{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T02:56:26Z","timestamp":1768704986609,"version":"3.49.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1007\/s11033-023-08729-2","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T17:02:30Z","timestamp":1692896550000},"page":"8705-8714","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Circular RNA ciRS-7 signature as a potential biomarker for the early detection of diabetes with Alzheimer\u2019s disease: a hypothesis"],"prefix":"10.1007","volume":"50","author":[{"given":"Mahima","family":"Singh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8583-9352","authenticated-orcid":false,"given":"Ajay","family":"Guru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raghul","family":"Murugan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muthukaruppan","family":"Gopi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesu","family":"Arockiaraj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"key":"8729_CR1","doi-asserted-by":"publisher","unstructured":"Khalifa O, Errafii K, Al-Akl NS, Arredouani A (2020) Noncoding RNAs in nonalcoholic fatty liver disease: potential diagnosis and prognosis biomarkers. https:\/\/doi.org\/10.1155\/2020\/8822859. Dis Markers 2020:","DOI":"10.1155\/2020\/8822859"},{"key":"8729_CR2","doi-asserted-by":"publisher","first-page":"3852","DOI":"10.1073\/pnas.73.11.3852","volume":"73","author":"HL Sanger","year":"1976","unstructured":"Sanger HL, Klotz G, Riesner D et al (1976) Viroids are single stranded covalently closed circular RNA molecules existing as highly base paired rod like structures. Proc Natl Acad Sci U S A 73:3852\u20133856. https:\/\/doi.org\/10.1073\/pnas.73.11.3852","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8729_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmolb.2017.00038","volume":"4","author":"J Greene","year":"2017","unstructured":"Greene J, Baird AM, Brady L et al (2017) Circular RNAs: Biogenesis, function and role in human diseases. Front Mol Biosci 4:1\u201311. https:\/\/doi.org\/10.3389\/fmolb.2017.00038","journal-title":"Front Mol Biosci"},{"key":"8729_CR4","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/nrg.2016.114","volume":"17","author":"L Szabo","year":"2016","unstructured":"Szabo L, Salzman J (2016) Detecting circular RNAs: bioinformatic and experimental challenges. Nat Rev Genet 17:679\u2013692. https:\/\/doi.org\/10.1038\/nrg.2016.114","journal-title":"Nat Rev Genet"},{"key":"8729_CR5","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/nsmb.2580","volume":"20","author":"R Taulli","year":"2013","unstructured":"Taulli R, Loretelli C, Pandolfi PP (2013) From pseudo-ceRNAs to circ-ceRNAs: a tale of cross-talk and competition. Nat Struct Mol Biol 20:541\u2013543. https:\/\/doi.org\/10.1038\/nsmb.2580","journal-title":"Nat Struct Mol Biol"},{"key":"8729_CR6","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1038\/nrg.2016.20","volume":"17","author":"DW Thomson","year":"2016","unstructured":"Thomson DW, Dinger ME (2016) Endogenous microRNA sponges: evidence and controversy. Nat Rev Genet 17:272\u2013283. https:\/\/doi.org\/10.1038\/nrg.2016.20","journal-title":"Nat Rev Genet"},{"key":"8729_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fendo.2013.00037","volume":"4","author":"ME Cerf","year":"2013","unstructured":"Cerf ME (2013) Beta cell dysfunction and insulin resistance. Front Endocrinol (Lausanne) 4:1\u201312. https:\/\/doi.org\/10.3389\/fendo.2013.00037","journal-title":"Front Endocrinol (Lausanne)"},{"key":"8729_CR8","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1002\/cbin.11608","volume":"45","author":"A Guru","year":"2021","unstructured":"Guru A, Issac PK, Saraswathi