{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T18:49:40Z","timestamp":1763837380222,"version":"3.37.3"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1007\/s11033-023-08878-4","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T04:02:13Z","timestamp":1697688133000},"page":"9875-9886","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Antihyperglycemic activity of 14-deoxy, 11, 12-didehydro andrographolide on streptozotocin-nicotinamide induced type 2 diabetic rats"],"prefix":"10.1007","volume":"50","author":[{"given":"Nagalakshmi","family":"Kamaraj","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kadhirmathiyan","family":"Velumani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8583-9352","authenticated-orcid":false,"given":"Ajay","family":"Guru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Praveen Kumar","family":"Issac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,10,19]]},"reference":[{"key":"8878_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/S11892-017-0965-1\/METRICS","volume":"17","author":"U Pedersen-Bjergaard","year":"2017","unstructured":"Pedersen-Bjergaard U, Thorsteinsson B (2017) Reporting severe hypoglycemia in type 1 diabetes: facts and pitfalls. Curr Diab Rep 17:1\u201311. https:\/\/doi.org\/10.1007\/S11892-017-0965-1\/METRICS","journal-title":"Curr Diab Rep"},{"key":"8878_CR2","doi-asserted-by":"publisher","first-page":"5857","DOI":"10.1007\/S11033-021-06580-X\/METRICS","volume":"48","author":"PK Issac","year":"2021","unstructured":"Issac PK, Karan R, Guru A et al (2021) Insulin signaling pathway assessment by enhancing antioxidant activity due to morin using in vitro rat skeletal muscle L6 myotubes cells. Mol Biol Rep 48:5857\u20135872. https:\/\/doi.org\/10.1007\/S11033-021-06580-X\/METRICS","journal-title":"Mol Biol Rep"},{"key":"8878_CR3","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1038\/NATURE05482","volume":"444","author":"SE Kahn","year":"2006","unstructured":"Kahn SE, Hull RL, Utzschneider KM (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444:840\u2013846. https:\/\/doi.org\/10.1038\/NATURE05482","journal-title":"Nature"},{"key":"8878_CR4","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/J.ETP.2010.12.009","volume":"64","author":"P Bansal","year":"2012","unstructured":"Bansal P, Paul P, Mudgal J et al (2012) Antidiabetic, antihyperlipidemic and antioxidant effects of the flavonoid rich fraction of Pilea microphylla (L.) in high fat diet\/streptozotocin-induced diabetes in mice. Exp Toxicol Pathol 64:651\u2013658. https:\/\/doi.org\/10.1016\/J.ETP.2010.12.009","journal-title":"Exp Toxicol Pathol"},{"key":"8878_CR5","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0140-6736(11)60679-X","volume":"378","author":"G Danaei","year":"2011","unstructured":"Danaei G, Finucane MM, Lu Y et al (2011) National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2\u00b77 million participants. Lancet 378:31\u201340. https:\/\/doi.org\/10.1016\/S0140-6736(11)60679-X","journal-title":"Lancet"},{"key":"8878_CR6","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.2337\/DIACARE.27.5.1047","volume":"27","author":"S Wild","year":"2004","unstructured":"Wild S, Roglic G, Green A et al (2004) Global Prevalence of DiabetesEstimates for the year 2000 and projections for 2030. Diabetes Care 27:1047\u20131053. https:\/\/doi.org\/10.2337\/DIACARE.27.5.1047","journal-title":"Diabetes Care"},{"key":"8878_CR7","doi-asserted-by":"publisher","first-page":"e049737","DOI":"10.1136\/bmjopen-2021-049737","volume":"11","author":"C Jimeno","year":"2021","unstructured":"Jimeno C, Sy RA, La PPD et al (2021) Direct medical costs of type 2 diabetes mellitus in the Philippines: findings from two hospital databases and physician surveys. BMJ Open 11:e049737. https:\/\/doi.org\/10.1136\/bmjopen-2021-049737","journal-title":"BMJ Open"},{"key":"8878_CR8","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.pcd.2019.12.006","volume":"14","author":"S Ak\u0131n","year":"2020","unstructured":"Ak\u0131n S, B\u00f6l\u00fck C (2020) Prevalence of comorbidities in patients with type-2 diabetes mellitus. Prim Care Diabetes 14:431\u2013434. https:\/\/doi.org\/10.1016\/j.pcd.2019.12.006","journal-title":"Prim Care Diabetes"},{"key":"8878_CR9","doi-asserted-by":"publisher","first-page":"108942","DOI":"10.1016\/j.diabres.2021.108942","volume":"178","author":"N Barzegar","year":"2021","unstructured":"Barzegar N, Ramezankhani A, Tohidi M et al (2021) Long-term glucose variability and incident cardiovascular diseases and all-cause mortality events in subjects with and without diabetes: Tehran lipid and glucose study. Diabetes Res Clin Pract 178:108942","journal-title":"Diabetes Res Clin Pract"},{"key":"8878_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.798329","author":"T Nie","year":"2021","unstructured":"Nie T, Cooper GJS (2021) Mechanisms Underlying the Antidiabetic Activities of Polyphenolic Compounds: A Review. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2021.798329","journal-title":"Front Pharmacol"},{"key":"8878_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01338-2","author":"SM Agarwal","year":"2021","unstructured":"Agarwal SM, Panda R, Costa-Dookhan KA et al (2021) Metformin for early comorbid glucose dysregulation and schizophrenia spectrum disorders: a pilot double-blind randomized clinical trial. Transl Psychiatry. https:\/\/doi.org\/10.1038\/s41398-021-01338-2","journal-title":"Transl Psychiatry"},{"key":"8878_CR12","doi-asserted-by":"publisher","first-page":"115","DOI":"10.4314\/AJTCAM.V8I5S.5","volume":"8","author":"AA Abdullahi","year":"2011","unstructured":"Abdullahi AA (2011) Trends and challenges of traditional medicine in Africa. Afr J Tradit Complement Altern Med 8:115. https:\/\/doi.org\/10.4314\/AJTCAM.V8I5S.5","journal-title":"Afr J Tradit Complement Altern Med"},{"key":"8878_CR13","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1089\/ACM.2016.0289","volume":"23","author":"A Jang","year":"2017","unstructured":"Jang A, Kang DH, Kim DU (2017) Complementary and Alternative medicine use and its association with emotional status and quality of life in patients with a solid tumor: a cross-sectional study. J Altern Complement Med 23:362\u2013369. https:\/\/doi.org\/10.1089\/ACM.2016.0289","journal-title":"J Altern Complement Med"},{"key":"8878_CR14","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.3390\/PH15091095","volume":"15","author":"A Salazar-G\u00f3mez","year":"2022","unstructured":"Salazar-G\u00f3mez A, Alonso-Castro AJ (2022) Medicinal plants from latin America with wound healing activity: ethnomedicine, phytochemistry, preclinical and clinical Studies: a review. Pharmaceuticals 15:1095. https:\/\/doi.org\/10.3390\/PH15091095","journal-title":"Pharmaceuticals"},{"key":"8878_CR15","doi-asserted-by":"publisher","first-page":"135","DOI":"10.3109\/13880209509055213","volume":"33","author":"R Chander","year":"2008","unstructured":"Chander R, Srivastava V, Tandon And JS, Kapoor NK (2008) Antihepatotoxic activity of diterpenes of andrographis paniculata (Kal-Megh) against plasmodium Berghei-Induced hepatic damage in mastomys natalensis. Int J Pharmacogn 33:135\u2013138. https:\/\/doi.org\/10.3109\/13880209509055213","journal-title":"Int J Pharmacogn"},{"key":"8878_CR16","doi-asserted-by":"publisher","first-page":"4207","DOI":"10.4049\/JIMMUNOL.173.6.4207","volume":"173","author":"Y-F Xia","year":"2004","unstructured":"Xia Y-F, Ye B-Q, Li Y-D et al (2004) Andrographolide attenuates inflammation by