{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:53:53Z","timestamp":1781520833879,"version":"3.54.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100012155","name":"National Institute for Medical Research Development","doi-asserted-by":"publisher","award":["983886"],"award-info":[{"award-number":["983886"]}],"id":[{"id":"10.13039\/501100012155","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s11033-024-09560-z","type":"journal-article","created":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T18:01:30Z","timestamp":1717264890000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Distinct neurological phenotypes associated with biallelic loss of NOTCH3 function: evidence for recessive inheritance"],"prefix":"10.1007","volume":"51","author":[{"given":"Behnoosh","family":"Tasharrofi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Najafi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Pourbakhtyaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Amirsalari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Golazin Shahbodagh","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud Reza","family":"Ashrafi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Reza","family":"Tavasoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Keramatipour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morteza","family":"Heidari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,1]]},"reference":[{"key":"9560_CR1","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.3390\/ijms18091964","volume":"18","author":"E Mui\u00f1o","year":"2017","unstructured":"Mui\u00f1o E, Gallego-Fabrega C, Cullell N, Carrera C, Torres N, Krupinski J, Roquer J, Montaner J et al (2017) Systematic review of cysteine-sparing NOTCH3 missense mutations in patients with clinical suspicion of CADASIL. Int J Mol Sci 18:1964","journal-title":"Int J Mol Sci"},{"key":"9560_CR2","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/nrm.2016.94","volume":"17","author":"SJ Bray","year":"2016","unstructured":"Bray SJ (2016) Notch signalling in context. Nat Rev Mol Cell Biol 17:722\u2013735","journal-title":"Nat Rev Mol Cell Biol"},{"key":"9560_CR3","first-page":"279","volume":"45","author":"M Katoh","year":"2020","unstructured":"Katoh M, Katoh M (2020) Precision medicine for human cancers with notch signaling dysregulation. Int J Mol Med 45:279\u2013297","journal-title":"Int J Mol Med"},{"key":"9560_CR4","doi-asserted-by":"publisher","first-page":"e84659","DOI":"10.1371\/journal.pone.0084659","volume":"8","author":"C Li","year":"2013","unstructured":"Li C, Zhang S, Lu Y, Zhang Y, Wang E, Cui Z (2013) The roles of Notch3 on the cell proliferation and apoptosis induced by CHIR99021 in NSCLC cell lines: a functional link between wnt and notch signaling pathways. PLoS ONE 8:e84659","journal-title":"PLoS ONE"},{"key":"9560_CR5","doi-asserted-by":"publisher","first-page":"220004","DOI":"10.1098\/rsob.220004","volume":"12","author":"F Del Gaudio","year":"2022","unstructured":"Del Gaudio F, Liu D, Lendahl U (2022) Notch signalling in healthy and diseased vasculature. Open Biology 12:220004","journal-title":"Open Biology"},{"key":"9560_CR6","doi-asserted-by":"publisher","first-page":"2730","DOI":"10.1101\/gad.308904","volume":"18","author":"V Domenga","year":"2004","unstructured":"Domenga V, Fardoux P, Lacombe P, Monet M, Maciazek J, Krebs LT, Klonjkowski B, Berrou E et al (2004) Notch3 is required for arterial identity and maturation of vascular smooth muscle cells. Genes Dev 18:2730\u20132735","journal-title":"Genes Dev"},{"key":"9560_CR7","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s00011-021-01442-5","volume":"70","author":"RC Castro","year":"2021","unstructured":"Castro RC, Gon\u00e7ales RA, Zambuzi FA, Frantz FG (2021) Notch signaling pathway in infectious diseases: role in the regulation of immune response. Inflamm Res 70:261\u2013274","journal-title":"Inflamm Res"},{"key":"9560_CR8","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1038\/s41573-020-00091-3","volume":"20","author":"S Majumder","year":"2021","unstructured":"Majumder S, Crabtree JS, Golde TE, Minter LM, Osborne BA, Miele L (2021) Targeting notch in oncology: the path forward. Nat Rev Drug Discovery 20:125\u2013144","journal-title":"Nat Rev Drug Discovery"},{"key":"9560_CR9","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1042\/CS20190835","volume":"133","author":"HE Morris","year":"2019","unstructured":"Morris HE, Neves KB, Montezano AC, MacLean MR, Touyz RM (2019) Notch3 signalling and vascular remodelling in pulmonary arterial hypertension. Clin Sci 133:2481\u20132498","journal-title":"Clin Sci"},{"key":"9560_CR10","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.1161\/STROKEAHA.121.036307","volume":"53","author":"RJ Hack","year":"2022","unstructured":"Hack RJ, Gravesteijn G, Cerfontaine MN, Hegeman IM, Mulder AA, Lesnik Oberstein SA, Rutten JW (2022) Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy family members with a pathogenic NOTCH3 variant can have a normal brain magnetic resonance imaging and skin biopsy beyond age 50 years. Stroke 53:1964\u20131974","journal-title":"Stroke"},{"key":"9560_CR11","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3988\/jcn.2023.19.1.12","volume":"19","author":"Y Yamamoto","year":"2023","unstructured":"Yamamoto Y, Liao Y-C, Lee Y-C, Ihara M, Choi JC (2023) Update on the Epidemiology, Pathogenesis, and biomarkers of cerebral autosomal Dominant Arteriopathy with Subcortical infarcts and Leukoencephalopathy. J Clin Neurol 19:12\u201327","journal-title":"J Clin Neurol"},{"key":"9560_CR12","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1111\/ene.14293","volume":"27","author":"H Chabriat","year":"2020","unstructured":"Chabriat H, Joutel A, Tournier-Lasserve E, Bousser M (2020) CADASIL: yesterday, today, tomorrow. Eur J Neurol 27:1588\u20131595","journal-title":"Eur J Neurol"},{"key":"9560_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11940-017-0468-z","volume":"19","author":"A Bersano","year":"2017","unstructured":"Bersano A, Bedini G, Oskam J, Mariotti C, Taroni F, Baratta S, Parati EA (2017) CADASIL: treatment and management options. Curr Treat Options Neurol 19:1\u201315","journal-title":"Curr Treat Options Neurol"},{"key":"9560_CR14","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.jns.2016.05.061","volume":"367","author":"H Abou Al-Shaar","year":"2016","unstructured":"Abou Al-Shaar H, Qadi N, Al-Hamed MH, Meyer BF, Bohlega S (2016) Phenotypic comparison of individuals with homozygous or heterozygous mutation of NOTCH3 in a large CADASIL family. J Neurol Sci 367:239\u2013243","journal-title":"J Neurol Sci"},{"key":"9560_CR15","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.jns.2018.08.029","volume":"394","author":"M Mukai","year":"2018","unstructured":"Mukai M, Mizuta I, Ueda A, Nakashima D, Kushimura Y, Noto Y-i, Ohara T, Itoh K et al (2018) A Japanese CADASIL patient with homozygous NOTCH3 p. Arg544Cys mutation confirmed pathologically. J Neurol Sci 394:38\u201340","journal-title":"J Neurol Sci"},{"key":"9560_CR16","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s10072-013-1580-9","volume":"35","author":"C Vinciguerra","year":"2014","unstructured":"Vinciguerra C, Rufa A, Bianchi S, Sperduto A, De Santis M, Malandrini A, Dotti MT, Federico A (2014) Homozygosity and severity of phenotypic presentation in a CADASIL family. Neurol Sci 35:91\u201393","journal-title":"Neurol Sci"},{"key":"9560_CR17","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3389\/fnagi.2020.00091","volume":"12","author":"T Mizuno","year":"2020","unstructured":"Mizuno T, Mizuta I, Watanabe-Hosomi A, Mukai M, Koizumi T (2020) Clinical and genetic aspects of CADASIL. Front Aging Neurosci 12:91","journal-title":"Front Aging Neurosci"},{"key":"9560_CR18","first-page":"88","volume":"64","author":"B Gunda","year":"2011","unstructured":"Gunda B, Chabriat H, Bereczki D (2011) Cadasil and other hereditary small vessel diseases of the brain\u2013increasingly diagnosed conditions underlying familial ischaemic stroke and dementia. Ideggyogyaszati Sz 64:88\u2013100","journal-title":"Ideggyogyaszati Sz"},{"key":"9560_CR19","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1007\/s00415-020-10081-5","volume":"268","author":"EK Greisenegger","year":"2021","unstructured":"Greisenegger EK, Llufriu S, Chamorro A, Cervera A, Jimenez-Escrig A, Rappersberger K, Marik W, Greisenegger S et al (2021) A NOTCH3 homozygous nonsense mutation in familial Sneddon syndrome with pediatric stroke. J Neurol 268:810\u2013816","journal-title":"J Neurol"},{"key":"9560_CR20","doi-asserted-by":"publisher","first-page":"848","DOI":"10.15252\/emmm.201404399","volume":"7","author":"T Pippucci","year":"2015","unstructured":"Pippucci T, Maresca A, Magini P, Cenacchi G, Donadio V, Palombo F, Papa V, Incensi A et al (2015) Homozygous NOTCH 3 null mutation and impaired NOTCH 3 signaling in recessive early-onset arteriopathy and cavitating leukoencephalopathy. EMBO Mol Med 