{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T06:30:54Z","timestamp":1751524254564,"version":"3.37.3"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81760277"],"award-info":[{"award-number":["81760277"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20192BAB20502"],"award-info":[{"award-number":["20192BAB20502"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Project of Jiangxi Provincial Health Commission","award":["20191773"],"award-info":[{"award-number":["20191773"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1007\/s11033-022-08070-0","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T19:10:54Z","timestamp":1669835454000},"page":"1267-1279","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Global DNA and protein interactomes of FLT1P1 (Fms-related tyrosine kinase 1 pseudogene 1) revealed its molecular regulatory functions associated with preeclampsia"],"prefix":"10.1007","volume":"50","author":[{"given":"Lu","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siming","family":"Xin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunfei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaofang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kangxiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingqi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8339-7589","authenticated-orcid":false,"given":"Xiaoju","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"key":"8070_CR1","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1161\/CIRCRESAHA.118.313276","volume":"124","author":"S Rana","year":"2019","unstructured":"Rana S, Lemoine E, Granger JP, Karumanchi SA (2019) Preeclampsia: pathophysiology, challenges, and perspectives. Circ Res 124:1094\u20131112","journal-title":"Circ Res"},{"key":"8070_CR2","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1136\/bmj.38380.674340.E0","volume":"330","author":"K Duckitt","year":"2005","unstructured":"Duckitt K, Harrington D (2005) Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies. BMJ 330:565","journal-title":"BMJ"},{"key":"8070_CR3","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1126\/science.1111726","volume":"308","author":"CW Redman","year":"2005","unstructured":"Redman CW, Sargent IL (2005) Latest advances in understanding preeclampsia. Science 308:1592\u20131594","journal-title":"Science"},{"key":"8070_CR4","doi-asserted-by":"publisher","first-page":"2775","DOI":"10.1172\/JCI70431","volume":"123","author":"R Romero","year":"2013","unstructured":"Romero R, Chaiworapongsa T (2013) Preeclampsia: a link between trophoblast dysregulation and an antiangiogenic state. J Clin Invest 123:2775\u20132777","journal-title":"J Clin Invest"},{"key":"8070_CR5","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1161\/HYPERTENSIONAHA.117.10688","volume":"72","author":"KJ Gray","year":"2018","unstructured":"Gray KJ, Kovacheva VP, Mirzakhani H, Bjonnes AC, Almoguera B, DeWan AT, Triche EW, Saftlas AF, Hoh J, Bodian DL (2018) Gene-centric analysis of preeclampsia identifies maternal association at PLEKHG1. Hypertension 72:408\u2013416","journal-title":"Hypertension"},{"doi-asserted-by":"crossref","unstructured":"McGinnis, R., Steinthorsdottir, V., Williams, N. O., Thorleifsson, G., Shooter, S., Hjartardottir, S., Bumpstead, S., Stefansdottir, L., Hildyard, L., Sigurdsson, J. K., Kemp, J. P., Silva, G. B., Thomsen, L. C. V., Jaaskelainen, T., Kajantie, E., Chappell, S., Kalsheker, N., Moffett, A., Hiby, S., Lee, W. K., Padmanabhan, S., Simpson, N. A. B., Dolby, V. A., Staines-Urias, E., Engel, S. M., Haugan, A., Trogstad, L., Svyatova, G., Zakhidova, N., Najmutdinova, D., Consortium, F., Consortium, G., Dominiczak, A. F., Gjessing, H. K., Casas, J. P., Dudbridge, F., Walker, J. J., Pipkin, F. B., Thorsteinsdottir, U., Geirsson, R. T., Lawlor, D. A., Iversen, A. C., Magnus, P., Laivuori, H., Stefansson, K. & Morgan, L. (2017) Variants in the fetal genome near FLT1 are associated with risk of preeclampsia, Nat Genet. 