{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:33:55Z","timestamp":1740123235701,"version":"3.37.3"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2702204, 2022YFC2704702","2022YFC2702204, 2022YFC2704702"],"award-info":[{"award-number":["2022YFC2702204, 2022YFC2704702","2022YFC2702204, 2022YFC2704702"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["22ZR1480400, 23ZR1450400"],"award-info":[{"award-number":["22ZR1480400, 23ZR1450400"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001552, 81730039, 82271701, and 82071653","82001552, 81730039, 82271701, and 82071653"],"award-info":[{"award-number":["82001552, 81730039, 82271701, and 82071653","82001552, 81730039, 82271701, and 82071653"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Sailing Program","award":["20YF1438300"],"award-info":[{"award-number":["20YF1438300"]}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["20224Y0321"],"award-info":[{"award-number":["20224Y0321"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s11033-023-09169-8","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T16:02:26Z","timestamp":1705593746000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Novel LDLR variants affecting low density lipoprotein metabolism identified in familial hypercholesterolemia"],"prefix":"10.1007","volume":"51","author":[{"given":"Miao","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luyi","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningdong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Ying","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingpeng","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3554-4142","authenticated-orcid":false,"given":"Zhiyun","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0792-1158","authenticated-orcid":false,"given":"Yao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,1,18]]},"reference":[{"issue":"1","key":"9169_CR1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.5334\/gh.759","volume":"15","author":"F Alnouri","year":"2020","unstructured":"Alnouri F et al (2020) Xanthomas can be misdiagnosed and mistreated in homozygous familial hypercholesterolemia patients: a call for increased awareness among dermatologists and Health Care practitioners. Glob Heart 15(1):19","journal-title":"Glob Heart"},{"issue":"32","key":"9169_CR2","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1093\/eurheartj\/ehu274","volume":"35","author":"M Cuchel","year":"2014","unstructured":"Cuchel M et al (2014) Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society. Eur Heart J 35(32):2146\u20132157","journal-title":"Eur Heart J"},{"issue":"1","key":"9169_CR3","first-page":"49","volume":"25","author":"AD Marais","year":"2004","unstructured":"Marais AD (2004) Familial hypercholesterolaemia. Clin Biochem Rev 25(1):49\u201368","journal-title":"Clin Biochem Rev"},{"key":"9169_CR4","doi-asserted-by":"crossref","first-page":"574474","DOI":"10.3389\/fgene.2020.574474","volume":"11","author":"M Vrablik","year":"2020","unstructured":"Vrablik M et al (2020) Genetics of Familial Hypercholesterolemia: New insights. Front Genet 11:574474","journal-title":"Front Genet"},{"key":"9169_CR5","unstructured":"Nordestgaard BG et al (2013) Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society Eur Heart J, 34(45): p.\u00a03478-90a"},{"issue":"11","key":"9169_CR6","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1210\/jc.2012-1563","volume":"97","author":"M Benn","year":"2012","unstructured":"Benn M et al (2012) Familial hypercholesterolemia in the Danish general population: prevalence, coronary artery Disease, and cholesterol-lowering medication. J Clin Endocrinol Metab 97(11):3956\u20133964","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"9169_CR7","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1093\/eurheartj\/ehu058","volume":"36","author":"B Sjouke","year":"2015","unstructured":"Sjouke B et al (2015) Homozygous autosomal dominant hypercholesterolaemia in the Netherlands: prevalence, genotype-phenotype relationship, and clinical outcome. Eur Heart J 36(9):560\u2013565","journal-title":"Eur Heart J"},{"issue":"2","key":"9169_CR8","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.atherosclerosis.2012.02.019","volume":"223","author":"FJ Raal","year":"2012","unstructured":"Raal FJ, Santos RD (2012) Homozygous familial hypercholesterolemia: current perspectives on diagnosis and treatment. Atherosclerosis 223(2):262\u2013268","journal-title":"Atherosclerosis"},{"issue":"2","key":"9169_CR9","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ccl.2015.01.001","volume":"33","author":"VE Bouhairie","year":"2015","unstructured":"Bouhairie VE, Goldberg AC (2015) Familial hypercholesterolemia. Cardiol Clin 33(2):169\u2013179","journal-title":"Cardiol