{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T21:05:44Z","timestamp":1766869544498,"version":"3.37.3"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1007\/s11033-023-08546-7","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T15:02:36Z","timestamp":1686927756000},"page":"6435-6443","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Unusual serological profile in hepatitis B virus (HBV) infection associated with a probable clinical case of acute exacerbation of pre-existing chronic HBV infection"],"prefix":"10.1007","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8909-9091","authenticated-orcid":false,"given":"Rob\u00e9rio Amorim de Almeida","family":"Pond\u00e9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,6,16]]},"reference":[{"issue":"7","key":"8546_CR1","doi-asserted-by":"publisher","first-page":"e6088","DOI":"10.1097\/MD.0000000000006088","volume":"96","author":"X Du","year":"2017","unstructured":"Du X, Liu Y, Ma L et al (2017) Virological and serological features of acute hepatitis B in adults. Med (Baltim) 96(7):e6088. https:\/\/doi.org\/10.1097\/MD.0000000000006088","journal-title":"Med (Baltim)"},{"issue":"9","key":"8546_CR2","doi-asserted-by":"publisher","first-page":"e75267","DOI":"10.1371\/journal.pone.0075267","volume":"8","author":"V Thibault","year":"2013","unstructured":"Thibault V, Laperche S, Thiers V, Sayon S, Dela-rocque-Astagneau LetortM-J, Antona E D (2013) Molecular epidemiology and clinical characteristics of hepatitis B identified through the french mandatory notification system. PLoS ONE 8(9):e75267. https:\/\/doi.org\/10.1371\/journal.pone.0075267","journal-title":"PLoS ONE"},{"key":"8546_CR3","doi-asserted-by":"publisher","first-page":"18035","DOI":"10.1038\/nrdp.2018.35","volume":"4","author":"MF Yuen","year":"2018","unstructured":"Yuen MF, Chen DS, Dusheiko GM, Janssen HLA, Lau DTY, Locarnini SA, Peters MG, Lai CL (2018) Hepatitis B virus infection. Nat Rev Dis Primers 4:18035. https:\/\/doi.org\/10.1038\/nrdp.2018.35. PMID: 29877316","journal-title":"Nat Rev Dis Primers"},{"key":"8546_CR4","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.22034\/APJCP.2018.19.8.2125","volume":"8","author":"M Makvandi","year":"2018","unstructured":"Makvandi M, Soleimani R, Samarbafzadeh A et al (2018) Natural history of chronic hepatites B virus in Ahvaz City, Iran. Asian Pac J Cancer Prev 8:2125\u20132129. https:\/\/doi.org\/10.22034\/APJCP.2018.19.8.2125","journal-title":"Asian Pac J Cancer Prev"},{"issue":"11","key":"8546_CR5","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1002\/jmv.24032","volume":"86","author":"G Song","year":"2014","unstructured":"Song G, Rao H, Feng B, Wei L (2014) Prediction of spontaneous HBeAg seroconversion in HBeAg-positive chronic hepatitis B patients during the immune clearance phase. J Med Virol 86(11):1838\u20131844. https:\/\/doi.org\/10.1002\/jmv.24032","journal-title":"J Med Virol"},{"issue":"2","key":"8546_CR6","doi-asserted-by":"publisher","first-page":"191","DOI":"10.7861\/clinmedicine.15-2-191","volume":"15","author":"US Gill","year":"2015","unstructured":"Gill US, Kennedy PT (2015) New insights in the management of chronic hepatitis B. Clin Med (Lond) 15(2):191\u2013196","journal-title":"Clin Med (Lond)"},{"key":"8546_CR7","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1007\/s00535-017-1315-4","volume":"52","author":"T Tomoko","year":"2017","unstructured":"Tomoko T, Hitoshi T, Satoyo H (2017) Natural history of chronic hepatitis B virus infection in children in Japan: a comparison of mother-to-child transmission with horizontal transmission. J Gastroenterol 52:1041\u20131050","journal-title":"J Gastroenterol"},{"issue":"10","key":"8546_CR8","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1038\/s41575-019-0197-8","volume":"16","author":"YF Liaw","year":"2019","unstructured":"Liaw YF (2019) Clinical utility of HBV surface antigen quantification in HBV e antigen-negative chronic HBV infection. Nat Rev Gastroenterol Hepatol 16(10):631\u2013641","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"8546_CR9","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1053\/j.gastro.2007.08.010","volume":"133","author":"SE