{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T01:14:57Z","timestamp":1770340497885,"version":"3.49.0"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science & Engineering Research Board","doi-asserted-by":"crossref","award":["CRG\/2019\/001352"],"award-info":[{"award-number":["CRG\/2019\/001352"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1007\/s11033-022-07904-1","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T21:03:01Z","timestamp":1668718981000},"page":"1931-1941","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Multifaceted roles of MAGOH Proteins"],"prefix":"10.1007","volume":"50","author":[{"given":"Rumela","family":"Mitra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayushi","family":"Rehman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kusum Kumari","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5955-1371","authenticated-orcid":false,"given":"Bithiah Grace","family":"Jaganathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,11,17]]},"reference":[{"issue":"22","key":"7904_CR1","doi-asserted-by":"publisher","first-page":"6424","DOI":"10.1093\/emboj\/20.22.6424","volume":"20","author":"N Kataoka","year":"2001","unstructured":"Kataoka N et al (2001) Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon\u2013exon junction complex. Embo j 20(22):6424\u20136433","journal-title":"Embo j"},{"issue":"11","key":"7904_CR2","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/S0960-9822(03)00328-2","volume":"13","author":"CK Lau","year":"2003","unstructured":"Lau CK et al (2003) Structure of the Y14-Magoh core of the exon junction complex. Curr Biol 13(11):933\u2013941","journal-title":"Curr Biol"},{"issue":"12","key":"7904_CR3","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1093\/embo-reports\/kve245","volume":"2","author":"H Le Hir","year":"2001","unstructured":"Le Hir H et al (2001) The protein Mago provides a link between splicing and mRNA localization. EMBO Rep 2(12):1119\u20131124","journal-title":"EMBO Rep"},{"issue":"24","key":"7904_CR4","doi-asserted-by":"publisher","first-page":"6860","DOI":"10.1093\/emboj\/19.24.6860","volume":"19","author":"H Le Hir","year":"2000","unstructured":"Le Hir H et al (2000) The spliceosome deposits multiple proteins 20\u201324 nucleotides upstream of mRNA exon\u2013exon junctions. EMBO J 19(24):6860\u20136869","journal-title":"EMBO J"},{"issue":"9","key":"7904_CR5","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1101\/gad.14.9.1098","volume":"14","author":"H Le Hir","year":"2000","unstructured":"Le Hir H, Moore MJ, Maquat LE (2000) Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon\u2013exon junctions. Genes and development 14(9):1098\u20131108","journal-title":"Genes and development"},{"issue":"1","key":"7904_CR6","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1006\/geno.1999.6064","volume":"63","author":"XF Zhao","year":"2000","unstructured":"Zhao XF et al (2000) MAGOH interacts with a novel RNA-binding protein. Genomics 63(1):145\u2013148","journal-title":"Genomics"},{"issue":"5795","key":"7904_CR7","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.1126\/science.1131981","volume":"313","author":"CB Andersen","year":"2006","unstructured":"Andersen CB et al (2006) Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA. Science 313(5795):1968\u20131972","journal-title":"Science"},{"issue":"10","key":"7904_CR8","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1038\/nsmb990","volume":"12","author":"L Ballut","year":"2005","unstructured":"Ballut L et al (2005) The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity. Nat Struct Mol biology 12(10):861\u2013869","journal-title":"Nat Struct Mol biology"},{"issue":"4","key":"7904_CR9","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.cell.2006.08.006","volume":"126","author":"F Bono","year":"2006","unstructured":"Bono F et al (2006) The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA. Cell 126(4):713\u2013725","journal-title":"Cell"},{"issue":"3","key":"7904_CR10","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/sj.embor.7400091","volume":"5","author":"F Bono","year":"2004","unstructured":"Bono F et al (2004) Molecular insights into