{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T04:05:52Z","timestamp":1775102752820,"version":"3.50.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1007\/s11033-022-07384-3","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T18:07:42Z","timestamp":1650996462000},"page":"4055-4059","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Possible cytoprotective mechanisms of oxytocin against 5-fluorouracil-induced gastrointestinal mucositis"],"prefix":"10.1007","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1280-6725","authenticated-orcid":false,"given":"Ugochukwu","family":"Chukwunyere","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merve","family":"Mercan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5175-9290","authenticated-orcid":false,"given":"Ahmet Ozer","family":"Sehirli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6609-1505","authenticated-orcid":false,"given":"Nurettin","family":"Abacioglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,4,26]]},"reference":[{"key":"7384_CR1","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1002\/cncr.22484","volume":"109","author":"D Keefe","year":"2007","unstructured":"Keefe D, Schubert M, Elting L et al (2007) Updated clinical practice guidelines for the prevention and treatment of mucositis. Cancer 109:820\u2013831. https:\/\/doi.org\/10.1002\/cncr.22484","journal-title":"Cancer"},{"key":"7384_CR2","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1002\/cncr.20162","volume":"100","author":"ST Sonis","year":"2004","unstructured":"Sonis ST, Elting LS, Keefe D et al (2004) Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 100:1995\u20132025. https:\/\/doi.org\/10.1002\/cncr.20162","journal-title":"Cancer"},{"key":"7384_CR3","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/nrc1318","volume":"4","author":"ST Sonis","year":"2004","unstructured":"Sonis ST (2004) The pathobiology of mucositis. Nat Rev Cancer 4:277\u2013284. https:\/\/doi.org\/10.1038\/nrc1318","journal-title":"Nat Rev Cancer"},{"key":"7384_CR4","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.oraloncology.2019.05.013","volume":"95","author":"A Blakaj","year":"2019","unstructured":"Blakaj A, Bonomi M, Gamez ME, Blakaj DM (2019) Oral mucositis in head and neck cancer: Evidence-based management and review of clinical trial data. Oral Oncol 95:29\u201334. https:\/\/doi.org\/10.1016\/j.oraloncology.2019.05.013","journal-title":"Oral Oncol"},{"key":"7384_CR5","doi-asserted-by":"publisher","unstructured":"Nigro O, Tuzi A, Tartaro T, Giaquinto A, Vallini I, Pinotti G Biological effects of verbascoside and its anti-inflammatory activity on oral mucositis: a review of the literature.Anti-cancer drugs 202031(1):1\u20135. https:\/\/doi.org\/10.1097\/CAD.0000000000000818","DOI":"10.1097\/CAD.0000000000000818"},{"issue":"11","key":"7384_CR6","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1016\/j.molmed.2020.06.006","volume":"26","author":"AR Bourgonje","year":"2020","unstructured":"Bourgonje AR, Feelisch M, Faber KN, Pasch A, Dijkstra G, van Goor H (2020) Oxidative stress and redox-modulating therapeutics in inflammatory bowel disease. Trends Mol Med 26(11):1034\u20131046. https:\/\/doi.org\/10.1016\/j.molmed.2020.06.006","journal-title":"Trends Mol Med"},{"key":"7384_CR7","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1385\/CBB:34:2:237","volume":"34","author":"RJ Reiter","year":"2001","unstructured":"Reiter RJ, Tan DX, Manchester LC, Qi W (2001) Biochemical reactivity of melatonin with reactive oxygen and nitrogen species. A review of the evidence. Cell Biochem Biophys 