{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T07:34:34Z","timestamp":1787297674904,"version":"build-2736575974"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1007\/s11033-023-08780-z","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:01:35Z","timestamp":1693785695000},"page":"8855-8866","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Fucoidan from Sargassum wightii reduces oxidative stress through upregulating Nrf2\/HO-1 signaling pathway in alloxan-induced diabetic cardiomyopathy rats"],"prefix":"10.1007","volume":"50","author":[{"given":"Shanavas Syed Mohamed","family":"Puhari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subramani","family":"Yuvaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varadaraj","family":"Vasudevan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tharmarajan","family":"Ramprasath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kulanthaiyesu","family":"Arunkumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinnaiah","family":"Amutha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govindan Sadasivam","family":"Selvam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,4]]},"reference":[{"key":"8780_CR1","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1161\/CIRCRESAHA.118.314665","volume":"124","author":"WH Dillmann","year":"2019","unstructured":"Dillmann WH (2019) Diabetic cardiomyopathy: what is it and can it be fixed? Circul Res 124:1160\u20131162. https:\/\/doi.org\/10.1161\/CIRCRESAHA.118.314665","journal-title":"Circul Res"},{"key":"8780_CR2","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1161\/CIRCRESAHA.117.311586","volume":"122","author":"G Jia","year":"2018","unstructured":"Jia G, Hill MA, Sowers JR (2018) Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity. Circ Res 122:624\u2013638. https:\/\/doi.org\/10.1161\/CIRCRESAHA.117.311586","journal-title":"Circ Res"},{"key":"8780_CR3","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/S0008-6363(96)88507-5","volume":"30","author":"GW Booz","year":"1995","unstructured":"Booz GW, Baker KM (1995) Molecular signalling mechanisms controlling growth and function of cardiac fibroblasts. Cardiovasc Res 30:537\u2013543","journal-title":"Cardiovasc Res"},{"key":"8780_CR4","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s10741-013-9377-8","volume":"19","author":"M Isfort","year":"2014","unstructured":"Isfort M, Stevens SC, Schaffer S, Jong CJ, Wold LE (2014) Metabolic dysfunction in diabetic cardiomyopathy. Heart Fail Rev 19:35\u201348. https:\/\/doi.org\/10.1007\/s10741-013-9377-8","journal-title":"Heart Fail Rev"},{"key":"8780_CR5","doi-asserted-by":"publisher","first-page":"784","DOI":"10.3390\/antiox11040784","volume":"11","author":"B De Geest","year":"2022","unstructured":"De Geest B, Mishra M (2022) Role of oxidative stress in diabetic cardiomyopathy. Antioxid (Basel 11:784. https:\/\/doi.org\/10.3390\/antiox11040784","journal-title":"Antioxid (Basel"},{"key":"8780_CR6","doi-asserted-by":"publisher","first-page":"H2181","DOI":"10.1152\/ajpheart.00554.2011","volume":"301","author":"H Tsutsui","year":"2011","unstructured":"Tsutsui H, Kinugawa S, Matsushima S (2011) Oxidative stress and heart failure. Am J Physiol Heart Circ Physiol 301:H2181\u2013H2190. https:\/\/doi.org\/10.1152\/ajpheart.00554.2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"8780_CR7","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1536\/ihj.18-476","volume":"60","author":"Z-D Ge","year":"2019","unstructured":"Ge Z-D, Lian Q, Mao X, Xia Z (2019) Current status and challenges of NRF2 as a potential therapeutic target for diabetic cardiomyopathy. Int Heart J 60:512\u2013520. https:\/\/doi.org\/10.1536\/ihj.18-476","journal-title":"Int Heart J"},{"key":"8780_CR8","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s10741-018-9749-1","volume":"24","author":"B Parim","year":"2019","unstructured":"Parim B, Sathibabu Uddandrao VV, Saravanan G (2019) Diabetic