7:848\u2013858","journal-title":"EMBO Mol Med"},{"key":"9560_CR21","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1055\/a-1739-2722","volume":"53","author":"MD Stellingwerff","year":"2022","unstructured":"Stellingwerff MD, Nulton C, Helman G, Roosendaal SD, Benko WS, Pizzino A, Bugiani M, Vanderver A et al (2022) Early-onset vascular Leukoencephalopathy caused by bi-allelic NOTCH3 variants. Neuropediatrics 53:115\u2013121","journal-title":"Neuropediatrics"},{"key":"9560_CR22","doi-asserted-by":"crossref","unstructured":"Al-Amrani F, Al-Maawali A, Al-Thihli K, Al-Ajmi E, Ganesh A, Al Futaisi A (2023) Autosomal recessive NOTCH3-related leukodystrophy in two siblings and review of the literature. Pediatr. Neurol","DOI":"10.1016\/j.pediatrneurol.2023.07.007"},{"key":"9560_CR23","unstructured":"McKusick VA (2023) NOTCH RECEPTOR 3; NOTCH3. Online Mendelian Inheritance in Man"},{"key":"9560_CR24","doi-asserted-by":"publisher","first-page":"11506","DOI":"10.3390\/ijms231911506","volume":"23","author":"Y Kim","year":"2022","unstructured":"Kim Y, Bae JS, Lee J-Y, Song HK, Lee J-H, Lee M, Kim C, Lee S-H (2022) Genotype and phenotype differences in CADASIL from an Asian perspective. Int J Mol Sci 23:11506","journal-title":"Int J Mol Sci"},{"key":"9560_CR25","unstructured":"Hack RJ, Rutten J and S A J Lesnik Oberstein (2019) Cadasil. GeneReviews&#174"},{"key":"9560_CR26","unstructured":"WANG MM (2018) CADASIL, in Handbook of Clinical Neurology, D.H. Geschwind, H.L. Paulson, and C. Klein, Editors. Nikki Levy: Amsterdam, Netherlands. pp. 733\u2013736"},{"key":"9560_CR27","first-page":"305","volume-title":"HANKEY\u2019S CLINICAL NEUROLOGY","author":"GJ Hankey","year":"2021","unstructured":"Hankey GJ, STROKE AND TRANSIENT ISCHEMIC ATTACKS OF THE (2021) BRAIN AND EYE. HANKEY\u2019S CLINICAL NEUROLOGY. CRC, Boca Raton, p 305"},{"key":"9560_CR28","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s12916-017-0778-8","volume":"15","author":"I Di Donato","year":"2017","unstructured":"Di Donato I, Bianchi S, De Stefano N, Dichgans M, Dotti MT, Duering M, Jouvent E, Korczyn AD et al (2017) Cerebral autosomal Dominant Arteriopathy with Subcortical infarcts and Leukoencephalopathy (CADASIL) as a model of small vessel disease: update on clinical, diagnostic, and management aspects. BMC Med 15:41. https:\/\/doi.org\/10.1186\/s12916-017-0778-8","journal-title":"BMC Med"},{"key":"9560_CR29","first-page":"29","volume":"6","author":"S Choudhary","year":"2013","unstructured":"Choudhary S, McLEOD M, Torchia D, Romanelli P (2013) Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). J Clin Aesthetic Dermatol 6:29","journal-title":"J Clin Aesthetic Dermatol"},{"key":"9560_CR30","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1016\/j.ajpath.2020.11.015","volume":"191","author":"KZ Young","year":"2021","unstructured":"Young KZ, Xu G, Keep SG, Borjigin J, Wang MM (2021) Overlapping protein accumulation profiles of CADASIL and CAA: is there a common mechanism driving cerebral small-vessel disease? Am J Pathol 191:1871\u20131887","journal-title":"Am J Pathol"},{"key":"9560_CR31","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1161\/STROKEAHA.113.003339","volume":"45","author":"E Cognat","year":"2014","unstructured":"Cognat E, Baron-Menguy C, Domenga-Denier V, Cleophax S, Fouillade C, Monet-Lepr\u00eatre M, Dewerchin M, Joutel A (2014) Archetypal Arg169Cys mutation in NOTCH3 does not drive the Pathogenesis in cerebral autosomal Dominant Arteriopathy with Subcortical infarcts and Leucoencephalopathy via a loss-of-function mechanism. Stroke 45:842\u2013849. https:\/\/doi.org\/10.1161\/STROKEAHA.113.003339","journal-title":"Stroke"},{"key":"9560_CR32","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1002\/humu.22432","volume":"34","author":"JW Rutten","year":"2013","unstructured":"Rutten JW, Boon EM, Liem MK, Dauwerse JG, Pont MJ, Vollebregt E, Maat-Kievit AJ, Ginjaar HB et al (2013) Hypomorphic NOTCH 3 alleles do not cause CADASIL in humans. Hum Mutat 34:1486\u20131489","journal-title":"Hum Mutat"},{"key":"9560_CR33","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1161\/01.STR.32.8.1767","volume":"32","author":"S Tuominen","year":"2001","unstructured":"Tuominen S, Juvonen V, Amberla K, Jolma T, Rinne JO, Tuisku S, Kurki T, Marttila R et al (2001) Phenotype of a homozygous CADASIL patient in comparison to 9 age-matched heterozygous patients with the same R133C Notch3 mutation. Stroke 