NT et al (2021) Deteriorating insulin resistance due to WL15 peptide from cysteine and glycine-rich protein 2 in high glucose\u2010induced rat skeletal muscle L6 cells. Cell Biol Int 45:1698\u20131709. https:\/\/doi.org\/10.1002\/cbin.11608","journal-title":"Cell Biol Int"},{"key":"8729_CR9","doi-asserted-by":"publisher","first-page":"5857","DOI":"10.1007\/s11033-021-06580-x","volume":"48","author":"PK Issac","year":"2021","unstructured":"Issac PK, Karan R, Guru A et al (2021) Insulin signaling pathway assessment by enhancing antioxidant activity due to morin using in vitro rat skeletal muscle L6 myotubes cells. Mol Biol Rep 48:5857\u20135872. https:\/\/doi.org\/10.1007\/s11033-021-06580-x","journal-title":"Mol Biol Rep"},{"key":"8729_CR10","doi-asserted-by":"crossref","unstructured":"Sharma HS, Castellani RJ, Smith MA, Sharma A (2012) The blood-brain barrier in Alzheimer\u2019s Disease. Novel therapeutic targets and nanodrug delivery, 1st edn. Elsevier Inc","DOI":"10.1016\/B978-0-12-386986-9.00003-X"},{"key":"8729_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/jcm9061713","volume":"9","author":"GD Stanciu","year":"2020","unstructured":"Stanciu GD, Bild V, Ababei DC et al (2020) Link between diabetes and Alzheimer\u2019s disease due to the shared amyloid aggregation and deposition involving both neurodegenerative changes and neurovascular damages. J Clin Med 9:1\u201325. https:\/\/doi.org\/10.3390\/jcm9061713","journal-title":"J Clin Med"},{"key":"8729_CR12","doi-asserted-by":"publisher","first-page":"4134","DOI":"10.3390\/ijms23084134","volume":"23","author":"M D\u2019Anca","year":"2022","unstructured":"D\u2019Anca M, Buccellato FR, Fenoglio C, Galimberti D (2022) Circular RNAs: emblematic players of neurogenesis and neurodegeneration. Int J Mol Sci 23:4134. https:\/\/doi.org\/10.3390\/ijms23084134","journal-title":"Int J Mol Sci"},{"key":"8729_CR13","doi-asserted-by":"publisher","unstructured":"Fan W, Pang H, Xie Z et al (2022) Circular RNAs in diabetes mellitus and its complications. Front Endocrinol (Lausanne) 13. https:\/\/doi.org\/10.3389\/fendo.2022.885650","DOI":"10.3389\/fendo.2022.885650"},{"key":"8729_CR14","doi-asserted-by":"publisher","unstructured":"Liu K, Zhang Q, Pan F et al (2019) Expression of circular RNAs in gynecological tumors: a systematic review. Med (United States) 98. https:\/\/doi.org\/10.1097\/MD.0000000000015736","DOI":"10.1097\/MD.0000000000015736"},{"key":"8729_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms19113454","volume":"19","author":"S Greco","year":"2018","unstructured":"Greco S, Cardinali B, Falcone G, Martelli F (2018) Circular rnas in muscle function and disease. Int J Mol Sci 19:1\u201318. https:\/\/doi.org\/10.3390\/ijms19113454","journal-title":"Int J Mol Sci"},{"key":"8729_CR16","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.molcel.2013.08.017","volume":"51","author":"Y Zhang","year":"2013","unstructured":"Zhang Y, Zhang XO, Chen T et al (2013) Circular intronic long noncoding RNAs. Mol Cell 51:792\u2013806. https:\/\/doi.org\/10.1016\/j.molcel.2013.08.017","journal-title":"Mol Cell"},{"key":"8729_CR17","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.jbiotec.2016.09.011","volume":"238","author":"FR Kulcheski","year":"2016","unstructured":"Kulcheski FR, Christoff AP, Margis R (2016) Circular RNAs are miRNA sponges and can be used as a new class of biomarker. J Biotechnol 238:42\u201351. https:\/\/doi.org\/10.1016\/j.jbiotec.2016.09.011","journal-title":"J Biotechnol"},{"key":"8729_CR18","doi-asserted-by":"publisher","first-page":"25","DOI":"10.2174\/15733998130104","volume":"9","author":"Z Fu","year":"2012","unstructured":"Fu Z, Gilbert R, Liu E D (2012) Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes. Curr Diabetes Rev 9:25\u201353. https:\/\/doi.org\/10.2174\/15733998130104","journal-title":"Curr Diabetes Rev"},{"key":"8729_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms22041503","volume":"22","author":"F Brozzi","year":"2021","unstructured":"Brozzi F, Regazzi R (2021) Circular RNAs as novel regulators of \u03b2-cell functions under physiological and pathological conditions. Int J Mol Sci 22:1\u201316. https:\/\/doi.org\/10.3390\/ijms22041503","journal-title":"Int J Mol Sci"},{"key":"8729_CR20","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.molmet.2018.01.010","volume":"9","author":"L Stoll","year":"2018","unstructured":"Stoll L, Sobel J, Rodriguez-Trejo A et al (2018) Circular RNAs as novel regulators of \u03b2-cell functions in normal and disease conditions. Mol Metab 9:69\u201383. https:\/\/doi.org\/10.1016\/j.molmet.2018.01.010","journal-title":"Mol Metab"},{"key":"8729_CR21","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/978-981-13-1426-1_16","volume":"1087","author":"L Constantin","year":"2018","unstructured":"Constantin L (2018) Circular RNAs and neuronal development. Adv Exp Med Biol 1087:205\u2013213. https:\/\/doi.org\/10.1007\/978-981-13-1426-1_16","journal-title":"Adv Exp Med Biol"},{"key":"8729_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep12453","volume":"5","author":"H Xu","year":"2015","unstructured":"Xu H, Guo S, Li W, Yu P (2015) The circular RNA Cdr1as, via miR-7 and its targets, regulates insulin transcription and secretion in islet cells. Sci Rep 5:1\u201312. https:\/\/doi.org\/10.1038\/srep12453","journal-title":"Sci Rep"},{"key":"8729_CR23","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1016\/j.ymthe.2021.02.008","volume":"29","author":"N Ma","year":"2021","unstructured":"Ma N, Pan J, Wen Y et al (2021) circTulp4 functions in Alzheimer\u2019s disease pathogenesis by regulating its parental gene, Tulp4. Mol Ther 29:2167\u20132181. https:\/\/doi.org\/10.1016\/j.ymthe.2021.02.008","journal-title":"Mol Ther"},{"key":"8729_CR24","doi-asserted-by":"publisher","unstructured":"Shi Z, Chen T, Yao Q et al (2017) The circular RNA ciRS-7 promotes APP and BACE1 degradation in an NF- j B-dependent manner. 1\u201314. https:\/\/doi.org\/10.1111\/febs.14045","DOI":"10.1111\/febs.14045"},{"key":"8729_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms21124302","volume":"21","author":"D Das","year":"2020","unstructured":"Das D, Das A, Sahu M et al (2020) Identification and characterization of circular intronic RNAs derived from insulin gene. Int J Mol Sci 21:1\u201317. https:\/\/doi.org\/10.3390\/ijms21124302","journal-title":"Int J Mol Sci"},{"key":"8729_CR26","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.2337\/db12-0701","volume":"62","author":"JY Chan","year":"2013","unstructured":"Chan JY, Luzuriaga J, Bensellam M et al (2013) Failure of the adaptive unfolded protein response in islets of obese mice is linked with abnormalities in \u03b2-cell gene expression and progression to diabetes. Diabetes 62:1557\u20131568. https:\/\/doi.org\/10.2337\/db12-0701","journal-title":"Diabetes"},{"key":"8729_CR27","doi-asserted-by":"publisher","unstructured":"Seda Yar Saglam A, Alp E, Ilke Onen H (2020) Circular RNAs and its Biological Functions in Health and Disease. Gene Expr Phenotypic Trait 1\u201337. https:\/\/doi.org\/10.5772\/intechopen.88764","DOI":"10.5772\/intechopen.88764"},{"key":"8729_CR28","doi-asserted-by":"publisher","unstructured":"Zhao Y, Alexandrov PN, Jaber V, Lukiw WJ (2016) Deficiency in the ubiquitin conjugating enzyme UBE2A in Alzheimer\u2019s Disease (AD) is linked to deficits in a natural circular miRNA-7 sponge (circRNA; ciRS-7). Genes (Basel) 7. https:\/\/doi.org\/10.3390\/genes7120116","DOI":"10.3390\/genes7120116"},{"key":"8729_CR29","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1007\/s12264-019-00361-0","volume":"35","author":"Y Lu","year":"2019","unstructured":"Lu Y, Tan L, Wang X (2019) Circular HDAC9\/microRNA-138\/Sirtuin-1 pathway mediates synaptic and amyloid precursor protein Processing Deficits in Alzheimer\u2019s Disease. Neurosci Bull 35:877\u2013888. https:\/\/doi.org\/10.1007\/s12264-019-00361-0","journal-title":"Neurosci Bull"},{"key":"8729_CR30","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1080\/15384101.2019.1629773","volume":"18","author":"H Yang","year":"2019","unstructured":"Yang H, Wang H, Shang H et al (2019) Circular RNA circ_0000950 promotes neuron apoptosis, suppresses neurite outgrowth and elevates inflammatory cytokines levels via directly sponging miR-103 in Alzheimer\u2019s disease. Cell Cycle 18:2197\u20132214. https:\/\/doi.org\/10.1080\/15384101.2019.1629773","journal-title":"Cell Cycle"},{"key":"8729_CR31","doi-asserted-by":"publisher","unstructured":"Bigarr\u00e9 IM, Trombetta BA, Steven YG, Carlyle BC (2021) ORIGINAL RESEARCH I GF2R circular RNA hsa _ circ _ 0131235 expression in the middle temporal cortex is associated with AD pathology. 1\u20138. https:\/\/doi.org\/10.1002\/brb3.2048","DOI":"10.1002\/brb3.2048"},{"key":"8729_CR32","doi-asserted-by":"publisher","unstructured":"Shamsuzzama A, Kumar L, Haque R, Nazir A (2018) Non-coding RNAs as potential targets for treatment and early diagnosis of age-associated neurodegenerative diseases. Mol Basis Emerg Strateg Anti-aging Interv 19\u201333. https:\/\/doi.org\/10.1007\/978-981-13-1699-9_2","DOI":"10.1007\/978-981-13-1699-9_2"},{"key":"8729_CR33","doi-asserted-by":"crossref","unstructured":"Zhao Y, Zhao B (2013) Review Article Oxidative Stress and the Pathogenesis of Alzheimer \u2019 s Disease. Oxid Med Cell Longev 2013","DOI":"10.1155\/2013\/316523"},{"key":"8729_CR34","doi-asserted-by":"publisher","unstructured":"Zaiou M (2020) The emerging role and promise of circular RNAs in obesity and related metabolic Disorders. https:\/\/doi.org\/10.3390\/cells9061473. Cells 9:","DOI":"10.3390\/cells9061473"},{"key":"8729_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11892-014-0476-2","volume":"14","author":"A Jayaraman","year":"2014","unstructured":"Jayaraman A, Pike CJ (2014) Alzheimer\u2019s Disease and Type 2 diabetes: multiple mechanisms contribute to interactions. Curr Diab Rep 14:1\u201315. https:\/\/doi.org\/10.1007\/s11892-014-0476-2","journal-title":"Curr Diab Rep"},{"key":"8729_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnmol.2016.00025","volume":"9","author":"Y Shao","year":"2016","unstructured":"Shao Y, Chen Y (2016) Roles of circular RNAs in neurologic disease. Front Mol Neurosci 9:1\u20135. https:\/\/doi.org\/10.3389\/fnmol.2016.00025","journal-title":"Front Mol Neurosci"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-023-08729-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-023-08729-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-023-08729-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T02:28:28Z","timestamp":1695695308000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-023-08729-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,24]]},"references-count":36,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["8729"],"URL":"https:\/\/doi.org\/10.1007\/s11033-023-08729-2","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,24]]},"assertion":[{"value":"12 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no conflict of Interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}