{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:28:57Z","timestamp":1793834937872,"version":"4.6.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100012330","name":"Cognitive Sciences and Technologies Council","doi-asserted-by":"publisher","award":["2717"],"award-info":[{"award-number":["2717"]}],"id":[{"id":"10.13039\/100012330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s11033-022-07987-w","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T13:09:27Z","timestamp":1666012167000},"page":"11925-11932","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Potential of hsa-miR200a-3p and hsa-miR502-3p as blood-based biomarker for Alzheimer\u2019s disease"],"prefix":"10.1007","volume":"49","author":[{"given":"Negin","family":"Biglari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Khalaj-Kondori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayyebeh","family":"Ghasemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"issue":"1","key":"7987_CR1","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1186\/s40478-019-0771-x","volume":"7","author":"C Gary","year":"2019","unstructured":"Gary C et al (2019) Encephalopathy induced by Alzheimer brain inoculation in a non-human primate. Acta Neuropathol Commun 7(1):126","journal-title":"Acta Neuropathol Commun"},{"issue":"10","key":"7987_CR2","doi-asserted-by":"publisher","first-page":"16122","DOI":"10.18632\/oncotarget.15109","volume":"8","author":"S Nagaraj","year":"2017","unstructured":"Nagaraj S et al (2017) Profile of 6 microRNA in blood plasma distinguish early stage Alzheimer\u2019s disease patients from non-demented subjects. Oncotarget 8(10):16122\u201316143","journal-title":"Oncotarget"},{"issue":"6","key":"7987_CR3","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.jalz.2016.02.010","volume":"12","author":"V Calsolaro","year":"2016","unstructured":"Calsolaro V, Edison P (2016) Neuroinflammation in Alzheimer\u2019s disease: current evidence and future directions. Alzheimers Dement 12(6):719\u2013732","journal-title":"Alzheimers Dement"},{"issue":"6","key":"7987_CR4","doi-asserted-by":"publisher","first-page":"4651","DOI":"10.1007\/s11033-020-05438-y","volume":"47","author":"SN Fotuhi","year":"2020","unstructured":"Fotuhi SN et al (2020) Memory-related process in physiological status and alzheimer\u2019s disease. Mol Biol Rep 47(6):4651\u20134657","journal-title":"Mol Biol Rep"},{"key":"7987_CR5","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/bs.pmbts.2016.12.009","volume":"146","author":"PH Reddy","year":"2017","unstructured":"Reddy PH et al (2017) MicroRNAs, aging, cellular senescence, and Alzheimer\u2019s Disease. Prog Mol Biol Transl Sci 146:127\u2013171","journal-title":"Prog Mol Biol Transl Sci"},{"key":"7987_CR6","doi-asserted-by":"publisher","first-page":"175628641988881","DOI":"10.1177\/1756286419888819","volume":"12","author":"M Mil\u00e0-Alom\u00e0","year":"2019","unstructured":"Mil\u00e0-Alom\u00e0 M, Su\u00e1rez-Calvet M, Molinuevo JL (2019) Latest advances in cerebrospinal fluid and blood biomarkers of Alzheimer\u2019s disease. Ther Adv Neurol Disord 12:1756286419888819","journal-title":"Ther Adv Neurol Disord"},{"issue":"1","key":"7987_CR7","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1186\/s13195-021-00862-z","volume":"13","author":"SC Yuen","year":"2021","unstructured":"Yuen SC et al (2021) Prediction of differentially expressed microRNAs in blood as potential biomarkers for Alzheimer\u2019s disease by meta-analysis and adaptive boosting ensemble learning. Alzheimers Res Ther 13(1):126","journal-title":"Alzheimers Res Ther"},{"issue":"2","key":"7987_CR8","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1002\/wrna.1320","volume":"7","author":"A Keller","year":"2016","unstructured":"Keller A, Meese E (2016) Can circulating miRNAs live up to the promise of being minimal invasive biomarkers in clinical settings? Wiley Interdiscip Rev RNA 7(2):148\u2013156","journal-title":"Wiley Interdiscip Rev RNA"},{"issue":"3","key":"7987_CR9","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/s12031-019-01364-2","volume":"69","author":"SN Fotuhi","year":"2019","unstructured":"Fotuhi SN et al (2019) Long non-coding RNA BACE1-AS may serve as an Alzheimer\u2019s Disease blood-based biomarker. J Mol Neurosci 69(3):351\u2013359","journal-title":"J Mol Neurosci"},{"issue":"12","key":"7987_CR10","doi-asserted-by":"publisher","first-page":"2464","DOI":"10.1002\/cbin.11692","volume":"45","author":"T Ghasemi","year":"2021","unstructured":"Ghasemi T et al (2021) Aberrant expression of lncRNAs SNHG6, TRPM2-AS1, MIR4435-2HG, and hypomethylation of TRPM2-AS1 promoter in colorectal cancer. Cell