inhibition of NF-\u03baB activation through covalent modification of reduced cysteine 62 of p50. J Immunol 173:4207\u20134217. https:\/\/doi.org\/10.4049\/JIMMUNOL.173.6.4207","journal-title":"J Immunol"},{"key":"8878_CR17","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1002\/ptr.1765","volume":"19","author":"C Wiart","year":"2005","unstructured":"Wiart C, Kumar K, Yusof MY et al (2005) Antiviral properties of ent-labdene diterpenes of Andrographis paniculata Nees, inhibitors of herpes simplex virus type 1. Phyther Res 19:1069\u20131070. https:\/\/doi.org\/10.1002\/ptr.1765","journal-title":"Phyther Res"},{"key":"8878_CR18","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/J.INTIMP.2006.10.002","volume":"7","author":"K Sheeja","year":"2007","unstructured":"Sheeja K, Guruvayoorappan C, Kuttan G (2007) Antiangiogenic activity of Andrographis paniculata extract and andrographolide. Int Immunopharmacol 7:211\u2013221. https:\/\/doi.org\/10.1016\/J.INTIMP.2006.10.002","journal-title":"Int Immunopharmacol"},{"key":"8878_CR19","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1007\/s10571-014-0086-1","volume":"34","author":"AK Thakur","year":"2014","unstructured":"Thakur AK, Soni UK, Rai G et al (2014) Protective effects of andrographis paniculata extract and pure andrographolide against chronic stress-triggered pathologies in rats. Cell Mol Neurobiol 34:1111\u20131121. https:\/\/doi.org\/10.1007\/s10571-014-0086-1","journal-title":"Cell Mol Neurobiol"},{"key":"8878_CR20","unstructured":"Anju D, Jugnu G, Kavita S, et al (2012) A review on medicinal prospectives of Andrographis paniculata Nees. J Pharm Sci Innov 1(1):1\u20134."},{"key":"8878_CR21","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1055\/s-2003-45185","volume":"69","author":"BC Yu","year":"2003","unstructured":"Yu BC, Hung CR, Chen WC, Cheng JT (2003) Antihyperglycemic effect of Andrographolide in Streptozotocin-induced diabetic rats. Planta Med 69:1075\u20131079. https:\/\/doi.org\/10.1055\/s-2003-45185","journal-title":"Planta Med"},{"key":"8878_CR22","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1002\/pca.789","volume":"15","author":"N Pholphana","year":"2004","unstructured":"Pholphana N, Rangkadilok N, Thongnest S et al (2004) Determination and variation of three active diterpenoids in Andrographis paniculata (Burm.f.) Nees. Phytochem Anal 15:365\u2013371. https:\/\/doi.org\/10.1002\/pca.789","journal-title":"Phytochem Anal"},{"key":"8878_CR23","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1021\/np2002572","volume":"74","author":"S-P Guan","year":"2011","unstructured":"Guan S-P, Kong L-R, Cheng C et al (2011) Protective role of 14-deoxy-11,12-didehydroandrographolide, a Noncytotoxic Analogue of Andrographolide, in allergic airway inflammation. J Nat Prod 74:1484\u20131490. https:\/\/doi.org\/10.1021\/np2002572","journal-title":"J Nat Prod"},{"key":"8878_CR24","doi-asserted-by":"publisher","first-page":"152841","DOI":"10.1016\/j.phymed.2019.152841","volume":"61","author":"C-C Yen","year":"2019","unstructured":"Yen C-C, Liu Y-T, Lin Y-J et al (2019) Bioavailability of the diterpenoid 14-deoxy-11,12-didehydroandrographolide in rats and up-regulation of hepatic drug-metabolizing enzyme and drug transporter expression. Phytomedicine 61:152841. https:\/\/doi.org\/10.1016\/j.phymed.2019.152841","journal-title":"Phytomedicine"},{"key":"8878_CR25","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/J.AJPS.2017.02.003","volume":"12","author":"N Kamaraj","year":"2017","unstructured":"Kamaraj N, Rajaguru PY, Issac P, kumar, Sundaresan S, (2017) Fabrication, characterization, in vitro drug release and glucose uptake activity of 14-deoxy, 11, 12-didehydroandrographolide loaded polycaprolactone nanoparticles. Asian J