the interaction of PYM with the Mago\u2013Y14 core of the exon junction complex. EMBO Rep 5(3):304\u2013310","journal-title":"EMBO Rep"},{"issue":"16","key":"7904_CR11","doi-asserted-by":"publisher","first-page":"2774","DOI":"10.1242\/jcs.009225","volume":"120","author":"A Baguet","year":"2007","unstructured":"Baguet A et al (2007) The exon-junction-complex-component metastatic lymph node 51 functions in stress-granule assembly. J Cell Sci 120(16):2774\u20132784","journal-title":"J Cell Sci"},{"issue":"32","key":"7904_CR12","doi-asserted-by":"publisher","first-page":"33702","DOI":"10.1074\/jbc.M402754200","volume":"279","author":"S Degot","year":"2004","unstructured":"Degot S et al (2004) Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module. J Biol Chem 279(32):33702\u201333715","journal-title":"J Biol Chem"},{"issue":"1","key":"7904_CR13","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1261\/rna.058826.116","volume":"23","author":"H Mao","year":"2017","unstructured":"Mao H, Brown HE, Silver DL (2017) Mouse models of Casc3 reveal developmental functions distinct from other components of the exon junction complex. RNA 23(1):23\u201331","journal-title":"RNA"},{"issue":"2","key":"7904_CR14","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1101\/gad.1163204","volume":"18","author":"A Nott","year":"2004","unstructured":"Nott A, Le Hir H, Moore MJ (2004) Splicing enhances translation in mammalian cells: an additional function of the exon junction complex. Genes Dev 18(2):210\u2013222","journal-title":"Genes Dev"},{"issue":"8","key":"7904_CR15","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.3390\/ijms17081153","volume":"17","author":"K Fukumura","year":"2016","unstructured":"Fukumura K et al (2016) The exon junction complex controls the efficient and faithful splicing of a subset of transcripts involved in mitotic cell-cycle progression. Int J Mol Sci 17(8):1153","journal-title":"Int J Mol Sci"},{"issue":"5","key":"7904_CR16","doi-asserted-by":"publisher","first-page":"e1009563","DOI":"10.1371\/journal.pgen.1009563","volume":"17","author":"B Joseph","year":"2021","unstructured":"Joseph B, Lai EC (2021) The Exon Junction Complex and intron removal prevent re-splicing of mRNA. PLoS Genet 17(5):e1009563","journal-title":"PLoS Genet"},{"issue":"1","key":"7904_CR17","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s00418-013-1135-4","volume":"141","author":"Y Ishigaki","year":"2014","unstructured":"Ishigaki Y et al (2014) RNA-binding protein RBM8A (Y14) and MAGOH localize to centrosome in human A549 cells. Histochem Cell Biol 141(1):101\u2013109","journal-title":"Histochem Cell Biol"},{"issue":"1","key":"7904_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-021-21590-w","volume":"12","author":"OS Kwon","year":"2021","unstructured":"Kwon OS et al (2021) Exon junction complex dependent mRNA localization is linked to centrosome organization during ciliogenesis. Nat Commun 12(1):1\u201316","journal-title":"Nat Commun"},{"issue":"9","key":"7904_CR19","doi-asserted-by":"publisher","first-page":"e1006282","DOI":"10.1371\/journal.pgen.1006282","volume":"12","author":"H Mao","year":"2016","unstructured":"Mao H et al (2016) Haploinsufficiency for core exon junction complex components disrupts embryonic neurogenesis and causes p53-mediated microcephaly. PLoS Genet 12(9):e1006282","journal-title":"PLoS Genet"},{"issue":"8","key":"7904_CR20","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.4161\/rna.25827","volume":"10","author":"KK Singh","year":"2013","unstructured":"Singh KK et al (2013) Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay. RNA Biol 10(8):1291\u20131298","journal-title":"RNA Biol"},{"issue":"7","key":"7904_CR21","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1038\/s41588-018-0155-3","volume":"50","author":"SR Viswanathan","year":"2018","unstructured":"Viswanathan SR et al (2018) Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer. Nat Genet 50(7):937\u2013943","journal-title":"Nat Genet"},{"issue":"1","key":"7904_CR22","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.bbrc.2009.02.127","volume":"382","author":"R Muromoto","year":"2009","unstructured":"Muromoto R et