{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:32:19Z","timestamp":1740123139327,"version":"3.37.3"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T00:00:00Z","timestamp":1674691200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T00:00:00Z","timestamp":1674691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R21 NS121394"],"award-info":[{"award-number":["R21 NS121394"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1007\/s11033-023-08264-0","type":"journal-article","created":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T06:02:20Z","timestamp":1674712940000},"page":"3179-3187","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early adaptive responses in the skeletal muscle of young mice with hereditary hemochromatosis"],"prefix":"10.1007","volume":"50","author":[{"given":"Varun V.","family":"Dhorajia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonghan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6038-4358","authenticated-orcid":false,"given":"Yuho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,1,26]]},"reference":[{"issue":"1","key":"8264_CR1","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1038\/nchembio.721","volume":"8","author":"DJ Netz","year":"2011","unstructured":"Netz DJ et al (2011) Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes. Nat Chem Biol 8(1):125\u2013132","journal-title":"Nat Chem Biol"},{"issue":"9","key":"8264_CR2","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1016\/j.bbamcr.2012.05.010","volume":"1823","author":"CP Anderson","year":"2012","unstructured":"Anderson CP et al (2012) Mammalian iron metabolism and its control by iron regulatory proteins. Biochim Biophys Acta 1823(9):1468\u20131483","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"8264_CR3","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1182\/blood-2013-06-508325","volume":"123","author":"NJ Kassebaum","year":"2014","unstructured":"Kassebaum NJ et al (2014) A systematic analysis of global anemia burden from 1990 to 2010. Blood 123(5):615\u2013624","journal-title":"Blood"},{"issue":"1","key":"8264_CR4","doi-asserted-by":"publisher","first-page":"5756","DOI":"10.1038\/s41598-017-05810-2","volume":"7","author":"A Sukumaran","year":"2017","unstructured":"Sukumaran A et al (2017) Iron overload exacerbates age-associated cardiac hypertrophy in a mouse model of hemochromatosis. Sci Rep 7(1):5756","journal-title":"Sci Rep"},{"issue":"5","key":"8264_CR5","doi-asserted-by":"publisher","first-page":"521","DOI":"10.3748\/wjg.v25.i5.521","volume":"25","author":"KJ Mehta","year":"2019","unstructured":"Mehta KJ, Farnaud SJ, Sharp PA (2019) Iron and liver fibrosis: Mechanistic and clinical aspects. World J Gastroenterol 25(5):521\u2013538","journal-title":"World J Gastroenterol"},{"issue":"5","key":"8264_CR6","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1007\/s10741-018-9700-5","volume":"23","author":"R Gordan","year":"2018","unstructured":"Gordan R et al (2018) Involvement of cytosolic and mitochondrial iron in iron overload cardiomyopathy: an update. Heart Fail Rev 23(5):801\u2013816","journal-title":"Heart Fail Rev"},{"key":"8264_CR7","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/0378-4274(95)03532-X","volume":"82\u201383","author":"CC Winterbourn","year":"1995","unstructured":"Winterbourn CC (1995) Toxicity of iron and hydrogen peroxide: the Fenton reaction. Toxicol Lett 82\u201383:969\u2013974","journal-title":"Toxicol Lett"},{"issue":"5","key":"8264_CR8","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1016\/j.jhep.2012.06.015","volume":"57","author":"F D'Alessio","year":"2012","unstructured":"D\u2019Alessio F, Hentze MW, Muckenthaler MU (2012) The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation. J Hepatol 57(5):1052\u20131060","journal-title":"J Hepatol"},{"issue":"2","key":"8264_CR9","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/0009-8981(95)06212-2","volume":"245","author":"DL Witte","year":"1996","unstructured":"Witte DL et al (1996) Hereditary hemochromatosis. Clin Chim Acta 245(2):139\u2013200","journal-title":"Clin Chim Acta"},{"issue":"2","key":"8264_CR10","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.gene.2015.10.009","volume":"574","author":"JC Barton","year":"2015","unstructured":"Barton JC, Edwards CQ, Acton RT (2015) HFE gene: structure, function, mutations, and associated iron abnormalities. Gene 574(2):179\u2013192","journal-title":"Gene"},{"issue":"4","key":"8264_CR11","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1053\/gast.1996.v110.pm8613000","volume":"110","author":"C Niederau","year":"1996","unstructured":"Niederau C et al (1996) Long-term survival in patients with hereditary hemochromatosis. Gastroenterology 110(4):1107\u20131119","journal-title":"Gastroenterology"},{"issue":"3","key":"8264_CR12","doi-asserted-by":"publisher","first-page":"276","DOI":"10.3138\/physio.62.3.276","volume":"62","author":"MK Allen","year":"2010","unstructured":"Allen