Livingston","year":"2007","unstructured":"Livingston SE, Simonetti JP, Bulkow LR, Homan CE, Snowball MM, Cagle HH, Negus SE et al (2007) Clearance of hepatitis B e antigen in patients with chronic hepatitis B and genotypes a, B, C, D, and F. Gastroenterology 133:1452\u20131457","journal-title":"Gastroenterology"},{"key":"8546_CR10","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1002\/hep.23348","volume":"51","author":"YC Chen","year":"2010","unstructured":"Chen YC, Chu CM, Liaw YF (2010) Age-specific prognosis following spontaneous hepatitis B e antigen seroconversion in chronic B. Hepatology 51:435\u2013444","journal-title":"Hepatology"},{"key":"8546_CR11","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1016\/j.cgh.2008.08.021","volume":"6","author":"EB Keeffe","year":"2008","unstructured":"Keeffe EB, Dieterich DT, Han SH, Jacobson IM, Martin P, SchiffER et al (2008) A treatment algorithm for the management of chronic hepatitis B v\u00edrus infection in the United States: 2008 update. Clin Gastroenterol Hepatol 6:1315\u20131341","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"4","key":"8546_CR12","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s10096-012-1781-9","volume":"32","author":"RAA Pond\u00e9","year":"2013","unstructured":"Pond\u00e9 RA (2013) Atypical serological profiles in hepatitis B virus infection. Eur J Clin Microbiol Infect Dis 32(4):461\u2013476. https:\/\/doi.org\/10.1007\/s10096-012-1781-9","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"24","key":"8546_CR13","doi-asserted-by":"publisher","first-page":"7653","DOI":"10.3748\/wjg.v20.i24.7653","volume":"20","author":"I Lazarevic","year":"2014","unstructured":"Lazarevic I (2014) Clinical implications of hepatitis B virus mutations: recent advances. World J Gastroenterol 20(24):7653\u20137664. https:\/\/doi.org\/10.3748\/wjg.v20.i24.7653","journal-title":"World J Gastroenterol"},{"issue":"5","key":"8546_CR14","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1007\/s11262-020-01773-1","volume":"56","author":"H Ye","year":"2020","unstructured":"Ye H, Teng J, Lin Z, Wang Y, Fu X (2020) Analysis of HBsAg mutations in the 25 years after the implementation of the hepatitis B vaccination plan in China. Virus Genes 56(5):546\u2013556. https:\/\/doi.org\/10.1007\/s11262-020-01773-1","journal-title":"Virus Genes"},{"issue":"1","key":"8546_CR15","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3748\/wjg.v22.i1.145","volume":"22","author":"P Caligiuri","year":"2016","unstructured":"Caligiuri P, Cerruti R, Icardi G, Bruzzone B (2016) Overview of hepatitis B virus mutations and their implications in the management of infection. World J Gastroenterol 22(1):145\u2013154. https:\/\/doi.org\/10.3748\/wjg.v22.i1.145","journal-title":"World J Gastroenterol"},{"issue":"4","key":"8546_CR16","doi-asserted-by":"publisher","first-page":"401","DOI":"10.3934\/microbiol.2020024","volume":"6","author":"MK Rajput","year":"2020","unstructured":"Rajput MK (2020) Mutations and methods of analysis of mutations in Hepatitis B virus. AIMS Microbiol 6(4):401\u2013421. https:\/\/doi.org\/10.3934\/microbiol.2020024","journal-title":"AIMS Microbiol"},{"issue":"11","key":"8546_CR17","doi-asserted-by":"publisher","first-page":"3268","DOI":"10.3748\/wjg.v22.i11.3268","volume":"22","author":"XL Wang","year":"2016","unstructured":"Wang XL, Ren JP, Wang XQ, Wang XH, Yang SF, Xiong Y (2016) Mutations in pre-core and basic core promoter regions of hepatitis B virus in chronic hepatitis B patients. World J Gastroenterol 22(11):3268\u20133274. https:\/\/doi.org\/10.3748\/wjg.v22.i11.3268","journal-title":"World J Gastroenterol"},{"issue":"6","key":"8546_CR18","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1007\/s00281-017-0641-1","volume":"39","author":"M Hong","year":"2017","unstructured":"Hong M, Bertoletti A (2017) Tolerance and immunity to pathogens in early life: insights from HBV infection. Semin Immunopathol 39(6):643\u2013652. https:\/\/doi.org\/10.1007\/s00281-017-0641-1","journal-title":"Semin