al (2009) The exon-junction complex proteins, Y14 and MAGOH regulate STAT3 activation. Biochem Biophys Res Commun 382(1):63\u201368","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"7904_CR23","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1242\/dev.113.1.373","volume":"113","author":"RE Boswell","year":"1991","unstructured":"Boswell RE, Prout ME, Steichen JC (1991) Mutations in a newly identified Drosophila melanogaster gene, mago nashi, disrupt germ cell formation and result in the formation of mirror-image symmetrical double abdomen embryos. Development 113(1):373\u2013384","journal-title":"Development"},{"issue":"5","key":"7904_CR24","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1242\/dev.120.5.1303","volume":"120","author":"PA Newmark","year":"1994","unstructured":"Newmark PA, Boswell RE (1994) The mago nashi locus encodes an essential product required for germ plasm assembly in Drosophila. Development 120(5):1303\u20131313","journal-title":"Development"},{"issue":"6385","key":"7904_CR25","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/358387a0","volume":"358","author":"A Ephrussi","year":"1992","unstructured":"Ephrussi A, Lehmann R (1992) Induction of germ cell formation by oskar. Nature 358(6385):387\u2013392","journal-title":"Nature"},{"issue":"1","key":"7904_CR26","doi-asserted-by":"publisher","first-page":"15","DOI":"10.4161\/fly.3.1.7751","volume":"3","author":"J-M Kugler","year":"2009","unstructured":"Kugler J-M, Lasko P (2009) Localization, anchoring and translational control of oskar, gurken, bicoid and nanos mRNA during Drosophila oogenesis. Fly 3(1):15\u201328","journal-title":"Fly"},{"issue":"7","key":"7904_CR27","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/S0960-9822(06)00218-1","volume":"7","author":"DR Micklem","year":"1997","unstructured":"Micklem DR et al (1997) The mago nashi gene is required for the polarisation of the oocyte and the formation of perpendicular axes in Drosophila. Curr Biol 7(7):468\u2013478","journal-title":"Curr Biol"},{"issue":"2","key":"7904_CR28","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1006\/geno.1997.5126","volume":"47","author":"XF Zhao","year":"1998","unstructured":"Zhao XF et al (1998) The mammalian homologue of mago nashi encodes a serum-inducible protein. Genomics 47(2):319\u2013322","journal-title":"Genomics"},{"issue":"8","key":"7904_CR29","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1101\/gad.260403","volume":"17","author":"H Shi","year":"2003","unstructured":"Shi H, Xu RM (2003) Crystal structure of the Drosophila Mago nashi-Y14 complex. Genes Dev 17(8):971\u2013976","journal-title":"Genes Dev"},{"issue":"6","key":"7904_CR30","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/nsb926","volume":"10","author":"S Fribourg","year":"2003","unstructured":"Fribourg S et al (2003) A novel mode of RBD-protein recognition in the Y14-Mago complex. Nat Struct Biol 10(6):433\u2013439","journal-title":"Nat Struct Biol"},{"issue":"1","key":"7904_CR31","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1756-8935-2-5","volume":"2","author":"S Glaser","year":"2009","unstructured":"Glaser S et al (2009) The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis. Epigenetics Chromatin 2(1):5","journal-title":"Epigenetics Chromatin"},{"issue":"5","key":"7904_CR32","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/nn.2527","volume":"13","author":"DL Silver","year":"2010","unstructured":"Silver DL et al (2010) The exon junction complex component Magoh controls brain size by regulating neural stem cell division. Nat Neurosci 13(5):551\u2013558","journal-title":"Nat Neurosci"},{"key":"7904_CR33","doi-asserted-by":"publisher","first-page":"101214","DOI":"10.1016\/j.genrep.2021.101214","volume":"24","author":"A Rehman","year":"2021","unstructured":"Rehman A, Chandra P, Singh KK (2021) The MAGOH paralogs - MAGOH, MAGOHB and their multiple isoforms. Gene Rep 24:101214","journal-title":"Gene Rep"},{"issue":"7","key":"7904_CR34","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1128\/MCB.01721-12","volume":"33","author":"V Ladopoulos","year":"2013","unstructured":"Ladopoulos V et al (2013) The histone methyltransferase KMT2B