34:237\u2013256. https:\/\/doi.org\/10.1385\/CBB:34:2:237","journal-title":"Cell Biochem Biophys"},{"issue":"3","key":"7384_CR8","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.peptides.2004.10.005","volume":"26","author":"S \u0130\u015feri","year":"2005","unstructured":"\u0130\u015feri S, \u015eener G, Sa\u011flam B, Gedik N, Ercan F, Ye\u011fen B (2005) Oxytocin ameliorates oxidative colonic inflammation by a neutrophil-dependent mechanism. Peptides 26(3):483\u2013491. https:\/\/doi.org\/10.1016\/j.peptides.2004.10.005","journal-title":"Peptides"},{"key":"7384_CR9","doi-asserted-by":"publisher","first-page":"2911","DOI":"10.4049\/jimmunol.167.5.2911","volume":"167","author":"S Majumdar","year":"2001","unstructured":"Majumdar S, Aggarwal BB (2001) Methotrexate suppresses NF- {kappa}B activation through inhibition of I{kappa}B{alpha} phosphorylation and degradation. J Immunol 167:2911\u20132920. https:\/\/doi.org\/10.4049\/jimmunol.167.5.2911","journal-title":"J Immunol"},{"issue":"3B","key":"7384_CR10","first-page":"2233","volume":"26","author":"M Mencoboni","year":"2006","unstructured":"Mencoboni M, Tredici S, Rebella L, Bergaglio M, Galbusera V, Manzara A, Claudiani F, Malcangi B, Varaldo M (2006) Effect of chemotherapy on somatostatin receptor detection with octreotide scintigraphy in hormone-refractory prostate cancer patients. Anticancer Res 26(3B):2233\u20132235 PMID: 16821593","journal-title":"Anticancer Res"},{"key":"7384_CR11","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1002\/cncr.20162","volume":"100","author":"ST Sonis","year":"2004","unstructured":"Sonis ST, Elting LS, Keefe D, Peterson DE, Schubert M, Hauer- Jensen M, Bekele BN, Raber-Durlacher J, Donnelly JP, Rubenstein EB (2004) Mucositis Study Section of the Multinational Association for Supportive Care in Cancer; International Society for Oral Oncology. Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 100:1995\u20132025. https:\/\/doi.org\/10.1002\/cncr.20162","journal-title":"Cancer"},{"issue":"2","key":"7384_CR12","doi-asserted-by":"publisher","first-page":"G231","DOI":"10.1152\/ajpgi.00204.2017","volume":"314","author":"PT Sangild","year":"2018","unstructured":"Sangild PT, Shen RL, Pontoppidan P, Rathe M (2018) Animal models of chemotherapy-induced mucositis: translational relevance and challenges. Am J Physiol Gastrointest Liver Physiol 314(2):G231\u2013G246. https:\/\/doi.org\/10.1152\/ajpgi.00204.2017","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"5","key":"7384_CR13","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/nrc1074","volume":"3","author":"DB Longley","year":"2003","unstructured":"Longley DB, Harkin DP, Johnston PG (2003) 5-Fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer 3(5):330\u2013338. https:\/\/doi.org\/10.1038\/nrc1074","journal-title":"Nat Rev Cancer"},{"issue":"2","key":"7384_CR14","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s00280-008-0732-8","volume":"63","author":"RM Logan","year":"2009","unstructured":"Logan RM, Stringer AM, Bowen JM, Gibson RJ, Sonis ST, Keefe DM (2009) Is the pathobiology of chemotherapy-induced alimentary tract mucositis influenced by the type of mucotoxic drug administered? Cancer Chemother Pharmacol 63(2):239\u2013251. https:\/\/doi.org\/10.1007\/s00280-008-0732-8","journal-title":"Cancer Chemother Pharmacol"},{"key":"7384_CR15","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.ctrv.2007.03.001","volume":"33","author":"RM Logan","year":"2007","unstructured":"Logan RM, Stringer AM, Bowen JM et al (2007) The role of pro- inflammatory cytokines in cancer treatment-induced