Immunopathol"},{"issue":"3","key":"8546_CR19","doi-asserted-by":"publisher","first-page":"117","DOI":"10.14744\/hf.2021.2021.0019","volume":"2","author":"HK Bedi","year":"2021","unstructured":"Bedi HK, Trasolini R, Lowe CF, Hussaini T, Bigham M, Ritchie G, Yoshida EM (2021) De novo hepatitis B surface antigen (HBsAg)-positive, core antibody (anti-HBc)-negative, hepatitis B virus infection post-liver transplant from an anti-HBc, HBsAg-negative donor. Hepatol Forum 2(3):117\u2013119. https:\/\/doi.org\/10.14744\/hf.2021.2021.0019","journal-title":"Hepatol Forum"},{"issue":"1","key":"8546_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/1348-0421.12943","volume":"66","author":"RA de Almeida Pond\u00e9","year":"2022","unstructured":"de Almeida Pond\u00e9 RA (2022) Detection of the serological markers hepatitis B virus surface antigen (HBsAg) and hepatitis B core IgM antibody (anti-HBcIgM) in the diagnosis of acute hepatitis B virus infection after recent exposure. Microbiol Immunol 66(1):1\u20139. https:\/\/doi.org\/10.1111\/1348-0421.12943","journal-title":"Microbiol Immunol"},{"key":"8546_CR21","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1002\/jmv.10291","volume":"69","author":"VP Chulanov","year":"2003","unstructured":"Chulanov VP, Shipulin GA, Schaefer S, Gerlich WH (2003) Kinetics of HBV DNA and HBsAg in acute hepatitis B patients with and without coinfection by other hepatitis viruses. J Med Virol 69:313\u2013323","journal-title":"J Med Virol"},{"key":"8546_CR22","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1007\/BF02014141","volume":"1","author":"GG Fr\u00f6sner","year":"1982","unstructured":"Fr\u00f6sner GG, Schomerus H, Wiedmann KH, Zachoval R, Bayerl B, B\u00e4cker U, Gathof GA, Sugg U (1982) Diagnostic significance of quantitative determination of hepatitis B surface antigen in acute and chronic hepatites B infection. Eur J Clin Microbiol 1:52\u201358","journal-title":"Eur J Clin Microbiol"},{"issue":"1","key":"8546_CR23","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1186\/s12985-021-01706-w","volume":"18","author":"MC Kuhns","year":"2021","unstructured":"Kuhns MC, Holzmayer V, McNamara AL, Anderson M, Cloherty GA (2021) Hepatitis B seroconversion revisited: new insights into the natural history of acute hepatitis B virus (HBV) infection from quantitative and highly sensitive assays and novel biomarkers. Virol J 18(1):235. https:\/\/doi.org\/10.1186\/s12985-021-01706-w","journal-title":"Virol J"},{"key":"8546_CR24","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1111\/j.1440-1746.2008.05600.x","volume":"23","author":"Y Han","year":"2008","unstructured":"Han Y, Tang Q, Zhu W, Zhang X, You L (2008) Clinical, biochemical, immunological and virological profiles of, and differential diagnosis between, patients with acute hepatitis B and chronic hepatites B with acute flare. J Gastroenterol Hepatol 23:1728\u20131733","journal-title":"J Gastroenterol Hepatol"},{"key":"8546_CR25","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1002\/hep.24732","volume":"55","author":"DY Dao","year":"2012","unstructured":"Dao DY, Hynan LS, Yuan H-J, Sanders C, Balko J, Attar N, LokAS, Word RA, Lee WM (2012) Two distinct subtypes of hepatitis B virus-related acute liver failureare separable by quantitative serum immunoglobulin M anti-hepatitis B core antibody and hepatitis B virus DNA levels. Hepatology 55:676\u2013684","journal-title":"Hepatology"},{"key":"8546_CR26","doi-asserted-by":"publisher","first-page":"847854","DOI":"10.1084\/jem.193.7.847","volume":"193","author":"SA Whalley","year":"2001","unstructured":"Whalley SA, Murray JM, Brown D, Webster GJ, Emery VC, Dusheiko GM, Perelson AS (2001) Kinetics of acute hepatites B v\u00edrus infection in humans. J Exp Med 193:847854","journal-title":"J Exp Med"},{"issue":"7","key":"8546_CR27","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1093\/cid\/cit348","volume":"57","author":"H Yotsuyanagi","year":"2013","unstructured":"Yotsuyanagi H, Ito K, Yamada N, Takahashi H, Okuse C, Yasuda K, Suzuki M, Moriya K, Mizokami M, Miyakawa Y, Koike K (2013) High levels of hepatitis B virus after the onset of disease lead to