Clin"},{"issue":"2","key":"9169_CR10","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1161\/01.ATV.9.2.211","volume":"9","author":"S Moorjani","year":"1989","unstructured":"Moorjani S et al (1989) Homozygous familial hypercholesterolemia among French canadians in Quebec Province. Arteriosclerosis 9(2):211\u2013216","journal-title":"Arteriosclerosis"},{"issue":"2","key":"9169_CR11","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.gim.2021.09.012","volume":"24","author":"JR Chora","year":"2022","unstructured":"Chora JR et al (2022) The Clinical Genome Resource (ClinGen) familial hypercholesterolemia variant Curation Expert Panel consensus guidelines for LDLR variant classification. Genet Med 24(2):293\u2013306","journal-title":"Genet Med"},{"issue":"4746","key":"9169_CR12","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1126\/science.3513311","volume":"232","author":"MS Brown","year":"1986","unstructured":"Brown MS, Goldstein JL (1986) A receptor-mediated pathway for cholesterol homeostasis. Science 232(4746):34\u201347","journal-title":"Science"},{"issue":"8","key":"9169_CR13","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/S0022-2275(20)42605-7","volume":"31","author":"TL Innerarity","year":"1990","unstructured":"Innerarity TL et al (1990) Familial defective apolipoprotein B-100: a mutation of apolipoprotein B that causes hypercholesterolemia. J Lipid Res 31(8):1337\u20131349","journal-title":"J Lipid Res"},{"issue":"2","key":"9169_CR14","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/ng1161","volume":"34","author":"M Abifadel","year":"2003","unstructured":"Abifadel M et al (2003) Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat Genet 34(2):154\u2013156","journal-title":"Nat Genet"},{"issue":"11","key":"9169_CR15","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1161\/ATVBAHA.119.313051","volume":"39","author":"P Banerjee","year":"2019","unstructured":"Banerjee P et al (2019) Functional analysis of LDLR (low-Density lipoprotein receptor) variants in patient lymphocytes to assess the Effect of Evinacumab in homozygous familial hypercholesterolemia patients with a spectrum of LDLR activity. Arterioscler Thromb Vasc Biol 39(11):2248\u20132260","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"9169_CR16","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1146\/annurev.biochem.74.082803.133354","volume":"74","author":"H Jeon","year":"2005","unstructured":"Jeon H, Blacklow SC (2005) Structure and physiologic function of the low-density lipoprotein receptor. Annu Rev Biochem 74:535\u2013562","journal-title":"Annu Rev Biochem"},{"issue":"24","key":"9169_CR17","doi-asserted-by":"crossref","first-page":"8567","DOI":"10.1073\/pnas.82.24.8567","volume":"82","author":"V Lindgren","year":"1985","unstructured":"Lindgren V et al (1985) Human genes involved in cholesterol metabolism: chromosomal mapping of the loci for the low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl-coenzyme A reductase with cDNA probes. Proc Natl Acad Sci U S A 82(24):8567\u20138571","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4701","key":"9169_CR18","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1126\/science.2988123","volume":"228","author":"TC Sudhof","year":"1985","unstructured":"Sudhof TC et al (1985) The LDL receptor gene: a mosaic of exons shared with different proteins. Science 228(4701):815\u2013822","journal-title":"Science"},{"issue":"6","key":"9169_CR19","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/humu.1380010602","volume":"1","author":"HH Hobbs","year":"1992","unstructured":"Hobbs HH, Brown MS, Goldstein JL (1992) Molecular genetics of the LDL receptor gene in familial hypercholesterolemia. Hum Mutat 1(6):445\u2013466","journal-title":"Hum Mutat"},{"issue":"3","key":"9169_CR20","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/0092-8674(82)90276-8","volume":"30","author":"H Tolleshaug","year":"1982","unstructured":"Tolleshaug H et al (1982) Posttranslational processing of the LDL receptor and its genetic disruption in familial hypercholesterolemia. Cell 30(3):715\u2013724","journal-title":"Cell"},{"issue":"6643","key":"9169_CR21","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/41672","volume":"388","author":"MS Brown","year":"1997","unstructured":"Brown MS, Herz J, Goldstein JL (1997) LDL-receptor structure. Calcium cages, acid baths and recycling receptors. Nature 388(6643):629\u2013630","journal-title":"Nature"},{"issue":"19\u201320","key":"9169_CR22","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1007\/s00018-004-4090-3","volume":"61","author":"J Gent","year":"2004","unstructured":"Gent J, Braakman I (2004) Low-density lipoprotein receptor structure and folding. Cell Mol Life Sci 61(19\u201320):2461\u20132470","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"9169_CR23","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.atherosclerosis.2012.08.017","volume":"225","author":"S