Pharm Sci 12:353\u2013362. https:\/\/doi.org\/10.1016\/J.AJPS.2017.02.003","journal-title":"Asian J Pharm Sci"},{"key":"8878_CR26","first-page":"1153","volume":"10","author":"S Lee","year":"2015","unstructured":"Lee S, Morita H, Tezuka Y (2015) Preferentially cytotoxic constituents of andrographis paniculata and their preferential cytotoxicity against human pancreatic cancer cell lines. Nat Prod Commun 10:1153\u20131158","journal-title":"Nat Prod Commun"},{"key":"8878_CR27","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.taap.2016.03.017","volume":"300","author":"HK Tan","year":"2016","unstructured":"Tan HK, Muhammad TST, Tan ML (2016) 14-Deoxy-11,12-didehydroandrographolide induces DDIT3-dependent endoplasmic reticulum stress-mediated autophagy in T-47D breast carcinoma cells. Toxicol Appl Pharmacol 300:55\u201369. https:\/\/doi.org\/10.1016\/j.taap.2016.03.017","journal-title":"Toxicol Appl Pharmacol"},{"key":"8878_CR28","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.antiviral.2015.03.008","volume":"118","author":"W Cai","year":"2015","unstructured":"Cai W, Li Y, Chen S et al (2015) 14-Deoxy-11,12-dehydroandrographolide exerts anti-influenza A virus activity and inhibits replication of H5N1 virus by restraining nuclear export of viral ribonucleoprotein complexes. Antiviral Res 118:82\u201392. https:\/\/doi.org\/10.1016\/j.antiviral.2015.03.008","journal-title":"Antiviral Res"},{"key":"8878_CR29","doi-asserted-by":"publisher","first-page":"876458","DOI":"10.1155\/2012\/876458","volume":"2012","author":"K Awang","year":"2012","unstructured":"Awang K, Abdullah NH, Hadi AHA, Fong YS (2012) Cardiovascular activity of labdane diterpenes from Andrographis paniculata in isolated rat hearts. J Biomed Biotechnol 2012:876458. https:\/\/doi.org\/10.1155\/2012\/876458","journal-title":"J Biomed Biotechnol"},{"key":"8878_CR30","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1055\/S-2007-967181\/ID\/2","volume":"73","author":"N Yoopan","year":"2007","unstructured":"Yoopan N, Thisoda P, Rangkadilok N et al (2007) Cardiovascular effects of 14-Deoxy-11,12-didehydroandrographolide and Andrographis paniculata extracts. Planta Med 73:503\u2013511. https:\/\/doi.org\/10.1055\/S-2007-967181\/ID\/2","journal-title":"Planta Med"},{"key":"8878_CR31","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1080\/10286020701273627","volume":"10","author":"TS Wu","year":"2007","unstructured":"Wu TS, Chern HJ, Damu AG et al (2007) Flavonoids and ent-labdane diterpenoids from Andrographis paniculata and their antiplatelet aggregatory and vasorelaxing effects. J Asian Nat Prod Res 10:17\u201324. https:\/\/doi.org\/10.1080\/10286020701273627","journal-title":"J Asian Nat Prod Res"},{"key":"8878_CR32","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/J.JEP.2010.07.057","volume":"132","author":"MJ Lee","year":"2010","unstructured":"Lee MJ, Rao YK, Chen K et al (2010) Andrographolide and 14-deoxy-11,12-didehydroandrographolide from Andrographis paniculata attenuate high glucose-induced fibrosis and apoptosis in murine renal mesangeal cell lines. J Ethnopharmacol 132:497\u2013505. https:\/\/doi.org\/10.1016\/J.JEP.2010.07.057","journal-title":"J Ethnopharmacol"},{"key":"8878_CR33","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1258\/EBM.2012.011372","volume":"237","author":"T Szkudelski","year":"2012","unstructured":"Szkudelski T (2012) Streptozotocin\u2013nicotinamide-induced diabetes in the rat. Charact Exp Model 237:481\u2013490. https:\/\/doi.org\/10.1258\/EBM.2012.011372","journal-title":"Charact Exp Model"},{"key":"8878_CR34","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/J.JEP.2007.10.038","volume":"115","author":"TS Fr\u00f6de","year":"2008","unstructured":"Fr\u00f6de TS, Medeiros YS (2008) Animal models to test drugs with potential antidiabetic activity. J Ethnopharmacol 115:173\u2013183. https:\/\/doi.org\/10.1016\/J.JEP.2007.10.038","journal-title":"J Ethnopharmacol"},{"key":"8878_CR35","doi-asserted-by":"publisher","first-page":"102223","DOI":"10.1016\/J.JKSUS.2022.102223","volume":"34","author":"IP Kumar","year":"2022","unstructured":"Kumar IP, Snega Priya P, Meenatchi R et al (2022) Potential mechanism of Jatropha gossypifolia phenolic derivatives in enhancing insulin-signalling cascades GLUT 4, IR\u03b2 and GSK-3\u03b2 in streptozotocin nicotinamide induced type II diabetic in wistar rat model. J King Saud Univ: Sci 34:102223. https:\/\/doi.org\/10.1016\/J.JKSUS.2022.102223","journal-title":"J King Saud Univ: Sci"},{"key":"8878_CR36","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","volume":"18","author":"WT Friedewald","year":"1972","unstructured":"Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499\u2013502. https:\/\/doi.org\/10.1093\/clinchem\/18.6.499","journal-title":"Clin Chem"},{"key":"8878_CR37","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/J.EJPHAR.2016.02.054","volume":"777","author":"E Bhakkiyalakshmi","year":"2016","unstructured":"Bhakkiyalakshmi E, Sireesh D, Sakthivadivel M et al (2016) Anti-hyperlipidemic and anti-peroxidative role of pterostilbene via Nrf2 signaling in experimental diabetes. Eur J Pharmacol 777:9\u201316. https:\/\/doi.org\/10.1016\/J.EJPHAR.2016.02.054","journal-title":"Eur J Pharmacol"},{"key":"8878_CR38","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/BF00280883\/METRICS","volume":"28","author":"DR Matthews","year":"1985","unstructured":"Matthews DR, Hosker JP, Rudenski AS et al (1985) Homeostasis model assessment: insulin resistance and \u03b2-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412\u2013419. https:\/\/doi.org\/10.1007\/BF00280883\/METRICS","journal-title":"Diabetologia"},{"key":"8878_CR39","doi-asserted-by":"publisher","unstructured":"Abdollahi M, Zuki ABZ, Goh YM et al (2011) Effects of Momordica charantia on pancreatichistopathological changes associated withstreptozotocin-induced diabetes in neonatal rats. Histol Histopathol 26(1):13\u201321. https:\/\/doi.org\/10.14670\/HH-26.13.PMID:21117023.","DOI":"10.14670\/HH-26.13.PMID:21117023"},{"key":"8878_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1472-6882-13-222\/FIGURES\/25","volume":"13","author":"V Kumar","year":"2013","unstructured":"Kumar V, Ahmed D, Gupta PS et al (2013) Anti-diabetic, anti-oxidant and anti-hyperlipidemic activities of Melastoma malabathricum Linn. leaves in streptozotocin induced diabetic rats. BMC Complement Altern Med 13:1\u201319. https:\/\/doi.org\/10.1186\/1472-6882-13-222\/FIGURES\/25","journal-title":"BMC Complement Altern Med"},{"key":"8878_CR41","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/J.FSI.2011.04.004","volume":"31","author":"J Arockiaraj","year":"2011","unstructured":"Arockiaraj J, Vanaraja P, Easwvaran S et al (2011) Gene profiling and characterization of arginine kinase-1 (MrAK-1) from freshwater giant prawn (Macrobrachium rosenbergii). Fish Shellfish Immunol 31:81\u201389. https:\/\/doi.org\/10.1016\/J.FSI.2011.04.004","journal-title":"Fish Shellfish Immunol"},{"key":"8878_CR42","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.molimm.2015.03.015","volume":"66","author":"R Palanisamy","year":"2015","unstructured":"Palanisamy R, Kumaresan V, Harikrishnan R et al (2015) Functional roles and gene regulation of tumor necrosis factor receptor 1 in freshwater striped murrel. Mol Immunol 66:240\u2013252. https:\/\/doi.org\/10.1016\/j.molimm.2015.03.015","journal-title":"Mol Immunol"},{"key":"8878_CR43","doi-asserted-by":"publisher","first-page":"4422","DOI":"10.1074\/jbc.M410610200","volume":"280","author":"Z