chronic infection in patients with acute hepatitis B. Clin Infect Dis 57(7):935\u2013942. https:\/\/doi.org\/10.1093\/cid\/cit348","journal-title":"Clin Infect Dis"},{"key":"8546_CR28","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1053\/jhep.2000.19324","volume":"32","author":"GJ Webster","year":"2000","unstructured":"Webster GJ, Reignat S, Maini MK, Whalley SA, Ogg GS, KingA, Brown D, Amlot PL, Williams R, Vergani D, DusheikoGM, Bertoletti A (2000) Incubation phase of acute hepatitis B in man: dynamic of cellular immune mechanisms. Hepatology 32:1117\u20131124","journal-title":"Hepatology"},{"key":"8546_CR29","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/S1665-2681(19)31575-3","volume":"10","author":"A Singhal","year":"2011","unstructured":"Singhal A, Kanagala R, Jalil S, Wright HI, Kohli V (2011) Chronic HBV with pregnancy: reactivation flare causing fulminant hepatic failure. Ann Hepatol 10:233\u2013236","journal-title":"Ann Hepatol"},{"key":"8546_CR30","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.jcma.2012.06.006","volume":"75","author":"YH Huang","year":"2012","unstructured":"Huang YH, Lin HC, Lee SD (2012) Management of chemotherapy-induced hepatitis B virus reactivation. J Chin Med Assoc 75:359\u2013362. https:\/\/doi.org\/10.1016\/j.jcma.2012.06.006","journal-title":"J Chin Med Assoc"},{"key":"8546_CR31","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1111\/j.1440-1746.2008.05600.x","volume":"23","author":"Y Han","year":"2008","unstructured":"Han Y, Tang Q, Zhu W, Zhang X, You L (2008) Clinical, biochemical, immunological and virological profiles of, and differential diagnosis between, patients with acute hepatitis B and chronic hepatitis B with acute flare. J Gastroenterol Hepatol 23:1728\u20131733","journal-title":"J Gastroenterol Hepatol"},{"issue":"1","key":"8546_CR32","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1007\/s11033-020-06056-4","volume":"48","author":"RA de Almeida Pond\u00e9","year":"2021","unstructured":"de Almeida Pond\u00e9 RA (2021) Dynamic profile of the HBeAg-anti-HBe system in acute and chronic hepatitis B virus infection: a clinical-laboratory approach. Mol Biol Rep 48(1):843\u2013854. https:\/\/doi.org\/10.1007\/s11033-020-06056-4","journal-title":"Mol Biol Rep"},{"issue":"11","key":"8546_CR33","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1007\/s00705-019-04369-9","volume":"164","author":"RAA Pond\u00e9","year":"2019","unstructured":"Pond\u00e9 RAA (2019) Expression and detection of anti-HBs antibodies after hepatitis B virus infection or vaccination in the context of protective immunity. Arch Virol 164(11):2645\u20132658. https:\/\/doi.org\/10.1007\/s00705-019-04369-9","journal-title":"Arch Virol"},{"issue":"3","key":"8546_CR34","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.jhep.2013.12.001","volume":"60","author":"MR Brunetto","year":"2014","unstructured":"Brunetto MR (2014) Chance and necessity of simultaneous HBsAg and anti-HBs detection in the serum of chronic HBsAg carriers. J Hepatol 60(3):473\u2013475. https:\/\/doi.org\/10.1016\/j.jhep.2013.12.001","journal-title":"J Hepatol"},{"issue":"4","key":"8546_CR35","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.7150\/ijbs.55724","volume":"17","author":"X Jiang","year":"2021","unstructured":"Jiang X, Chang L, Yan Y, Wang L (2021) Paradoxical HBsAg and anti-HBs coexistence among chronic HBV infections: causes and consequences. Int J Biol Sci 17(4):1125\u20131137. https:\/\/doi.org\/10.7150\/ijbs.55724","journal-title":"Int J Biol Sci"},{"key":"8546_CR36","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1002\/jmv.24782","volume":"89","author":"X Fu","year":"2017","unstructured":"Fu X, Chen J, Chen H, Lin J, Xun Z, Li S et al (2017) Mutation in the S gene of hepatitis B virus and anti-HBs subtype-nonspecificity contributed to the co-existence of HBsAg and anti-HBs in patients with chronic hepatitis B virus infection. J Med Virol 89:1419\u20131426","journal-title":"J Med Virol"},{"issue":"12","key":"8546_CR37","doi-asserted-by":"publisher","first-page":"747","DOI":"10.2169\/internalmedicine.45.0158","volume":"45","author":"T