is required for RNA polymerase II association and protection from DNA methylation at the MagohB CpG island promoter. Mol Cell Biol 33(7):1383\u20131393","journal-title":"Mol Cell Biol"},{"issue":"10","key":"7904_CR35","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1038\/nsmb.2380","volume":"19","author":"I Barbosa","year":"2012","unstructured":"Barbosa I et al (2012) Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly. Nat Struct Mol Biol 19(10):983\u2013990","journal-title":"Nat Struct Mol Biol"},{"issue":"3","key":"7904_CR36","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.celrep.2012.08.017","volume":"2","author":"AL Steckelberg","year":"2012","unstructured":"Steckelberg AL et al (2012) CWC22 connects pre-mRNA splicing and exon junction complex assembly. Cell Rep 2(3):454\u2013461","journal-title":"Cell Rep"},{"issue":"3","key":"7904_CR37","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.molcel.2018.08.030","volume":"72","author":"V Boehm","year":"2018","unstructured":"Boehm V et al (2018) Exon Junction Complexes Suppress Spurious Splice Sites to Safeguard Transcriptome Integrity. Mol Cell 72(3):482\u2013495e7","journal-title":"Mol Cell"},{"issue":"2","key":"7904_CR38","first-page":"213","volume":"133","author":"H Le Hir","year":"2008","unstructured":"Le Hir H, S\u00e9raphin B (2008) EJCs at the heart of translational control Cell 133(2):213\u2013216","journal-title":"EJCs at the heart of translational control Cell"},{"issue":"2","key":"7904_CR39","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1002\/bab.1915","volume":"68","author":"EF Mufarrege","year":"2021","unstructured":"Mufarrege EF et al (2021) Development of Magoh protein-overexpressing HEK cells for optimized therapeutic protein production. Biotechnol Appl Biochem 68(2):230\u2013238","journal-title":"Biotechnol Appl Biochem"},{"issue":"7","key":"7904_CR40","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1038\/s41580-019-0126-2","volume":"20","author":"T Kurosaki","year":"2019","unstructured":"Kurosaki T, Popp MW, Maquat LE (2019) Quality and quantity control of gene expression by nonsense-mediated mRNA decay. Nat Rev Mol Cell Biol 20(7):406\u2013420","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"7904_CR41","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1007\/s00018-009-0177-1","volume":"67","author":"P Nicholson","year":"2010","unstructured":"Nicholson P et al (2010) Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors. Cell Mol Life Sci 67(5):677\u2013700","journal-title":"Cell Mol Life Sci"},{"issue":"2","key":"7904_CR42","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1101\/gad.1382806","volume":"20","author":"Q Pan","year":"2006","unstructured":"Pan Q et al (2006) Quantitative microarray profiling provides evidence against widespread coupling of alternative splicing with nonsense-mediated mRNA decay to control gene expression. Genes Dev 20(2):153\u2013158","journal-title":"Genes Dev"},{"issue":"7","key":"7904_CR43","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1016\/S0092-8674(00)00214-2","volume":"103","author":"J Lykke-Andersen","year":"2000","unstructured":"Lykke-Andersen J, Shu MD, Steitz JA (2000) Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. Cell 103(7):1121\u20131131","journal-title":"Cell"},{"issue":"1","key":"7904_CR44","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.molcel.2005.08.012","volume":"20","author":"NH Gehring","year":"2005","unstructured":"Gehring NH et al (2005) Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements. Mol Cell 20(1):65\u201375","journal-title":"Mol Cell"},{"issue":"12","key":"7904_CR45","doi-asserted-by":"publisher","first-page":"3484","DOI":"10.1093\/emboj\/17.12.3484","volume":"17","author":"R Thermann","year":"1998","unstructured":"Thermann R et al (1998) Binary specification of nonsense codons by splicing and cytoplasmic translation. Embo j 17(12):3484\u20133494","journal-title":"Embo j"},{"issue":"6","key":"7904_CR46","doi-asserted-by":"publisher","first-page":"e1008830","DOI":"10.1371\/journal.pgen.1008830","volume":"16","author":"P Gangras","year":"2020","unstructured":"Gangras P et al (2020) Zebrafish rbm8a and magoh