Biol Int 45(12):2464\u20132478","journal-title":"Cell Biol Int"},{"issue":"2","key":"7987_CR11","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/s10620-020-06200-x","volume":"66","author":"M Khajehdehi","year":"2021","unstructured":"Khajehdehi M et al (2021) Long noncoding RNAs in gastrointestinal cancer: tumor suppression versus tumor promotion. Dig Dis Sci 66(2):381\u2013397","journal-title":"Dig Dis Sci"},{"issue":"3","key":"7987_CR12","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1097\/HCO.0000000000000280","volume":"31","author":"P Gurha","year":"2016","unstructured":"Gurha P (2016) MicroRNAs in cardiovascular disease. Curr Opin Cardiol 31(3):249\u2013254","journal-title":"Curr Opin Cardiol"},{"issue":"3","key":"7987_CR13","first-page":"477","volume":"74","author":"A Jusic","year":"2019","unstructured":"Jusic A, Devaux Y (2019) Noncoding RNAs in Hypertension Hypertension 74(3):477\u2013492","journal-title":"Noncoding RNAs in Hypertension Hypertension"},{"key":"7987_CR14","doi-asserted-by":"publisher","first-page":"173809","DOI":"10.1016\/j.ejphar.2020.173809","volume":"892","author":"S Ghafouri-Fard","year":"2021","unstructured":"Ghafouri-Fard S, Taheri M (2021) The expression profile and role of non-coding RNAs in obesity. Eur J Pharmacol 892:173809","journal-title":"Eur J Pharmacol"},{"key":"7987_CR15","first-page":"772","volume":"21","author":"M Khodayi","year":"2022","unstructured":"Khodayi M et al (2022) Plasma lncRNA profiling identified BC200 and NEAT1 lncRNAs as potential blood-based biomarkers for late-onset Alzheimer\u2019s disease. EXCLI J 21:772\u2013785","journal-title":"EXCLI J"},{"key":"7987_CR16","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3389\/fnagi.2016.00013","volume":"8","author":"YB Hu","year":"2016","unstructured":"Hu YB et al (2016) Diagnostic value of microRNA for Alzheimer\u2019s Disease: a systematic review and meta-analysis. Front Aging Neurosci 8:13","journal-title":"Front Aging Neurosci"},{"issue":"3","key":"7987_CR17","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s12038-017-9698-1","volume":"42","author":"QS Zhang","year":"2017","unstructured":"Zhang QS, Liu W, Lu GX (2017) miR-200a-3p\nPromotes b-Amyloid-induced neuronal apoptosis through down-regulation of SIRT1 in Alzheimer\u2019s disease. J Biosci 42(3):397\u2013404","journal-title":"J Biosci"},{"issue":"10","key":"7987_CR18","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.4103\/1673-5374.308104","volume":"16","author":"L Zeng","year":"2021","unstructured":"Zeng L et al (2021) MicroRNA and mRNA profiling of cerebral cortex in a transgenic mouse model of Alzheimer\u2019s disease by RNA sequencing. Neural Regen Res 16(10):2099\u20132108","journal-title":"Neural Regen Res"},{"key":"7987_CR19","doi-asserted-by":"publisher","first-page":"806","DOI":"10.3389\/fphar.2019.00806","volume":"10","author":"L Wang","year":"2019","unstructured":"Wang L et al (2019) MicroRNA-200a-3p mediates neuroprotection in Alzheimer-related deficits and attenuates amyloid-beta overproduction and Tau hyperphosphorylation via coregulating BACE1 and PRKACB. Front Pharmacol 10:806","journal-title":"Front Pharmacol"},{"issue":"10","key":"7987_CR20","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1002\/emmm.201201974","volume":"5","author":"P Lau","year":"2013","unstructured":"Lau P et al (2013) Alteration of the microRNA network during the progression of Alzheimer\u2019s disease. EMBO Mol Med 5(10):1613\u20131634","journal-title":"EMBO Mol Med"},{"issue":"2","key":"7987_CR21","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.expneurol.2011.11.026","volume":"235","author":"H Geekiyanage","year":"2012","unstructured":"Geekiyanage H et al (2012) Blood serum miRNA: non-invasive biomarkers for Alzheimer\u2019s disease. Exp Neurol 235(2):491\u2013496","journal-title":"Exp Neurol"},{"issue":"8","key":"7987_CR22","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1089\/omi.2016.0099","volume":"20","author":"\u015e Y\u0131lmaz","year":"2016","unstructured":"Y\u0131lmaz \u015e (2016) Can peripheral microRNA expression data serve as epigenomic (Upstream) biomarkers of Alzheimer\u2019s Disease? Omics 20(8):456\u2013461","journal-title":"Omics"},{"key":"7987_CR23","doi-asserted-by":"publisher","first-page":"620899","DOI":"10.3389\/fnins.2021.620899","volume":"15","author":"QS Li","year":"2021","unstructured":"Li QS, Cai D (2021) Integrated miRNA-Seq and mRNA-Seq Study to Identify miRNAs associated with Alzheimer\u2019s disease using post-mortem brain tissue samples. Front Neurosci 15:620899","journal-title":"Front Neurosci"},{"issue":"6","key":"7987_CR24","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.3390\/cells9061443","volume":"9","author":"M