microbiota. Hepatobiliary Surg Nutr 9(5):597\u2013602. https:\/\/doi.org\/10.21037\/hbsn-20-317","journal-title":"Hepatobiliary Surg Nutr"},{"issue":"6","key":"7142_CR8","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.nutres.2016.02.001","volume":"36","author":"W Yang","year":"2016","unstructured":"Yang W, Cao M, Mao X, Wei X, Li X, Chen G, Zhang J, Wang Z, Shi J, Huang H, Yao X, Liu C (2016) Alternate-day fasting protects the livers of mice against high-fat diet-induced inflammation associated with the suppression of Toll-like receptor 4\/nuclear factor \u03baB signaling. Nutr Res 36(6):586\u2013593. https:\/\/doi.org\/10.1016\/j.nutres.2016.02.001","journal-title":"Nutr Res"},{"issue":"1","key":"7142_CR9","doi-asserted-by":"publisher","first-page":"11232","DOI":"10.1038\/s41598-019-47763-8","volume":"9","author":"MI Johari","year":"2019","unstructured":"Johari MI, Yusoff K, Haron J, Nadarajan C, Ibrahim KN, Wong MS, Hafidz MIA, Chua BE, Hamid N, Arifin WN, Ma ZF, Lee YY (2019) A randomised controlled trial on the effectiveness and adherence of modified alternate-day calorie restriction in improving activity of non-alcoholic fatty liver disease. Sci Rep 9(1):11232. https:\/\/doi.org\/10.1038\/s41598-019-47763-8","journal-title":"Sci Rep"},{"issue":"1","key":"7142_CR10","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1186\/s12876-019-1132-8","volume":"19","author":"H Cai","year":"2019","unstructured":"Cai H, Qin YL, Shi ZY, Chen JH, Zeng MJ, Zhou W, Chen RQ, Chen ZY (2019) Effects of alternate-day fasting on body weight and dyslipidaemia in patients with non-alcoholic fatty liver disease: a randomised controlled trial. BMC Gastroenterol 19(1):219. https:\/\/doi.org\/10.1186\/s12876-019-1132-8","journal-title":"BMC Gastroenterol"},{"key":"7142_CR11","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1146\/annurev-physiol-021115-105339","volume":"78","author":"FM Fisher","year":"2016","unstructured":"Fisher FM, Maratos-Flier E (2016) Understanding the physiology of Fgf21. Annu Rev Physiol 78:223\u2013241. https:\/\/doi.org\/10.1146\/annurev-physiol-021115-105339","journal-title":"Annu Rev Physiol"},{"issue":"1","key":"7142_CR12","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1038\/s41467-020-14384-z","volume":"11","author":"S Byun","year":"2020","unstructured":"Byun S, Seok S, Kim YC, Zhang Y, Yau P, Iwamori N, Xu HE, Ma J, Kemper B, Kemper JK (2020) Fasting-induced Fgf21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase. Nat Commun 11(1):807. https:\/\/doi.org\/10.1038\/s41467-020-14384-z","journal-title":"Nat Commun"},{"issue":"7","key":"7142_CR13","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1136\/gutjnl-2015-310798","volume":"65","author":"A Montagner","year":"2016","unstructured":"Montagner A, Polizzi A, Fouch\u00e9 E, Ducheix S, Lippi Y, Lasserre F, Barquissau V, R\u00e9gnier M, Lukowicz C, Benhamed F, Iroz A, Bertrand-Michel J, Al Saati T, Cano P, Mselli-Lakhal L, Mithieux G, Rajas F, Lagarrigue S, Pineau T, Loiseau N, Postic C, Langin D, Wahli W, Guillou H (2016) Liver PPAR\u03b1 is crucial for whole-body fatty acid homeostasis and is protective against NAFLD. Gut 65(7):1202\u20131214. https:\/\/doi.org\/10.1136\/gutjnl-2015-310798","journal-title":"Gut"},{"key":"7142_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2020.108403","volume":"83","author":"H Zhang","year":"2020","unstructured":"Zhang H, Zhang W, Yun D, Li L, Zhao W, Li Y, Liu X, Liu Z (2020) Alternate-day fasting