{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T23:27:04Z","timestamp":1774049224102,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s11033-024-09475-9","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T10:01:43Z","timestamp":1712743303000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["\u201cDecoding inflammation: glycoprotein a repetition predominant, microRNA-142-3-p, and metastasis associated lung adenocarcinoma transcript 1: as novel inflammatory biomarkers of inflammatory bowel disease\u201d"],"prefix":"10.1007","volume":"51","author":[{"given":"Mohammad Reza","family":"Lahimchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mousa","family":"Mohammadnia-Afrouzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasoul","family":"Baharlou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dariush","family":"Haghmorad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Hassan","family":"Abedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delaram","family":"Arjmandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoomeh","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahman","family":"Yousefi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,10]]},"reference":[{"issue":"4\u20135","key":"9475_CR1","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.cyto.2004.07.012","volume":"28","author":"P Stokkers","year":"2004","unstructured":"Stokkers P, Hommes D (2004) New cytokine therapeutics for inflammatory bowel disease. Cytokine 28(4\u20135):167\u2013173","journal-title":"Cytokine"},{"issue":"12","key":"9475_CR2","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1136\/jcp.2003.015214","volume":"57","author":"M Guindi","year":"2004","unstructured":"Guindi M, Riddell RH (2004) Indeterminate colitis. J Clin Pathol 57(12):1233\u20131244","journal-title":"J Clin Pathol"},{"key":"9475_CR3","unstructured":"Centers for Disease Control and Prevention. Inflammatory bowel disease (IBD). August 6, (2012); http:\/\/www.cdc.gov\/ibd\/#epidIBD"},{"issue":"1","key":"9475_CR4","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/nrgastro.2015.186","volume":"13","author":"HSP de Souza","year":"2016","unstructured":"de Souza HSP, Fiocchi C (2016) Immunopathogenesis of IBD: current state of the art. Nat Reviews Gastroenterol Hepatol 13(1):13\u201327","journal-title":"Nat Reviews Gastroenterol Hepatol"},{"key":"9475_CR5","doi-asserted-by":"crossref","unstructured":"Atreya R, Neurath MF (2010) Factors affecting mucosal homeostasis: a fine balance Inflammatory Bowel Disease: Translating basic science into clinical practice, pp. 52\u201363","DOI":"10.1002\/9781444318418.ch6"},{"issue":"3","key":"9475_CR6","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.4049\/jimmunol.157.3.1261","volume":"157","author":"IJ Fuss","year":"1996","unstructured":"Fuss IJ et al (1996) Disparate CD4\u2009+\u2009lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn\u2019s disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol 157(3):1261\u20131270","journal-title":"J Immunol"},{"key":"9475_CR7","doi-asserted-by":"crossref","unstructured":"G\u00e1lvez J (2014) Role of Th17 cells in the pathogenesis of human IBD International Scholarly Research Notices, 2014","DOI":"10.1155\/2014\/928461"},{"issue":"5","key":"9475_CR8","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1136\/gutjnl-2019-319850","volume":"69","author":"JN Clough","year":"2020","unstructured":"Clough JN et al (2020) Regulatory T-cell therapy in Crohn\u2019s disease: challenges and advances. Gut 69(5):942\u2013952","journal-title":"Gut"},{"issue":"2","key":"9475_CR9","first-page":"213","volume":"5","author":"V Ollendorff","year":"1994","unstructured":"Ollendorff V et al (1994) The GARP gene encodes a new member of the family of leucine-rich repeat-containing proteins. Cell Growth Differ 5(2):213\u2013219","journal-title":"Cell Growth Differ"},{"issue":"8","key":"9475_CR10","doi-asserted-by":"publisher","first-page":"3260","DOI":"10.1182\/blood-2006-07-036269","volume":"109","author":"IC Macaulay","year":"2007","unstructured":"Macaulay IC et al (2007) Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. Blood 109(8):3260\u20133269","journal-title":"Blood"},{"key":"9475_CR11","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/978-981-13-0719-5_2","volume":"1094","author":"Y Xiao","year":"2018","unstructured":"Xiao Y, Hu J, Yin W (2018) Systematic identification of non-coding RNAs. Adv Exp Med Biol 1094:9\u201318","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"9475_CR12","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s41544-019-0024-y","volume":"1","author":"Y Fu","year":"2019","unstructured":"Fu Y, Chen J, Huang Z (2019) Recent progress in microRNA-based delivery systems for the treatment of human disease. ExRNA 1(1):24","journal-title":"ExRNA"},{"issue":"9","key":"9475_CR13","doi-asserted-by":"publisher","first-page":"e76186","DOI":"10.1371\/journal.pone.0076186","volume":"8","author":"E Gauthy","year":"2013","unstructured":"Gauthy E et al (2013) GARP is regulated by miRNAs and controls latent TGF-\u03b21 production by human regulatory T cells. PLoS ONE 8(9):e76186","journal-title":"PLoS ONE"},{"issue":"5","key":"9475_CR14","first-page":"440","volume":"113","author":"I Sukma Dewi","year":"2017","unstructured":"Sukma Dewi I et al (2017) Exosomal mir-142-3p is increased during cardiac allograft rejection and augments vascular permeability through down-regulation of endothelial RAB11FIP2 expression. Cardiovascular Res 113(5):440\u2013452","journal-title":"Cardiovascular