49, 1255-1260.","key":"8070_CR6","DOI":"10.1038\/ng.3895"},{"key":"8070_CR7","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1002\/ajmg.a.30257","volume":"130A","author":"S Cnattingius","year":"2004","unstructured":"Cnattingius S, Reilly M, Pawitan Y, Lichtenstein P (2004) Maternal and fetal genetic factors account for most of familial aggregation of preeclampsia: a population-based Swedish cohort study. Am J Med Genet A 130A:365\u2013371","journal-title":"Am J Med Genet A"},{"key":"8070_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2010.10.004","author":"SE Maynard","year":"2011","unstructured":"Maynard SE, Karumanchi SA (2011) Angiogenic factors and preeclampsia. Semin Nephrol. https:\/\/doi.org\/10.1016\/j.semnephrol.2010.10.004","journal-title":"Semin Nephrol"},{"key":"8070_CR9","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1056\/NEJMoa031884","volume":"350","author":"RJ Levine","year":"2004","unstructured":"Levine RJ, Maynard SE, Qian C, Lim K-H, England LJ, Yu KF, Schisterman EF, Thadhani R, Sachs BP, Epstein FH (2004) Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 350:672\u2013683","journal-title":"N Engl J Med"},{"key":"8070_CR10","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1172\/JCI17189","volume":"111","author":"SE Maynard","year":"2003","unstructured":"Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S, Libermann TA, Morgan JP, Sellke FW, Stillman IE, Epstein FH, Sukhatme VP, Karumanchi SA (2003) Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 111:649\u2013658","journal-title":"J Clin Invest"},{"key":"8070_CR11","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a023473","volume":"5","author":"T Hod","year":"2015","unstructured":"Hod T, Cerdeira AS, Karumanchi SA (2015) Molecular mechanisms of preeclampsia. Cold Spring Harb Perspect Med 5:a023473","journal-title":"Cold Spring Harb Perspect Med"},{"key":"8070_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mvr.2007.04.009","volume":"75","author":"WP Mutter","year":"2008","unstructured":"Mutter WP, Karumanchi SA (2008) Molecular mechanisms of preeclampsia. Microvasc Res 75:1\u20138","journal-title":"Microvasc Res"},{"key":"8070_CR13","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1056\/NEJMcibr1817501","volume":"380","author":"SA Robertson","year":"2019","unstructured":"Robertson SA (2019) Preventing preeclampsia by silencing soluble Flt-1? N Engl J Med 380:1080\u20131082","journal-title":"N Engl J Med"},{"key":"8070_CR14","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/s41580-020-00315-9","volume":"22","author":"L Statello","year":"2021","unstructured":"Statello L, Guo CJ, Chen LL, Huarte M (2021) Gene regulation by long non-coding RNAs and its biological functions. Nat Rev Mol Cell Biol 22:96\u2013118","journal-title":"Nat Rev Mol Cell Biol"},{"key":"8070_CR15","doi-asserted-by":"crossref","first-page":"D118","DOI":"10.1093\/nar\/gkaa845","volume":"48","author":"H Zhao","year":"2020","unstructured":"Zhao H, Shi J, Zhang Y, Xie A, Yu L, Zhang C, Lei J, Xu H, Leng Z, Li T, Huang W, Lin S, Wang L, Xiao Y, Li X (2020) LncTarD: a manually-curated database of experimentally-supported functional lncRNA-target regulations in human diseases. Nucleic Acids Res 48:D118\u2013D126","journal-title":"Nucleic Acids Res"},{"key":"8070_CR16","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.2174\/1389450118666170404160000","volume":"18","author":"X Song","year":"2017","unstructured":"Song X, Luo X, Gao Q, Wang Y, Gao Q, Long W (2017) Dysregulation of LncRNAs in placenta and pathogenesis of preeclampsia. Curr Drug Targets 18:1165\u20131170","journal-title":"Curr Drug Targets"},{"key":"8070_CR17","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14870","author":"C Liu","year":"2021","unstructured":"Liu C, Li H, Zhang Y, Ding H (2021) Long intergenic noncoding RNA 00473 promoting migration and invasion of trophoblastic cell line HTR-8\/SVneo via regulating miR-424\u20135p-mediated wnt3a\/beta-catenin signaling pathway. J Obstet Gynaecol Res. https:\/\/doi.org\/10.1111\/jog.14870","journal-title":"J Obstet Gynaecol