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Dysregulation of miRNA could result in dysregulation of genes which may contribute to diseases affecting the brain and behavior (e.g., schizophrenia). miR-29 family is a miRNA family contributing to brain maturation. miR-29 knockout in animal studies is reported to correlate with psychiatric disorders very similar to those seen in schizophrenia. In this study, we aimed to evaluate the miR-29a level in patients with schizophrenia and its potential value in the diagnosis of schizophrenia.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Materials and methods<\/jats:title>\n            <jats:p>The serum sample of 42 patients with schizophrenia and 40 healthy subjects were obtained from the Azeri Recent onset\/Acute phase psychosis Survey (ARAS) Cohort study. After preparations, the expression level of miR-29a was investigated by real-time PCR. The SPSS and GraphPad prism software were used to analyze the relation between miR-29a level and clinical parameters and its potential as a biomarker for the diagnosis of schizophrenia.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Our study showed a significantly lower miR-29a level in patients compared to healthy controls (<jats:italic>p<\/jats:italic>\u2009=\u20090.0012). Furthermore, miR-29a level was significantly lower in some types of schizophrenia (<jats:italic>p<\/jats:italic>\u2009=\u20090.024). miR-29a level was not related to sex, age, or heredity (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). miR-29a also showed 80% specificity and 71.43% sensitivity in the diagnosis of schizophrenia.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Downregulation of miR-29a in schizophrenia is significantly related to the development of this illness. It might have the potential as a biomarker for schizophrenia.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s11033-024-09428-2","type":"journal-article","created":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T16:01:30Z","timestamp":1714924890000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Downregulation of miR-29a as a possible diagnostic biomarker for schizophrenia"],"prefix":"10.1007","volume":"51","author":[{"given":"Parya Alizadeh","family":"Khosroshahi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2593-9810","authenticated-orcid":false,"given":"Hamidreza","family":"Ashayeri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Ghanbari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6545-2935","authenticated-orcid":false,"given":"Ayyoub","family":"Malek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8552-138X","authenticated-orcid":false,"given":"Sara","family":"Farhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8400-4209","authenticated-orcid":false,"given":"Mehdi","family":"Haghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,5,5]]},"reference":[{"key":"9428_CR1","doi-asserted-by":"crossref","unstructured":"Velligan DI, Rao S (2023) The Epidemiology and Global Burden of Schizophrenia. 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