{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T00:53:44Z","timestamp":1794272024441,"version":"4.9.0"},"reference-count":276,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T00:00:00Z","timestamp":1706400000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T00:00:00Z","timestamp":1706400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["DST-INSPIRE-Fellowship; IF 190797"],"award-info":[{"award-number":["DST-INSPIRE-Fellowship; IF 190797"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s11033-023-09170-1","type":"journal-article","created":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T16:01:56Z","timestamp":1706457716000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Converged avenues: depression and Alzheimer\u2019s disease\u2013 shared pathophysiology and novel therapeutics"],"prefix":"10.1007","volume":"51","author":[{"given":"Shivanshu","family":"Bajaj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhakrishnan","family":"Mahesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,28]]},"reference":[{"key":"9170_CR1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2022.114187","volume":"438","author":"E Leyder","year":"2023","unstructured":"Leyder E, Suresh P, Jun R, Overbey K, Banerjee T, Melnikova T et al (2023) Depression-related phenotypes at early stages of A\u03b2 and tau accumulation in inducible Alzheimer\u2019s disease mouse model: task-oriented and concept-driven interpretations. Behav Brain Res 438:114187","journal-title":"Behav Brain Res"},{"issue":"1","key":"9170_CR2","first-page":"1","volume":"24","author":"J Song","year":"2023","unstructured":"Song J, Ma Z, Zhang H, Liang T, Zhang J (2023) Identification of novel biomarkers linking depressive disorder and Alzheimer\u2019s disease based on an integrative bioinformatics analysis. BMC Genomic Data 24(1):1\u201313","journal-title":"BMC Genomic Data"},{"key":"9170_CR3","unstructured":"Association As (2023) Stages and behavior in Alzheimer\u2019s disease. https:\/\/www.alz.org\/help-support\/caregiving\/stages-behaviors\/depression. Accessed 2023"},{"issue":"1","key":"9170_CR4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41398-020-0839-1","volume":"10","author":"FS Dafsari","year":"2020","unstructured":"Dafsari FS, Jessen F (2020) Depression\u2014an underrecognized target for prevention of dementia in Alzheimer\u2019s disease. Transl Psychiatry 10(1):1\u201313","journal-title":"Transl Psychiatry"},{"key":"9170_CR5","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s10571-014-0074-5","volume":"34","author":"R Rodrigues","year":"2014","unstructured":"Rodrigues R, Petersen RB, Perry G (2014) Parallels between major depressive disorder and Alzheimer\u2019s disease: role of oxidative stress and genetic vulnerability. Cell Mol Neurobiol 34:925\u2013949","journal-title":"Cell Mol Neurobiol"},{"issue":"11","key":"9170_CR6","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1111\/cns.12835","volume":"24","author":"FF Zhang","year":"2018","unstructured":"Zhang FF, Peng W, Sweeney JA, Jia ZY, Gong QY (2018) Brain structure alterations in depression: psychoradiological evidence. CNS Neurosci Ther 24(11):994\u20131003","journal-title":"CNS Neurosci Ther"},{"issue":"2","key":"9170_CR7","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/bjc.12333","volume":"61","author":"S Shorey","year":"2022","unstructured":"Shorey S, Ng ED, Wong CH (2022) Global prevalence of depression and elevated depressive symptoms among adolescents: a systematic review and meta-analysis. Br J Clin Psychol 61(2):287\u2013305","journal-title":"Br J Clin Psychol"},{"key":"9170_CR8","unstructured":"Health NIoM (2021) Prevalence of major depressive episode among adults. https:\/\/www.nimh.nih.gov\/health\/statistics\/major-depression. Accessed 20 Aug 2023"},{"key":"9170_CR9","unstructured":"Prevention CfDCa (2023) National Centers for Health Statistics. https:\/\/www.cdc.gov\/nchs\/fastats\/depression.htm. Accessed 20 Aug 2023"},{"issue":"10","key":"9170_CR10","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1001\/jamaneurol.2019.1971","volume":"76","author":"CR Jack","year":"2019","unstructured":"Jack CR, Therneau TM, Weigand SD, Wiste HJ, Knopman DS, Vemuri P et al (2019) Prevalence of biologically vs clinically defined Alzheimer spectrum entities using the National Institute on Aging\u2013Alzheimer\u2019s Association research framework. JAMA Neurol 76(10):1174\u20131183","journal-title":"JAMA Neurol"},{"key":"9170_CR11","doi-asserted-by":"crossref","unstructured":"Bajaj S, Jain S, Vyas P, Bawa S, Vohora D (2021) The role of endocannabinoid pathway in the neuropathology of Alzheimer\u2019s disease: can the inhibitors of MAGL and FAAH prove to be potential therapeutic targets against the cognitive impairment associated with Alzheimer\u2019s disease? Brain Res Bull","DOI":"10.1016\/j.brainresbull.2021.06.022"},{"key":"9170_CR12","unstructured":"Prevention CfDCa (2021) Alzheimer\u2019s disease and related dementias. https:\/\/www.cdc.gov\/aging\/aginginfo\/alzheimers.htm. Accessed 25 July 2023"},{"issue":"7","key":"9170_CR13","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1093\/brain\/awab099","volume":"144","author":"S Spina","year":"2021","unstructured":"Spina S, La Joie R, Petersen C, Nolan AL, Cuevas D, Cosme C et al (2021) Comorbid neuropathological diagnoses in early versus late-onset Alzheimer\u2019s disease. Brain 144(7):2186\u20132198","journal-title":"Brain"},{"key":"9170_CR14","doi-asserted-by":"crossref","unstructured":"Tao P, Yang S-N, Tung Y-C, Yang M-C (2019) Development of Alzheimer disease in old major depressive patients based upon their health status: a retrospective study in Taiwan. Medicine 98(20)","DOI":"10.1097\/MD.0000000000015527"},{"issue":"3","key":"9170_CR15","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1001\/archpsyc.63.3.273","volume":"63","author":"DE Barnes","year":"2006","unstructured":"Barnes DE, Alexopoulos GS, Lopez OL, Williamson JD, Yaffe K (2006) Depressive symptoms, vascular disease, and mild cognitive impairment: findings from the Cardiovascular Health Study. Arch Gen Psychiatry 63(3):273\u2013279","journal-title":"Arch Gen Psychiatry"},{"key":"9170_CR16","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jad.2015.09.069","volume":"190","author":"Q-F Zhao","year":"2016","unstructured":"Zhao Q-F, Tan L, Wang H-F, Jiang T, Tan M-S, Tan L et al (2016) The prevalence of neuropsychiatric symptoms in Alzheimer\u2019s disease: systematic review and meta-analysis. J Affect Disord 190:264\u2013271","journal-title":"J Affect Disord"},{"key":"9170_CR17","unstructured":"(GBD) GBoD (2019) The Institute for Health Metrics and Evaluation. https:\/\/vizhub.healthdata.org\/gbd-results\/. Accessed 14 June 2023"},{"key":"9170_CR18","unstructured":"(WHO) WHO (2023) Depressive disorder (depression). https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/depression. Accessed 20 Aug 2023"},{"key":"9170_CR19","unstructured":"Prevention CfDCa (2021) National Center for Injury Prevention and Control (Suicide Prevention). https:\/\/www.cdc.gov\/suicide\/facts\/. Accessed 23 Aug 2023"},{"issue":"7","key":"9170_CR20","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1001\/jamapsychiatry.2017.0658","volume":"74","author":"DC Steffens","year":"2017","unstructured":"Steffens DC (2017) Late-life depression and the prodromes of dementia. JAMA Psychiatry 74(7):673\u2013674","journal-title":"JAMA Psychiatry"},{"issue":"5","key":"9170_CR21","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1001\/archpsyc.63.5.530","volume":"63","author":"RL Ownby","year":"2006","unstructured":"Ownby RL, Crocco E, Acevedo A, John V, Loewenstein D (2006) Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis. Arch Gen Psychiatry 63(5):530\u2013538","journal-title":"Arch Gen Psychiatry"},{"issue":"11","key":"9170_CR22","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3390\/biomedicines8110457","volume":"8","author":"V Cant\u00f3n-Habas","year":"2020","unstructured":"Cant\u00f3n-Habas V, Rich-Ruiz M, Romero-Salda\u00f1a M, Carrera-Gonz\u00e1lez MDP (2020) Depression as a risk factor for dementia and Alzheimer\u2019s disease. Biomedicines 8(11):457","journal-title":"Biomedicines"},{"key":"9170_CR23","doi-asserted-by":"crossref","unstructured":"Yang W, Li X, Pan KY, Yang R, Song R, Qi X et al (2021) Association of life\u2010course depression with the risk of dementia in late life: a nationwide twin study. Alzheimer\u2019s Dement","DOI":"10.1002\/alz.051569"},{"issue":"9","key":"9170_CR24","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1056\/NEJMp2110468","volume":"385","author":"GC Alexander","year":"2021","unstructured":"Alexander GC, Knopman DS, Emerson SS, Ovbiagele B, Kryscio RJ, Perlmutter JS et al (2021) Revisiting FDA approval of aducanumab. N Engl J Med 385(9):769\u2013771","journal-title":"N Engl J Med"},{"issue":"1","key":"9170_CR25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13195-021-00948-8","volume":"14","author":"E McDade","year":"2022","unstructured":"McDade E, Cummings JL, Dhadda S, Swanson CJ, Reyderman L, Kanekiyo M et al (2022) Lecanemab in patients with early Alzheimer\u2019s disease: detailed results on biomarker, cognitive, and clinical effects from the randomized and open-label extension of the phase 2 proof-of-concept study. Alzheimer\u2019s Res Ther 14(1):1\u201317","journal-title":"Alzheimer\u2019s Res Ther"},{"key":"9170_CR26","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neubiorev.2019.04.002","volume":"102","author":"CP Galts","year":"2019","unstructured":"Galts CP, Bettio LE, Jewett DC, Yang CC, Brocardo PS, Rodrigues ALS et al (2019) Depression in neurodegenerative diseases: common mechanisms and current treatment options. Neurosci Biobehav Rev 102:56\u201384","journal-title":"Neurosci Biobehav Rev"},{"key":"9170_CR27","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.neubiorev.2019.04.010","volume":"102","author":"C Park","year":"2019","unstructured":"Park C, Rosenblat JD, Brietzke E, Pan Z, Lee Y, Cao B et al (2019) Stress, epigenetics and depression: a systematic review. Neurosci Biobehav Rev 102:139\u2013152","journal-title":"Neurosci Biobehav Rev"},{"issue":"7","key":"9170_CR28","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/syn.20637","volume":"63","author":"JM Miller","year":"2009","unstructured":"Miller JM, Kinnally EL, Ogden RT, Oquendo MA, Mann JJ, Parsey RV (2009) Reported childhood abuse is associated with low serotonin transporter binding in vivo in major depressive disorder. Synapse 63(7):565\u2013573","journal-title":"Synapse"},{"issue":"1","key":"9170_CR29","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41531-021-00213-7","volume":"7","author":"H Wang","year":"2021","unstructured":"Wang H, Yang F, Zhang S, Xin R, Sun Y (2021) Genetic and environmental factors in Alzheimer\u2019s and Parkinson\u2019s diseases and promising therapeutic intervention via fecal microbiota transplantation. npj Parkinson\u2019s Dis 7(1):70","journal-title":"npj Parkinson\u2019s Dis"},{"issue":"7","key":"9170_CR30","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/s41380-018-0237-8","volume":"24","author":"C Lassale","year":"2019","unstructured":"Lassale C, Batty GD, Baghdadli A, Jacka F, S\u00e1nchez-Villegas A, Kivim\u00e4ki M et al (2019) Healthy dietary indices and risk of depressive outcomes: a systematic review and meta-analysis of observational studies. Mol Psychiatry 24(7):965\u2013986","journal-title":"Mol Psychiatry"},{"key":"9170_CR31","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s13668-019-0271-4","volume":"8","author":"AM McGrattan","year":"2019","unstructured":"McGrattan AM, McGuinness B, McKinley MC, Kee F, Passmore P, Woodside JV et al (2019) Diet and inflammation in cognitive ageing and Alzheimer\u2019s disease. Current nutrition reports 8:53\u201365","journal-title":"Current nutrition reports"},{"issue":"3","key":"9170_CR32","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.nbd.2007.10.005","volume":"29","author":"H Xiong","year":"2008","unstructured":"Xiong H, Callaghan D, Jones A, Walker DG, Lue L-F, Beach TG et al (2008) Cholesterol retention in Alzheimer\u2019s brain is responsible for high \u03b2-and \u03b3-secretase activities and A\u03b2 production. Neurobiol Dis 29(3):422\u2013437","journal-title":"Neurobiol Dis"},{"key":"9170_CR33","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2020.617071","volume":"12","author":"M Thelen","year":"2020","unstructured":"Thelen M, Brown-Borg HM (2020) Does diet have a role in the treatment of Alzheimer\u2019s disease? Front Aging Neurosci 12:617071","journal-title":"Front Aging Neurosci"},{"issue":"1","key":"9170_CR34","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/s41380-020-00925-x","volume":"26","author":"W Marx","year":"2021","unstructured":"Marx W, Lane M, Hockey M, Aslam H, Berk M, Walder K et al (2021) Diet and depression: exploring the biological mechanisms of action. Mol Psychiatry 26(1):134\u2013150","journal-title":"Mol Psychiatry"},{"issue":"7","key":"9170_CR35","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1097\/PSY.0b013e318148c19a","volume":"69","author":"JA Blumenthal","year":"2007","unstructured":"Blumenthal JA, Babyak MA, Doraiswamy PM, Watkins L, Hoffman BM, Barbour KA et al (2007) Exercise and pharmacotherapy in the treatment of major depressive disorder. Psychosom Med 69(7):587","journal-title":"Psychosom Med"},{"key":"9170_CR36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12877-018-1019-5","volume":"19","author":"R-X Jia","year":"2019","unstructured":"Jia R-X, Liang J-H, Xu Y, Wang Y-Q (2019) Effects of physical activity and exercise on the cognitive function of patients with Alzheimer disease: a meta-analysis. BMC Geriatr 19:1\u201314","journal-title":"BMC Geriatr"},{"key":"9170_CR37","doi-asserted-by":"crossref","first-page":"424","DOI":"10.3389\/fgene.2020.00424","volume":"11","author":"E