Silva","year":"2012","unstructured":"Silva S et al (2012) In vitro functional characterization of missense mutations in the LDLR gene. Atherosclerosis 225(1):128\u2013134","journal-title":"Atherosclerosis"},{"issue":"1","key":"9169_CR24","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.atherosclerosis.2004.01.001","volume":"174","author":"RP Naoumova","year":"2004","unstructured":"Naoumova RP et al (2004) Genetic diagnosis of familial hypercholesterolaemia: a mutation and a rare non-pathogenic amino acid variant in the same family. Atherosclerosis 174(1):67\u201371","journal-title":"Atherosclerosis"},{"issue":"1","key":"9169_CR25","doi-asserted-by":"crossref","first-page":"e100","DOI":"10.1002\/cpmb.100","volume":"128","author":"CJ Giuliano","year":"2019","unstructured":"Giuliano CJ et al (2019) Generating single cell-derived knockout clones in mammalian cells with CRISPR\/Cas9. Curr Protoc Mol Biol 128(1):e100","journal-title":"Curr Protoc Mol Biol"},{"issue":"3","key":"9169_CR26","doi-asserted-by":"crossref","first-page":"e92703","DOI":"10.1371\/journal.pone.0092703","volume":"9","author":"H Wang","year":"2014","unstructured":"Wang H et al (2014) Functional characterization of two low-density lipoprotein receptor gene mutations in two Chinese patients with familial hypercholesterolemia. PLoS ONE 9(3):e92703","journal-title":"PLoS ONE"},{"issue":"1","key":"9169_CR27","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1074\/jbc.M507071200","volume":"281","author":"S Sorensen","year":"2006","unstructured":"Sorensen S et al (2006) Retention of mutant low density lipoprotein receptor in endoplasmic reticulum (ER) leads to ER stress. J Biol Chem 281(1):468\u2013476","journal-title":"J Biol Chem"},{"issue":"5","key":"9169_CR28","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","volume":"17","author":"S Richards","year":"2015","unstructured":"Richards S et al (2015) Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med 17(5):405\u2013424","journal-title":"Genet Med"},{"key":"9169_CR29","doi-asserted-by":"crossref","unstructured":"Benito-Vicente A et al (2018) Familial hypercholesterolemia: the most frequent cholesterol metabolism disorder caused Disease. Int J Mol Sci, 19(11)","DOI":"10.3390\/ijms19113426"},{"issue":"32","key":"9169_CR30","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1093\/eurheartj\/ehx144","volume":"38","author":"BA Ference","year":"2017","unstructured":"Ference BA et al (2017) Low-density lipoproteins cause atherosclerotic Cardiovascular Disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel. Eur Heart J 38(32):2459\u20132472","journal-title":"Eur Heart J"},{"key":"9169_CR31","doi-asserted-by":"crossref","unstructured":"Benito-Vicente A et al (2018) Validation of LDLr activity as a Tool to improve genetic diagnosis of familial hypercholesterolemia: a retrospective on functional characterization of LDLr variants. Int J Mol Sci, 19(6)","DOI":"10.3390\/ijms19061676"},{"issue":"1","key":"9169_CR32","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1161\/01.ATV.14.1.85","volume":"14","author":"XM Sun","year":"1994","unstructured":"Sun XM et al (1994) Familial hypercholesterolemia in China. Identification of mutations in the LDL-receptor gene that result in a receptor-negative phenotype. Arterioscler Thromb 14(1):85\u201394","journal-title":"Arterioscler Thromb"},{"issue":"4","key":"9169_CR33","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.jacc.2019.05.043","volume":"74","author":"M Trinder","year":"2019","unstructured":"Trinder M et al (2019) Risk of premature atherosclerotic Disease in patients with monogenic Versus Polygenic Familial Hypercholesterolemia. J Am Coll Cardiol 74(4):512\u2013522","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"9169_CR34","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.atherosclerosis.2013.01.007","volume":"227","author":"S Bertolini","year":"2013","unstructured":"Bertolini S et al (2013) Spectrum of mutations and phenotypic expression in patients with autosomal dominant hypercholesterolemia identified in Italy. Atherosclerosis 227(2):342\u2013348","journal-title":"Atherosclerosis"},{"issue":"2","key":"9169_CR35","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jpeds.2009.02.022","volume":"155","author":"O Guardamagna","year":"2009","unstructured":"Guardamagna O et al (2009) The type of LDLR gene mutation predicts cardiovascular risk in children with familial hypercholesterolemia. J Pediatr 155(2):199\u2013204e2","journal-title":"J Pediatr"},{"issue":"2","key":"9169_CR36","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0021-9150(99)00469-4","volume":"148","author":"H Schmidt","year":"2000","unstructured":"Schmidt H, Kostner GM (2000) Familial hypercholesterolemia in Austria reflects the