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Lanthipeptides are an attractive natural product group that has been only partially explored and shows engaging biological activities. These molecules are small peptides with potential application as therapeutic agents. Some members show antibiotic activity against problematic drug-resistant pathogens and against a wide variety of viruses. Nevertheless, their biological activities are not restricted to antimicrobials, as their contribution to the treatment of cystic fibrosis, cancer, pain symptoms, control of inflammation, and blood pressure has been demonstrated. The study of biosynthetic gene clusters through genome mining has contributed to accelerating the discovery, enlargement, and diversification of this group of natural products. In this review, we provide insight into the recent advances in the development and research of actinobacterial lanthipeptides that hold great potential as therapeutics.<\/jats:p>","DOI":"10.1007\/s11033-023-08880-w","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T10:01:49Z","timestamp":1699351309000},"page":"10605-10616","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The untapped potential of actinobacterial lanthipeptides as therapeutic agents"],"prefix":"10.1007","volume":"50","author":[{"given":"Dulce","family":"Ram\u00edrez-Rend\u00f3n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Guzm\u00e1n-Ch\u00e1vez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Garc\u00eda-Ausencio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Rodr\u00edguez-Sanoja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"8880_CR1","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1039\/c7np00019g","volume":"34","author":"GD Wright","year":"2017","unstructured":"Wright GD (2017) Opportunities for natural products in 21(st) century antibiotic discovery. 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