Cano-Gamez","year":"2020","unstructured":"Cano-Gamez E, Trynka G (2020) From GWAS to function: using functional genomics to identify the mechanisms underlying complex diseases. Front Genet 11:424","journal-title":"Front Genet"},{"key":"9170_CR38","doi-asserted-by":"crossref","first-page":"334","DOI":"10.3389\/fpsyt.2018.00334","volume":"9","author":"M Shadrina","year":"2018","unstructured":"Shadrina M, Bondarenko EA, Slominsky PA (2018) Genetics factors in major depression disease. Front Psychiatry 9:334","journal-title":"Front Psychiatry"},{"issue":"3","key":"9170_CR39","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/s41593-020-0599-5","volume":"23","author":"R Sims","year":"2020","unstructured":"Sims R, Hill M, Williams J (2020) The multiplex model of the genetics of Alzheimer\u2019s disease. Nat Neurosci 23(3):311\u2013322","journal-title":"Nat Neurosci"},{"issue":"7","key":"9170_CR40","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.3390\/biomedicines10071560","volume":"10","author":"S Bonk","year":"2022","unstructured":"Bonk S, Kirchner K, Ameling S, Garvert L, V\u00f6lzke H, Nauck M et al (2022) APOE \u03b54 in depression-associated memory impairment\u2014evidence from genetic and MicroRNA analyses. Biomedicines 10(7):1560","journal-title":"Biomedicines"},{"issue":"2","key":"9170_CR41","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.neulet.2009.03.007","volume":"455","author":"MA Slifer","year":"2009","unstructured":"Slifer MA, Martin ER, Gilbert JR, Haines JL, Pericak-Vance MA (2009) Resolving the relationship between ApolipoproteinE and depression. Neurosci Lett 455(2):116\u2013119","journal-title":"Neurosci Lett"},{"issue":"4","key":"9170_CR42","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3233\/JAD-180276","volume":"64","author":"H Ni","year":"2018","unstructured":"Ni H, Xu M, Zhan G-L, Fan Y, Zhou H, Jiang H-Y et al (2018) The GWAS risk genes for depression may be actively involved in Alzheimer\u2019s disease. J Alzheimer\u2019s Dis 64(4):1149\u20131161","journal-title":"J Alzheimer\u2019s Dis"},{"issue":"6","key":"9170_CR43","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1161\/STROKEAHA.118.020811","volume":"49","author":"LC Rutten-Jacobs","year":"2018","unstructured":"Rutten-Jacobs LC, Tozer DJ, Duering M, Malik R, Dichgans M, Markus HS et al (2018) Genetic study of white matter integrity in UK Biobank (N= 8448) and the overlap with stroke, depression, and dementia. Stroke 49(6):1340\u20131347","journal-title":"Stroke"},{"issue":"10","key":"9170_CR44","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.jagp.2016.07.017","volume":"24","author":"AP Mendes-Silva","year":"2016","unstructured":"Mendes-Silva AP, Pereira KS, Tolentino-Araujo GT, de Souza NE, Silva-Ferreira CM, Teixeira AL et al (2016) Shared biologic pathways between Alzheimer disease and major depression: a systematic review of MicroRNA expression studies. Am J Geriatr Psychiatry 24(10):903\u2013912","journal-title":"Am J Geriatr Psychiatry"},{"issue":"6","key":"9170_CR45","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.biopsych.2020.09.010","volume":"89","author":"L Dall\u2019Aglio","year":"2021","unstructured":"Dall\u2019Aglio L, Lewis CM, Pain O (2021) Delineating the genetic component of gene expression in major depression. Biol Psychiatry 89(6):627\u201336","journal-title":"Biol Psychiatry"},{"key":"9170_CR46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/alzrt231","volume":"6","author":"J-I Satoh","year":"2014","unstructured":"Satoh J-I, Kino Y, Kawana N, Yamamoto Y, Ishida T, Saito Y et al (2014) TMEM106B expression is reduced in Alzheimer\u2019s disease brains. Alzheimer\u2019s Res Ther 6:1\u201314","journal-title":"Alzheimer\u2019s Res Ther"},{"key":"9170_CR47","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.653130","volume":"15","author":"J Monereo-S\u00e1nchez","year":"2021","unstructured":"Monereo-S\u00e1nchez J, Schram MT, Frei O, O\u2019Connell K, Shadrin AA, Smeland OB et al (2021) Genetic overlap between Alzheimer\u2019s disease and depression mapped onto the brain. Front Neurosci 15:653130","journal-title":"Front Neurosci"},{"issue":"3","key":"9170_CR48","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jpsychires.2008.05.008","volume":"43","author":"E Gr\u00fcnblatt","year":"2009","unstructured":"Gr\u00fcnblatt E, Zehetmayer S, Bartl J, L\u00f6ffler C, Wichart I, Rainer MK et al (2009) Genetic risk factors and markers for Alzheimer\u2019s disease and\/or depression in the VITA study. J Psychiatr Res 43(3):298\u2013308","journal-title":"J Psychiatr Res"},{"issue":"4","key":"9170_CR49","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.neurobiolaging.2010.06.011","volume":"33","author":"P Proitsi","year":"2012","unstructured":"Proitsi P, Lupton MK, Reeves SJ, Hamilton G, Archer N, Martin BM et al (2012) Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementia. Neurobiol Aging 33(4):791\u2013803","journal-title":"Neurobiol Aging"},{"key":"9170_CR50","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.biopha.2017.12.053","volume":"98","author":"K Kumar","year":"2018","unstructured":"Kumar K, Kumar A, Keegan RM, Deshmukh R (2018) Recent advances in the neurobiology and neuropharmacology of Alzheimer\u2019s disease. Biomed Pharmacother 98:297\u2013307","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"9170_CR51","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejphar.2009.10.022","volume":"626","author":"F Caraci","year":"2010","unstructured":"Caraci F, Copani A, Nicoletti F, Drago F (2010) Depression and Alzheimer\u2019s disease: neurobiological links and common pharmacological targets. Eur J Pharmacol 626(1):64\u201371","journal-title":"Eur J Pharmacol"},{"key":"9170_CR52","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.nbd.2016.05.008","volume":"97","author":"H Tanila","year":"2017","unstructured":"Tanila H (2017) The role of BDNF in Alzheimer\u2019s disease. Neurobiol Dis 97:114\u2013118","journal-title":"Neurobiol Dis"},{"issue":"1","key":"9170_CR53","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/aps.2010.184","volume":"32","author":"H Yu","year":"2011","unstructured":"Yu H, Chen Z-Y (2011) The role of BDNF in depression on the basis of its location in the neural circuitry. Acta Pharmacologica Sinica 32(1):3\u201311","journal-title":"Acta Pharmacologica Sinica"},{"key":"9170_CR54","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bbr.2015.08.027","volume":"296","author":"J De Vry","year":"2016","unstructured":"De Vry J, Vanmierlo T, Mart\u00ednez-Mart\u00ednez P, Losen M, Temel Y, Boere J et al (2016) TrkB in the hippocampus and nucleus accumbens differentially modulates depression-like behavior in mice. Behav Brain Res 296:15\u201325","journal-title":"Behav Brain Res"},{"issue":"2","key":"9170_CR55","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1124\/pr.111.005108","volume":"64","author":"AE Autry","year":"2012","unstructured":"Autry AE, Monteggia LM (2012) Brain-derived neurotrophic factor and neuropsychiatric disorders. Pharmacol Rev 64(2):238\u2013258","journal-title":"Pharmacol Rev"},{"issue":"7","key":"9170_CR56","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.biopsych.2007.09.019","volume":"63","author":"M Adachi","year":"2008","unstructured":"Adachi M, Barrot M, Autry AE, Theobald D, Monteggia LM (2008) Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy. Biol Psychiatry 63(7):642\u2013649","journal-title":"Biol Psychiatry"},{"issue":"10","key":"9170_CR57","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1038\/sj.npp.1301345","volume":"32","author":"T Rantam\u00e4ki","year":"2007","unstructured":"Rantam\u00e4ki T, Hendolin P, Kankaanp\u00e4\u00e4 A, Mijatovic J, Piepponen P, Domenici E et al (2007) Pharmacologically diverse antidepressants rapidly activate brain-derived neurotrophic factor receptor TrkB and induce phospholipase-C\u03b3 signaling pathways in mouse brain. Neuropsychopharmacology 32(10):2152\u20132162","journal-title":"Neuropsychopharmacology"},{"issue":"5","key":"9170_CR58","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.cell.2021.01.034","volume":"184","author":"PC Casarotto","year":"2021","unstructured":"Casarotto PC, Girych M, Fred SM, Kovaleva V, Moliner R, Enkavi G et al (2021) Antidepressant drugs act by directly binding to TRKB neurotrophin receptors. Cell. 184(5):1299\u2013313. e19","journal-title":"Cell."},{"issue":"7","key":"9170_CR59","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/mp.2013.105","volume":"19","author":"M Molendijk","year":"2014","unstructured":"Molendijk M, Spinhoven P, Polak M, Bus B, Penninx B, Elzinga B (2014) Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N= 9484). Mol Psychiatry 19(7):791\u2013800","journal-title":"Mol Psychiatry"},{"key":"9170_CR60","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.jad.2014.11.044","volume":"174","author":"M Polyakova","year":"2015","unstructured":"Polyakova M, Stuke K, Schuemberg K, Mueller K, Schoenknecht P, Schroeter ML (2015) BDNF as a biomarker for successful treatment of mood disorders: a systematic & quantitative meta-analysis. J Affect Disord 174:432\u2013440","journal-title":"J Affect Disord"},{"key":"9170_CR61","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3389\/fpsyt.2017.00308","volume":"8","author":"T Kishi","year":"2018","unstructured":"Kishi T, Yoshimura R, Ikuta T, Iwata N (2018) Brain-derived neurotrophic factor and major depressive disorder: evidence from meta-analyses. Front Psychiatry 8:308","journal-title":"Front Psychiatry"},{"key":"9170_CR62","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jpsychires.2017.02.005","volume":"89","author":"B Roy","year":"2017","unstructured":"Roy B, Shelton RC, Dwivedi Y (2017) DNA methylation and expression of stress related genes in PBMC of MDD patients with and without serious suicidal ideation. J Psychiatr Res 89:115\u2013124","journal-title":"J Psychiatr Res"},{"issue":"11","key":"9170_CR63","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1176\/appi.ajp.2012.12020248","volume":"169","author":"A Tripp","year":"2012","unstructured":"Tripp A, Oh H, Guilloux J-P, Martinowich K, Lewis DA, Sibille E (2012) Brain-derived neurotrophic factor signaling and subgenual anterior cingulate cortex dysfunction in major depressive disorder. Am J Psychiatry 169(11):1194\u20131202","journal-title":"Am J Psychiatry"},{"issue":"2","key":"9170_CR64","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.biopsych.2021.05.008","volume":"90","author":"E Castr\u00e9n","year":"2021","unstructured":"Castr\u00e9n E, Monteggia LM (2021) Brain-derived neurotrophic factor signaling in depression and antidepressant action. Biol Psychiatry 90(2):128\u2013136","journal-title":"Biol Psychiatry"},{"issue":"10","key":"9170_CR65","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1093\/ijnp\/pyaa048","volume":"23","author":"H Wang","year":"2020","unstructured":"Wang H, Zhang F-F, Xu Y, Fu H-R, Wang X-D, Wang L et al (2020) The phosphodiesterase-4 inhibitor roflumilast, a potential treatment for the comorbidity of memory loss and depression in Alzheimer\u2019s disease: a preclinical study in APP\/PS1 transgenic mice. Int J Neuropsychopharmacol 23(10):700\u201311","journal-title":"Int J Neuropsychopharmacol"},{"issue":"7","key":"9170_CR66","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/mp.2011.26","volume":"16","author":"C Anacker","year":"2011","unstructured":"Anacker C, Zunszain PA, Cattaneo A, Carvalho LA, Garabedian MJ, Thuret S et al (2011) Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor. Mol Psychiatry 16(7):738\u2013750","journal-title":"Mol Psychiatry"},{"issue":"22","key":"9170_CR67","doi-asserted-by":"crossref","first-page":"12796","DOI":"10.1073\/pnas.211427898","volume":"98","author":"B Cz\u00e9h","year":"2001","unstructured":"Cz\u00e9h B, Michaelis T, Watanabe T, Frahm J, De Biurrun G, Van Kampen M et al (2001) Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine. Proc Natl Acad Sci 98(22):12796\u201312801","journal-title":"Proc Natl Acad Sci"},{"issue":"12","key":"9170_CR68","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0006-3223(00)00228-6","volume":"47","author":"TM Madsen","year":"2000","unstructured":"Madsen TM, Treschow A, Bengzon J, Bolwig TG, Lindvall O, Tingstr\u00f6m A (2000) Increased neurogenesis in a model of electroconvulsive therapy. Biol Psychiatry 47(12):1043\u20131049","journal-title":"Biol Psychiatry"},{"issue":"1\u20132","key":"9170_CR69","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0014-2999(00)00904-3","volume":"411","author":"H Manev","year":"2001","unstructured":"Manev H, Uz T, Smalheiser NR, Manev R (2001) Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro. Eur J Pharmacol 411(1\u20132):67\u201370","journal-title":"Eur J Pharmacol"},{"issue":"5634","key":"9170_CR70","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.1083328","volume":"301","author":"L Santarelli","year":"2003","unstructured":"Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S et al (2003) Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301(5634):805\u20139","journal-title":"Science"},{"issue":"5","key":"9170_CR71","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1111\/j.1460-9568.2005.03968.x","volume":"21","author":"T Hajszan","year":"2005","unstructured":"Hajszan T, MacLusky NJ, Leranth C (2005) Short-term treatment with the antidepressant fluoxetine triggers pyramidal dendritic spine synapse formation in rat hippocampus. Eur J Neurosci 21(5):1299\u20131303","journal-title":"Eur J Neurosci"},{"issue":"3","key":"9170_CR72","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/syn.10006","volume":"42","author":"SD Norrholm","year":"2001","unstructured":"Norrholm SD, Ouimet CC (2001) Altered dendritic spine density in animal models of