cardiomyopathy: molecular mechanisms, detrimental effects of conventional treatment, and beneficial effects of natural therapy. Heart Fail Rev 24:279\u2013299. https:\/\/doi.org\/10.1007\/s10741-018-9749-1","journal-title":"Heart Fail Rev"},{"key":"8780_CR9","doi-asserted-by":"publisher","first-page":"365","DOI":"10.3390\/antiox8090365","volume":"8","author":"NC Afonso","year":"2019","unstructured":"Afonso NC, Catarino MD, Silva AMS, Cardoso SM (2019) Brown macroalgae as valuable food ingredients. Antioxid (Basel) 8:365. https:\/\/doi.org\/10.3390\/antiox8090365","journal-title":"Antioxid (Basel)"},{"key":"8780_CR10","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.jep.2012.05.046","volume":"142","author":"L Liu","year":"2012","unstructured":"Liu L, Heinrich M, Myers S, Dworjanyn SA (2012) Towards a better understanding of medicinal uses of the brown seaweed Sargassum in Traditional Chinese Medicine: a phytochemical and pharmacological review. J Ethnopharmacol 142:591\u2013619. https:\/\/doi.org\/10.1016\/j.jep.2012.05.046","journal-title":"J Ethnopharmacol"},{"key":"8780_CR11","doi-asserted-by":"publisher","first-page":"8131","DOI":"10.1039\/C3RA23373A","volume":"3","author":"MT Ale","year":"2013","unstructured":"Ale MT, Meyer AS (2013) Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation. RSC Adv 3:8131\u20138141. https:\/\/doi.org\/10.1039\/C3RA23373A","journal-title":"RSC Adv"},{"key":"8780_CR12","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.3390\/molecules13081671","volume":"13","author":"B Li","year":"2008","unstructured":"Li B, Lu F, Wei X, Zhao R (2008) Fucoidan: structure and bioactivity. Molecules 13:1671\u20131695. https:\/\/doi.org\/10.3390\/molecules13081671","journal-title":"Molecules"},{"key":"8780_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231810685","author":"Y Ji","year":"2022","unstructured":"Ji Y, Jin D, Qi J, Wang X, Zhang C, An P, Luo Y, Luo J (2022) Fucoidan protects against doxorubicin-Induced cardiotoxicity by reducing oxidative stress and preventing mitochondrial function Injury. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms231810685","journal-title":"Int J Mol Sci"},{"key":"8780_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/md17010069","author":"PM Chang","year":"2019","unstructured":"Chang PM, Li KL, Lin YC (2019) Fucoidan(-)Fucoxanthin ameliorated cardiac function via IRS1\/GRB2\/ SOS1, GSK3beta\/CREB pathways and metabolic pathways in senescent mice. Mar Drugs. https:\/\/doi.org\/10.3390\/md17010069","journal-title":"Mar Drugs"},{"key":"8780_CR15","doi-asserted-by":"publisher","first-page":"420929","DOI":"10.1155\/2014\/420929","volume":"2014","author":"X Yu","year":"2014","unstructured":"Yu X, Zhang Q, Cui W, Zeng Z, Yang W, Zhang C, Zhao H, Gao W, Wang X, Luo D (2014) Low molecular weight fucoidan alleviates cardiac dysfunction in diabetic Goto-Kakizaki rats by reducing oxidative stress and cardiomyocyte apoptosis. J Diabetes Res 2014:420929. https:\/\/doi.org\/10.1155\/2014\/420929","journal-title":"J Diabetes Res"},{"key":"8780_CR16","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7901","author":"Z Lin","year":"2023","unstructured":"Lin Z, Wang F, Yan Y, Jin J, Quan Z, Tong H, Du J (2023) Fucoidan derived from Sargassum pallidum alleviates metabolism disorders associated with improvement of cardiac injury and oxidative stress in diabetic mice. Phytother Res. https:\/\/doi.org\/10.1002\/ptr.7901","journal-title":"Phytother Res"},{"key":"8780_CR17","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.aquaculture.2003.09.025","volume":"233","author":"W Chotigeat","year":"2004","unstructured":"Chotigeat W, Tongsupa S, Supamataya K, Phongdara A (2004) Effect of fucoidan on disease resistance of black tiger shrimp. Aquaculture 233:23\u201330. https:\/\/doi.org\/10.1016\/j.aquaculture.2003.09.025","journal-title":"Aquaculture"},{"key":"8780_CR18","doi-asserted-by":"publisher","first-page":"e14412","DOI":"10.1111\/jfbc.14412","volume":"46","author":"SSM