mutants reveal EJC developmental functions and new 3\u2019UTR intron-containing NMD targets. PLoS Genet 16(6):e1008830","journal-title":"PLoS Genet"},{"issue":"6","key":"7904_CR47","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.conb.2013.08.001","volume":"23","author":"O Reiner","year":"2013","unstructured":"Reiner O, Sapir T (2013) LIS1 functions in normal development and disease. Curr Opin Neurobiol 23(6):951\u2013956","journal-title":"Curr Opin Neurobiol"},{"key":"7904_CR48","doi-asserted-by":"crossref","unstructured":"Sheehan CJ et al (2020) Dosage-dependent requirements of Magoh for cortical interneuron generation and survival.Development, 147(1)","DOI":"10.1242\/dev.182295"},{"key":"7904_CR49","unstructured":"Gra\u00f1a X, Reddy EPJO (1995) Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). 11:211\u20132202"},{"issue":"1","key":"7904_CR50","first-page":"126","volume":"59","author":"A Obaya","year":"2002","unstructured":"Obaya A, Sedivy JMJC, CMLS MLS (2002) Regul cyclin-Cdk activity mammalian cells 59(1):126\u2013142","journal-title":"Regul cyclin-Cdk activity mammalian cells"},{"issue":"2","key":"7904_CR51","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1111\/j.1365-2443.2010.01479.x","volume":"16","author":"M Inaki","year":"2011","unstructured":"Inaki M et al (2011) Genetic analyses using a mouse cell cycle mutant identifies magoh as a novel gene involved in Cdk regulation. Genes Cells 16(2):166\u2013178","journal-title":"Genes Cells"},{"issue":"2","key":"7904_CR52","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.ydbio.2013.01.004","volume":"375","author":"DL Silver","year":"2013","unstructured":"Silver DL et al (2013) The EJC component Magoh regulates proliferation and expansion of neural crest-derived melanocytes. Dev Biol 375(2):172\u2013181","journal-title":"Dev Biol"},{"issue":"4","key":"7904_CR53","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1056\/NEJM199601253340404","volume":"334","author":"H Caron","year":"1996","unstructured":"Caron H et al (1996) Allelic loss of chromosome 1p as a predictor of unfavorable outcome in patients with neuroblastoma. N Engl J Med 334(4):225\u2013230","journal-title":"N Engl J Med"},{"issue":"6","key":"7904_CR54","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1097\/PAI.0b013e3181a2c6a4","volume":"17","author":"D Kaneshiro","year":"2009","unstructured":"Kaneshiro D et al (2009) Chromosome 1p and 19q deletions in glioblastoma multiforme. Appl Immunohistochem Mol Morphology 17(6):512\u2013516","journal-title":"Appl Immunohistochem Mol Morphology"},{"issue":"14","key":"7904_CR55","doi-asserted-by":"publisher","first-page":"3685","DOI":"10.1093\/emboj\/20.14.3685","volume":"20","author":"JM Mingot","year":"2001","unstructured":"Mingot JM et al (2001) Importin 13: a novel mediator of nuclear import and export. Embo j 20(14):3685\u20133694","journal-title":"Embo j"},{"key":"7904_CR56","doi-asserted-by":"publisher","first-page":"12723","DOI":"10.2147\/OTT.S263913","volume":"13","author":"Y Zhou","year":"2020","unstructured":"Zhou Y et al (2020) MAGOH\/MAGOHB Inhibits the Tumorigenesis of Gastric Cancer via Inactivation of b-RAF\/MEK\/ERK Signaling. Onco Targets Ther 13:12723\u201312735","journal-title":"Onco Targets Ther"},{"issue":"2","key":"7904_CR57","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1002\/1878-0261.12602","volume":"14","author":"H Toda","year":"2020","unstructured":"Toda H et al (2020) RNA-sequence-based microRNA expression signature in breast cancer: tumor-suppressive miR-101-5p regulates molecular pathogenesis. Mol Oncol 14(2):426\u2013446","journal-title":"Mol Oncol"},{"issue":"3","key":"7904_CR58","doi-asserted-by":"publisher","first-page":"e1006589","DOI":"10.1371\/journal.pgen.1006589","volume":"13","author":"TP Stricker","year":"2017","unstructured":"Stricker TP et al (2017) Robust stratification of breast cancer subtypes using differential patterns of transcript isoform expression. PLoS Genet 13(3):e1006589","journal-title":"PLoS Genet"},{"issue":"12","key":"7904_CR59","doi-asserted-by":"publisher","first-page":"6519","DOI":"10.3390\/ijms22126519","volume":"22","author":"Y Otani","year":"2021","unstructured":"Otani