alimentary tract mucositis: pathobiology, animal models and cytotoxic drugs. Cancer Treat Rev 33:448\u2013460. https:\/\/doi.org\/10.1016\/j.ctrv.2007.03.001","journal-title":"Cancer Treat Rev"},{"key":"7384_CR16","doi-asserted-by":"publisher","first-page":"322","DOI":"10.15430\/jcp.2013.18.4.322","volume":"18","author":"M-K Song","year":"2013","unstructured":"Song M-K, Park M-Y (2013) 5-Fluorouracil-Induced Changes of Intestinal Integrity Biomarkers in BALB\/C Mice. J Cancer Prev 18:322\u2013329. https:\/\/doi.org\/10.15430\/jcp.2013.18.4.322","journal-title":"J Cancer Prev"},{"key":"7384_CR17","doi-asserted-by":"publisher","first-page":"G1133","DOI":"10.1152\/ajpgi.00535.2011","volume":"302","author":"M Yasuda","year":"2012","unstructured":"Yasuda M, Kato S, Yamanaka N, Iimori M, Utsumi D, Kita- hara Y et al (2012) Potential role of the NADPH oxidase NOX1 in the pathogenesis of 5-fluorouracil-induced intestinal mucositis in mice. Am J Physiol Gastrointest Liver Physiol 302:G1133\u2013G1142. https:\/\/doi.org\/10.1152\/ajpgi.00535.2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"7384_CR18","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.ejphar.2016.02.008","volume":"774","author":"S Khan","year":"2016","unstructured":"Khan S, Choi RJ, Lee J, Kim YS (2016) Attenuation of neuropathic pain and neu- roinflammatory responses by a pyranocoumarin derivative, anomalin in animal and cellular models. Eur J Pharmacol 774:95\u2013104. https:\/\/doi.org\/10.1016\/j.ejphar.2016.02.008","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"7384_CR19","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s00280-008-0715-9","volume":"63","author":"PM Soares","year":"2008","unstructured":"Soares PM, Mota JM, Gomes AS, Oliveira RB, Assreuy AM, Brito GA, Santos AA, Ribeiro RA, Souza MH (2008) Gastrointestinal dysmotility in 5-fluorouracil-induced intestinal mucositis outlasts inflammatory process resolution. Cancer Chemother Pharmacol 63(1):91\u201398. https:\/\/doi.org\/10.1007\/s00280-008-0715-9","journal-title":"Cancer Chemother Pharmacol"},{"issue":"6","key":"7384_CR20","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1016\/j.cell.2012.01.035","volume":"148","author":"JC Clemente","year":"2012","unstructured":"Clemente JC, Ursell LK, Parfrey LW, Knight R (2012) The impact of the gut microbiota on human health: an integrative view. Cell 148(6):1258\u20131270. https:\/\/doi.org\/10.1016\/j.cell.2012.01.035","journal-title":"Cell"},{"key":"7384_CR21","doi-asserted-by":"publisher","first-page":"223","DOI":"10.3389\/fimmu.2015.00223","volume":"6","author":"K de Punder","year":"2015","unstructured":"de Punder K, Pruimboom L (2015) Stress induces endotoxemia and low-grade inflammation by increasing barrier permeability. Front Immunol 6:223. https:\/\/doi.org\/10.3389\/fimmu.2015.00223","journal-title":"Front Immunol"},{"key":"7384_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2017.03.001","author":"JA Foster","year":"2017","unstructured":"Foster JA, Rinaman L, Cryan JF (2017) Stress & the gut-brain axis: regulation by the microbiome. Neurobiol. https:\/\/doi.org\/10.1016\/j.ynstr.2017.03.001. 