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TGF\u03b2 is one of the key signaling pathways in melanoma progression. Previous studies on various types of cancer have shown that both: polyphenols and a static magnetic field (SMF) can be potential chemopreventive\/therapeutic agents. Therefore, the aim of the study was to evaluate the effect of a SMF and selected polyphenols on the transcriptional activity of TGF\u03b2 genes in melanoma cells.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods and results<\/jats:title>\n                <jats:p>Experiments were performed on the C32 cell line treated with caffeic or chlorogenic acids, and with simultaneous exposure to a moderate-strength SMF. The RT-qPCR method was used to determine the mRNA level of genes encoding the TGF\u03b2 isoforms and their receptors. The concentration of the TGF\u03b21 and TGF\u03b22 proteins were also measured in the cell culture supernates. The first response of C32 melanoma cells to both factors is the reduction of TGF\u03b2 levels. Then, mRNA level of these molecules returned to values close to pre-treatment level by the end of experiment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our study results demonstrate the potential of polyphenols and a moderate-strength SMF to support cancer therapy by altering TGF\u03b2 expression, which is a very promising topic for the diagnosis and treatment of melanoma.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11033-023-08336-1","type":"journal-article","created":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T21:47:00Z","timestamp":1679867220000},"page":"4207-4216","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Phenolic acids and a static magnetic field change the expression of transforming growth factor \u03b2 isoforms in amelanotic melanoma cells"],"prefix":"10.1007","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6113-7006","authenticated-orcid":false,"given":"Magdalena","family":"Kimsa-Dudek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7560-8983","authenticated-orcid":false,"given":"Agnieszka","family":"Synowiec-Wojtarowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0706-0543","authenticated-orcid":false,"given":"Agata","family":"Krawczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,10]]},"reference":[{"issue":"4","key":"8336_CR1","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/j.cps.2021.05.001","volume":"48","author":"WW Dzwierzynski","year":"2021","unstructured":"Dzwierzynski WW (2021) Melanoma Risk factors and Prevention. 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