Res"},{"key":"8070_CR18","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.ymthe.2019.11.025","volume":"28","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, He XY, Qin S, Mo HQ, Li X, Wu F, Zhang J, Li X, Mao L, Peng YQ, Guo YN, Lin Y, Tian FJ (2020) Upregulation of PUM1 expression in preeclampsia impairs trophoblast invasion by negatively regulating the expression of the lncRNA HOTAIR. Mol Ther 28:631\u2013641","journal-title":"Mol Ther"},{"key":"8070_CR19","doi-asserted-by":"publisher","first-page":"17677","DOI":"10.1002\/jcb.29034","volume":"120","author":"Y Gao","year":"2019","unstructured":"Gao Y, Guo X, Li Y, Sha W, She R (2019) The decreased lncRNA ZEB2-AS1 in pre-eclampsia controls the trophoblastic cell line HTR-8\/SVneo\u2019s invasive and migratory abilities via the miR-149\/PGF axis. J Cell Biochem 120:17677\u201317686","journal-title":"J Cell Biochem"},{"key":"8070_CR20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081437","volume":"8","author":"X He","year":"2013","unstructured":"He X, He Y, Xi B, Zheng J, Zeng X, Cai Q, Ouyang Y, Wang C, Zhou X, Huang H, Deng W, Xin S, Huang Q, Liu H (2013) LncRNAs expression in preeclampsia placenta reveals the potential role of LncRNAs contributing to preeclampsia pathogenesis. PLoS ONE 8:e81437","journal-title":"PLoS ONE"},{"key":"8070_CR21","doi-asserted-by":"publisher","first-page":"8885","DOI":"10.1080\/21655979.2021.1988366","volume":"12","author":"Z Chi","year":"2021","unstructured":"Chi Z, Sun Y, Yu Z, Zhou F, Wang H, Zhang M (2021) Pseudogene fms-related tyrosine kinase 1 pseudogene 1 (FLT1P1) cooperates with RNA binding protein dyskeratosis congenita 1 (DKC1) to restrain trophoblast cell proliferation and angiogenesis by targeting fms-related tyrosine kinase 1 (FLT1) in preeclampsia. Bioengineered 12:8885\u20138897","journal-title":"Bioengineered"},{"key":"8070_CR22","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1038\/nature09144","volume":"465","author":"L Poliseno","year":"2010","unstructured":"Poliseno L, Salmena L, Zhang J, Carver B, Haveman WJ, Pandolfi PP (2010) A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature 465:1033\u20131038","journal-title":"Nature"},{"key":"8070_CR23","doi-asserted-by":"publisher","first-page":"2374","DOI":"10.1093\/nar\/gki531","volume":"33","author":"PM Harrison","year":"2005","unstructured":"Harrison PM, Zheng D, Zhang Z, Carriero N, Gerstein M (2005) Transcribed processed pseudogenes in the human genome: an intermediate form of expressed retrosequence lacking protein-coding ability. Nucleic Acids Res 33:2374\u20132383","journal-title":"Nucleic Acids Res"},{"key":"8070_CR24","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.00762","volume":"2","author":"NA Rapicavoli","year":"2013","unstructured":"Rapicavoli NA, Qu K, Zhang J, Mikhail M, Laberge RM, Chang HY (2013) A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics. Elife 2:e00762","journal-title":"Elife"},{"key":"8070_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/gb-2012-13-9-r51","volume":"13","author":"B Pei","year":"2012","unstructured":"Pei B, Sisu C, Frankish A, Howald C, Habegger L, Mu XJ, Harte R, Balasubramanian S, Tanzer A, Diekhans M (2012) The GENCODE pseudogene resource. Genome Biol 13:1\u201326","journal-title":"Genome Biol"},{"key":"8070_CR26","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1261\/rna.2658311","volume":"17","author":"RC Pink","year":"2011","unstructured":"Pink RC, Wicks K, Caley DP, Punch EK, Jacobs L, Carter DRF (2011) Pseudogenes: pseudo-functional or key regulators in health and disease? RNA 17:792\u2013798","journal-title":"RNA"},{"key":"8070_CR27","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.1923","volume":"9","author":"B Langmead","year":"2012","unstructured":"Langmead B, Salzberg S (2012) Fast gapped-read alignment with Bowtie 2. Nat Methods 9:357\u2013359","journal-title":"Nat Methods"},{"key":"8070_CR28","doi-asserted-by":"publisher","first-page":"R137","DOI":"10.1186\/gb-2008-9-9-r137","volume":"9","author":"Y Zhang","year":"2008","unstructured":"Zhang Y, Liu T, Meyer C, Eeckhoute J, Johnson D, Bernstein B, Nusbaum C, Myers