depression and in response to antidepressant treatment. Synapse 42(3):151\u2013163","journal-title":"Synapse"},{"issue":"2\u20133","key":"9170_CR73","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0014-2999(99)00163-6","volume":"371","author":"AM Magari\u00f1os","year":"1999","unstructured":"Magari\u00f1os AM, Deslandes A, McEwen BS (1999) Effects of antidepressants and benzodiazepine treatments on the dendritic structure of CA3 pyramidal neurons after chronic stress. Eur J Pharmacol 371(2\u20133):113\u2013122","journal-title":"Eur J Pharmacol"},{"key":"9170_CR74","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.neuropharm.2017.08.037","volume":"126","author":"D-S Sun","year":"2017","unstructured":"Sun D-S, Gao L-F, Jin L, Wu H, Wang Q, Zhou Y et al (2017) Fluoxetine administration during adolescence attenuates cognitive and synaptic deficits in adult 3\u00d7 TgAD mice. Neuropharmacology 126:200\u2013212","journal-title":"Neuropharmacology"},{"issue":"35","key":"9170_CR75","doi-asserted-by":"publisher","first-page":"9047","DOI":"10.1523\/jneurosci.2797-06.2006","volume":"26","author":"KN Green","year":"2006","unstructured":"Green KN, Billings LM, Roozendaal B, McGaugh JL, LaFerla FM (2006) Glucocorticoids increase amyloid-\u03b2 and tau pathology in a mouse model of Alzheimer\u2019s disease. J Neurosci 26(35):9047\u20139056. https:\/\/doi.org\/10.1523\/jneurosci.2797-06.2006","journal-title":"J Neurosci"},{"issue":"3","key":"9170_CR76","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.bbi.2011.12.011","volume":"26","author":"RJ Tynan","year":"2012","unstructured":"Tynan RJ, Weidenhofer J, Hinwood M, Cairns MJ, Day TA, Walker FR (2012) A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia. Brain Behav Immun 26(3):469\u2013479","journal-title":"Brain Behav Immun"},{"issue":"2","key":"9170_CR77","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/npp.2014.176","volume":"40","author":"P Patr\u00edcio","year":"2015","unstructured":"Patr\u00edcio P, Mateus-Pinheiro A, Irmler M, Alves ND, Machado-Santos AR, Morais M et al (2015) Differential and converging molecular mechanisms of antidepressants\u2019 action in the hippocampal dentate gyrus. Neuropsychopharmacology 40(2):338\u2013349","journal-title":"Neuropsychopharmacology"},{"issue":"6","key":"9170_CR78","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.intimp.2005.12.007","volume":"6","author":"D Brustolim","year":"2006","unstructured":"Brustolim D, Ribeiro-dos-Santos R, Kast R, Altschuler E, Soares MBP (2006) A new chapter opens in anti-inflammatory treatments: the antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice. Int Immunopharmacol 6(6):903\u2013907","journal-title":"Int Immunopharmacol"},{"issue":"5\u20136","key":"9170_CR79","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00210-010-0535-4","volume":"382","author":"A Bielecka","year":"2010","unstructured":"Bielecka A, Paul-Samojedny M, Obuchowicz E (2010) Moclobemide exerts anti-inflammatory effect in lipopolysaccharide-activated primary mixed glial cell culture. Naunyn-Schmiedeberg\u2019s Arch Pharmacol 382(5\u20136):409\u2013417","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"},{"issue":"1","key":"9170_CR80","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1017\/S1461145707007729","volume":"11","author":"P Vollmar","year":"2008","unstructured":"Vollmar P, Haghikia A, Dermietzel R, Faustmann PM (2008) Venlafaxine exhibits an anti-inflammatory effect in an inflammatory co-culture model. Int J Neuropsychopharmacol 11(1):111\u2013117","journal-title":"Int J Neuropsychopharmacol"},{"issue":"3","key":"9170_CR81","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.neuint.2005.03.004","volume":"47","author":"M P\u00e1k\u00e1ski","year":"2005","unstructured":"P\u00e1k\u00e1ski M, Bjelik A, Hugyecz M, K\u00e1sa P, Janka Z, K\u00e1lm\u00e1n J (2005) Imipramine and citalopram facilitate amyloid precursor protein secretion in vitro. Neurochem Int 47(3):190\u2013195","journal-title":"Neurochem Int"},{"issue":"1","key":"9170_CR82","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.expneurol.2007.01.037","volume":"205","author":"RL Nelson","year":"2007","unstructured":"Nelson RL, Guo Z, Halagappa VM, Pearson M, Gray AJ, Matsuoka Y et al (2007) Prophylactic treatment with paroxetine ameliorates behavioral deficits and retards the development of amyloid and tau pathologies in 3xTgAD mice. Exp Neurol 205(1):166\u2013176","journal-title":"Exp Neurol"},{"issue":"3","key":"9170_CR83","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1385\/JMN:20:3:267","volume":"20","author":"S Payton","year":"2003","unstructured":"Payton S, Cahill CM, Randall JD, Gullans SR, Rogers JT (2003) Drug discovery targeted to the Alzheimer\u2019s APP mRNA 5\u2032-untranslated region. J Mol Neurosci 20(3):267\u2013275","journal-title":"J Mol Neurosci"},{"key":"9170_CR84","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3389\/fnagi.2018.00164","volume":"10","author":"M Huang","year":"2018","unstructured":"Huang M, Liang Y, Chen H, Xu B, Chai C, Xing P (2018) The role of fluoxetine in activating Wnt\/\u03b2-catenin signaling and repressing \u03b2-amyloid production in an Alzheimer mouse model. Front Aging Neurosci 10:164","journal-title":"Front Aging Neurosci"},{"issue":"36","key":"9170_CR85","doi-asserted-by":"crossref","first-page":"14968","DOI":"10.1073\/pnas.1107411108","volume":"108","author":"JR Cirrito","year":"2011","unstructured":"Cirrito JR, Disabato BM, Restivo JL, Verges DK, Goebel WD, Sathyan A et al (2011) Serotonin signaling is associated with lower amyloid-\u03b2 levels and plaques in transgenic mice and humans. Proc Natl Acad Sci 108(36):14968\u201314973","journal-title":"Proc Natl Acad Sci"},{"issue":"236","key":"9170_CR86","doi-asserted-by":"crossref","first-page":"236re4","DOI":"10.1126\/scitranslmed.3008169","volume":"6","author":"YI Sheline","year":"2014","unstructured":"Sheline YI, West T, Yarasheski K, Swarm R, Jasielec MS, Fisher JR et al (2014) An antidepressant decreases CSF A\u03b2 production in healthy individuals and in transgenic AD mice. Science Transl Med 6(236):236re4","journal-title":"Science Transl Med"},{"key":"9170_CR87","doi-asserted-by":"crossref","unstructured":"Wei Z, Junhong G, Xiaoyuan N, Jie W, Zhaojun W, Meina W et al (2017) Citalopram ameliorates impairments in spatial memory and synaptic plasticity in female 3xTgAD mice. BioMed Res Int 2017","DOI":"10.1155\/2017\/1238687"},{"key":"9170_CR88","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ejphar.2015.07.015","volume":"764","author":"F Caraci","year":"2015","unstructured":"Caraci F, Pappalardo G, Basile L, Giuffrida A, Copani A, Tosto R et al (2015) Neuroprotective effects of the monoamine oxidase inhibitor tranylcypromine and its amide derivatives against A\u03b2 (1\u201342)-induced toxicity. Eur J Pharmacol 764:256\u2013263","journal-title":"Eur J Pharmacol"},{"key":"9170_CR89","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1590\/1414-431X20133275","volume":"47","author":"C Yang","year":"2014","unstructured":"Yang C, Guo X, Wang G, Wang H, Liu Z, Liu H et al (2014) Changes in tau phosphorylation levels in the hippocampus and frontal cortex following chronic stress. Braz J Med Biol Res 47:237\u2013244","journal-title":"Braz J Med Biol Res"},{"issue":"12","key":"9170_CR90","doi-asserted-by":"crossref","first-page":"13328","DOI":"10.18632\/oncotarget.7798","volume":"7","author":"Y-J Wang","year":"2016","unstructured":"Wang Y-J, Ren Q-G, Gong W-G, Wu D, Tang X, Li X-L et al (2016) Escitalopram attenuates \u03b2-amyloid-induced tau hyperphosphorylation in primary hippocampal neurons through the 5-HT1A receptor mediated Akt\/GSK-3\u03b2 pathway. Oncotarget 7(12):13328","journal-title":"Oncotarget"},{"issue":"2","key":"9170_CR91","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/s12031-015-0519-4","volume":"56","author":"Q-G Ren","year":"2015","unstructured":"Ren Q-G, Wang Y-J, Gong W-G, Zhou Q-D, Xu L, Zhang Z-J (2015) Escitalopram ameliorates forskolin-induced tau hyperphosphorylation in HEK239\/tau441 cells. J Mol Neurosci 56(2):500\u2013508","journal-title":"J Mol Neurosci"},{"issue":"12","key":"9170_CR92","doi-asserted-by":"crossref","first-page":"4898","DOI":"10.1073\/pnas.0703615105","volume":"105","author":"M Gonzalez","year":"2008","unstructured":"Gonzalez M, Aston-Jones G (2008) Light deprivation damages monoamine neurons and produces a depressive behavioral phenotype in rats. Proc Natl Acad Sci 105(12):4898\u20134903","journal-title":"Proc Natl Acad Sci"},{"issue":"7","key":"9170_CR93","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1038\/sj.npp.1301527","volume":"33","author":"TA Kosten","year":"2008","unstructured":"Kosten TA, Galloway MP, Duman RS, Russell DS, D\u2019sa C (2008) Repeated unpredictable stress and antidepressants differentially regulate expression of the bcl-2 family of apoptotic genes in rat cortical, hippocampal, and limbic brain structures. Neuropsychopharmacology 33(7):1545\u20131558","journal-title":"Neuropsychopharmacology"},{"issue":"8","key":"9170_CR94","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.biopsych.2008.06.003","volume":"64","author":"V Krishnan","year":"2008","unstructured":"Krishnan V, Han M-H, Mazei-Robison M, I\u00f1iguez SD, Ables JL, Vialou V et al (2008) AKT signaling within the ventral tegmental area regulates cellular and behavioral responses to stressful stimuli. Biol Psychiatry 64(8):691\u2013700","journal-title":"Biol Psychiatry"},{"issue":"1","key":"9170_CR95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40035-021-00276-9","volume":"11","author":"L Gao","year":"2022","unstructured":"Gao L, Zhang Y, Sterling K, Song W (2022) Brain-derived neurotrophic factor in Alzheimer\u2019s disease and its pharmaceutical potential. Trans Neurodegen 11(1):1\u201334","journal-title":"Trans Neurodegen"},{"issue":"45","key":"9170_CR96","doi-asserted-by":"crossref","first-page":"34708","DOI":"10.1074\/jbc.M110.150821","volume":"285","author":"Z Zheng","year":"2010","unstructured":"Zheng Z, Sabirzhanov B, Keifer J (2010) Oligomeric amyloid-\u03b2 inhibits the proteolytic conversion of brain-derived neurotrophic factor (BDNF), AMPA receptor trafficking, and classical conditioning. J Biol Chem 285(45):34708\u201334717","journal-title":"J Biol Chem"},{"key":"9170_CR97","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.neuroscience.2012.02.037","volume":"210","author":"J Wong","year":"2012","unstructured":"Wong J, Higgins M, Halliday G, Garner B (2012) Amyloid beta selectively modulates neuronal TrkB alternative transcript expression with implications for Alzheimer\u2019s disease. Neuroscience 210:363\u2013374","journal-title":"Neuroscience"},{"issue":"2","key":"9170_CR98","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/jnc.14034","volume":"142","author":"SM Nigam","year":"2017","unstructured":"Nigam SM, Xu S, Kritikou JS, Marosi K, Brodin L, Mattson MP (2017) Exercise and BDNF reduce A\u03b2 production by enhancing \u03b1-secretase processing of APP. J Neurochem 142(2):286\u2013296","journal-title":"J Neurochem"},{"issue":"5","key":"9170_CR99","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/0896-6273(91)90273-3","volume":"7","author":"HS Phillips","year":"1991","unstructured":"Phillips HS, Hains JM, Armanini M, Laramee GR, Johnson SA, Winslow JW (1991) BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer\u2019s disease. Neuron 7(5):695\u2013702","journal-title":"Neuron"},{"key":"9170_CR100","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2019.104540","volume":"132","author":"SD Ginsberg","year":"2019","unstructured":"Ginsberg SD, Malek-Ahmadi MH, Alldred MJ, Chen Y, Chen K, Chao MV et al (2019) Brain-derived neurotrophic factor (BDNF) and TrkB hippocampal gene expression are putative predictors of neuritic plaque and neurofibrillary tangle pathology. Neurobiol Dis 132:104540","journal-title":"Neurobiol Dis"},{"issue":"2","key":"9170_CR101","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/mp.2016.62","volume":"22","author":"X Qin","year":"2017","unstructured":"Qin X, Cao C, Cawley N, Liu T, Yuan J, Loh Y et al (2017) Decreased peripheral brain-derived neurotrophic factor levels in Alzheimer\u2019s disease: a meta-analysis study (N= 7277). Mol Psychiatry 22(2):312\u2013320","journal-title":"Mol Psychiatry"},{"key":"9170_CR102","doi-asserted-by":"publisher","unstructured":"Canet G, Hernandez C, Zussy C, Chevallier N, Desrumaux C, Givalois L (2019) Is AD a stress-related disorder? Focus on the HPA axis and its promising therapeutic targets. Front Aging Neurosci 11(269). https:\/\/doi.org\/10.3389\/fnagi.2019.00269","DOI":"10.3389\/fnagi.2019.00269"},{"issue":"5","key":"9170_CR103","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0893-133X(00)00159-7","volume":"23","author":"F Holsboer","year":"2000","unstructured":"Holsboer F (2000) The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 23(5):477\u2013501","journal-title":"Neuropsychopharmacology"},{"key":"9170_CR104","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3389\/fpsyt.2019.00101","volume":"10","author":"A Menke","year":"2019","unstructured":"Menke A (2019) Is the HPA axis as target for depression outdated, or is there a new hope? Front Psychiatry 10:101","journal-title":"Front Psychiatry"},{"issue":"3","key":"9170_CR105","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0169-328X(93)90189-V","volume":"18","author":"PM Plotsky","year":"1993","unstructured":"Plotsky PM, Meaney MJ (1993) Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats. Mol Brain Res 18(3):195\u2013200","journal-title":"Mol Brain Res"},{"issue":"4","key":"9170_CR106","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1210\/endo.137.4.8625891","volume":"137","author":"C Ladd","year":"1996","unstructured":"Ladd C, Owens M, Nemeroff C (1996) Persistent