Liberman","year":"2005","unstructured":"Liberman Z, Eldar-Finkelman H (2005) Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling. J Biol Chem 280:4422\u20134428. https:\/\/doi.org\/10.1074\/jbc.M410610200","journal-title":"J Biol Chem"},{"key":"8878_CR44","first-page":"263","volume":"17","author":"A Mohammadi","year":"2014","unstructured":"Mohammadi A, Gholamhoseinian A, Fallah H (2014) Zataria multiflora increases insulin sensitivity and PPAR\u03b3 gene expression in high fructose fed insulin resistant rats. Iran J Basic Med Sci 17:263","journal-title":"Iran J Basic Med Sci"},{"key":"8878_CR45","doi-asserted-by":"publisher","first-page":"e2148191","DOI":"10.1001\/jamanetworkopen.2021.48191","volume":"5","author":"D Mozaffarian","year":"2022","unstructured":"Mozaffarian D, Maki KC, Bays HE et al (2022) Effectiveness of a Novel $\u03c9$-3 Krill Oil Agent in Patients With Severe Hypertriglyceridemia. JAMA Netw Open 5:e2148191","journal-title":"JAMA Netw Open"},{"issue":"4","key":"8878_CR46","first-page":"2872","volume":"23","author":"S Kanoni","year":"2021","unstructured":"Kanoni S, Graham SE, Wang Y et al (2021) Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis. Genome Biol 23(4):2872","journal-title":"Genome Biol"},{"key":"8878_CR47","doi-asserted-by":"publisher","first-page":"205","DOI":"10.2188\/jea.JE20200305","volume":"32","author":"S Si","year":"2021","unstructured":"Si S, Hou L, Chen X et al (2021) Exploring the causal roles of circulating remnant lipid profile on cardiovascular and cerebrovascular diseases: mendelian randomization study. J Epidemiol 32:205\u2013214","journal-title":"J Epidemiol"},{"issue":"34","key":"8878_CR48","doi-asserted-by":"publisher","first-page":"3258","DOI":"10.1093\/eurheartj\/ehab705","volume":"43","author":"BN Wadstr\u00f6m","year":"2021","unstructured":"Wadstr\u00f6m BN, Wulff AB, Pedersen KM et al (2021) Elevated remnant cholesterol increases the risk of peripheral artery disease, myocardial infarction, and ischaemic stroke: a cohort-based study. Eur Heart J 43(34):3258\u20133269","journal-title":"Eur Heart J"},{"key":"8878_CR49","doi-asserted-by":"publisher","unstructured":"Nguyen T, Pham T, Nguyen TV (2023) Cardiovascular disease in older patients with end-stage renal disease and chronic dialysis in Vietnam. Eur Heart J 44(1):150. https:\/\/doi.org\/10.1093\/eurheartj\/ehac779.116","DOI":"10.1093\/eurheartj\/ehac779.116"},{"key":"8878_CR50","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1159\/000513869","volume":"145","author":"PP Shah","year":"2021","unstructured":"Shah PP, Brady TM, Meyers KE et al (2021) Association of obesity with cardiovascular risk factors and kidney disease outcomes in primary proteinuric glomerulopathies. Nephron 145:245\u2013255","journal-title":"Nephron"},{"issue":"12","key":"8878_CR51","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.5005\/jp-journals-10071-24043","volume":"25","author":"R Kant","year":"2021","unstructured":"Kant R, Naithani M, Jain G et al (2021) Quantifying insulin resistance (HOMA-IR) to predict mortality in multiorgan dysfunction syndrome. Indian J Crit Care Med. 25(12):1364\u20131369","journal-title":"Indian J Crit Care Med."