multi-ethnic origin of our country. Atherosclerosis 148(2):431\u2013432","journal-title":"Atherosclerosis"},{"issue":"6","key":"9169_CR37","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.numecd.2008.07.011","volume":"19","author":"L Wang","year":"2009","unstructured":"Wang L et al (2009) Mutations in the LDL receptor gene in four Chinese homozygous familial hypercholesterolemia phenotype patients. Nutr Metab Cardiovasc Dis 19(6):391\u2013400","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"3","key":"9169_CR38","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.jacl.2015.12.016","volume":"10","author":"L Jiang","year":"2016","unstructured":"Jiang L et al (2016) Characterization of the unique Chinese W483X mutation in the low-density lipoprotein-receptor gene in young patients with homozygous familial hypercholesterolemia. J Clin Lipidol 10(3):538\u2013546e5","journal-title":"J Clin Lipidol"},{"issue":"4","key":"9169_CR39","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nmeth0410-248","volume":"7","author":"IA Adzhubei","year":"2010","unstructured":"Adzhubei IA et al (2010) A method and server for predicting damaging missense mutations. Nat Methods 7(4):248\u2013249","journal-title":"Nat Methods"},{"issue":"8","key":"9169_CR40","first-page":"1181","volume":"40","author":"C Rodriguez-Jimenez","year":"2019","unstructured":"Rodriguez-Jimenez C et al (2019) Functional analysis of new variants at the low-density lipoprotein receptor associated with familial hypercholesterolemia. Hum Mutat 40(8):1181\u20131190","journal-title":"Hum Mutat"},{"issue":"6","key":"9169_CR41","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/88556","volume":"8","author":"H Jeon","year":"2001","unstructured":"Jeon H et al (2001) Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair. Nat Struct Biol 8(6):499\u2013504","journal-title":"Nat Struct Biol"},{"issue":"5602","key":"9169_CR42","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1126\/science.1078124","volume":"298","author":"G Rudenko","year":"2002","unstructured":"Rudenko G et al (2002) Structure of the LDL receptor extracellular domain at endosomal pH. Science 298(5602):2353\u20132358","journal-title":"Science"},{"issue":"4","key":"9169_CR43","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1006\/jmbi.1998.2115","volume":"283","author":"TA Springer","year":"1998","unstructured":"Springer TA (1998) An extracellular beta-propeller module predicted in lipoprotein and scavenger receptors, tyrosine kinases, epidermal growth factor precursor, and extracellular matrix components. J Mol Biol 283(4):837\u2013862","journal-title":"J Mol Biol"},{"key":"9169_CR44","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1146\/annurev.cb.05.110189.001425","volume":"5","author":"SM Hurtley","year":"1989","unstructured":"Hurtley SM, Helenius A (1989) Protein oligomerization in the endoplasmic reticulum. Annu Rev Cell Biol 5:277\u2013307","journal-title":"Annu Rev Cell Biol"},{"issue":"3 Suppl","key":"9169_CR45","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/j.jacl.2011.03.452","volume":"5","author":"PN Hopkins","year":"2011","unstructured":"Hopkins PN et al (2011) Familial hypercholesterolemias: prevalence, genetics, diagnosis and screening recommendations from the National Lipid Association Expert Panel on Familial Hypercholesterolemia. J Clin Lipidol 5(3 Suppl):S9\u201317","journal-title":"J Clin Lipidol"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-023-09169-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-023-09169-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-023-09169-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T20:19:05Z","timestamp":1738700345000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-023-09169-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,18]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["9169"],"URL":"https:\/\/doi.org\/10.1007\/s11033-023-09169-8","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"type":"print","value":"0301-4851"},{"type":"electronic","value":"1573-4978"}],"subject":[],"published":{"date-parts":[[2024,1,18]]},"assertion":[{"value":"12 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000 (5). Written informed consent was obtained from all patients for being included in the study. The authors affirm that human research participants provided informed consent for publication of the data in Fig.\u00a0a, b; Table\u00a0. No animal studies were carried out by the authors for this article. This study was approved by the ethical committee of Shanghai First Maternity and Infant Hospital affiliated with Tongji University School of Medicine.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human subjects\/informed consent statement"}},{"value":"The authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"153"}}