Y et al (2021) The Exon Junction Complex Core Represses Cancer-Specific Mature mRNA Re-splicing: A Potential Key Role in Terminating Splicing. Int J Mol Sci 22(12):6519","journal-title":"Int J Mol Sci"},{"issue":"9","key":"7904_CR60","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1172\/JCI0215617","volume":"109","author":"J Bromberg","year":"2002","unstructured":"Bromberg J (2002) Stat proteins and oncogenesis. J Clin Invest 109(9):1139\u20131142","journal-title":"J Clin Invest"},{"key":"7904_CR61","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.oraloncology.2015.11.022","volume":"56","author":"JL Geiger","year":"2016","unstructured":"Geiger JL, Grandis JR, Bauman JE (2016) The STAT3 pathway as a therapeutic target in head and neck cancer: Barriers and innovations. Oral Oncol 56:84\u201392","journal-title":"Oral Oncol"},{"issue":"13","key":"7904_CR62","doi-asserted-by":"publisher","first-page":"2058","DOI":"10.1038\/sj.onc.1205263","volume":"21","author":"LK Schaefer","year":"2002","unstructured":"Schaefer LK et al (2002) Constitutive activation of Stat3alpha in brain tumors: localization to tumor endothelial cells and activation by the endothelial tyrosine kinase receptor (VEGFR-2). Oncogene 21(13):2058\u20132065","journal-title":"Oncogene"},{"issue":"3","key":"7904_CR63","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1007\/s12094-012-0789-z","volume":"14","author":"A Sonnenblick","year":"2012","unstructured":"Sonnenblick A et al (2012) Tissue microarray-based study of patients with lymph node-positive breast cancer shows tyrosine phosphorylation of signal transducer and activator of transcription 3 (tyrosine705-STAT3) is a marker of good prognosis. Clin Transl Oncol 14(3):232\u2013236","journal-title":"Clin Transl Oncol"},{"key":"7904_CR64","doi-asserted-by":"crossref","unstructured":"Takemoto S et al (2009) expression of activated signal transducer and activator of transcription-3 predicts poor prognosis in cervical squamous-cell carcinoma. Br J Cancer, 101(6): p.\u00a0967 \u2013 72","DOI":"10.1038\/sj.bjc.6605212"},{"issue":"4","key":"7904_CR65","doi-asserted-by":"publisher","first-page":"448","DOI":"10.7150\/ijbs.11164","volume":"11","author":"Y Wang","year":"2015","unstructured":"Wang Y, Qu A, Wang H (2015) Signal transducer and activator of transcription 4 in liver diseases. Int J Biol Sci 11(4):448\u2013455","journal-title":"Int J Biol Sci"},{"issue":"10","key":"7904_CR66","doi-asserted-by":"publisher","first-page":"e75788","DOI":"10.1371\/journal.pone.0075788","volume":"8","author":"Z Wang","year":"2013","unstructured":"Wang Z et al (2013) Activation of STAT3 in human gastric cancer cells via interleukin (IL)-6-type cytokine signaling correlates with clinical implications. PLoS ONE 8(10):e75788","journal-title":"PLoS ONE"},{"issue":"11","key":"7904_CR67","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1038\/nrc2734","volume":"9","author":"H Yu","year":"2009","unstructured":"Yu H, Pardoll D, Jove R (2009) STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 9(11):798\u2013809","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"7904_CR68","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.trecan.2015.10.002","volume":"1","author":"FL Muller","year":"2015","unstructured":"Muller FL, Aquilanti EA, DePinho RA (2015) Collateral lethality: a new therapeutic strategy in oncology. Trends in cancer 1(3):161\u2013173","journal-title":"Trends in cancer"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-022-07904-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-022-07904-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-022-07904-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T13:53:13Z","timestamp":1675345993000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-022-07904-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,17]]},"references-count":68,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["7904"],"URL":"https:\/\/doi.org\/10.1007\/s11033-022-07904-1","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,17]]},"assertion":[{"value":"5 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 August 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}