R, Brown M, Li W, Liu X (2008) Model-based analysis of ChIP-Seq (MACS). Genome Biol 9:R137","journal-title":"Genome Biol"},{"key":"8070_CR29","doi-asserted-by":"publisher","first-page":"W160","DOI":"10.1093\/nar\/gkw257","volume":"44","author":"F Ram\u00edrez","year":"2016","unstructured":"Ram\u00edrez F, Ryan D, Gr\u00fcning B, Bhardwaj V, Kilpert F, Richter A, Heyne S, D\u00fcndar F, Manke T (2016) deepTools2: a next generation web server for deep-sequencing data analysis. Nucleic Acids Res 44:W160\u2013W165","journal-title":"Nucleic Acids Res"},{"key":"8070_CR30","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","volume":"38","author":"S Heinz","year":"2010","unstructured":"Heinz S, Benner C, Spann N, Bertolino E, Lin Y, Laslo P, Cheng J, Murre C, Singh H, Glass C (2010) Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell 38:576\u2013589","journal-title":"Mol Cell"},{"key":"8070_CR31","doi-asserted-by":"publisher","first-page":"D380","DOI":"10.1093\/nar\/gkx1013","volume":"46","author":"H Han","year":"2018","unstructured":"Han H, Cho JW, Lee S, Yun A, Kim H, Bae D, Yang S, Kim CY, Lee M, Kim E, Lee S, Kang B, Jeong D, Kim Y, Jeon HN, Jung H, Nam S, Chung M, Kim JH, Lee I (2018) TRRUST v2: an expanded reference database of human and mouse transcriptional regulatory interactions. Nucleic Acids Res 46:D380\u2013D386","journal-title":"Nucleic Acids Res"},{"key":"8070_CR32","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1093\/nar\/gkr483","volume":"39","author":"C Xie","year":"2011","unstructured":"Xie C, Mao X, Huang J, Ding Y, Wu J, Dong S, Kong L, Gao G, Li CY, Wei L (2011) KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases. Nucleic Acids Res 39:316\u2013322","journal-title":"Nucleic Acids Res"},{"key":"8070_CR33","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4297","author":"AA Turanov","year":"2018","unstructured":"Turanov AA, Lo A, Hassler MR, Makris A, Ashar-Patel A, Alterman JF, Coles AH, Haraszti RA, Roux L, Godinho B, Echeverria D, Pears S, Iliopoulos J, Shanmugalingam R, Ogle R, Zsengeller ZK, Hennessy A, Karumanchi SA, Moore MJ, Khvorova A (2018) RNAi modulation of placental sFLT1 for the treatment of preeclampsia. Nat Biotechnol. https:\/\/doi.org\/10.1038\/nbt.4297","journal-title":"Nat Biotechnol"},{"key":"8070_CR34","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.cell.2015.03.025","volume":"161","author":"C Chu","year":"2015","unstructured":"Chu C, Zhang QC, da Rocha ST, Flynn RA, Bharadwaj M, Calabrese JM, Magnuson T, Heard E, Chang HY (2015) Systematic discovery of Xist RNA binding proteins. Cell 161:404\u2013416","journal-title":"Cell"},{"key":"8070_CR35","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.biopha.2018.12.078","volume":"111","author":"M Cao","year":"2019","unstructured":"Cao M, Zhao J, Hu G (2019) Genome-wide methods for investigating long noncoding RNAs. Biomed Pharmacother 111:395\u2013401","journal-title":"Biomed Pharmacother"},{"key":"8070_CR36","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aao2110","volume":"3","author":"Y Long","year":"2017","unstructured":"Long Y, Wang X, Youmans DT, Cech TR (2017) How do lncRNAs regulate transcription? Sci Adv 3:eaao2110","journal-title":"Sci Adv"},{"key":"8070_CR37","doi-asserted-by":"publisher","first-page":"R137","DOI":"10.1186\/gb-2008-9-9-r137","volume":"9","author":"Y Zhang","year":"2008","unstructured":"Zhang Y, Liu T, Meyer CA, Eeckhoute J, Johnson DS, Bernstein BE, Nussbaum C, Myers RM, Brown M, Li W, Liu XS (2008) Model-based analysis of ChIP-Seq (MACS). Genome Biol 9:R137","journal-title":"Genome Biol"},{"key":"8070_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0083-6729(08)61037-7","volume":"51","author":"JF Habener","year":"1995","unstructured":"Habener JF, Miller CP, Vallejo M (1995) cAMP-dependent regulation of gene transcription by cAMP response element-binding protein and cAMP response element modulator. Vitam Horm 51:1\u201357","journal-title":"Vitam Horm"},{"key":"8070_CR39","doi-asserted-by":"publisher","first-page":"27948","DOI":"10.1074\/jbc.270.46.27948","volume":"270","author":"K