alleviates diabetes-induced glycolipid metabolism disorders: roles of Fgf21 and bile acids. J Nutr Biochem 83:108403. https:\/\/doi.org\/10.1016\/j.jnutbio.2020.108403","journal-title":"J Nutr Biochem"},{"issue":"18","key":"7142_CR15","doi-asserted-by":"publisher","first-page":"3231","DOI":"10.3390\/molecules24183231","volume":"24","author":"L Hu","year":"2019","unstructured":"Hu L, Tian K, Zhang T, Fan CH, Zhou P, Zeng D, Zhao S, Li LS, Smith HS, Li J, Ran JH (2019) Cyanate induces oxidative stress injury and abnormal lipid metabolism in liver through Nrf2\/HO-1. Molecules 24(18):3231. https:\/\/doi.org\/10.3390\/molecules24183231","journal-title":"Molecules"},{"key":"7142_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118831","volume":"267","author":"ML Zhu","year":"2021","unstructured":"Zhu ML, Zhao FR, Zhu TT, Wang QQ, Wu ZQ, Song P, Xu J, Wan GR, Yin YL, Li P (2021) The antihypertension effect of hydrogen sulfide (H2S) is induced by activating VEGFR2 signaling pathway. Life Sci 267:118831. https:\/\/doi.org\/10.1016\/j.lfs.2020.118831","journal-title":"Life Sci"},{"issue":"1","key":"7142_CR17","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1186\/s13287-018-1073-0","volume":"9","author":"J Du","year":"2018","unstructured":"Du J, Zhu X, Guo R, Xu Z, Cheng FF, Liu Q, Yang F, Guan L, Liu Y, Lin J (2018) Autophagy induces G0\/G1 arrest and apoptosis in menstrual blood-derived endometrial stem cells via GSK3-\u03b2\/\u03b2-catenin pathway. Stem Cell Res Ther 9(1):330. https:\/\/doi.org\/10.1186\/s13287-018-1073-0","journal-title":"Stem Cell Res Ther"},{"issue":"18","key":"7142_CR18","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.21037\/atm-20-5669","volume":"8","author":"H Chen","year":"2020","unstructured":"Chen H, Shi Z, Xing Y, Li X, Fu F (2020) Fangchinoline attenuates cardiac dysfunction in rats with endotoxemia via the inhibition of ERK1\/2 and NF-\u03baB p65 phosphorylation. Ann Transl Med 8(18):1167. https:\/\/doi.org\/10.21037\/atm-20-5669","journal-title":"Ann Transl Med"},{"key":"7142_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2019.153994","volume":"101","author":"B Tucker","year":"2019","unstructured":"Tucker B, Li H, Long X, Rye KA, Ong KL (2019) Fibroblast growth factor 21 in non-alcoholic fatty liver disease. Metabolism 101:153994. https:\/\/doi.org\/10.1016\/j.metabol.2019.153994","journal-title":"Metabolism"},{"issue":"12","key":"7142_CR20","doi-asserted-by":"publisher","first-page":"4064","DOI":"10.2337\/db14-0541","volume":"63","author":"Q Liang","year":"2014","unstructured":"Liang Q, Zhong L, Zhang J, Wang Y, Bornstein SR, Triggle CR, Ding H, Lam KS, Xu A (2014) FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting. Diabetes 63(12):4064\u20134075. https:\/\/doi.org\/10.2337\/db14-0541","journal-title":"Diabetes"},{"issue":"11","key":"7142_CR21","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1136\/gutjnl-2014-308430","volume":"65","author":"H Wu","year":"2016","unstructured":"Wu H, Ng R, Chen X, Steer CJ, Song G (2016) MicroRNA-21 is a potential link between non-alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1-p53-Srebp1c pathway. Gut 65(11):1850\u20131860. https:\/\/doi.org\/10.1136\/gutjnl-2014-308430","journal-title":"Gut"},{"issue":"6","key":"7142_CR22","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.3390\/ijms21062061","volume":"21","author":"Y Wang","year":"2020","unstructured":"Wang Y, Nakajima T, Gonzalez FJ, Tanaka N (2020) PPARs as