Umemura","year":"2006","unstructured":"Umemura T, Kiyosawa K (2006) Fatal HBV reactivation in a subject with anti-HBs and anti-HBc. Intern Med 45(12):747\u2013748","journal-title":"Intern Med"},{"issue":"9","key":"8546_CR38","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1086\/513200","volume":"44","author":"JM Zhang","year":"2007","unstructured":"Zhang JM, Xu Y, Wang XY, Yin YK, Wu XH, Weng XH, Lu M (2007) Coexistence of hepatitis B surface antigen (HBsAg) and heterologous subtype-specific antibodies to HBsAg among patients with chronic hepatitis B virus infection. Clin Infect Dis 44(9):1161\u20131169","journal-title":"Clin Infect Dis"},{"issue":"4","key":"8546_CR39","first-page":"502","volume":"4","author":"L-M Wu","year":"2005","unstructured":"Wu L-M, Xu X, Zheng S-S (2005) Hepatitis B virus reinfection after liver transplantation: related risk factors and perspective. Hepatobiliary Pancreat Dis Int 4(4):502\u2013507","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"8546_CR40","doi-asserted-by":"publisher","unstructured":"Lazarevic I, Banko A, Miljanovic D, Cupic M, Immune-Escape Hepatitis B Virus Mutations Associated with Viral Reactivation upon Immunosuppression. Viruses. 2019 Aug 24;11(9):778. doi: https:\/\/doi.org\/10.3390\/v11090778","DOI":"10.3390\/v11090778"},{"issue":"2","key":"8546_CR41","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1055\/s-0033-1345722","volume":"33","author":"D Shouval","year":"2013","unstructured":"Shouval D, Shibolet O (2013) Immunosuppression and HBV reactivation. Semin Liver Dis 33(2):167\u2013177. https:\/\/doi.org\/10.1055\/s-0033-1345722","journal-title":"Semin Liver Dis"},{"key":"8546_CR42","doi-asserted-by":"publisher","first-page":"m2200","DOI":"10.1136\/bmj.m2200","volume":"370","author":"Y Shi","year":"2020","unstructured":"Shi Y, Zheng M (2020) Hepatitis B virus persistence and reactivation. BMJ 370:m2200. https:\/\/doi.org\/10.1136\/bmj.m2200","journal-title":"BMJ"},{"issue":"4","key":"8546_CR43","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1002\/jmv.24115","volume":"87","author":"H Kamitsukasa","year":"2015","unstructured":"Kamitsukasa H, Iri M, Tanaka A, Nagashima S, Takahashi M, Nishizawa T, Okamoto H (2015) Spontaneous reactivation of hepatitis B virus (HBV) infection in patients with resolved or occult HBV infection. J Med Virol 87(4):589\u2013600. https:\/\/doi.org\/10.1002\/jmv.24115","journal-title":"J Med Virol"},{"issue":"2","key":"8546_CR44","doi-asserted-by":"publisher","first-page":"187","DOI":"10.3350\/cmh.2019.0060","volume":"26","author":"S Lall","year":"2020","unstructured":"Lall S, Agarwala P, Kumar G, Sharma MK, Gupta E (2020) The dilemma of differentiating between acute hepatitis B and chronic hepatitis B with acute exacerbation: is quantitative serology the answer? Clin Mol Hepatol 26(2):187\u2013195. https:\/\/doi.org\/10.3350\/cmh.2019.0060","journal-title":"Clin Mol Hepatol"},{"issue":"6","key":"8546_CR45","doi-asserted-by":"publisher","first-page":"e15937","DOI":"10.7759\/cureus.15937","volume":"13","author":"R Bestas","year":"2021","unstructured":"Bestas R, Yalcin K (2021) Clinical and virological features of Acute hepatic exacerbations in patients with chronic Hepatitis B Virus infection. Cureus 13(6):e15937. https:\/\/doi.org\/10.7759\/cureus.15937","journal-title":"Cureus"},{"key":"8546_CR46","doi-asserted-by":"publisher","first-page":"3358","DOI":"10.1128\/jvi.69.6.3358-3368.1995","volume":"69","author":"MC Jung","year":"1995","unstructured":"Jung MC, Diepolder HM, Spengler U, Wierenga EA, ZachovalR, Hoffmann RM, Eichenlaub D, Fr\u00f6sner G, Will H, Pape GR (1995) Activation of a heterogeneous hepatitis B (HB) core ande antigen-specific CD4 + T-cell population during seroconver-sion to anti-HBe and anti-HBs in hepatitis B v\u00edrus infection. J Virol 69:3358\u20133368","journal-title":"J Virol"},{"issue":"10","key":"8546_CR47","doi-asserted-by":"publisher","first-page":"2727","DOI":"10.1007\/s10620-010-1179-4","volume":"55","author":"YF Liaw","year":"2010","unstructured":"Liaw YF, Lau GK, Kao JH, Gane E (2010) Hepatitis B e antigen