Morishita","year":"1995","unstructured":"Morishita K, Johnson DE, Williams LT (1995) A novel promoter for vascular endothelial growth factor receptor (flt-1) that confers endothelial-specific gene expression. J Biol Chem 270:27948\u201327953","journal-title":"J Biol Chem"},{"key":"8070_CR40","doi-asserted-by":"publisher","first-page":"2914","DOI":"10.1038\/ncomms3914","volume":"5","author":"ZJ Rutnam","year":"2014","unstructured":"Rutnam ZJ, Du WW, Yang W, Yang X, Yang BB (2014) The pseudogene TUSC2P promotes TUSC2 function by binding multiple microRNAs. Nat Commun 5:2914","journal-title":"Nat Commun"},{"key":"8070_CR41","first-page":"476","volume":"5","author":"MJ Milligan","year":"2014","unstructured":"Milligan MJ, Lipovich L (2014) Pseudogene-derived lncRNAs: emerging regulators of gene expression. Front Genet 5:476","journal-title":"Front Genet"},{"key":"8070_CR42","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1093\/carcin\/bgy069","volume":"39","author":"M Giulietti","year":"2018","unstructured":"Giulietti M, Righetti A, Principato G, Piva F (2018) LncRNA co-expression network analysis reveals novel biomarkers for pancreatic cancer. Carcinogenesis 39:1016\u20131025","journal-title":"Carcinogenesis"},{"key":"8070_CR43","doi-asserted-by":"publisher","DOI":"10.1101\/gr.217463.116","author":"S Liu","year":"2017","unstructured":"Liu S, Wang Z, Chen D, Zhang B, Tian R, Wu J, Zhang Y, Xu K, Yang L, Cheng C, Ma J, Lv L, Zheng Y, Hu X, Zhang Y, Wang X, Li J (2017) Annotation and cluster analysis of spatiotemporal- and sex-related lncRNA expression in rhesus macaque brain. Genome Res. https:\/\/doi.org\/10.1101\/gr.217463.116","journal-title":"Genome Res"},{"key":"8070_CR44","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1067\/mob.2001.112906","volume":"184","author":"DN Leung","year":"2001","unstructured":"Leung DN, Smith SC, To K, Sahota DS, Baker PN (2001) Increased placental apoptosis in pregnancies complicated by preeclampsia. Am J Obstet Gynecol 184:1249\u20131250","journal-title":"Am J Obstet Gynecol"},{"key":"8070_CR45","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1159\/000320289","volume":"71","author":"SZ Tomas","year":"2011","unstructured":"Tomas SZ, Prusac IK, Roje D, Tadin I (2011) Trophoblast apoptosis in placentas from pregnancies complicated by preeclampsia. Gynecol Obstet Invest 71:250\u2013255","journal-title":"Gynecol Obstet Invest"},{"key":"8070_CR46","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3389\/fphys.2020.00098","volume":"11","author":"N Raguema","year":"2020","unstructured":"Raguema N, Moustadraf S, Bertagnolli M (2020) Immune and apoptosis mechanisms regulating placental development and vascularization in preeclampsia. Front Physiol 11:98","journal-title":"Front Physiol"},{"key":"8070_CR47","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1080\/15548627.2019.1707494","volume":"16","author":"A Nakashima","year":"2020","unstructured":"Nakashima A, Cheng SB, Ikawa M, Yoshimori T, Huber WJ, Menon R, Huang Z, Fierce J, Padbury JF, Sadovsky Y, Saito S, Sharma S (2020) Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia. Autophagy 16:1771\u20131785","journal-title":"Autophagy"},{"key":"8070_CR48","doi-asserted-by":"publisher","first-page":"1237973","DOI":"10.1126\/science.1237973","volume":"341","author":"JM Engreitz","year":"2013","unstructured":"Engreitz JM, Pandya-Jones A, McDonel P, Shishkin A, Sirokman K, Surka C, Kadri S, Xing J, Goren A, Lander ES, Plath K, Guttman M (2013) The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome. Science 341:1237973","journal-title":"Science"},{"key":"8070_CR49","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1038\/nbt.2943","volume":"32","author":"JJ Quinn","year":"2014","unstructured":"Quinn JJ, Ilik IA, Qu K, Georgiev P, Chu C, Akhtar A, Chang HY (2014) Revealing long noncoding RNA architecture and functions using domain-specific chromatin isolation by RNA purification. Nat Biotechnol 32:933\u2013940","journal-title":"Nat