changes in corticotropin-releasing factor neuronal systems induced by maternal deprivation. Endocrinology 137(4):1212\u20131218","journal-title":"Endocrinology"},{"issue":"4","key":"9170_CR107","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1176\/appi.ajp.158.4.575","volume":"158","author":"C Heim","year":"2001","unstructured":"Heim C, Newport DJ, Bonsall R, Miller AH, Nemeroff CB (2001) Altered pituitary-adrenal axis responses to provocative challenge tests in adult survivors of childhood abuse. Am J Psychiatry 158(4):575\u2013581","journal-title":"Am J Psychiatry"},{"issue":"9","key":"9170_CR108","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tins.2008.06.006","volume":"31","author":"CM Pariante","year":"2008","unstructured":"Pariante CM, Lightman SL (2008) The HPA axis in major depression: classical theories and new developments. Trends Neurosci 31(9):464\u2013468","journal-title":"Trends Neurosci"},{"key":"9170_CR109","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.phrs.2018.04.017","volume":"132","author":"A Caruso","year":"2018","unstructured":"Caruso A, Nicoletti F, Mango D, Saidi A, Orlando R, Scaccianoce S (2018) Stress as risk factor for Alzheimer\u2019s disease. Pharmacol Res 132:130\u2013134. https:\/\/doi.org\/10.1016\/j.phrs.2018.04.017","journal-title":"Pharmacol Res"},{"issue":"1","key":"9170_CR110","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1471-4159.1993.tb03537.x","volume":"61","author":"EM Elliott","year":"1993","unstructured":"Elliott EM, Mattson MP, Vanderklish P, Lynch G, Chang I, Sapolsky RM (1993) Corticosterone exacerbates kainate-induced alterations in hippocampal tau immunoreactivity and spectrin proteolysis in vivo. J Neurochem 61(1):57\u201367","journal-title":"J Neurochem"},{"issue":"1","key":"9170_CR111","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0304-3940(99)00790-9","volume":"276","author":"G Budas","year":"1999","unstructured":"Budas G, Coughlan CM, Seckl JR, Breen KC (1999) The effect of corticosteroids on amyloid \u03b2 precursor protein\/amyloid precursor-like protein expression and processing in vivo. Neurosci Lett 276(1):61\u201364","journal-title":"Neurosci Lett"},{"issue":"6","key":"9170_CR112","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1096\/fj.05-4265fje","volume":"20","author":"YH Jeong","year":"2006","unstructured":"Jeong YH, Park CH, Yoo J, Shin KY, Ahn SM, Kim HS et al (2006) Chronic stress accelerates learning and memory impairments and increases amyloid deposition in APPV717I-CT100 transgenic mice, an Alzheimer\u2019s disease model. FASEB J 20(6):729\u2013731","journal-title":"FASEB J"},{"issue":"1","key":"9170_CR113","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1471-4159.2008.05769.x","volume":"108","author":"KW Lee","year":"2009","unstructured":"Lee KW, Kim JB, Seo JS, Kim TK, Im JY, Baek IS et al (2009) Behavioral stress accelerates plaque pathogenesis in the brain of Tg2576 mice via generation of metabolic oxidative stress. J Neurochem 108(1):165\u2013175","journal-title":"J Neurochem"},{"issue":"11","key":"9170_CR114","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1016\/S0006-3223(97)00165-0","volume":"42","author":"MF Weiner","year":"1997","unstructured":"Weiner MF, Vobach S, Olsson K, Svetlik D, Risser RC (1997) Cortisol secretion and Alzheimer\u2019s disease progression. Biol Psychiatry 42(11):1030\u20131038. https:\/\/doi.org\/10.1016\/S0006-3223(97)00165-0","journal-title":"Biol Psychiatry"},{"key":"9170_CR115","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/jnc.13607","volume":"139","author":"DJ DiSabato","year":"2016","unstructured":"DiSabato DJ, Quan N, Godbout JP (2016) Neuroinflammation: the devil is in the details. J Neurochem 139:136\u2013153","journal-title":"J Neurochem"},{"key":"9170_CR116","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.bbi.2014.06.002","volume":"42","author":"AJ Tarr","year":"2014","unstructured":"Tarr AJ, Liu X, Reed NS, Quan N (2014) Kinetic characteristics of euflammation: the induction of controlled inflammation without overt sickness behavior. Brain Behav Immun 42:96\u2013108","journal-title":"Brain Behav Immun"},{"key":"9170_CR117","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3389\/fnins.2014.00447","volume":"8","author":"ES Wohleb","year":"2015","unstructured":"Wohleb ES, McKim DB, Sheridan JF, Godbout JP (2015) Monocyte trafficking to the brain with stress and inflammation: a novel axis of immune-to-brain communication that influences mood and behavior. Front Neurosci 8:447","journal-title":"Front Neurosci"},{"key":"9170_CR118","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3389\/fnins.2013.00145","volume":"7","author":"E Gebara","year":"2013","unstructured":"Gebara E, Sultan S, Kocher-Braissant J, Toni N (2013) Adult hippocampal neurogenesis inversely correlates with microglia in conditions of voluntary running and aging. Front Neurosci 7:145","journal-title":"Front Neurosci"},{"issue":"6","key":"9170_CR119","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1017\/S1092852900016734","volume":"13","author":"L McNally","year":"2008","unstructured":"McNally L, Bhagwagar Z, Hannestad J (2008) Inflammation, glutamate, and glia in depression: a literature review. CNS Spectr 13(6):501\u2013510","journal-title":"CNS Spectr"},{"key":"9170_CR120","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.bbi.2015.11.011","volume":"55","author":"LE Santos","year":"2016","unstructured":"Santos LE, Beckman D, Ferreira ST (2016) Microglial dysfunction connects depression and Alzheimer\u2019s disease. Brain Behav Immun 55:151\u2013165","journal-title":"Brain Behav Immun"},{"issue":"4","key":"9170_CR121","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/0306-9877(91)90272-Z","volume":"35","author":"RS Smith","year":"1991","unstructured":"Smith RS (1991) The macrophage theory of depression. Med Hypotheses 35(4):298\u2013306","journal-title":"Med Hypotheses"},{"key":"9170_CR122","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.pnpbp.2015.06.008","volume":"64","author":"Y-K Kim","year":"2016","unstructured":"Kim Y-K, Na K-S, Myint A-M, Leonard BE (2016) The role of pro-inflammatory cytokines in neuroinflammation, neurogenesis and the neuroendocrine system in major depression. Prog Neuropsychopharmacol Biol Psychiatry 64:277\u2013284","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"5","key":"9170_CR123","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.biopsych.2009.09.033","volume":"67","author":"Y Dowlati","year":"2010","unstructured":"Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK et al (2010) A meta-analysis of cytokines in major depression. Biol Psychiatry 67(5):446\u2013457","journal-title":"Biol Psychiatry"},{"key":"9170_CR124","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.neubiorev.2018.09.006","volume":"94","author":"LN Dooley","year":"2018","unstructured":"Dooley LN, Kuhlman KR, Robles TF, Eisenberger NI, Craske MG, Bower JE (2018) The role of inflammation in core features of depression: insights from paradigms using exogenously-induced inflammation. Neurosci Biobehav Rev 94:219\u2013237","journal-title":"Neurosci Biobehav Rev"},{"issue":"5","key":"9170_CR125","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/sj.mp.4002148","volume":"14","author":"JC O\u2019Connor","year":"2009","unstructured":"O\u2019Connor JC, Lawson MA, Andre C, Moreau M, Lestage J, Castanon N et al (2009) Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2, 3-dioxygenase activation in mice. Mol Psychiatry 14(5):511\u2013522","journal-title":"Mol Psychiatry"},{"issue":"5","key":"9170_CR126","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1192\/bjp.bp.109.076430","volume":"197","author":"JA Pasco","year":"2010","unstructured":"Pasco JA, Nicholson GC, Williams LJ, Jacka FN, Henry MJ, Kotowicz MA et al (2010) Association of high-sensitivity C-reactive protein with de novo major depression. Br J Psychiatry 197(5):372\u2013377","journal-title":"Br J Psychiatry"},{"key":"9170_CR127","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.brainresbull.2014.09.003","volume":"108","author":"S Holmgren","year":"2014","unstructured":"Holmgren S, Hjorth E, Schultzberg M, L\u00e4rks\u00e4ter M, Frenkel D, Tysen-B\u00e4ckstr\u00f6m AC et al (2014) Neuropsychiatric symptoms in dementia\u2014a role for neuroinflammation? Brain Res Bull 108:88\u201393","journal-title":"Brain Res Bull"},{"issue":"1","key":"9170_CR128","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","volume":"9","author":"R Dantzer","year":"2008","unstructured":"Dantzer R, O\u2019connor JC, Freund GG, Johnson RW, Kelley KW (2008) From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9(1):46\u201356","journal-title":"Nat Rev Neurosci"},{"issue":"5","key":"9170_CR129","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0893-133X(00)00226-8","volume":"24","author":"R Yirmiya","year":"2001","unstructured":"Yirmiya R, Pollak Y, Barak O, Avitsur R, Ovadia H, Bette M et al (2001) Effects of antidepressant drugs on the behavioral and physiological responses to lipopolysaccharide (LPS) in rodents. Neuropsychopharmacology 24(5):531\u2013544","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"9170_CR130","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1007\/s00213-018-5137-8","volume":"236","author":"M Amani","year":"2019","unstructured":"Amani M, Shokouhi G, Salari A-A (2019) Minocycline prevents the development of depression-like behavior and hippocampal inflammation in a rat model of Alzheimer\u2019s disease. Psychopharmacology 236(4):1281\u20131292","journal-title":"Psychopharmacology"},{"issue":"1","key":"9170_CR131","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep11252","volume":"5","author":"F Caraci","year":"2015","unstructured":"Caraci F, Gulisano W, Guida CA, Impellizzeri AA, Drago F, Puzzo D et al (2015) A key role for TGF-\u03b21 in hippocampal synaptic plasticity and memory. Sci Rep 5(1):1\u201310","journal-title":"Sci Rep"},{"issue":"2","key":"9170_CR132","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jad.2005.07.008","volume":"88","author":"A-M Myint","year":"2005","unstructured":"Myint A-M, Leonard BE, Steinbusch HW, Kim Y-K (2005) Th1, Th2, and Th3 cytokine alterations in major depression. J Affect Disord 88(2):167\u2013173","journal-title":"J Affect Disord"},{"issue":"9","key":"9170_CR133","doi-asserted-by":"crossref","first-page":"pyw028","DOI":"10.1093\/ijnp\/pyw028","volume":"19","author":"JL Remus","year":"2016","unstructured":"Remus JL, Dantzer R (2016) Inflammation models of depression in rodents: relevance to psychotropic drug discovery. Int J Neuropsychopharmacol 19(9):pyw028","journal-title":"Int J Neuropsychopharmacol"},{"issue":"1","key":"9170_CR134","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00441-011-1230-6","volume":"347","author":"F Caraci","year":"2012","unstructured":"Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V et al (2012) Dysfunction of TGF-\u03b21 signaling in Alzheimer\u2019s disease: perspectives for neuroprotection. Cell Tissue Res 347(1):291\u2013301","journal-title":"Cell Tissue Res"},{"key":"9170_CR135","doi-asserted-by":"crossref","unstructured":"Sutcigil L, Oktenli C, Musabak U, Bozkurt A, Cansever A, Uzun O et al (2007) Pro-and anti-inflammatory cytokine balance in major depression: effect of sertraline therapy. Clin Dev Immunol 2007","DOI":"10.1155\/2007\/76396"},{"issue":"1","key":"9170_CR136","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/s41598-021-04027-8","volume":"12","author":"HJ Cha","year":"2022","unstructured":"Cha HJ, Shen J, Kang J (2022) Regulation of gene expression by the APP family in the adult cerebral cortex. Sci Rep 12(1):66","journal-title":"Sci Rep"},{"issue":"9","key":"9170_CR137","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/aps.2017.28","volume":"38","author":"G-F Chen","year":"2017","unstructured":"Chen G-F, Xu T-H, Yan Y, Zhou Y-R, Jiang Y, Melcher K et al (2017) Amyloid beta: structure, biology and structure-based therapeutic development. Acta Pharmacologica Sinica. 38(9):1205\u201335","journal-title":"Acta Pharmacologica Sinica."},{"issue":"1","key":"9170_CR138","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.neuroscience.2008.05.017","volume":"155","author":"H Dong","year":"2008","unstructured":"Dong H, Yuede C, Yoo H-S, Martin M, Deal C, Mace A et al (2008) Corticosterone and related receptor expression are associated with increased \u03b2-amyloid plaques in isolated Tg2576 mice. Neuroscience 155(1):154\u2013163","journal-title":"Neuroscience"},{"key":"9170_CR139","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.1007\/s00213-014-3629-8","volume":"231","author":"H Dong","year":"2014","unstructured":"Dong H, Wang S, Zeng Z, Li F, Montalvo-Ortiz J, Tucker C et al (2014) Effects of corticotrophin-releasing factor receptor 1 antagonists on amyloid-\u03b2 and behavior in Tg2576 mice. Psychopharmacology 231:4711\u20134722","journal-title":"Psychopharmacology"},{"issue":"4","key":"9170_CR140","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.3233\/JAD-142844","volume":"45","author":"SN Campbell","year":"2015","unstructured":"Campbell SN, Zhang C, Roe AD, Lee N, Lao KU, Monte L et al (2015) Impact of CRFR1 ablation on amyloid-\u03b2 production and accumulation in a mouse model of Alzheimer\u2019s disease. J Alzheimer\u2019s Dis 45(4):1175\u20131184","journal-title":"J Alzheimer\u2019s Dis"},{"issue":"12","key":"9170_CR141","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.15252\/embj.201488795","volume":"34","author":"HJ Park","year":"2015","unstructured":"Park HJ, Ran Y, Jung JI, Holmes O, Price AR, Smithson L et al (2015) The stress response neuropeptide CRF increases amyloid-\u03b2 production by regulating \u03b3-secretase activity. EMBO J 34(12):1674\u20131686","journal-title":"EMBO J"},{"issue":"1","key":"9170_CR142","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1210\/mend.14.1.0403","volume":"14","author":"F Lezoualc\u2019h","year":"2000","unstructured":"Lezoualc\u2019h F, Engert S, Berning B, Behl C (2000) Corticotropin-releasing hormone-mediated neuroprotection against oxidative stress is associated with the increased release of non-amyloidogenic amyloid \u03b2 precursor protein and with the suppression of nuclear factor-\u03baB. Molr Endocrinol. 