32:1767\u20131774. https:\/\/doi.org\/10.1161\/01.STR.32.8.1767","journal-title":"Stroke"},{"key":"9560_CR34","doi-asserted-by":"publisher","first-page":"e0136501","DOI":"10.1371\/journal.pone.0136501","volume":"10","author":"Y-C Liao","year":"2015","unstructured":"Liao Y-C, Hsiao C-T, Fuh J-L, Chern C-M, Lee W-J, Guo Y-C, Wang S-J, Lee I-H et al (2015) Characterization of CADASIL among the Han Chinese in Taiwan: distinct genotypic and phenotypic profiles. PLoS ONE 10:e0136501","journal-title":"PLoS ONE"},{"key":"9560_CR35","first-page":"4","volume":"11","author":"A Kulesh","year":"2019","unstructured":"Kulesh A, Drobakha V, Shestakov V (2019) Cerebral small vessel disease: classification, clinical manifestations, diagnosis, and features of treatment. Neurol Neuropsychiatry Psychosom 11:4\u201317","journal-title":"Neurol Neuropsychiatry Psychosom"},{"key":"9560_CR36","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/S1474-4422(09)70127-9","volume":"8","author":"H Chabriat","year":"2009","unstructured":"Chabriat H, Joutel A, Dichgans M, Tournier-Lasserve E, Bousser M-G (2009) Cadasil. Lancet Neurol 8:643\u2013653","journal-title":"Lancet Neurol"},{"key":"9560_CR37","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1111\/cns.13917","volume":"28","author":"W Ni","year":"2022","unstructured":"Ni W, Zhang Y, Zhang L, Xie J-J, Li H-F, Wu Z-Y (2022) Genetic spectrum of NOTCH3 and clinical phenotype of CADASIL patients in different populations. CNS Neurosci Ther 28:1779\u20131789. https:\/\/doi.org\/10.1111\/cns.13917","journal-title":"CNS Neurosci Ther"},{"key":"9560_CR38","doi-asserted-by":"publisher","unstructured":"Ishiyama H, Kim H, Saito S, Takeda S, Takegami M, Yamamoto Y, Abe S, Nakazawa S et al Pro-hemorrhagic cerebral autosomal Dominant Arteriopathy with Subcortical infarcts and Leukoencephalopathy Associated with NOTCH3 p.R75P mutation with low vascular NOTCH3 aggregation property. Ann. Neurol. n\/a. https:\/\/doi.org\/10.1002\/ana.26916","DOI":"10.1002\/ana.26916"},{"key":"9560_CR39","doi-asserted-by":"publisher","first-page":"e0268225","DOI":"10.1371\/journal.pone.0268225","volume":"17","author":"E Canalis","year":"2022","unstructured":"Canalis E, Carrer M, Eller T, Schilling L, Yu J (2022) Use of antisense oligonucleotides to target Notch3 in skeletal cells. PLoS ONE 17:e0268225","journal-title":"PLoS ONE"},{"key":"9560_CR40","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1002\/ajmg.a.37541","volume":"170","author":"R Ejaz","year":"2016","unstructured":"Ejaz R, Qin W, Huang L, Blaser S, Tetreault M, Hartley T, Boycott KM, Carter MT et al (2016) Lateral meningocele (Lehman) syndrome: a child with a novel NOTCH3 mutation. Am J Med Genet A 170:1070\u20131075","journal-title":"Am J Med Genet A"},{"key":"9560_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.01.001","author":"L Yuan","year":"2024","unstructured":"Yuan L, Chen X, Jankovic J, Deng H (2024) CADASIL: a NOTCH3-associated cerebral small vessel disease. J Adv Res. https:\/\/doi.org\/10.1016\/j.jare.2024.01.001","journal-title":"J Adv Res"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-024-09560-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-024-09560-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-024-09560-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T03:18:59Z","timestamp":1738725539000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-024-09560-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["9560"],"URL":"https:\/\/doi.org\/10.1007\/s11033-024-09560-z","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,1]]},"assertion":[{"value":"26 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was approved by the ethical committee of National Institute for Medical Research Development under the approval ID: IR.NIMAD.REC.1399.066.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all participating subjects.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Consent to publish has been received from all the families.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors have no competing financial or non-financial interests to disclose.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"During the preparation of this work the authors used ChatGPT in order to improve readability and language. After using this tool\/service, the authors reviewed and edited the content as needed and take full responsibility for the content of the publication.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration of Generative AI and AI-assisted technologies in the writing process"}}],"article-number":"714"}}