Res"},{"issue":"1","key":"9475_CR15","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3109\/08820139.2015.1103749","volume":"45","author":"M Mohammadnia-Afrouzi","year":"2016","unstructured":"Mohammadnia-Afrouzi M et al (2016) Altered microRNA expression and Immunosuppressive Cytokine Production by Regulatory T Cells of Ulcerative Colitis Patients. Immunol Invest 45(1):63\u201374","journal-title":"Immunol Invest"},{"key":"9475_CR16","doi-asserted-by":"crossref","unstructured":"Xu W et al (2022) The Mayo Endoscopic score is a Novel Predictive Indicator for Malignant Transformation in Ulcerative Colitis: a long-term Follow-Up Multicenter Study. Frontiers in Surgery, p 9","DOI":"10.3389\/fsurg.2022.832219"},{"issue":"8167","key":"9475_CR17","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/S0140-6736(80)92767-1","volume":"1","author":"RF Harvey","year":"1980","unstructured":"Harvey RF, Bradshaw JM (1980) A simple index of Crohn\u2019s-disease activity. Lancet 1(8167):514","journal-title":"Lancet"},{"issue":"2","key":"9475_CR18","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1111\/apt.15542","volume":"51","author":"D Piovani","year":"2020","unstructured":"Piovani D et al (2020) Inflammatory bowel disease: estimates from the global burden of disease 2017 study. Aliment Pharmacol Ther 51(2):261\u2013270","journal-title":"Aliment Pharmacol Ther"},{"issue":"10114","key":"9475_CR19","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","volume":"390","author":"SC Ng","year":"2017","unstructured":"Ng SC et al (2017) Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet 390(10114):2769\u20132778","journal-title":"Lancet"},{"issue":"6","key":"9475_CR20","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1189\/jlb.3HI0614-303R","volume":"97","author":"EN McNamee","year":"2015","unstructured":"McNamee EN et al (2015) Chemokine receptor CCR7 regulates the intestinal TH1\/TH17\/Treg balance during Crohn\u2019s-like murine ileitis. J Leukoc Biol 97(6):1011\u20131022","journal-title":"J Leukoc Biol"},{"issue":"2","key":"9475_CR21","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1084\/jem.188.2.287","volume":"188","author":"AM Thornton","year":"1998","unstructured":"Thornton AM, Shevach EM (1998) CD4\u2009+\u2009CD25\u2009+\u2009immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 188(2):287\u2013296","journal-title":"J Exp Med"},{"issue":"27","key":"9475_CR22","doi-asserted-by":"publisher","first-page":"42826","DOI":"10.18632\/oncotarget.8753","volume":"7","author":"L Sun","year":"2016","unstructured":"Sun L, Jin H, Li H (2016) GARP: a surface molecule of regulatory T cells that is involved in the regulatory function and TGF-\u03b2 releasing. Oncotarget 7(27):42826","journal-title":"Oncotarget"},{"issue":"6","key":"9475_CR23","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1158\/0008-5472.CAN-18-2623","volume":"79","author":"M Salem","year":"2019","unstructured":"Salem M et al (2019) GARP dampens cancer immunity by sustaining function and accumulation of regulatory T cells in the colon. Cancer Res 79(6):1178\u20131190","journal-title":"Cancer Res"},{"issue":"1","key":"9475_CR24","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s12032-022-01881-y","volume":"40","author":"MR Lahimchi","year":"2022","unstructured":"Lahimchi MR, Eslami M, Yousefi B (2022) New insight into GARP striking role in cancer progression: application for cancer therapy. Med Oncol 40(1):33","journal-title":"Med Oncol"},{"key":"9475_CR25","doi-asserted-by":"crossref","unstructured":"Liu C, Li N, Liu G (2020) The role of microRNAs in regulatory T cells Journal of immunology research, 2020","DOI":"10.1155\/2020\/3232061"},{"issue":"12","key":"9475_CR26","doi-asserted-by":"publisher","first-page":"6579","DOI":"10.4049\/jimmunol.1202993","volume":"190","author":"Q Zhou","year":"2013","unstructured":"Zhou Q et al (2013) Mir-142-3p is involved in CD25\u2009+\u2009CD4 T cell proliferation by targeting the expression of glycoprotein A repetitions predominant. J Immunol 190(12):6579\u20136588","journal-title":"J Immunol"},{"issue":"1","key":"9475_CR27","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s13578-019-0299-6","volume":"9","author":"Q Yu","year":"2019","unstructured":"Yu Q et al (2019) MALAT1 functions as a competing endogenous RNA to regulate SMAD5 expression by acting as a sponge for mir-142-3p in hepatocellular carcinoma. Cell Bioscience 9(1):39","journal-title":"Cell Bioscience"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-024-09475-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-024-09475-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-024-09475-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T20:27:21Z","timestamp":1738700841000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-024-09475-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,10]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["9475"],"URL":"https:\/\/doi.org\/10.1007\/s11033-024-09475-9","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,10]]},"assertion":[{"value":"18 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study complied with the guidelines for human studies and was conducted following the World Medical Association Declaration of Helsinki. The study protocol was approved by the Ethical Board of the Semnan University of Medical Sciences (IR.SEMUMS.REC.1400.332).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Authors have no relevant financial or non-financial interests to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"500"}}