Biotechnol"},{"key":"8070_CR50","doi-asserted-by":"publisher","first-page":"20497","DOI":"10.1073\/pnas.1113536108","volume":"108","author":"MD Simon","year":"2011","unstructured":"Simon MD, Wang CI, Kharchenko PV, West JA, Chapman BA, Alekseyenko AA, Borowsky ML, Kuroda MI, Kingston RE (2011) The genomic binding sites of a noncoding RNA. Proc Natl Acad Sci USA 108:20497\u201320502","journal-title":"Proc Natl Acad Sci USA"},{"key":"8070_CR51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079598","volume":"8","author":"Y Zou","year":"2013","unstructured":"Zou Y, Jiang Z, Yu X, Sun M, Zhang Y, Zuo Q, Zhou J, Yang N, Han P, Ge Z (2013) Upregulation of long noncoding RNA SPRY4-IT1 modulates proliferation, migration, apoptosis, and network formation in trophoblast cells HTR-8SV\/neo. PLoS ONE 8:e79598","journal-title":"PLoS ONE"},{"issue":"113\u20137","key":"8070_CR52","first-page":"122","volume":"46","author":"YF Zou","year":"2015","unstructured":"Zou YF, Sun LZ (2015) Long noncoding RNA HOTAIR modulates the function of trophoblast cells in pre-eclampsia. Sichuan Da Xue Xue Bao Yi Xue Ban 46(113\u20137):122","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"key":"8070_CR53","first-page":"12718","volume":"8","author":"H Chen","year":"2015","unstructured":"Chen H, Meng T, Liu X, Sun M, Tong C, Liu J, Wang H, Du J (2015) Long non-coding RNA MALAT-1 is downregulated in preeclampsia and regulates proliferation, apoptosis, migration and invasion of JEG-3 trophoblast cells. Int J Clin Exp Pathol 8:12718","journal-title":"Int J Clin Exp Pathol"},{"key":"8070_CR54","first-page":"1435","volume":"6","author":"J Chen","year":"2012","unstructured":"Chen J, Xia J, Wang S, Wei Y, Wu J, Huang G, Chen F, Shi J (2012) Study on transcription regulation network in rheumatoid arthritis via bioinformatics analysis. Afr J Pharm Pharmacol 6:1435\u20131443","journal-title":"Afr J Pharm Pharmacol"},{"key":"8070_CR55","doi-asserted-by":"publisher","DOI":"10.1093\/database\/bax028","author":"S Fishilevich","year":"2017","unstructured":"Fishilevich S, Nudel R, Rappaport N, Hadar R, Plaschkes I, Iny Stein T, Rosen N, Kohn A, Twik M, Safran M, Lancet D, Cohen D (2017) GeneHancer: genome-wide integration of enhancers and target genes in GeneCards. Database (Oxford). https:\/\/doi.org\/10.1093\/database\/bax028","journal-title":"Database (Oxford)"},{"key":"8070_CR56","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1095\/biolreprod.112.102723","volume":"87","author":"R Tal","year":"2012","unstructured":"Tal R (2012) The role of hypoxia and hypoxia-inducible factor-1alpha in preeclampsia pathogenesis. Biol Reprod 87:134","journal-title":"Biol Reprod"},{"key":"8070_CR57","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3390\/ncrna7010016","volume":"7","author":"D Karakas","year":"2021","unstructured":"Karakas D, Ozpolat B (2021) The role of LncRNAs in translation. Noncoding RNA 7:16","journal-title":"Noncoding RNA"},{"key":"8070_CR58","doi-asserted-by":"publisher","first-page":"17558","DOI":"10.1038\/s41598-020-74840-0","volume":"10","author":"J Huang","year":"2020","unstructured":"Huang J, Ling Z, Zhong H, Yin Y, Qian Y, Gao M, Ding H, Cheng Q, Jia R (2020) Distinct expression profiles of peptides in placentae from preeclampsia and normal pregnancies. Sci Rep 10:17558","journal-title":"Sci Rep"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-022-08070-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-022-08070-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-022-08070-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T13:55:12Z","timestamp":1675346112000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-022-08070-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,30]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["8070"],"URL":"https:\/\/doi.org\/10.1007\/s11033-022-08070-0","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"type":"print","value":"0301-4851"},{"type":"electronic","value":"1573-4978"}],"subject":[],"published":{"date-parts":[[2022,11,30]]},"assertion":[{"value":"21 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}