metabolic regulators in the liver: lessons from liver-specific PPAR-null mice. Int J Mol Sci 21(6):2061. https:\/\/doi.org\/10.3390\/ijms21062061","journal-title":"Int J Mol Sci"},{"key":"7142_CR23","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.plipres.2013.12.001","volume":"53","author":"MT Nakamura","year":"2014","unstructured":"Nakamura MT, Yudell BE, Loor JJ (2014) Regulation of energy metabolism by long-chain fatty acids. Prog Lipid Res 53:124\u2013144. https:\/\/doi.org\/10.1016\/j.plipres.2013.12.001","journal-title":"Prog Lipid Res"},{"key":"7142_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2020.101221","author":"F Xiao","year":"2020","unstructured":"Xiao F, Shi X, Huang P, Zeng X, Wang L, Zeng J, Liu C, Yan B, Song H, Xu Y, Han L, Zhao Q, Lin M, Li X (2020) Dose-response relationship between serum fibroblast growth factor 21 and liver fat content in non-alcoholic fatty liver disease. Diabetes Metab. https:\/\/doi.org\/10.1016\/j.diabet.2020.101221","journal-title":"Diabetes Metab"},{"issue":"9","key":"7142_CR25","doi-asserted-by":"publisher","first-page":"12354","DOI":"10.1096\/fj.202000790R","volume":"34","author":"HY Kim","year":"2020","unstructured":"Kim HY, Kwon WY, Park JB, Lee MH, Oh YJ, Suh S, Baek YH, Jeong JS, Yoo YH (2020) Hepatic STAMP2 mediates recombinant Fgf21-induced improvement of hepatic iron overload in nonalcoholic fatty liver disease. FASEB J 34(9):12354\u201312366. https:\/\/doi.org\/10.1096\/fj.202000790R","journal-title":"FASEB J"},{"key":"7142_CR26","doi-asserted-by":"publisher","first-page":"6633022","DOI":"10.1155\/2020\/6633022","volume":"2020","author":"X Du","year":"2020","unstructured":"Du X, Wu M, Tian D, Zhou J, Wang L, Zhan L (2020) MicroRNA-21 contributes to acute liver injury in LPS-induced sepsis mice by inhibiting PPAR\u03b1 expression. PPAR Res 2020:6633022. https:\/\/doi.org\/10.1155\/2020\/6633022","journal-title":"PPAR Res"},{"key":"7142_CR27","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.arr.2016.10.005","volume":"39","author":"MP Mattson","year":"2017","unstructured":"Mattson MP, Longo VD, Harvie M (2017) Impact of intermittent fasting on health and disease processes. Ageing Res Rev 39:46\u201358. https:\/\/doi.org\/10.1016\/j.arr.2016.10.005","journal-title":"Ageing Res Rev"},{"issue":"6416","key":"7142_CR28","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1126\/science.aau2095","volume":"362","author":"A Di Francesco","year":"2018","unstructured":"Di Francesco A, Di Germanio C, Bernier M, de Cabo R (2018) A time to fast. Science 362(6416):770\u2013775. https:\/\/doi.org\/10.1126\/science.aau2095","journal-title":"Science"},{"issue":"1","key":"7142_CR29","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1017\/S0029665119000636","volume":"79","author":"I Templeman","year":"2020","unstructured":"Templeman I, Gonzalez JT, Thompson D, Betts JA (2020) The role of intermittent fasting and meal timing in weight management and metabolic health. Proc Nutr Soc 79(1):76\u201387. https:\/\/doi.org\/10.1017\/S0029665119000636","journal-title":"Proc Nutr Soc"},{"issue":"8","key":"7142_CR30","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.2337\/dbi20-0025","volume":"69","author":"M Kleinert","year":"2020","unstructured":"Kleinert M, M\u00fcller TD (2020) A new Fgf21 analog for the treatment of fatty liver disease. Diabetes 69(8):1605\u20131607. https:\/\/doi.org\/10.2337\/dbi20-0025","journal-title":"Diabetes"},{"key":"7142_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2021.107892","volume":"25","author":"\u00d6 