7:124 \u2013 36"},{"key":"7384_CR23","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.3389\/fpsyg.2021.617814","volume":"12","author":"P Grahn","year":"2021","unstructured":"Grahn P, Ottosson J, Uvn\u00e4s-Moberg K (2021) The Oxytocinergic System as a Mediator of Anti-stress and Instorative Effects Induced by Nature: The Calm and Connection Theory. Front Psychol 12:2425. https:\/\/doi.org\/10.3389\/fpsyg.2021.617814","journal-title":"Front Psychol"},{"issue":"19","key":"7384_CR24","doi-asserted-by":"publisher","first-page":"10250","DOI":"10.3390\/ijms221910250","volume":"22","author":"M Friuli","year":"2021","unstructured":"Friuli M, Eramo B, Valenza M, Scuderi C, Provensi G, Romano A (2021) Targeting the Oxytocinergic System: A Possible Pharmacological Strategy for the Treatment of Inflammation Occurring in Different Chronic Diseases. Int J Mol Sci 22(19):10250. https:\/\/dx.doi.org\/10.3390%2Fijms221910250","journal-title":"Int J Mol Sci"},{"key":"7384_CR25","doi-asserted-by":"publisher","first-page":"11731","DOI":"10.1038\/srep11731","volume":"5","author":"D Chen","year":"2015","unstructured":"Chen D, Zhao J, Wang H et al (2015) Oxytocin evokes a pulsatile PGE2 release from ileum mucosa and is required for repair of intestinal epithelium after injury. Sci Rep 5:11731. https:\/\/doi.org\/10.1038\/srep11731","journal-title":"Sci Rep"},{"key":"7384_CR26","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1007\/s12035-013-8597-1","volume":"49","author":"CC Lin","year":"2014","unstructured":"Lin CC et al (2014) Upregulation of COX-2\/PGE2 by ET-1 mediated through Ca2+-dependent signals in mouse brain microvascular endothelial cells. Mol Neurobiol 49:1256\u20131269. https:\/\/doi.org\/10.1007\/s12035-013-8597-1","journal-title":"Mol Neurobiol"},{"issue":"10","key":"7384_CR27","doi-asserted-by":"publisher","first-page":"e26816","DOI":"10.1371\/journal.pone.0026816","volume":"6","author":"LT Olsen Hult","year":"2011","unstructured":"Olsen Hult LT, Kleiveland CR, Fosnes K, Jacobsen M, Lea T (2011) EP receptor expression in human intestinal epithelium and localization relative to the stem cell zone of the crypts. PLoS ONE 6(10):e26816. https:\/\/doi.org\/10.1371\/journal.pone.0026816","journal-title":"PLoS ONE"},{"key":"7384_CR28","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.prostaglandins.2014.10.002","volume":"116","author":"DC Montrose","year":"2015","unstructured":"Montrose DC, Nakanishi M, Murphy RC, Zarini S, McAleer JP, Vella AT, Rosenberg DW (2015) The role of PGE2 in intestinal inflammation and tumorigenesis. Prostaglandins Other Lipid Mediat 116:26\u201336. https:\/\/doi.org\/10.1016\/j.prostaglandins.2014.10.002","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"7384_CR29","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.coemr.2021.04.006","volume":"19","author":"E Susan","year":"2021","unstructured":"Susan E, Erdman (2021) Oxytocin and the microbiome. Curr Opin Endocr Metab Res 19:8\u201314. https:\/\/doi.org\/10.1016\/j.coemr.2021.04.006","journal-title":"Curr Opin Endocr Metab Res"},{"issue":"10","key":"7384_CR30","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/nrn3346","volume":"13","author":"JF Cryan","year":"2012","unstructured":"Cryan JF, Dinan TG (2012) Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci 13(10):701\u2013712. https:\/\/doi.org\/10.1038\/nrn3346","journal-title":"Nat Rev Neurosci"},{"issue":"10","key":"7384_CR31","doi-asserted-by":"publisher","first-page":"e78898","DOI":"10.1371\/journal.pone.0078898","volume":"8","author":"T Poutahidis","year":"2013","unstructured":"Poutahidis T, Kearney SM, Levkovich T, Qi P, Varian BJ et al (2013) Microbial Symbionts Accelerate Wound Healing via the Neuropeptide Hormone Oxytocin. PLoS ONE 8(10):e78898. https:\/\/doi.org\/10.1371\/journal.pone.0078898","journal-title":"PLoS ONE"},{"issue":"6","key":"7384_CR32","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1007\/pl00005227","volume":"357","author":"M Petersson","year":"1998","unstructured":"Petersson M, Lundeberg T, Sohlstr\u00f6m