Serpente","year":"2020","unstructured":"Serpente M et al (2020) MiRNA profiling in plasma neural-derived small extracellular vesicles from patients with Alzheimer\u2019s Disease. Cells 9(6):1443","journal-title":"Cells"},{"key":"7987_CR25","first-page":"3281","volume":"9","author":"H Jin","year":"2016","unstructured":"Jin H et al (2016) MiR-502-3P suppresses cell proliferation, migration, and invasion in hepatocellular carcinoma by targeting SET. Onco Targets Ther 9:3281\u20133289","journal-title":"Onco Targets Ther"},{"issue":"6","key":"7987_CR26","doi-asserted-by":"publisher","first-page":"4477","DOI":"10.1007\/s12035-016-9967-2","volume":"54","author":"Y Feng","year":"2017","unstructured":"Feng Y et al (2017) Regulation of SET gene expression by NFkB. Mol Neurobiol 54(6):4477\u20134485","journal-title":"Mol Neurobiol"},{"key":"7987_CR27","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.cca.2012.08.013","volume":"414","author":"M Sathya","year":"2012","unstructured":"Sathya M et al (2012) BACE1 in Alzheimer\u2019s disease. Clin Chim Acta 414:171\u2013178","journal-title":"Clin Chim Acta"},{"issue":"Pt 2","key":"7987_CR28","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1042\/bj20020391","volume":"366","author":"T Okada","year":"2002","unstructured":"Okada T et al (2002) Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response. Biochem J 366(Pt 2):585\u2013594","journal-title":"Biochem J"},{"issue":"10","key":"7987_CR29","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1080\/00207454.2020.1715977","volume":"130","author":"Y Du","year":"2020","unstructured":"Du Y et al (2020) Activating transcription factor 6 reduces A\u03b21\u201342 and restores memory in Alzheimer\u2019s disease model mice. Int J Neurosci 130(10):1015\u20131023","journal-title":"Int J Neurosci"},{"issue":"22","key":"7987_CR30","doi-asserted-by":"publisher","first-page":"12180","DOI":"10.1073\/pnas.94.22.12180","volume":"94","author":"C.M Waterman-Storer","year":"1997","unstructured":"Waterman-Storer C.M et al (1997) The interaction between cytoplasmic dynein and dynactin is required for fast axonal\u2009transport. Proc Natl Acad Sci 94(22):12180\u201312185","journal-title":"Proc Natl Acad Sci"},{"issue":"5713","key":"7987_CR31","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1126\/science.1105681","volume":"307","author":"GB Stokin","year":"2005","unstructured":"Stokin GB et al (2005) Axonopathy and transport deficits early in the pathogenesis of Alzheimer\u2019s disease. Science 307(5713):1282\u20131288","journal-title":"Science"},{"issue":"19","key":"7987_CR32","doi-asserted-by":"publisher","first-page":"4657","DOI":"10.1523\/JNEUROSCI.0797-04.2004","volume":"24","author":"B Zhang","year":"2004","unstructured":"Zhang B et al (2004) Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy. J Neurosci 24(19):4657\u20134667","journal-title":"J Neurosci"},{"key":"7987_CR33","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3389\/fncel.2015.00103","volume":"9","author":"O Aboud","year":"2015","unstructured":"Aboud O et al (2015) Aging, Alzheimer\u2019s, and APOE genotype influence the expression and neuronal distribution patterns of microtubule motor protein dynactin-P50. Front Cell Neurosci 9:103","journal-title":"Front Cell Neurosci"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-022-07987-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-022-07987-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-022-07987-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T19:57:56Z","timestamp":1669838276000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-022-07987-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,17]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["7987"],"URL":"https:\/\/doi.org\/10.1007\/s11033-022-07987-w","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,17]]},"assertion":[{"value":"3 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Author Negin Biglari declares that she has no conflict of interest.\u00a0Author Mohammad Khalaj-kondori declares that he has no conflict of interest. Author Tayyebeh Ghasemi declares that she has no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Ethics Committee of the Tabriz University of Medical Sciences (TBZMED.REC.1394.1000) and written informed consent was signed by healthy controls or by the family members or legally authorized representatives of the Alzheimer\u2019s subjects.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individuals that gave their blood samples for including in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}