Tok","year":"2021","unstructured":"Tok \u00d6, Ki\u015fio\u011flu SV, Ers\u00f6z H\u00d6, Kahveci B, G\u00f6kta\u015f Z (2021) Effects of increased physical activity and\/or weight loss diet on serum myokine and adipokine levels in overweight adults with impaired glucose metabolism. J Diabetes Complicat 25:107892. https:\/\/doi.org\/10.1016\/j.jdiacomp.2021.107892","journal-title":"J Diabetes Complicat"},{"issue":"3","key":"7142_CR32","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/j.jhep.2014.10.039","volume":"62","author":"M Pawlak","year":"2015","unstructured":"Pawlak M, Lefebvre P, Staels B (2015) Molecular mechanism of PPAR\u03b1 action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease. J Hepatol 62(3):720\u2013733. https:\/\/doi.org\/10.1016\/j.jhep.2014.10.039","journal-title":"J Hepatol"},{"issue":"5","key":"7142_CR33","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1016\/j.jhep.2016.11.020","volume":"66","author":"K Huang","year":"2017","unstructured":"Huang K, Du M, Tan X, Yang L, Li X, Jiang Y, Wang C, Zhang F, Zhu F, Cheng M, Yang Q, Yu L, Wang L, Huang D, Huang K (2017) PARP1-mediated PPAR\u03b1 poly(ADP-ribosyl)ation suppresses fatty acid oxidation in non-alcoholic fatty liver disease. J Hepatol 66(5):962\u2013977. https:\/\/doi.org\/10.1016\/j.jhep.2016.11.020","journal-title":"J Hepatol"},{"key":"7142_CR34","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.tox.2017.01.016","volume":"379","author":"X Chen","year":"2017","unstructured":"Chen X, Ward SC, Cederbaum AI, Xiong H, Lu Y (2017) Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: the role of the PPAR\u03b1-Fgf21 axis. Toxicology 379:12\u201321. https:\/\/doi.org\/10.1016\/j.tox.2017.01.016","journal-title":"Toxicology"},{"issue":"3","key":"7142_CR35","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1002\/hep4.1629","volume":"5","author":"S Athinarayanan","year":"2020","unstructured":"Athinarayanan S, Fan YY, Wang X, Callaway E, Cai D, Chalasani N, Chapkin RS, Liu W (2020) Fatty acid desaturase 1 influences hepatic lipid homeostasis by modulating the PPAR\u03b1-Fgf21 axis. Hepatol Commun 5(3):461\u2013477. https:\/\/doi.org\/10.1002\/hep4.1629","journal-title":"Hepatol Commun"},{"issue":"12","key":"7142_CR36","doi-asserted-by":"publisher","first-page":"4601","DOI":"10.1172\/JCI83349","volume":"125","author":"PK Fazeli","year":"2015","unstructured":"Fazeli PK, Lun M, Kim SM, Bredella MA, Wright S, Zhang Y, Lee H, Catana C, Klibanski A, Patwari P, Steinhauser ML (2015) FGF21 and the late adaptive response to starvation in humans. J Clin Invest 125(12):4601\u20134611. https:\/\/doi.org\/10.1172\/JCI83349","journal-title":"J Clin Invest"},{"issue":"2","key":"7142_CR37","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.cmet.2008.06.014","volume":"8","author":"C G\u00e4lman","year":"2008","unstructured":"G\u00e4lman C, Lund\u00e5sen T, Kharitonenkov A, Bina HA, Eriksson M, Hafstr\u00f6m I, Dahlin M, Amark P, Angelin B, Rudling M (2008) The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man. Cell Metab 8(2):169\u2013174. https:\/\/doi.org\/10.1016\/j.cmet.2008.06.014","journal-title":"Cell Metab"},{"issue":"9","key":"7142_CR38","doi-asserted-by":"publisher","first-page":"3594","DOI":"10.1210\/jc.2009-0111","volume":"94","author":"C Christodoulides","year":"2009","unstructured":"Christodoulides C, Dyson P, Sprecher D, Tsintzas K, Karpe F (2009) Circulating fibroblast growth factor 21 is induced by peroxisome proliferator-activated receptor agonists but not ketosis in man. J Clin Endocrinol Metab 94(9):3594\u20133601. https:\/\/doi.org\/10.1210\/jc.2009-0111","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"7142_CR39","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1053\/j.gastro.2010.04.054","volume":"139","author":"J Dushay","year":"2010","unstructured":"Dushay J, Chui PC, Gopalakrishnan GS, Varela-Rey M, Crawley M, Fisher FM, Badman MK, Martinez-Chantar ML, Maratos-Flier E (2010) Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease. Gastroenterology 139(2):456\u2013463. https:\/\/doi.org\/10.1053\/j.gastro.2010.04.054","journal-title":"Gastroenterology"},{"issue":"11","key":"7142_CR40","doi-asserted-by":"publisher","first-page":"2601","DOI":"10.3390\/nu11112601","volume":"11","author":"S Drinda","year":"2019","unstructured":"Drinda S, Grundler F, Neumann T, Lehmann T, Steckhan N, Michalsen A, Wilhelmi de Toledo F (2019) Effects of periodic fasting on fatty liver index\u2014a prospective observational study. Nutrients 11(11):2601. https:\/\/doi.org\/10.3390\/nu11112601","journal-title":"Nutrients"},{"issue":"7","key":"7142_CR41","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1038\/s41591-021-01425-3","volume":"27","author":"SA Harrison","year":"2021","unstructured":"Harrison SA, Ruane PJ, Freilich BL, Neff G, Patil R, Behling CA, Hu C, Fong E, de Temple B, Tillman EJ, Rolph TP, Cheng A, Yale K (2021) Efruxifermin in non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled, phase 2a trial. Nat Med 27(7):1262\u20131271. https:\/\/doi.org\/10.1038\/s41591-021-01425-3","journal-title":"Nat Med"},{"issue":"4","key":"7142_CR42","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/j.cmet.2017.08.019","volume":"26","author":"G Li","year":"2017","unstructured":"Li G, Xie C, Lu S, Nichols RG, Tian Y, Li L, Patel D, Ma Y, Brocker CN, Yan T, Krausz KW, Xiang R, Gavrilova O, Patterson AD, Gonzalez FJ (2017) Intermittent fasting promotes white adipose browning and decreases obesity by shaping the gut microbiota. Cell Metab 26(4):672-685.e4. https:\/\/doi.org\/10.1016\/j.cmet.2017.08.019","journal-title":"Cell Metab"}],"updated-by":[{"DOI":"10.1007\/s11033-022-07342-z","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000}}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-022-07142-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-022-07142-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-022-07142-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T14:17:42Z","timestamp":1650982662000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-022-07142-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,2]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["7142"],"URL":"https:\/\/doi.org\/10.1007\/s11033-022-07142-5","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,2]]},"assertion":[{"value":"15 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2022","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s11033-022-07342-z","URL":"https:\/\/doi.org\/10.1007\/s11033-022-07342-z","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Ethics Review Board competent authority approval was obtained from the Xinxiang Medical University. Animal studies were carried out in accordance with the recommendations in the Guide for Animal Care Committee of Xinxiang Medical University.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}