MK (2010) Hereditary hemochromatosis: a literature review and case report. Physiother Can 62(3):276\u2013284","journal-title":"Physiother Can"},{"issue":"3","key":"8264_CR13","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1097\/HJR.0b013e3280ac151c","volume":"14","author":"ES Davidsen","year":"2007","unstructured":"Davidsen ES et al (2007) Reduced exercise capacity in genetic haemochromatosis. Eur J Cardiovasc Prev Rehabil 14(3):470\u2013475","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"issue":"6","key":"8264_CR14","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1113\/expphysiol.2008.046045","volume":"94","author":"TF Reardon","year":"2009","unstructured":"Reardon TF, Allen DG (2009) Iron injections in mice increase skeletal muscle iron content, induce oxidative stress and reduce exercise performance. Exp Physiol 94(6):720\u2013730","journal-title":"Exp Physiol"},{"issue":"3","key":"8264_CR15","doi-asserted-by":"publisher","first-page":"130082","DOI":"10.1016\/j.bbagen.2021.130082","volume":"1866","author":"FM Alves","year":"2022","unstructured":"Alves FM et al (2022) Disruption of Hfe leads to skeletal muscle iron loading and reduction of hemoproteins involved in oxidative metabolism in a mouse model of hereditary hemochromatosis. Biochim Biophys Acta Gen Subj 1866(3):130082","journal-title":"Biochim Biophys Acta Gen Subj"},{"issue":"1","key":"8264_CR16","doi-asserted-by":"publisher","first-page":"80","DOI":"10.2337\/db10-0593","volume":"60","author":"J Huang","year":"2010","unstructured":"Huang J et al (2010) Iron overload and diabetes risk: a shift from glucose to fatty acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis. Diabetes 60(1):80\u201387","journal-title":"Diabetes"},{"issue":"5","key":"8264_CR17","doi-asserted-by":"publisher","first-page":"e64944","DOI":"10.1371\/journal.pone.0064944","volume":"8","author":"J Kim","year":"2013","unstructured":"Kim J, Buckett PD, Wessling-Resnick M (2013) Absorption of manganese and iron in a mouse model of hemochromatosis. PLoS ONE 8(5):e64944","journal-title":"PLoS ONE"},{"issue":"31","key":"8264_CR18","doi-asserted-by":"publisher","first-page":"12754","DOI":"10.1074\/jbc.R117.787101","volume":"292","author":"JJ Braymer","year":"2017","unstructured":"Braymer JJ, Lill R (2017) Iron-sulfur cluster biogenesis and trafficking in mitochondria. J Biol Chem 292(31):12754\u201312763","journal-title":"J Biol Chem"},{"issue":"9","key":"8264_CR19","doi-asserted-by":"publisher","first-page":"2404","DOI":"10.1016\/j.celrep.2018.07.101","volume":"24","author":"HE Thomas","year":"2018","unstructured":"Thomas HE et al (2018) Mitochondrial complex I activity is required for maximal autophagy. Cell Rep 24(9):2404\u20132417","journal-title":"Cell Rep"},{"issue":"8","key":"8264_CR20","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1080\/15548627.2016.1187366","volume":"12","author":"W Hou","year":"2016","unstructured":"Hou W et al (2016) Autophagy promotes ferroptosis by degradation of ferritin. Autophagy 12(8):1425\u20131428","journal-title":"Autophagy"},{"issue":"10","key":"8264_CR21","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201947911","volume":"20","author":"JWS Jahng","year":"2019","unstructured":"Jahng JWS et al (2019) Iron overload inhibits late stage autophagic flux leading to insulin resistance. EMBO Rep 20(10):e47911","journal-title":"EMBO Rep"},{"issue":"14","key":"8264_CR22","doi-asserted-by":"publisher","first-page":"e00010","DOI":"10.1128\/MCB.00010-19","volume":"39","author":"M Fujimaki","year":"2019","unstructured":"Fujimaki M et al (2019) Iron supply via NCOA4-mediated ferritin degradation maintains mitochondrial functions. Mol Cell Biol 39(14):e00010-19","journal-title":"Mol Cell Biol"},{"key":"8264_CR23","doi-asserted-by":"crossref","unstructured":"Chao, X., et al., Impaired TFEB-Mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-Induced Liver Injury and Steatosis in Mice. Gastroenterology, 2018. 155(3): p. 865\u2013879 e12.","DOI":"10.1053\/j.gastro.2018.05.027"},{"issue":"1","key":"8264_CR24","doi-asserted-by":"publisher","first-page":"5155","DOI":"10.1038\/s41598-018-23408-0","volume":"8","author":"E Agmon","year":"2018","unstructured":"Agmon E et al (2018) Modeling the effects of lipid peroxidation during ferroptosis on membrane properties. Sci Rep 8(1):5155","journal-title":"Sci Rep"},{"issue":"2","key":"8264_CR25","first-page":"385","volume":"7","author":"M Wang","year":"2015","unstructured":"Wang M et al (2015) Combined histological and hematological assessment of iron-induced organ damage in a gerbil model of iron overload. Am J Transl Res 7(2):385\u2013392","journal-title":"Am J Transl Res"},{"issue":"3","key":"8264_CR26","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1093\/gerona\/gly270","volume":"74","author":"J Tamosauskaite","year":"2019","unstructured":"Tamosauskaite J et al (2019) Hereditary hemochromatosis associations with frailty, sarcopenia