14(1):147\u201359","journal-title":"Molr Endocrinol."},{"issue":"3","key":"9170_CR143","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jagp.2015.12.003","volume":"24","author":"N Mahgoub","year":"2016","unstructured":"Mahgoub N, Alexopoulos GS (2016) Amyloid hypothesis: is there a role for antiamyloid treatment in late-life depression? Am J Geriatr Psychiatry 24(3):239\u2013247","journal-title":"Am J Geriatr Psychiatry"},{"key":"9170_CR144","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.pnpbp.2017.05.004","volume":"78","author":"S Schiavone","year":"2017","unstructured":"Schiavone S, Tucci P, Mhillaj E, Bove M, Trabace L, Morgese MG (2017) Antidepressant drugs for beta amyloid-induced depression: a new standpoint? Prog Neuropsychopharmacol Biol Psychiatry 78:114\u2013122","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"3","key":"9170_CR145","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1007\/s12035-016-9809-2","volume":"54","author":"MG Morgese","year":"2017","unstructured":"Morgese MG, Tucci P, Mhillaj E, Bove M, Schiavone S, Trabace L et al (2017) Lifelong nutritional omega-3 deficiency evokes depressive-like state through soluble beta amyloid. Mol Neurobiol 54(3):2079\u20132089","journal-title":"Mol Neurobiol"},{"issue":"1","key":"9170_CR146","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41398-020-01158-w","volume":"11","author":"GS Smith","year":"2021","unstructured":"Smith GS, Workman CI, Protas H, Su Y, Savonenko A, Kuwabara H et al (2021) Positron emission tomography imaging of serotonin degeneration and beta-amyloid deposition in late-life depression evaluated with multi-modal partial least squares. Transl Psychiatry 11(1):1\u20138","journal-title":"Transl Psychiatry"},{"key":"9170_CR147","doi-asserted-by":"crossref","unstructured":"Avila J, Lucas JJ, Perez M, Hernandez F (2004) Role of tau protein in both physiological and pathological conditions. Physiol Rev","DOI":"10.1152\/physrev.00024.2003"},{"issue":"4","key":"9170_CR148","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.3233\/JAD-191078","volume":"74","author":"GM Babulal","year":"2020","unstructured":"Babulal GM, Roe CM, Stout SH, Rajasekar G, Wisch JK, Benzinger TL et al (2020) Depression is associated with tau and not amyloid positron emission tomography in cognitively normal adults. J Alzheimer\u2019s Dis 74(4):1045\u20131055","journal-title":"J Alzheimer\u2019s Dis"},{"issue":"3","key":"9170_CR149","doi-asserted-by":"crossref","first-page":"975","DOI":"10.3233\/JAD-170001","volume":"59","author":"JR Gatchel","year":"2017","unstructured":"Gatchel JR, Donovan NJ, Locascio JJ, Schultz AP, Becker JA, Chhatwal J et al (2017) Depressive symptoms and tau accumulation in the inferior temporal lobe and entorhinal cortex in cognitively normal older adults: a pilot study. J Alzheimer\u2019s Dis 59(3):975\u2013985","journal-title":"J Alzheimer\u2019s Dis"},{"issue":"2","key":"9170_CR150","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/JGP.0b013e31816029ec","volume":"16","author":"MA Rapp","year":"2008","unstructured":"Rapp MA, Schnaider-Beeri M, Purohit DP, Perl DP, Haroutunian V, Sano M (2008) Increased neurofibrillary tangles in patients with Alzheimer disease with comorbid depression. Am J Geriatr Psychiatry 16(2):168\u2013174","journal-title":"Am J Geriatr Psychiatry"},{"issue":"2","key":"9170_CR151","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1001\/archpsyc.63.2.161","volume":"63","author":"MA Rapp","year":"2006","unstructured":"Rapp MA, Schnaider-Beeri M, Grossman HT, Sano M, Perl DP, Purohit DP et al (2006) Increased hippocampal plaques and tangles in patients with Alzheimer disease with a lifetime history of major depression. Arch Gen Psychiatry 63(2):161\u2013167","journal-title":"Arch Gen Psychiatry"},{"key":"9170_CR152","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s10495-007-0754-4","volume":"12","author":"K Blomgren","year":"2007","unstructured":"Blomgren K, Leist M, Groc L (2007) Pathological apoptosis in the developing brain. Apoptosis 12:993\u20131010","journal-title":"Apoptosis"},{"issue":"s3","key":"9170_CR153","doi-asserted-by":"crossref","first-page":"S125","DOI":"10.3233\/JAD-132738","volume":"42","author":"E Radi","year":"2014","unstructured":"Radi E, Formichi P, Battisti C, Federico A (2014) Apoptosis and oxidative stress in neurodegenerative diseases. J Alzheimer\u2019s Dis 42(s3):S125\u2013S152","journal-title":"J Alzheimer\u2019s Dis"},{"issue":"2","key":"9170_CR154","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0092-8674(04)00046-7","volume":"116","author":"NN Danial","year":"2004","unstructured":"Danial NN, Korsmeyer SJ (2004) Cell death: critical control points. Cell 116(2):205\u2013219","journal-title":"Cell"},{"issue":"2","key":"9170_CR155","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3109\/10715762.2013.857018","volume":"48","author":"E Turunc Bayrakdar","year":"2014","unstructured":"Turunc Bayrakdar E, Uyanikgil Y, Kanit L, Koylu E, Yalcin A (2014) Nicotinamide treatment reduces the levels of oxidative stress, apoptosis, and PARP-1 activity in A\u03b2 (1\u201342)-induced rat model of Alzheimer\u2019s disease. Free Radical Res 48(2):146\u2013158","journal-title":"Free Radical Res"},{"key":"9170_CR156","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jpsychires.2018.11.021","volume":"109","author":"F Martini","year":"2019","unstructured":"Martini F, Rosa SG, Klann IP, Fulco BCW, Carvalho FB, Rahmeier FL et al (2019) A multifunctional compound ebselen reverses memory impairment, apoptosis and oxidative stress in a mouse model of sporadic Alzheimer\u2019s disease. J Psychiatr Res 109:107\u2013117","journal-title":"J Psychiatr Res"},{"issue":"1","key":"9170_CR157","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.mad.2005.08.006","volume":"127","author":"J Naderi","year":"2006","unstructured":"Naderi J, Lopez C, Pandey S (2006) Chronically increased oxidative stress in fibroblasts from Alzheimer\u2019s disease patients causes early senescence and renders resistance to apoptosis by oxidative stress. Mech Ageing Dev 127(1):25\u201335","journal-title":"Mech Ageing Dev"},{"key":"9170_CR158","doi-asserted-by":"crossref","first-page":"690344","DOI":"10.3389\/fnbeh.2021.690344","volume":"15","author":"F Liu","year":"2021","unstructured":"Liu F, Dong Y-Y, Lei G, Zhou Y, Liu P, Dang Y-H (2021) HINT1 is involved in the chronic mild stress elicited oxidative stress and apoptosis through the PKC \u03b5\/ALDH-2\/4HNE pathway in prefrontal cortex of rats. Front Behav Neurosci 15:690344","journal-title":"Front Behav Neurosci"},{"key":"9170_CR159","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00232-014-9652-1","volume":"247","author":"A Akpinar","year":"2014","unstructured":"Akpinar A, U\u011fuz AC, Naz\u0131ro\u011flu M (2014) Agomelatine and duloxetine synergistically modulates apoptotic pathway by inhibiting oxidative stress triggered intracellular calcium entry in neuronal PC12 cells: role of TRPM2 and voltage-gated calcium channels. J Membr Biol 247:451\u2013459","journal-title":"J Membr Biol"},{"issue":"1","key":"9170_CR160","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/sj.npp.1301574","volume":"33","author":"C Pittenger","year":"2008","unstructured":"Pittenger C, Duman RS (2008) Stress, depression, and neuroplasticity: a convergence of mechanisms. Neuropsychopharmacology 33(1):88\u2013109. https:\/\/doi.org\/10.1038\/sj.npp.1301574","journal-title":"Neuropsychopharmacology"},{"key":"9170_CR161","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.psychres.2018.08.017","volume":"269","author":"L Zhao","year":"2018","unstructured":"Zhao L, Ren H, Gu S, Li X, Jiang C, Li J et al (2018) rTMS ameliorated depressive-like behaviors by restoring HPA axis balance and prohibiting hippocampal neuron apoptosis in a rat model of depression. Psychiatry Res 269:126\u2013133","journal-title":"Psychiatry Res"},{"key":"9170_CR162","doi-asserted-by":"crossref","unstructured":"Lucassen PJ, Heine VM, Muller MB, van der Beek EM, Wiegant VM, Ron De Kloet E et al (2006) Stress, depression and hippocampal apoptosis. CNS Neurol Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders). 5(5):531\u2013546","DOI":"10.2174\/187152706778559273"},{"key":"9170_CR163","doi-asserted-by":"crossref","first-page":"1129186","DOI":"10.3389\/fphar.2023.1129186","volume":"14","author":"R Ding","year":"2023","unstructured":"Ding R, Su D, Zhao Q, Wang Y, Wang J-Y, Lv S et al (2023) The role of microRNAs in depression. Front Pharmacol 14:1129186","journal-title":"Front Pharmacol"},{"key":"9170_CR164","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev.med.60.042307.110802","volume":"60","author":"M Berger","year":"2009","unstructured":"Berger M, Gray JA, Roth BL (2009) The expanded biology of serotonin. Annu Rev Med 60:355\u2013366","journal-title":"Annu Rev Med"},{"key":"9170_CR165","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.nbd.2017.05.007","volume":"105","author":"GS Smith","year":"2017","unstructured":"Smith GS, Barrett FS, Joo JH, Nassery N, Savonenko A, Sodums DJ et al (2017) Molecular imaging of serotonin degeneration in mild cognitive impairment. Neurobiol Dis 105:33\u201341","journal-title":"Neurobiol Dis"},{"issue":"10","key":"9170_CR166","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1093\/hmg\/ddab054","volume":"30","author":"AP Reddy","year":"2021","unstructured":"Reddy AP, Yin X, Sawant N, Reddy PH (2021) Protective effects of antidepressant citalopram against abnormal APP processing and amyloid beta-induced mitochondrial dynamics, biogenesis, mitophagy and synaptic toxicities in Alzheimer\u2019s disease. Hum Mol Genet 30(10):847\u2013864","journal-title":"Hum Mol Genet"},{"issue":"6","key":"9170_CR167","first-page":"685","volume":"1","author":"J Masson","year":"2012","unstructured":"Masson J, Emerit MB, Hamon M, Darmon M (2012) Serotonergic signaling: multiple effectors and pleiotropic effects. Wiley Interdis Rev: Membr Trans Signal 1(6):685\u2013713","journal-title":"Wiley Interdis Rev: Membr Trans Signal"},{"issue":"10","key":"9170_CR168","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1212\/01.wnl.0000271377.52421.4a","volume":"69","author":"L Truchot","year":"2007","unstructured":"Truchot L, Costes S, Zimmer L, Laurent B, Le Bars D, Thomas-Ant\u00e9rion C et al (2007) Up-regulation of hippocampal serotonin metabolism in mild cognitive impairment. Neurology 69(10):1012\u20131017","journal-title":"Neurology"},{"issue":"9","key":"9170_CR169","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1097\/00001756-200207020-00021","volume":"13","author":"MK Lai","year":"2002","unstructured":"Lai MK, Tsang SW, Francis PT, Keene J, Hope T, Esiri MM et al (2002) Postmortem serotoninergic correlates of cognitive decline in Alzheimer\u2019s disease. NeuroReport 13(9):1175\u20131178","journal-title":"NeuroReport"},{"issue":"3","key":"9170_CR170","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1124\/jpet.105.086363","volume":"314","author":"LE Schechter","year":"2005","unstructured":"Schechter LE, Smith D, Rosenzweig-Lipson S, Sukoff S, Dawson L, Marquis K et al (2005) Lecozotan (SRA-333): a selective serotonin 1A receptor antagonist that enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties. J Pharmacol Exp Ther 314(3):1274\u20131289","journal-title":"J Pharmacol Exp Ther"},{"key":"9170_CR171","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.pharmthera.2016.10.008","volume":"170","author":"L Maroteaux","year":"2017","unstructured":"Maroteaux L, Ayme-Dietrich E, Aubertin-Kirch G, Banas S, Quentin E, Lawson R et al (2017) New therapeutic opportunities for 5-HT2 receptor ligands. Pharmacol Ther 170:14\u201336","journal-title":"Pharmacol Ther"},{"issue":"4","key":"9170_CR172","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.3233\/JAD-2010-100117","volume":"20","author":"P Holm","year":"2010","unstructured":"Holm P, Ettrup A, Klein AB, Santini MA, El-Sayed M, Elvang AB et al (2010) Plaque deposition dependent decrease in 5-HT 2A serotonin receptor in a\u03b2PPswe\/PS1dE9 amyloid overexpressing mice. J Alzheimer\u2019s Dis 20(4):1201\u20131213","journal-title":"J Alzheimer\u2019s Dis"},{"key":"9170_CR173","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jchemneu.2019.01.008","volume":"96","author":"S Afshar","year":"2019","unstructured":"Afshar S, Shahidi S, Rohani AH, Asl SS, Komaki A (2019) Protective effects of 5-HT1A receptor antagonist and 5-HT2A receptor agonist on the biochemical and histological features in a rat model of Alzheimer\u2019s disease. J Chem Neuroanat 96:140\u2013147","journal-title":"J Chem Neuroanat"},{"issue":"10","key":"9170_CR174","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1111\/eci.12141","volume":"43","author":"R Rahimian","year":"2013","unstructured":"Rahimian R, Fakhfouri G, Ejtemaei Mehr S, Ghia JE, Genazzani AA, Payandemehr B et al (2013) Tropisetron attenuates amyloid-beta-induced inflammatory and apoptotic responses in rats. Eur J Clin Invest 43(10):1039\u20131051","journal-title":"Eur J Clin Invest"},{"key":"9170_CR175","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.nlm.2016.06.014","volume":"138","author":"H Hagena","year":"2017","unstructured":"Hagena H, Manahan-Vaughan D (2017) The serotonergic 5-HT4 receptor: a unique modulator of hippocampal synaptic information processing and cognition. Neurobiol Learn Mem 