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With the development in gene analysis technology, the genetic research of MD has attracted extensive attention, resulting in a large number of studies on the research of the relationship between human genes and MD. This paper aims to review the studies on this topic in recent years. The studies mainly focused on the genetics of familial MD and the correlation between MD and potentially related functional genes. The results of these studies have demonstrated the complexity and diversity of the pathogenesis of MD with both genetic and epigenetic alterations, suggesting that MD might be related to inflammation, immunity, aqua and ion balance in the lymphatic fluid, virus infection, metabolism, and abnormal function of nerve conduction. The finding of rare mutations in\n                    <jats:italic>TECTA<\/jats:italic>\n                    ,\n                    <jats:italic>MYO7A<\/jats:italic>\n                    and\n                    <jats:italic>OTOG<\/jats:italic>\n                    genes and other genes such as\n                    <jats:italic>CDH23<\/jats:italic>\n                    ,\n                    <jats:italic>PCDH15<\/jats:italic>\n                    and\n                    <jats:italic>ADGRV1<\/jats:italic>\n                    in the same families suggest that the integrity of the stereocilia and their interaction with the tectorial and otolithic membranes could be involved in the pathophysiology of familial MD.\n                  <\/jats:p>","DOI":"10.1007\/s11033-022-08149-8","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T11:02:46Z","timestamp":1671879766000},"page":"2901-2908","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Genetic advances in Meniere Disease"],"prefix":"10.1007","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3064-8310","authenticated-orcid":false,"given":"Qingqing","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3200-3834","authenticated-orcid":false,"given":"Lili","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruikai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0199-2940","authenticated-orcid":false,"given":"Hong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8437-1583","authenticated-orcid":false,"given":"Maoli","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,24]]},"reference":[{"key":"8149_CR1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/ajmg.a.33114","volume":"152A","author":"CA Campbell","year":"2010","unstructured":"Campbell CA, Della Santina CC, Meyer NC et al (2010) Polymorphisms in KCNE1 or KCNE3 are not associated with Meniere disease in the Caucasian population. 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