A, Wiberg U, Uvn\u00e4s-Moberg K (1998) Oxytocin increases the survival of musculocutaneous flaps. Naunyn-Schmiedeberg\u2019s Arch Pharmacol 357(6):701\u2013704. https:\/\/doi.org\/10.1007\/pl00005227","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"},{"issue":"54","key":"7384_CR33","doi-asserted-by":"publisher","first-page":"92955","DOI":"10.18632\/oncotarget.21696","volume":"8","author":"P-F Xu","year":"2017","unstructured":"Xu P-F, Fang M-J, Jin Y-Z, Wang L-S, Lin D-S (2017) Effect of oxytocin on the survival of random skin flaps. Oncotarget 8(54):92955\u201392965. https:\/\/doi.org\/10.18632\/oncotarget.21696","journal-title":"Oncotarget"},{"key":"7384_CR34","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s12905-020-00935-5","volume":"20","author":"I Zohrabi","year":"2020","unstructured":"Zohrabi I, Abedi P, Ansari S, Maraghi E, Maram NS, Houshmand G (2020) The effect of oxytocin vaginal gel on vaginal atrophy in postmenopausal women: a randomized controlled trial. BMC Womens Health 20:108. https:\/\/doi.org\/10.1186\/s12905-020-00935-5","journal-title":"BMC Womens Health"},{"issue":"1","key":"7384_CR35","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1080\/01616412.2016.1249630","volume":"39","author":"O Erbas","year":"2017","unstructured":"Erbas O, Ta\u015fk\u0131ran D, Oltulu F, Yava\u015fo\u011flu A, Bora S, Bilge O, \u00c7\u0131nar BP, Peker G (2017) Oxytocin provides protection against diabetic polyneuropathy in rats. Neurol Res 39(1):45\u201353. https:\/\/doi.org\/10.1080\/01616412.2016.1249630","journal-title":"Neurol Res"},{"issue":"6","key":"7384_CR36","first-page":"488","volume":"22","author":"M Asad","year":"2001","unstructured":"Asad M, Shewade DG, Koumaravelou K, Abraham BK, Vasu S, Ramaswamy S (2001) Effect of centrally administered oxytocin on gastric and duodenal ulcers in rats. Acta Pharmacol Sin 22(6):488\u2013492 PMID: 11747752","journal-title":"Acta Pharmacol Sin"},{"key":"7384_CR37","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.peptides.2018.07.007","volume":"107","author":"V Khori","year":"2018","unstructured":"Khori V, Alizadeh AM, Khalighfard S, Heidarian Y, Khodayari H (2018) Oxytocin effects on the inhibition of the NF-\u03baB\/miR195 pathway in mice breast cancer. Peptides 107:54\u201360. https:\/\/doi.org\/10.1016\/j.peptides.2018.07.007","journal-title":"Peptides"},{"issue":"9","key":"7384_CR38","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1016\/S0196-9781(01)00469-7","volume":"22","author":"M Petersson","year":"2001","unstructured":"Petersson M, Wiberg U, Lundeberg T, Uvn\u00e4s-Moberg K (2001) Oxytocin decreases carrageenan induced inflammation in rats. Peptides 22(9):1479\u20131484. https:\/\/doi.org\/10.1016\/S0196-9781(01)00469-7","journal-title":"Peptides"},{"issue":"3","key":"7384_CR39","doi-asserted-by":"publisher","first-page":"E686","DOI":"10.1152\/ajpendo.90263.2008.0193","volume":"295","author":"M Clodi","year":"2008","unstructured":"Clodi M, Vila G, Geyeregger R, Riedl M, Stulnig TM, Struck J, Luger TA, Luger A (2008) Oxytocin alleviates the neuroendocrine and cytokine response to bacterial endotoxin in healthy men. Am J Physiol Endocrinol Metab 295(3):E686\u2013E691. https:\/\/doi.org\/10.1152\/ajpendo.90263.2008.0193","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"7384_CR40","doi-asserted-by":"publisher","first-page":"E1495","DOI":"10.1152\/ajpendo.90718.2008","volume":"295","author":"A Szeto","year":"2008","unstructured":"Szeto A, Nation DA, Mendez AJ, Dominguez-Bendala J, Brooks LG, Schneiderman N, McCabe PM (2008) Oxytocin attenuates NADPH-dependent