and chronic pain: evidence from 200,975 older UK Biobank participants. J Gerontol A Biol Sci Med Sci 74(3):337\u2013342","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"6","key":"8264_CR27","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/s12185-011-0961-1","volume":"94","author":"J Munoz","year":"2011","unstructured":"Munoz J, Ferrari N, Kuriakose P (2011) Iron-overload myopathy. Int J Hematol 94(6):503\u2013504","journal-title":"Int J Hematol"},{"issue":"7","key":"8264_CR28","doi-asserted-by":"publisher","first-page":"2973","DOI":"10.1182\/blood-2008-04-148767","volume":"112","author":"LJ Noetzli","year":"2008","unstructured":"Noetzli LJ et al (2008) Longitudinal analysis of heart and liver iron in thalassemia major. Blood 112(7):2973\u20132978","journal-title":"Blood"},{"issue":"7","key":"8264_CR29","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.bbagen.2008.09.008","volume":"1790","author":"S Levi","year":"2009","unstructured":"Levi S, Rovida E (2009) The role of iron in mitochondrial function. Biochim Biophys Acta 1790(7):629\u2013636","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"8264_CR30","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1111\/j.1474-9726.2008.00418.x","volume":"7","author":"AY Seo","year":"2008","unstructured":"Seo AY et al (2008) Mitochondrial iron accumulation with age and functional consequences. Aging Cell 7(5):706\u2013716","journal-title":"Aging Cell"},{"issue":"23","key":"8264_CR31","doi-asserted-by":"publisher","first-page":"19304","DOI":"10.1074\/jbc.M112.363747","volume":"287","author":"S-Y Jang","year":"2012","unstructured":"Jang S-Y, Kang HT, Hwang ES (2012) Nicotinamide-induced mitophagy: event mediated by high NAD+\/NADH ratio and SIRT1 protein activation. J Biol Chem 287(23):19304\u201319314","journal-title":"J Biol Chem"},{"issue":"1","key":"8264_CR32","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1111\/j.1471-4159.2008.05398.x","volume":"106","author":"W Lin","year":"2008","unstructured":"Lin W, Kang UJ (2008) Characterization of PINK1 processing, stability, and subcellular localization. J Neurochem 106(1):464\u2013474","journal-title":"J Neurochem"},{"issue":"2","key":"8264_CR33","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1111\/j.1471-4159.2010.06607.x","volume":"113","author":"JA Roth","year":"2010","unstructured":"Roth JA et al (2010) Parkin regulates metal transport via proteasomal degradation of the 1B isoforms of divalent metal transporter 1. J Neurochem 113(2):454\u2013464","journal-title":"J Neurochem"},{"issue":"7","key":"8264_CR34","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.tem.2021.04.010","volume":"32","author":"A Ajoolabady","year":"2021","unstructured":"Ajoolabady A et al (2021) Ferritinophagy and ferroptosis in the management of metabolic diseases. Trends Endocrinol Metab 32(7):444\u2013462","journal-title":"Trends Endocrinol Metab"},{"key":"8264_CR35","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.gde.2016.02.004","volume":"38","author":"TA Rouault","year":"2016","unstructured":"Rouault TA (2016) Mitochondrial iron overload: causes and consequences. Curr Opin Genet Dev 38:31\u201337","journal-title":"Curr Opin Genet Dev"},{"key":"8264_CR36","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.mito.2019.08.001","volume":"49","author":"N Kozhukhar","year":"2019","unstructured":"Kozhukhar N, Alexeyev MF (2019) Limited predictive value of TFAM in mitochondrial biogenesis. Mitochondrion 49:156\u2013165","journal-title":"Mitochondrion"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-023-08264-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-023-08264-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-023-08264-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T15:43:25Z","timestamp":1679931805000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-023-08264-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,26]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["8264"],"URL":"https:\/\/doi.org\/10.1007\/s11033-023-08264-0","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"type":"print","value":"0301-4851"},{"type":"electronic","value":"1573-4978"}],"subject":[],"published":{"date-parts":[[2023,1,26]]},"assertion":[{"value":"21 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Author V. Dhorajia declares that he has no conflict of interest. Author J. Kim declares that he has no conflict of interest. Author Y. Kim declares that he has no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All applicable international, national, and\/or institutional guidelines for the care and use of animals were followed. All animal experiments were performed in accordance with the Guide for Care and Use of Laboratory Animals of the National Institutes of Health, and the procedure was approved by University of Massachusetts Lowell Institutional Animal Care and Use Committee (IACUC).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}