seroconversion: a critical event in chronic hepatitis B virus infection. Dig Dis Sci 55(10):2727\u20132734. https:\/\/doi.org\/10.1007\/s10620-010-1179-4","journal-title":"Dig Dis Sci"},{"issue":"10","key":"8546_CR48","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1111\/jvh.13731","volume":"29","author":"D Mutimer","year":"2022","unstructured":"Mutimer D, Elsharkawy A, Hathorn E, Arunkumar S (2022) Hepatitis B e antigen and e antibody in a multi-ethnic cohort of adult chronic hepatitis B virus patients followed at a single liver unit for a period of 20 years. J Viral Hepat 29(10):879\u2013889. https:\/\/doi.org\/10.1111\/jvh.13731","journal-title":"J Viral Hepat"},{"issue":"2","key":"8546_CR49","first-page":"97","volume":"3","author":"CF Huang","year":"2006","unstructured":"Huang CF, Lin SS, Ho YC, Chen FL, Yang CC (2006) The immune response induced by hepatitis B virus principal antigens. Cell Mol Immunol 3(2):97\u2013106","journal-title":"Cell Mol Immunol"},{"key":"8546_CR50","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.amjmed.2003.12.040","volume":"116","author":"CM Chu","year":"2004","unstructured":"Chu CM, Hung SJ, Lin J, Tai DI, Liaw YF (2004) Natural history of hepatitis B e antigen to antibody seroconversion inpatients with normal serum aminotransferase levels. Am J Med 116:829\u2013834","journal-title":"Am J Med"},{"issue":"1 Suppl","key":"8546_CR51","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1016\/j.jhep.2016.01.027","volume":"64","author":"S Tong","year":"2016","unstructured":"Tong S, Revill P (2016) Overview of hepatitis B viral replicationand genetic variability. J Hepatol 64(1 Suppl):S4\u2013S16. https:\/\/doi.org\/10.1016\/j.jhep.2016.01.027","journal-title":"J Hepatol"},{"issue":"2","key":"8546_CR52","doi-asserted-by":"publisher","first-page":"541","DOI":"10.3748\/wjg.v21.i2.541","volume":"21","author":"N Kamijo","year":"2015","unstructured":"Kamijo N, Matsumoto A, Umemura T, Shibata S, Ichikawa Y, Kimura T, Komatsu M, Tanaka E (2015) Mutations of pre-core and basal core promoter before and after hepatitis B e antigenseroconversion. World J Gastroenterol 21(2):541\u2013548","journal-title":"World J Gastroenterol"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-023-08546-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-023-08546-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-023-08546-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T16:41:34Z","timestamp":1690476094000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-023-08546-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,16]]},"references-count":52,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["8546"],"URL":"https:\/\/doi.org\/10.1007\/s11033-023-08546-7","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"type":"print","value":"0301-4851"},{"type":"electronic","value":"1573-4978"}],"subject":[],"published":{"date-parts":[[2023,6,16]]},"assertion":[{"value":"28 March 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2023","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The citation of the author name is corrected from \u201cAmorim de Almeida Pond\u00e9 R\u201d to \u201cPond\u00e9 RAA\u201d.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financialinterestsor personal relationships that could have appeared to influence the work reported in this paper. The author further states that this paper comprises a review article that, for its compilation, it did not require research involving human participants and\/or animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest\/Competing interests"}},{"value":"Informed consent was obtained from the patient participating in this study, as demonstrated in the attached document.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The author states that the patient participating in this study provided informed consent for the publication of his laboratory results released from this article, as demonstrated in an attached document.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"\u2018Not applicable\u2019 for that section.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}