superoxide activity and IL-6 secretion in macrophages and vascular cells. Am J Physiol Endocrinol Metab 295:E1495\u2013E1501. https:\/\/doi.org\/10.1152\/ajpendo.90718.2008","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"7384_CR41","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1046\/j.1365-3083.2000.00623.x","volume":"51","author":"S Sasaki","year":"2000","unstructured":"Sasaki S, Hirata I, Maemura K, Hamamoto N, Murano M, Toshina K et al (2000) Prostaglandin E2 inhibits lesion formation in dextran sodium sulphate-induced colitis in rats and reduces the level of mucosal inflammatory cytokines. Scand J Immunol 51:23\u201328. https:\/\/doi.org\/10.1046\/j.1365-3083.2000.00623.x","journal-title":"Scand J Immunol"},{"issue":"1","key":"7384_CR42","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1164\/rccm.202005-1906ED","volume":"202","author":"RA Alvarez","year":"2020","unstructured":"Alvarez RA, Berra L, Gladwin MT (2020) Home nitric oxide therapy for COVID-19. Am J Respir Crit Care Med 202(1):16\u201320. https:\/\/doi.org\/10.1164\/rccm.202005-1906ED","journal-title":"Am J Respir Crit Care Med"},{"key":"7384_CR43","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/s42003-020-0799-2","volume":"3","author":"Y Yamamoto","year":"2020","unstructured":"Yamamoto Y, Higashida H (2020) RAGE regulates oxytocin transport into the brain. Commun Biol 3:70. https:\/\/doi.org\/10.1038\/s42003-020-0799-2","journal-title":"Commun Biol"},{"key":"7384_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.psyneuen.2017.01.010","volume":"78","author":"S Bernaerts","year":"2017","unstructured":"Bernaerts S, Prinsen J, Berra E, Bosmans G, Steyaert J, Alaerts K (2017) Long-term oxytocin administration enhances the experience of attachment. Psychoneuroendocrinology 78:1\u20139. https:\/\/doi.org\/10.1016\/j.psyneuen.2017.01.010","journal-title":"Psychoneuroendocrinology"},{"issue":"3","key":"7384_CR45","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/pcn.12627","volume":"72","author":"Q Cai","year":"2018","unstructured":"Cai Q, Feng L, Yap KZ (2018) Systematic review and meta-analysis of reported adverse events of long\u2010term intranasal oxytocin treatment for autism spectrum disorder. Psychiatry Clin Neurosci 72(3):140\u2013151. https:\/\/doi.org\/10.1111\/pcn.12627","journal-title":"Psychiatry Clin Neurosci"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-022-07384-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-022-07384-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-022-07384-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T20:28:47Z","timestamp":1654633727000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-022-07384-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,26]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["7384"],"URL":"https:\/\/doi.org\/10.1007\/s11033-022-07384-3","relation":{"references":[{"id-type":"uri","id":"","asserted-by":"subject"}]},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,26]]},"assertion":[{"value":"3 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 March 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"We declare that this manuscript is original, has not been published before and is not currently being considered for publication elsewhere.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statements & Declarations"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The Authors declare that there is no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration of Conflicting Interests"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}