138:145\u2013153","journal-title":"Neurobiol Learn Mem"},{"issue":"3","key":"9170_CR176","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3233\/JAD-2011-110056","volume":"26","author":"K Madsen","year":"2011","unstructured":"Madsen K, Neumann W-J, Holst K, Marner L, Haahr MT, Lehel S et al (2011) Cerebral serotonin 4 receptors and amyloid-\u03b2 in early Alzheimer\u2019s disease. J Alzheimer\u2019s Dis 26(3):457\u2013466","journal-title":"J Alzheimer\u2019s Dis"},{"key":"9170_CR177","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.neuropharm.2017.08.031","volume":"126","author":"K Baranger","year":"2017","unstructured":"Baranger K, Giannoni P, Girard SD, Girot S, Gaven F, Stephan D et al (2017) Chronic treatments with a 5-HT4 receptor agonist decrease amyloid pathology in the entorhinal cortex and learning and memory deficits in the 5xFAD mouse model of Alzheimer\u2019s disease. Neuropharmacology 126:128\u2013141","journal-title":"Neuropharmacology"},{"issue":"15","key":"9170_CR178","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.1007\/s00213-017-4664-z","volume":"234","author":"T Freret","year":"2017","unstructured":"Freret T, Lelong-Boulouard V, Lecouflet P, Hamidouche K, Dauphin F, Boulouard M (2017) Co-modulation of an allosteric modulator of nicotinic receptor-cholinesterase inhibitor (galantamine) and a 5-HT4 receptor agonist (RS-67333): effect on scopolamine-induced memory deficit in the mouse. Psychopharmacology 234(15):2365\u20132374. https:\/\/doi.org\/10.1007\/s00213-017-4664-z","journal-title":"Psychopharmacology"},{"issue":"29","key":"9170_CR179","doi-asserted-by":"crossref","first-page":"26716","DOI":"10.18632\/oncotarget.5777","volume":"6","author":"H-M Yun","year":"2015","unstructured":"Yun H-M, Park K-R, Kim E-C, Kim S, Hong JT (2015) Serotonin 6 receptor controls Alzheimer\u2019s disease and depression. Oncotarget 6(29):26716","journal-title":"Oncotarget"},{"issue":"6","key":"9170_CR180","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1080\/13543784.2018.1483334","volume":"27","author":"R Khoury","year":"2018","unstructured":"Khoury R, Grysman N, Gold J, Patel K, Grossberg GT (2018) The role of 5 HT6-receptor antagonists in Alzheimer\u2019s disease: an update. Exp Opin Investig Drugs 27(6):523\u2013533","journal-title":"Exp Opin Investig Drugs"},{"key":"9170_CR181","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.neuropharm.2017.07.010","volume":"125","author":"IE de Jong","year":"2017","unstructured":"de Jong IE, M\u00f8rk A (2017) Antagonism of the 5-HT6 receptor\u2013Preclinical rationale for the treatment of Alzheimer\u2019s disease. Neuropharmacology 125:50\u201363","journal-title":"Neuropharmacology"},{"issue":"1","key":"9170_CR182","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s40120-018-0095-y","volume":"7","author":"M Andrews","year":"2018","unstructured":"Andrews M, Tousi B, Sabbagh MN (2018) 5HT6 antagonists in the treatment of Alzheimer\u2019s dementia: current progress. Neurology and therapy 7(1):51\u201358","journal-title":"Neurology and therapy"},{"issue":"2","key":"9170_CR183","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11062-019-09796-7","volume":"51","author":"S Shahidi","year":"2019","unstructured":"Shahidi S, Mahmoodi M, Sadeghimehr N (2019) Involvement of serotonin 5-HT7 receptors in learning and memory in mice. Neurophysiology 51(2):77\u201382","journal-title":"Neurophysiology"},{"key":"9170_CR184","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.brainresbull.2017.10.004","volume":"135","author":"N Hashemi-Firouzi","year":"2017","unstructured":"Hashemi-Firouzi N, Komaki A, Asl SS, Shahidi S (2017) The effects of the 5-HT7 receptor on hippocampal long-term potentiation and apoptosis in a rat model of Alzheimer\u2019s disease. Brain Res Bull 135:85\u201391","journal-title":"Brain Res Bull"},{"key":"9170_CR185","first-page":"31","volume":"4","author":"X Li","year":"2011","unstructured":"Li X, Polter A (2011) Glycogen synthase kinase-3 is an intermediate modulator of serotonin neurotransmission. Front Mol Neurosci 4:31","journal-title":"Front Mol Neurosci"},{"issue":"S1","key":"9170_CR186","doi-asserted-by":"crossref","first-page":"S120","DOI":"10.1038\/sj.bjp.0706474","volume":"147","author":"DA Brown","year":"2006","unstructured":"Brown DA (2006) Acetylcholine. Br J Pharmacol 147(S1):S120\u2013S126","journal-title":"Br J Pharmacol"},{"issue":"4","key":"9170_CR187","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1212\/WNL.47.4.876","volume":"47","author":"JL Cummings","year":"1996","unstructured":"Cummings JL, Kaufer D (1996) Neuropsychiatric aspects of Alzheimer\u2019s disease: the cholinergic hypothesis revisited. Neurology 47(4):876\u2013883","journal-title":"Neurology"},{"key":"9170_CR188","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.neuroimage.2019.05.044","volume":"199","author":"BL Klaassens","year":"2019","unstructured":"Klaassens BL, van Gerven JM, Klaassen ES, van der Grond J, Rombouts SA (2019) Cholinergic and serotonergic modulation of resting state functional brain connectivity in Alzheimer\u2019s disease. Neuroimage 199:143\u2013152","journal-title":"Neuroimage"},{"issue":"9","key":"9170_CR189","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1073\/pnas.1219731110","volume":"110","author":"YS Mineur","year":"2013","unstructured":"Mineur YS, Obayemi A, Wigestrand MB, Fote GM, Calarco CA, Li AM et al (2013) Cholinergic signaling in the hippocampus regulates social stress resilience and anxiety-and depression-like behavior. Proc Natl Acad Sci 110(9):3573\u20133578","journal-title":"Proc Natl Acad Sci"},{"issue":"1\u20132","key":"9170_CR190","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.brainresrev.2011.04.003","volume":"67","author":"V Frisardi","year":"2011","unstructured":"Frisardi V, Panza F, Farooqui AA (2011) Late-life depression and Alzheimer\u2019s disease: the glutamatergic system inside of this mirror relationship. Brain Res Rev 67(1\u20132):344\u2013355","journal-title":"Brain Res Rev"},{"issue":"6","key":"9170_CR191","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.neuron.2005.08.023","volume":"47","author":"Y Tozuka","year":"2005","unstructured":"Tozuka Y, Fukuda S, Namba T, Seki T, Hisatsune T (2005) GABAergic excitation promotes neuronal differentiation in adult hippocampal progenitor cells. Neuron 47(6):803\u2013815","journal-title":"Neuron"},{"issue":"1","key":"9170_CR192","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.neuron.2019.03.013","volume":"102","author":"RS Duman","year":"2019","unstructured":"Duman RS, Sanacora G, Krystal JH (2019) Altered connectivity in depression: GABA and glutamate neurotransmitter deficits and reversal by novel treatments. Neuron 102(1):75\u201390","journal-title":"Neuron"},{"issue":"21","key":"9170_CR193","doi-asserted-by":"crossref","first-page":"11677","DOI":"10.3390\/ijms222111677","volume":"22","author":"GA Czapski","year":"2021","unstructured":"Czapski GA, Strosznajder JB (2021) Glutamate and GABA in microglia-neuron cross-talk in Alzheimer\u2019s disease. Int J Mol Sci 22(21):11677","journal-title":"Int J Mol Sci"},{"issue":"4","key":"9170_CR194","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1111\/j.1471-4159.2007.04832.x","volume":"103","author":"RA Rissman","year":"2007","unstructured":"Rissman RA, De Blas AL, Armstrong DM (2007) GABAA receptors in aging and Alzheimer\u2019s disease. J Neurochem 103(4):1285\u20131292","journal-title":"J Neurochem"},{"issue":"11","key":"9170_CR195","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.tips.2009.09.002","volume":"30","author":"P Skolnick","year":"2009","unstructured":"Skolnick P, Popik P, Trullas R (2009) Glutamate-based antidepressants: 20 years on. Trends Pharmacol Sci 30(11):563\u2013569","journal-title":"Trends Pharmacol Sci"},{"issue":"6","key":"9170_CR196","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.stem.2009.10.003","volume":"5","author":"B Sun","year":"2009","unstructured":"Sun B, Halabisky B, Zhou Y, Palop JJ, Yu G, Mucke L et al (2009) Imbalance between GABAergic and glutamatergic transmission impairs adult neurogenesis in an animal model of Alzheimer\u2019s disease. Cell Stem Cell 5(6):624\u2013633","journal-title":"Cell Stem Cell"},{"key":"9170_CR197","doi-asserted-by":"crossref","first-page":"561","DOI":"10.3389\/fpsyt.2018.00561","volume":"9","author":"C Madeira","year":"2018","unstructured":"Madeira C, Vargas-Lopes C, Brand\u00e3o CO, Reis T, Laks J, Panizzutti R et al (2018) Elevated glutamate and glutamine levels in the cerebrospinal fluid of patients with probable Alzheimer\u2019s disease and depression. Front Psychiatry 9:561","journal-title":"Front Psychiatry"},{"issue":"3","key":"9170_CR198","doi-asserted-by":"crossref","first-page":"739","DOI":"10.3233\/JAD-140324","volume":"42","author":"S Chi","year":"2014","unstructured":"Chi S, Yu J-T, Tan M-S, Tan L (2014) Depression in Alzheimer\u2019s disease: epidemiology, mechanisms, and management. J Alzheimer\u2019s Dis 42(3):739\u2013755","journal-title":"J Alzheimer\u2019s Dis"},{"issue":"4","key":"9170_CR199","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1017\/S0033291700038459","volume":"22","author":"H F\u00f6rstl","year":"1992","unstructured":"F\u00f6rstl H, Burns A, Luthert P, Cairns N, Lantos P, Levy R (1992) Clinical and neuropathological correlates of depression in Alzheimer\u2019s disease. Psychol Med 22(4):877\u2013884","journal-title":"Psychol Med"},{"issue":"15","key":"9170_CR200","doi-asserted-by":"crossref","first-page":"10298","DOI":"10.1074\/jbc.M112.415141","volume":"288","author":"D Wang","year":"2013","unstructured":"Wang D, Fu Q, Zhou Y, Xu B, Shi Q, Igwe B et al (2013) \u03b22 adrenergic receptor, protein kinase A (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in Alzheimer disease models. J Biol Chem 288(15):10298\u201310307","journal-title":"J Biol Chem"},{"issue":"2","key":"9170_CR201","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.pnpbp.2008.12.019","volume":"33","author":"K Mizukami","year":"2009","unstructured":"Mizukami K, Hatanaka K, Tanaka Y, Sato S, Asada T (2009) Therapeutic effects of the selective serotonin noradrenaline reuptake inhibitor milnacipran on depressive symptoms in patients with Alzheimer\u2019s disease. Prog Neuropsychopharmacol Biol Psychiatry 33(2):349\u2013352","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"9170_CR202","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3389\/fphar.2019.00483","volume":"10","author":"MG Morgese","year":"2019","unstructured":"Morgese MG, Trabace L (2019) Monoaminergic system modulation in depression and Alzheimer\u2019s disease: a new standpoint? Front Pharmacol 10:483","journal-title":"Front Pharmacol"},{"issue":"7","key":"9170_CR203","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.neurobiolaging.2013.01.016","volume":"34","author":"M Pievani","year":"2013","unstructured":"Pievani M, Bocchetta M, Boccardi M, Cavedo E, Bonetti M, Thompson PM et al (2013) Striatal morphology in early-onset and late-onset Alzheimer\u2019s disease: a preliminary study. Neurobiol Aging 34(7):1728\u20131739","journal-title":"Neurobiol Aging"},{"issue":"5","key":"9170_CR204","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1038\/sj.npp.1301485","volume":"33","author":"S Preda","year":"2008","unstructured":"Preda S, Govoni S, Lanni C, Racchi M, Mura E, Grilli M et al (2008) Acute \u03b2-amyloid administration disrupts the cholinergic control of dopamine release in the nucleus accumbens. Neuropsychopharmacology 33(5):1062\u20131070","journal-title":"Neuropsychopharmacology"},{"key":"9170_CR205","unstructured":"Joerg SH, Stefanie G, Tomas M-T (2004) 5-Hydroxyindoleacetic acid and homovanillic acid concentrations in cerebrospinal fluid in patients with Alzheimer\u2019s disease, depression and mild cognitive impairment. Neuroendocrinol Lett 25(6)"},{"issue":"3","key":"9170_CR206","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/WAD.0b013e318231e5fc","volume":"26","author":"JY Kang","year":"2012","unstructured":"Kang JY, Lee JS, Kang H, Lee H-W, Kim YK, Jeon HJ et al (2012) Regional cerebral blood flow abnormalities associated with apathy and depression in Alzheimer disease. Alzheimer Dis Assoc Disord 26(3):217\u2013224","journal-title":"Alzheimer Dis Assoc Disord"},{"issue":"1","key":"9170_CR207","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/13651501.2016.1248852","volume":"21","author":"M Dold","year":"2017","unstructured":"Dold M, Kasper S (2017) Evidence-based pharmacotherapy of treatment-resistant unipolar depression. Int J Psychiatry Clin Pract 21(1):13\u201323","journal-title":"Int J Psychiatry Clin Pract"},{"key":"9170_CR208","doi-asserted-by":"crossref","unstructured":"Nascimento A, Fernandes R, Carvalho A, Frigieri I, Alves R, Chorilli M (2022) Insights for Alzheimer\u2019s disease pharmacotherapy and current clinical trials. Neurochem Int 105401","DOI":"10.1016\/j.neuint.2022.105401"},{"issue":"8","key":"9170_CR209","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1080\/14656566.2018.1471136","volume":"19","author":"M Lozupone","year":"2018","unstructured":"Lozupone M, La Montagna M, D\u2019Urso F, Piccininni C, Sardone R, Dibello V et al (2018) Pharmacotherapy for the treatment of depression in patients with Alzheimer\u2019s disease: a treatment-resistant depressive disorder. Exp Opin Pharmacother 19(8):823\u2013842","journal-title":"Exp Opin Pharmacother"},{"key":"9170_CR210","unstructured":"Association AP (2019) APA clinical practice guideline for the treatment of depression across three age cohorts. https:\/\/www.apa.org\/depression-guideline\/guideline.pdf"},{"key":"9170_CR211","unstructured":"Permanente K (2021) Adult & adolescent depression screening, diagnosis, and treatment guideline. https:\/\/thrive.kaiserpermanente.org\/. Accessed 2 Aug 