Puhari","year":"2022","unstructured":"Puhari SSM, Yuvaraj S, Vasudevan V, Ramprasath T, Rajkumar P, Arunkumar K, Amutha C, Selvam GS (2022) Isolation and characterization of fucoidan from four brown algae and study of the cardioprotective effect of fucoidan from Sargassum wightii against high glucose-induced oxidative stress in H9c2 cardiomyoblast cells. J Food Biochem 46:e14412. https:\/\/doi.org\/10.1111\/jfbc.14412","journal-title":"J Food Biochem"},{"key":"8780_CR19","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351\u2013358. https:\/\/doi.org\/10.1016\/0003-2697(79)90738-3","journal-title":"Anal Biochem"},{"key":"8780_CR20","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/978-981-10-4307-9_12","volume":"999","author":"AM Mahmoud","year":"2017","unstructured":"Mahmoud AM (2017) Exercise amaliorates metabolic disturbances and oxidative stress in diabetic cardiomyopathy: possible underlying mechanisms. Adv Exp Med Biol 999:207\u2013230. https:\/\/doi.org\/10.1007\/978-981-10-4307-9_12","journal-title":"Adv Exp Med Biol"},{"key":"8780_CR21","doi-asserted-by":"publisher","first-page":"746382","DOI":"10.3389\/fcvm.2021.746382","volume":"8","author":"M Mohan","year":"2021","unstructured":"Mohan M, Dihoum A, Mordi IR, Choy AM, Rena G, Lang CC (2021) Left ventricular hypertrophy in diabetic cardiomyopathy: a target for intervention. Front Cardiovasc Med 8:746382. https:\/\/doi.org\/10.3389\/fcvm.2021.746382","journal-title":"Front Cardiovasc Med"},{"key":"8780_CR22","volume-title":"Oral hypoglycemic medications","author":"K Ganesan","year":"2018","unstructured":"Ganesan K, Rana MBM, Sultan S (2018) Oral hypoglycemic medications. StatPearls Publishing, StatPearls"},{"key":"8780_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/md19050252","author":"Saraswati","year":"2021","unstructured":"Saraswati, Giriwono PE, Iskandriati D, Andarwulan N (2021) Screening of In-Vitro anti-inflammatory and antioxidant activity of Sargassum ilicifolium crude lipid extracts from different coastal areas in Indonesia. Mar Drugs. https:\/\/doi.org\/10.3390\/md19050252","journal-title":"Mar Drugs"},{"key":"8780_CR24","doi-asserted-by":"publisher","DOI":"10.3390\/foods12010033","author":"C Zhang","year":"2022","unstructured":"Zhang C, Jia J, Zhang P, Zheng W, Guo X, Ai C, Song S (2022) Fucoidan from Laminaria japonica ameliorates type 2 diabetes mellitus in association with modulation of gut microbiota and metabolites in streptozocin-treated mice. Foods. https:\/\/doi.org\/10.3390\/foods12010033","journal-title":"Foods"},{"key":"8780_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24183319","author":"X Wang","year":"2019","unstructured":"Wang X, Shan X, Dun Y, Cai C, Hao J, Li G, Cui K, Yu G (2019) Anti-metabolic syndrome effects of fucoidan from Fucus vesiculosus via reactive oxygen species-mediated regulation of JNK, akt, and AMPK signaling. Molecules. https:\/\/doi.org\/10.3390\/molecules24183319","journal-title":"Molecules"},{"key":"8780_CR26","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.ijbiomac.2019.08.002","volume":"140","author":"D Ren","year":"2019","unstructured":"Ren D, Wang Q, Yang Y, Hu Y, Song Y, He Y, Liu S, Wu L (2019) Hypolipidemic effects of fucoidan fractions from Saccharina sculpera (Laminariales, Phaeophyceae). Int J Biol Macromol 140:188\u2013195. https:\/\/doi.org\/10.1016\/j.ijbiomac.2019.08.002","journal-title":"Int J Biol Macromol"},{"key":"8780_CR27","doi-asserted-by":"publisher","first-page":"743","DOI":"10.3892\/br.2015.500","volume":"3","author":"S Mythili","year":"2015","unstructured":"Mythili S, Malathi N (2015) Diagnostic markers of acute myocardial infarction. Biomed Rep 3:743\u2013748. https:\/\/doi.org\/10.3892\/br.2015.500","journal-title":"Biomed Rep"},{"key":"8780_CR28","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.cbi.2019.05.044","volume":"308","author":"VS