},{"key":"8878_CR52","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/J.JEP.2014.02.001","volume":"152","author":"Y Weng","year":"2014","unstructured":"Weng Y, Yu L, Cui J et al (2014) Antihyperglycemic, hypolipidemic and antioxidant activities of total saponins extracted from Aralia taibaiensis in experimental type 2 diabetic rats. J Ethnopharmacol 152:553\u2013560. https:\/\/doi.org\/10.1016\/J.JEP.2014.02.001","journal-title":"J Ethnopharmacol"},{"key":"8878_CR53","first-page":"13","volume":"13","author":"H Mizukami","year":"2021","unstructured":"Mizukami H, Kudoh K (2021) Diversity of pathophysiology in type 2 diabetes shown by islet pathology. J Diabetes Investig 13:13\u201316","journal-title":"J Diabetes Investig"},{"key":"8878_CR54","doi-asserted-by":"publisher","first-page":"2444","DOI":"10.2337\/dbi21-0012","volume":"70","author":"MA Charles","year":"2021","unstructured":"Charles MA, Leslie RD (2021) Diabetes: concepts of $\u03b2$-cell organ dysfunction and failure would lead to earlier diagnoses and prevention. Diabetes 70:2444\u20132456","journal-title":"Diabetes"},{"key":"8878_CR55","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/s41419-022-04894-7","volume":"13","author":"J Zhang","year":"2022","unstructured":"Zhang J, Bai J, Zhou Q et al (2022) Glutathione prevents high glucose-induced pancreatic fibrosis by suppressing pancreatic stellate cell activation via the ROS\/TGF\u03b2\/SMAD pathway. Cell Death Dis 13:440. https:\/\/doi.org\/10.1038\/s41419-022-04894-7","journal-title":"Cell Death Dis"},{"key":"8878_CR56","doi-asserted-by":"publisher","DOI":"10.29219\/fnr.v65.4527","author":"W Fu","year":"2021","unstructured":"Fu W, Li H, Li T et al (2021) Pentadecanoic acid promotes basal and insulin-stimulated glucose uptake in C2C12 myotubes. Food & Nutr Res. https:\/\/doi.org\/10.29219\/fnr.v65.4527","journal-title":"Food & Nutr Res"},{"key":"8878_CR57","doi-asserted-by":"publisher","first-page":"153178","DOI":"10.1016\/j.phymed.2020.153178","volume":"68","author":"E-B Kwon","year":"2020","unstructured":"Kwon E-B, Kang M-J, Ryu HW et al (2020) Acacetin enhances glucose uptake through insulin-independent GLUT4 translocation in L6 myotubes. Phytomedicine 68:153178. https:\/\/doi.org\/10.1016\/j.phymed.2020.153178","journal-title":"Phytomedicine"},{"key":"8878_CR58","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1002\/CBIN.11608","volume":"45","author":"A Guru","year":"2021","unstructured":"Guru A, Issac PK, Saraswathi NT et al (2021) Deteriorating insulin resistance due to WL15 peptide from cysteine and glycine-rich protein 2 in high glucose-induced rat skeletal muscle L6 cells. Cell Biol Int 45:1698\u20131709. https:\/\/doi.org\/10.1002\/CBIN.11608","journal-title":"Cell Biol Int"},{"key":"8878_CR59","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1042\/BJ20060696","volume":"399","author":"SS Im","year":"2006","unstructured":"Im SS, Kwon SK, Kang SY et al (2006) Regulation of GLUT4 gene expression by SREBP-1c in adipocytes. Biochem J 399:131\u2013139. https:\/\/doi.org\/10.1042\/BJ20060696","journal-title":"Biochem J"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-023-08878-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-023-08878-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-023-08878-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T16:10:31Z","timestamp":1700928631000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-023-08878-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,19]]},"references-count":59,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["8878"],"URL":"https:\/\/doi.org\/10.1007\/s11033-023-08878-4","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"type":"print","value":"0301-4851"},{"type":"electronic","value":"1573-4978"}],"subject":[],"published":{"date-parts":[[2023,10,19]]},"assertion":[{"value":"30 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The Institutional Animal Ethics Committee (53\/IAEC\/2011) examined and sanctioned the research study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All the authors listed in the manuscript have approved the manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The data provided in the manuscript isapproved by all authors for publication.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}