2023"},{"issue":"4","key":"9170_CR212","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1177\/070674370705200407","volume":"52","author":"S Thompson","year":"2007","unstructured":"Thompson S, Herrmann N, Rapoport MJ, Lanct\u00f4t KL (2007) Efficacy and safety of antidepressants for treatment of depression in Alzheimer\u2019s disease: a metaanalysis. Can J Psychiatry 52(4):248\u2013255","journal-title":"Can J Psychiatry"},{"key":"9170_CR213","doi-asserted-by":"crossref","unstructured":"Nelson JC, Devanand DP (2011) A systematic review and meta\u2010analysis of placebo\u2010controlled antidepressant studies in people with depression and dementia: [See Editorial Comments by Lenze EJ, MD on pp 0000\u20130000]. J Am Geriatr Soc 59(4):577\u2013585","DOI":"10.1111\/j.1532-5415.2011.03355.x"},{"issue":"7","key":"9170_CR214","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1001\/archpsyc.60.7.737","volume":"60","author":"CG Lyketsos","year":"2003","unstructured":"Lyketsos CG, DelCampo L, Steinberg M, Miles Q, Steele CD, Munro C et al (2003) Treating depression in Alzheimer disease: efficacy and safety of sertraline therapy, and the benefits of depression reduction: the DIADS. Arch Gen Psychiatry 60(7):737\u2013746","journal-title":"Arch Gen Psychiatry"},{"issue":"2","key":"9170_CR215","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1097\/JGP.0b013e3181c796eb","volume":"18","author":"PB Rosenberg","year":"2010","unstructured":"Rosenberg PB, Drye LT, Martin BK, Frangakis C, Mintzer JE, Weintraub D et al (2010) Sertraline for the treatment of depression in Alzheimer disease. Am J Geriatr Psychiatry 18(2):136\u2013145. https:\/\/doi.org\/10.1097\/JGP.0b013e3181c796eb","journal-title":"Am J Geriatr Psychiatry"},{"issue":"9789","key":"9170_CR216","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0140-6736(11)60830-1","volume":"378","author":"S Banerjee","year":"2011","unstructured":"Banerjee S, Hellier J, Dewey M, Romeo R, Ballard C, Baldwin R et al (2011) Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial. Lancet 378(9789):403\u2013411","journal-title":"Lancet"},{"issue":"6","key":"9170_CR217","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1192\/bjp.157.6.894","volume":"157","author":"AL Nyth","year":"1990","unstructured":"Nyth AL, Gottfries CG (1990) The clinical efficacy of citalopram in treatment of emotional disturbances in dementia disorders A Nordic multicentre study. Br J Psychiatry 157(6):894\u2013901","journal-title":"Br J Psychiatry"},{"issue":"7","key":"9170_CR218","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1001\/jama.2014.93","volume":"311","author":"AP Porsteinsson","year":"2014","unstructured":"Porsteinsson AP, Drye LT, Pollock BG, Devanand D, Frangakis C, Ismail Z et al (2014) Effect of citalopram on agitation in Alzheimer disease: the CitAD randomized clinical trial. JAMA 311(7):682\u2013691","journal-title":"JAMA"},{"issue":"3","key":"9170_CR219","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/gps.1459","volume":"21","author":"V Rao","year":"2006","unstructured":"Rao V, Spiro J, Rosenberg P, Lee H, Rosenblatt A, Lyketsos C (2006) An open-label study of escitalopram (Lexapro\u00ae) for the treatment of \u2018Depression of Alzheimer\u2019s disease\u2019 (dAD). Int J Geriatr Psychiatry: A J Psychiatry Late Life Allied Sci 21(3):273\u2013274","journal-title":"Int J Geriatr Psychiatry: A J Psychiatry Late Life Allied Sci"},{"key":"9170_CR220","unstructured":"Sverdlik A (2005) Study of escitalopram versus placebo in the treatment of depressive syndrome in Alzheimer\u2019s disease, vascular dementia, and mixed vascular and Alzheimer\u2019s dementia"},{"issue":"2","key":"9170_CR221","doi-asserted-by":"crossref","first-page":"727","DOI":"10.3233\/JAD-160225","volume":"55","author":"H An","year":"2017","unstructured":"An H, Choi B, Park K-W, Kim D-H, Yang D-W, Hong CH et al (2017) The effect of escitalopram on mood and cognition in depressive Alzheimer\u2019s disease subjects. J Alzheimer\u2019s Dis 55(2):727\u2013735","journal-title":"J Alzheimer\u2019s Dis"},{"issue":"04\/05","key":"9170_CR222","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1055\/s-0034-1377041","volume":"47","author":"N Mokhber","year":"2014","unstructured":"Mokhber N, Abdollahian E, Soltanifar A, Samadi R, Saghebi A, Haghighi M et al (2014) Comparison of sertraline, venlafaxine and desipramine effects on depression, cognition and the daily living activities in Alzheimer patients. Pharmacopsychiatry 47(04\/05):131\u2013140","journal-title":"Pharmacopsychiatry"},{"key":"9170_CR223","doi-asserted-by":"crossref","unstructured":"de Vasconcelos Cunha UG, Lopes Rocha F, \u00c1vila de Melo R, Alves Valle E, de Souza Neto JJ, Mendes Brega R et al (2007) A placebo-controlled double-blind randomized study of venlafaxine in the treatment of depression in dementia. Dement Geriatr Cognit Disorders 24(1):36\u201341","DOI":"10.1159\/000102570"},{"issue":"12","key":"9170_CR224","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1001\/archpsyc.61.12.1235","volume":"61","author":"H Jahn","year":"2004","unstructured":"Jahn H, Schick M, Kiefer F, Kellner M, Yassouridis A, Wiedemann K (2004) Metyrapone as additive treatment in major depression: a double-blind and placebo-controlled trial. Arch Gen Psychiatry 61(12):1235\u20131244","journal-title":"Arch Gen Psychiatry"},{"issue":"4","key":"9170_CR225","doi-asserted-by":"publisher","first-page":"487","DOI":"10.9758\/cpn.2019.17.4.487","volume":"17","author":"T-Y Tsai","year":"2019","unstructured":"Tsai T-Y, Tseng H-H, Chi MH, Chang HH, Wu C-K, Yang YK et al (2019) The Interaction of Oxytocin and Social Support, Loneliness, and Cortisol Level in Major Depression. Clin Psychopharmacol Neurosci 17(4):487\u2013494. https:\/\/doi.org\/10.9758\/cpn.2019.17.4.487","journal-title":"Clin Psychopharmacol Neurosci"},{"issue":"1","key":"9170_CR226","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1001\/2013.jamapsychiatry.4","volume":"70","author":"CL Raison","year":"2013","unstructured":"Raison CL, Rutherford RE, Woolwine BJ, Shuo C, Schettler P, Drake DF et al (2013) A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers. JAMA Psychiatry 70(1):31\u201341","journal-title":"JAMA Psychiatry"},{"issue":"1","key":"9170_CR227","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/JCP.0b013e31823f3b5f","volume":"32","author":"L Gertsik","year":"2012","unstructured":"Gertsik L, Poland RE, Bresee C, Rapaport MH (2012) Omega-3 fatty acid augmentation of citalopram treatment for patients with major depressive disorder. J Clin Psychopharmacol 32(1):61","journal-title":"J Clin Psychopharmacol"},{"issue":"12","key":"9170_CR228","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1177\/0269881112458732","volume":"26","author":"AL Lopresti","year":"2012","unstructured":"Lopresti AL, Hood SD, Drummond PD (2012) Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects. J Psychopharmacol 26(12):1512\u20131524","journal-title":"J Psychopharmacol"},{"issue":"3","key":"9170_CR229","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3390\/biom11030353","volume":"11","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Anoopkumar-Dukie S, Davey AK (2021) SIRT1 and SIRT2 modulators: potential anti-inflammatory treatment for depression? Biomolecules 11(3):353","journal-title":"Biomolecules"},{"key":"9170_CR230","volume":"110","author":"B-H Lee","year":"2021","unstructured":"Lee B-H, Park Y-M, Hwang J-A, Kim Y-K (2021) Variable alterations in plasma erythropoietin and brain-derived neurotrophic factor levels in patients with major depressive disorder with and without a history of suicide attempt. Prog Neuropsychopharmacol Biol Psychiatry 110:110324","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"2","key":"9170_CR231","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1159\/000106378","volume":"86","author":"C Benedict","year":"2007","unstructured":"Benedict C, Hallschmid M, Schultes B, Born J, Kern W (2007) Intranasal insulin to improve memory function in humans. Neuroendocrinology 86(2):136\u2013142","journal-title":"Neuroendocrinology"},{"issue":"9","key":"9170_CR232","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1038\/npp.2012.58","volume":"37","author":"K Sepanjnia","year":"2012","unstructured":"Sepanjnia K, Modabbernia A, Ashrafi M, Modabbernia M-J, Akhondzadeh S (2012) Pioglitazone adjunctive therapy for moderate-to-severe major depressive disorder: randomized double-blind placebo-controlled trial. Neuropsychopharmacology 37(9):2093\u20132100","journal-title":"Neuropsychopharmacology"},{"key":"9170_CR233","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.bbr.2012.09.021","volume":"237","author":"RS McIntyre","year":"2013","unstructured":"McIntyre RS, Powell AM, Kaidanovich-Beilin O, Soczynska JK, Alsuwaidan M, Woldeyohannes HO et al (2013) The neuroprotective effects of GLP-1: possible treatments for cognitive deficits in individuals with mood disorders. Behav Brain Res 237:164\u2013171","journal-title":"Behav Brain Res"},{"issue":"1\u20133","key":"9170_CR234","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.jad.2011.07.010","volume":"135","author":"DG Kondo","year":"2011","unstructured":"Kondo DG, Sung Y-H, Hellem TL, Fiedler KK, Shi X, Jeong E-K et al (2011) Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: a 31-phosphorus magnetic resonance spectroscopy study. J Affect Disord 135(1\u20133):354\u2013361","journal-title":"J Affect Disord"},{"issue":"34","key":"9170_CR235","doi-asserted-by":"crossref","first-page":"8627","DOI":"10.1073\/pnas.1801609115","volume":"115","author":"C Nasca","year":"2018","unstructured":"Nasca C, Bigio B, Lee FS, Young SP, Kautz MM, Albright A et al (2018) Acetyl-l-carnitine deficiency in patients with major depressive disorder. Proc Natl Acad Sci 115(34):8627\u20138632","journal-title":"Proc Natl Acad Sci"},{"issue":"4","key":"9170_CR236","doi-asserted-by":"publisher","first-page":"370","DOI":"10.4088\/JCP.13m08591","volume":"75","author":"D Mischoulon","year":"2014","unstructured":"Mischoulon D, Price LH, Carpenter LL, Tyrka AR, Papakostas GI, Baer L et al (2014) A double-blind, randomized, placebo-controlled clinical trial of S-adenosyl-L-methionine (SAMe) versus escitalopram in major depressive disorder. J Clin Psychiatry 75(4):370\u2013376. https:\/\/doi.org\/10.4088\/JCP.13m08591","journal-title":"J Clin Psychiatry"},{"issue":"6","key":"9170_CR237","doi-asserted-by":"crossref","first-page":"5936","DOI":"10.4088\/JCP.13m08454","volume":"75","author":"M Berk","year":"2014","unstructured":"Berk M, Dean OM, Cotton SM, Jeavons S, Tanious M, Kohlmann K et al (2014) The efficacy of adjunctive N-acetylcysteine in major depressive disorder: a double-blind, randomized, placebo-controlled trial. J Clin Psychiatry 75(6):5936","journal-title":"J Clin Psychiatry"},{"issue":"2","key":"9170_CR238","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.psychres.2015.08.042","volume":"230","author":"CNS de Sousa","year":"2015","unstructured":"de Sousa CNS, Meneses LN, Vasconcelos GS, Silva MCC, da Silva JC, Mac\u00eado D et al (2015) Reversal of corticosterone-induced BDNF alterations by the natural antioxidant alpha-lipoic acid alone and combined with desvenlafaxine: emphasis on the neurotrophic hypothesis of depression. Psychiatry Res 230(2):211\u2013219","journal-title":"Psychiatry Res"},{"issue":"3","key":"9170_CR239","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0924-977X(02)00175-X","volume":"13","author":"S Lepp\u00e4m\u00e4ki","year":"2003","unstructured":"Lepp\u00e4m\u00e4ki S, Partonen T, Vakkuri O, L\u00f6nnqvist J, Partinen M, Laudon M (2003) Effect of controlled-release melatonin on sleep quality, mood, and quality of life in subjects with seasonal or weather-associated changes in mood and behaviour. Eur Neuropsychopharmacol 13(3):137\u2013145","journal-title":"Eur Neuropsychopharmacol"},{"key":"9170_CR240","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1192\/bjp.178.3.200","volume":"178","author":"MP Austin","year":"2001","unstructured":"Austin MP, Mitchell P, Goodwin GM (2001) Cognitive deficits in depression: possible implications for functional neuropathology. Br J Psychiatry 178:200\u2013206. https:\/\/doi.org\/10.1192\/bjp.178.3.200","journal-title":"Br J Psychiatry"},{"issue":"2","key":"9170_CR241","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/YIC.0000000000000334","volume":"36","author":"FL Rocha","year":"2021","unstructured":"Rocha FL, de Vasconcelos Cunha UG, Paschoalin RC, Hara C, Thomaz DP (2021) Use of subcutaneous ketamine to rapidly improve severe treatment-resistant depression in a patient with Alzheimer\u2019s disease. Int Clin Psychopharmacol 36(2):104\u2013105","journal-title":"Int Clin Psychopharmacol"},{"issue":"6","key":"9170_CR242","doi-asserted-by":"crossref","first-page":"922","DOI":"10.4088\/JCP.08m04606","volume":"70","author":"H Hampel","year":"2009","unstructured":"Hampel H, Ewers M, B\u00fcrger K, Annas P, M\u00f6rtberg A, Bogstedt A et al (2009) Lithium trial in Alzheimer\u2019s disease: a randomized, single-blind, placebo-controlled, multicenter 10-week study. J Clin Psychiatry 70(6):922","journal-title":"J Clin Psychiatry"},{"key":"9170_CR243","unstructured":"Roche HL (2016) MARIGOLD study: a study of RO4917523 Versus placebo as adjunctive therapy in patients with major depressive disorder and an inadequate response to ongoing antidepressant therapy. https:\/\/ClinicalTrials.gov\/show\/NCT01437657. Accessed 18 Jan 2023"},{"issue":"11","key":"9170_CR244","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1038\/npp.2010.105","volume":"35","author":"X Li","year":"2010","unstructured":"Li X, Jope RS (2010) Is glycogen synthase kinase-3 a central modulator in mood regulation? Neuropsychopharmacology 