Lekshmi","year":"2019","unstructured":"Lekshmi VS, Rauf AA, Kurup GM (2019) Sulfated polysaccharides from the edible marine algae Padina tetrastromatica attenuates isoproterenol-induced oxidative damage via activation of PI3K\/Akt\/Nrf2 signaling pathway - an in vitro and in vivo approach. Chem Biol Interact 308:258\u2013268. https:\/\/doi.org\/10.1016\/j.cbi.2019.05.044","journal-title":"Chem Biol Interact"},{"key":"8780_CR29","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.vascn.2015.11.004","volume":"78","author":"M Radenkovic","year":"2016","unstructured":"Radenkovic M, Stojanovic M, Prostran M (2016) Experimental diabetes induced by alloxan and streptozotocin: the current state of the art. J Pharmacol Toxicol Methods 78:13\u201331. https:\/\/doi.org\/10.1016\/j.vascn.2015.11.004","journal-title":"J Pharmacol Toxicol Methods"},{"key":"8780_CR30","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.2337\/db08-1697","volume":"58","author":"Y Wang","year":"2009","unstructured":"Wang Y, Feng W, Xue W, Tan Y, Hein DW, Li XK, Cai L (2009) Inactivation of GSK-3beta by metallothionein prevents diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage, and remodeling. Diabetes 58:1391\u20131402. https:\/\/doi.org\/10.2337\/db08-1697","journal-title":"Diabetes"},{"key":"8780_CR31","doi-asserted-by":"publisher","first-page":"11554","DOI":"10.1007\/s11356-020-07711-w","volume":"27","author":"MM Abdel-Daim","year":"2020","unstructured":"Abdel-Daim MM, Abushouk AI, Bahbah EI, Bungau SG, Alyousif MS, Aleya L, Alkahtani S (2020) Fucoidan protects against subacute diazinon-induced oxidative damage in cardiac, hepatic, and renal tissues. Environ Sci Pollut Res Int 27:11554\u201311564. https:\/\/doi.org\/10.1007\/s11356-020-07711-w","journal-title":"Environ Sci Pollut Res Int"},{"key":"8780_CR32","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1089\/ars.2005.7.385","volume":"7","author":"M Kobayashi","year":"2005","unstructured":"Kobayashi M, Yamamoto M (2005) Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation. Antioxid Redox Signal 7:385\u2013394. https:\/\/doi.org\/10.1089\/ars.2005.7.385","journal-title":"Antioxid Redox Signal"},{"key":"8780_CR33","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/216512","author":"B Li","year":"2012","unstructured":"Li B, Liu S, Miao L, Cai L (2012) Prevention of diabetic complications by activation of Nrf2: diabetic cardiomyopathy and nephropathy. Exp Diabetes Res. https:\/\/doi.org\/10.1155\/2012\/216512","journal-title":"Exp Diabetes Res"},{"key":"8780_CR34","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s00395-004-0440-4","volume":"99","author":"MM El-Omar","year":"2004","unstructured":"El-Omar MM, Yang ZK, Phillips AO, Shah AM (2004) Cardiac dysfunction in the Goto-Kakizaki rat. A model of type II diabetes mellitus. Basic Res Cardiol 99:133\u2013141. https:\/\/doi.org\/10.1007\/s00395-004-0440-4","journal-title":"Basic Res Cardiol"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-023-08780-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-023-08780-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-023-08780-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T07:22:10Z","timestamp":1699514530000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-023-08780-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,4]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["8780"],"URL":"https:\/\/doi.org\/10.1007\/s11033-023-08780-z","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,4]]},"assertion":[{"value":"17 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The experimental procedure was approved by the Internal Research and Review Board, Ethical Clearance, Biosafety and Animal Welfare Committee of Madurai Kamaraj University.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All authors have contributed significantly and agree with publication the content of the paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}