35(11):2143\u20132154","journal-title":"Neuropsychopharmacology"},{"issue":"6","key":"9170_CR245","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/mp.2014.136","volume":"20","author":"Y Cheng","year":"2015","unstructured":"Cheng Y, Rodriguiz RM, Murthy SR, Senatorov V, Thouennon E, Cawley NX et al (2015) Neurotrophic factor-\u03b11 prevents stress-induced depression through enhancement of neurogenesis and is activated by rosiglitazone. Mol Psychiatry 20(6):744\u2013754","journal-title":"Mol Psychiatry"},{"issue":"8","key":"9170_CR246","doi-asserted-by":"publisher","first-page":"e785","DOI":"10.4088\/JCP.13m08725","volume":"75","author":"JF Karp","year":"2014","unstructured":"Karp JF, Butters MA, Begley AE, Miller MD, Lenze EJ, Blumberger DM et al (2014) Safety, tolerability, and clinical effect of low-dose buprenorphine for treatment-resistant depression in midlife and older adults. J Clin Psychiatry 75(8):e785\u2013e793. https:\/\/doi.org\/10.4088\/JCP.13m08725","journal-title":"J Clin Psychiatry"},{"issue":"5","key":"9170_CR247","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1177\/0269881113480990","volume":"27","author":"E Ratti","year":"2013","unstructured":"Ratti E, Bettica P, Alexander R, Archer G, Carpenter D, Evoniuk G et al (2013) Full central neurokinin-1 receptor blockade is required for efficacy in depression: evidence from orvepitant clinical studies. J Psychopharmacol 27(5):424\u2013434","journal-title":"J Psychopharmacol"},{"key":"9170_CR248","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2022.104743","volume":"139","author":"S Rosson","year":"2022","unstructured":"Rosson S, De Filippis R, Croatto G, Collantoni E, Pallottino S, Guinart D et al (2022) Brain stimulation and other biological non-pharmacological interventions in mental disorders: an umbrella review. Neurosci Biobehav Rev 139:104743","journal-title":"Neurosci Biobehav Rev"},{"issue":"1","key":"9170_CR249","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.expneurol.2008.01.011","volume":"211","author":"CA Zarate Jr","year":"2008","unstructured":"Zarate CA Jr, Manji HK (2008) The role of AMPA receptor modulation in the treatment of neuropsychiatric diseases. Exp Neurol 211(1):7","journal-title":"Exp Neurol"},{"key":"9170_CR250","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.neuropharm.2017.06.009","volume":"123","author":"A Giralt","year":"2017","unstructured":"Giralt A, G\u00f3mez-Climent M\u00c1, Alcal\u00e1 R, Bretin S, Bertrand D, Delgado-Garc\u00eda JM et al (2017) The AMPA receptor positive allosteric modulator S 47445 rescues in vivo CA3-CA1 long-term potentiation and structural synaptic changes in old mice. Neuropharmacology 123:395\u2013409","journal-title":"Neuropharmacology"},{"key":"9170_CR251","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.trci.2019.04.002","volume":"5","author":"K Bernard","year":"2019","unstructured":"Bernard K, Gouttefangeas S, Bretin S, Galtier S, Robert P, Holthoff-Detto V et al (2019) A 24-week double-blind placebo-controlled study of the efficacy and safety of the AMPA modulator S47445 in patients with mild to moderate Alzheimer\u2019s disease and depressive symptoms. Alzheimer\u2019s Dement: Trans Res Clin Interven 5:231\u2013240","journal-title":"Alzheimer\u2019s Dement: Trans Res Clin Interven"},{"issue":"5994","key":"9170_CR252","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.1190287","volume":"329","author":"N Li","year":"2010","unstructured":"Li N, Lee B, Liu R-J, Banasr M, Dwyer JM, Iwata M et al (2010) mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science 329(5994):959\u2013964","journal-title":"Science"},{"key":"9170_CR253","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jad.2017.04.072","volume":"218","author":"JW Murrough","year":"2017","unstructured":"Murrough JW, Wade E, Sayed S, Ahle G, Kiraly DD, Welch A et al (2017) Dextromethorphan\/quinidine pharmacotherapy in patients with treatment resistant depression: a proof of concept clinical trial. J Affect Disord 218:277\u2013283","journal-title":"J Affect Disord"},{"key":"9170_CR254","unstructured":"T-Cells C. Axsome therapeutics announces AXS-05 achieves primary endpoint in the ADVANCE-1 pivotal phase 2\/3 trial in Alzheimer\u2019s disease agitation"},{"issue":"6","key":"9170_CR255","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1080\/14656566.2017.1308484","volume":"18","author":"K Patel","year":"2017","unstructured":"Patel K, Abdool PS, Rajji TK, Mulsant BH (2017) Pharmacotherapy of major depression in late life: what is the role of new agents? Exp Opin Pharmacother 18(6):599\u2013609","journal-title":"Exp Opin Pharmacother"},{"issue":"4","key":"9170_CR256","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/YIC.0b013e3283542457","volume":"27","author":"C Katona","year":"2012","unstructured":"Katona C, Hansen T, Olsen CK (2012) A randomized, double-blind, placebo-controlled, duloxetine-referenced, fixed-dose study comparing the efficacy and safety of Lu AA21004 in elderly patients with major depressive disorder. Int Clin Psychopharmacol 27(4):215\u2013223","journal-title":"Int Clin Psychopharmacol"},{"issue":"10011","key":"9170_CR257","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1016\/S0140-6736(15)00308-6","volume":"386","author":"EJ Lenze","year":"2015","unstructured":"Lenze EJ, Mulsant BH, Blumberger DM, Karp JF, Newcomer JW, Anderson SJ et al (2015) Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: a randomised, double-blind, placebo-controlled trial. Lancet 386(10011):2404\u20132412","journal-title":"Lancet"},{"issue":"4","key":"9170_CR258","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1080\/03007995.2018.1430220","volume":"34","author":"M Hobart","year":"2018","unstructured":"Hobart M, Skuban A, Zhang P, Josiassen MK, Hefting N, Augustine C et al (2018) Efficacy and safety of flexibly dosed brexpiprazole for the adjunctive treatment of major depressive disorder: a randomized, active-referenced, placebo-controlled study. Curr Med Res Opin 34(4):633\u2013642","journal-title":"Curr Med Res Opin"},{"issue":"11","key":"9170_CR259","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/S1474-4422(14)70198-X","volume":"13","author":"D Wilkinson","year":"2014","unstructured":"Wilkinson D, Windfeld K, Colding-J\u00f8rgensen E (2014) Safety and efficacy of idalopirdine, a 5-HT6 receptor antagonist, in patients with moderate Alzheimer\u2019s disease (LADDER): a randomised, double-blind, placebo-controlled phase 2 trial. Lancet Neurol 13(11):1092\u20131099","journal-title":"Lancet Neurol"},{"issue":"2","key":"9170_CR260","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1001\/jama.2017.20373","volume":"319","author":"A Atri","year":"2018","unstructured":"Atri A, Fr\u00f6lich L, Ballard C, Tariot PN, Molinuevo JL, Boneva N et al (2018) Effect of idalopirdine as adjunct to cholinesterase inhibitors on change in cognition in patients with Alzheimer disease: three randomized clinical trials. JAMA 319(2):130\u2013142","journal-title":"JAMA"},{"issue":"11","key":"9170_CR261","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/mp.2011.47","volume":"16","author":"E Beurel","year":"2011","unstructured":"Beurel E, Song L, Jope R (2011) Inhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice. Mol Psychiatry 16(11):1068\u20131070","journal-title":"Mol Psychiatry"},{"issue":"1","key":"9170_CR262","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3233\/JAD-2012-120805","volume":"33","author":"T Del Ser","year":"2013","unstructured":"Del Ser T, Steinwachs KC, Gertz HJ, Andres MV, Gomez-Carrillo B, Medina M et al (2013) Treatment of Alzheimer\u2019s disease with the GSK-3 inhibitor tideglusib: a pilot study. J Alzheimer\u2019s Dis 33(1):205\u2013215","journal-title":"J Alzheimer\u2019s Dis"},{"issue":"1","key":"9170_CR263","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/YCT.0000000000000602","volume":"36","author":"A Karayagmurlu","year":"2020","unstructured":"Karayagmurlu A, Coskun M, Elboga G, Ghaziuddin N, Karayagmurlu E, G\u00f6k\u00e7en C et al (2020) Efficacy and safety of electroconvulsive therapy in adolescents: a retrospective chart review study from Turkey. J ECT 36(1):54\u201359","journal-title":"J ECT"},{"key":"9170_CR264","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s40501-020-00216-w","volume":"7","author":"SJ van Rooij","year":"2020","unstructured":"van Rooij SJ, Riva-Posse P, McDonald WM (2020) The efficacy and safety of neuromodulation treatments in late-life depression. Curr Treat Opt Psychiatry 7:337\u2013348","journal-title":"Curr Treat Opt Psychiatry"},{"key":"9170_CR265","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3389\/fpsyg.2020.00080","volume":"11","author":"M Li","year":"2020","unstructured":"Li M, Yao X, Sun L, Zhao L, Xu W, Zhao H et al (2020) Effects of electroconvulsive therapy on depression and its potential mechanism. Front Psychol 11:80","journal-title":"Front Psychol"},{"issue":"3","key":"9170_CR266","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/YCT.0000000000000832","volume":"38","author":"KR McManus","year":"2022","unstructured":"McManus KR, Lapid MI, Forester BP, Mueller M, Hermida AP, Nykamp L et al (2022) Simulated electroconvulsive therapy: a novel approach to a control group in clinical trials. J ECT 38(3):165\u2013170","journal-title":"J ECT"},{"issue":"4","key":"9170_CR267","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jagp.2017.09.023","volume":"26","author":"JF van den Berg","year":"2018","unstructured":"van den Berg JF, Kruithof HC, Kok RM, Verwijk E, Spaans H-P (2018) Electroconvulsive therapy for agitation and aggression in dementia: a systematic review. Am J Geriatr Psychiatry 26(4):419\u2013434","journal-title":"Am J Geriatr Psychiatry"},{"key":"9170_CR268","doi-asserted-by":"crossref","unstructured":"Jiang F, Jiang Y, Zhi H, Dong Y, Li H, Ma S et al (2017) Artificial intelligence in healthcare: past, present and future. Stroke Vasc Neurol 2(4)","DOI":"10.1136\/svn-2017-000101"},{"issue":"6","key":"9170_CR269","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1001\/jama.2015.18421","volume":"315","author":"AM Darcy","year":"2016","unstructured":"Darcy AM, Louie AK, Roberts LW (2016) Machine learning and the profession of medicine. JAMA 315(6):551\u2013552","journal-title":"JAMA"},{"issue":"2","key":"9170_CR270","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3390\/jpm10020021","volume":"10","author":"G Battineni","year":"2020","unstructured":"Battineni G, Sagaro GG, Chinatalapudi N, Amenta F (2020) Applications of machine learning predictive models in the chronic disease diagnosis. J Person Med 10(2):21","journal-title":"J Person Med"},{"key":"9170_CR271","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.neucom.2014.09.072","volume":"151","author":"L Khedher","year":"2015","unstructured":"Khedher L, Ram\u00edrez J, G\u00f3rriz JM, Brahim A, Segovia F (2015) Early diagnosis of Alzheimer\u2019s disease based on partial least squares, principal component analysis and support vector machine using segmented MRI images. Neurocomputing 151:139\u2013150. https:\/\/doi.org\/10.1016\/j.neucom.2014.09.072","journal-title":"Neurocomputing"},{"issue":"16","key":"9170_CR272","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1186\/1471-2105-15-S16-S11","volume":"15","author":"P Johnson","year":"2014","unstructured":"Johnson P, Vandewater L, Wilson W, Maruff P, Savage G, Graham P et al (2014) Genetic algorithm with logistic regression for prediction of progression to Alzheimer\u2019s disease. BMC Bioinform 15(16):S11. https:\/\/doi.org\/10.1186\/1471-2105-15-S16-S11","journal-title":"BMC Bioinform"},{"key":"9170_CR273","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.1007\/s11042-020-09738-0","volume":"80","author":"R Xiao","year":"2021","unstructured":"Xiao R, Cui X, Qiao H, Zheng X, Zhang Y (2021) Early diagnosis model of Alzheimer\u2019s disease based on sparse logistic regression. Multimed Tools Appl 80:3969\u20133980","journal-title":"Multimed Tools Appl"},{"key":"9170_CR274","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.imu.2018.12.003","volume":"14","author":"K Kruthika","year":"2019","unstructured":"Kruthika K, Maheshappa H (2019) Initiative AsDN. Multistage classifier-based approach for Alzheimer\u2019s disease prediction and retrieval. Inform Med Unlocked 14:34\u201342","journal-title":"Inform Med Unlocked"},{"key":"9170_CR275","doi-asserted-by":"crossref","DOI":"10.1016\/j.imu.2019.100200","volume":"16","author":"G Battineni","year":"2019","unstructured":"Battineni G, Chintalapudi N, Amenta F (2019) Machine learning in medicine: performance calculation of dementia prediction by support vector machines (SVM). Inform Med Unlocked 16:100200","journal-title":"Inform Med Unlocked"},{"issue":"8","key":"9170_CR276","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.3390\/app8081244","volume":"8","author":"C-T Wu","year":"2018","unstructured":"Wu C-T, Dillon DG, Hsu H-C, Huang S, Barrick E, Liu Y-H (2018) Depression detection using relative EEG power induced by emotionally positive images and a conformal kernel support vector machine. Appl Sci 8(8):1244","journal-title":"Appl Sci"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-023-09170-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-023-09170-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-023-09170-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T20:27:21Z","timestamp":1738700841000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-023-09170-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,28]]},"references-count":276,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["9170"],"URL":"https:\/\/doi.org\/10.1007\/s11033-023-09170-1","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,28]]},"assertion":[{"value":"6 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no conflict of interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"225"}}