{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T23:16:42Z","timestamp":1772666202071,"version":"3.50.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T00:00:00Z","timestamp":1714867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T00:00:00Z","timestamp":1714867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["F. No. 2019-4208\/SCR-BMS"],"award-info":[{"award-number":["F. No. 2019-4208\/SCR-BMS"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["EMDR\/SG\/9\/2023-0470"],"award-info":[{"award-number":["EMDR\/SG\/9\/2023-0470"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Biotechnology","award":["BT\/PR 13929\/MED\/31\/304\/2015"],"award-info":[{"award-number":["BT\/PR 13929\/MED\/31\/304\/2015"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s11033-024-09564-9","type":"journal-article","created":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T00:02:36Z","timestamp":1714867356000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Heterozygous RB1 mutation enhanced ATP production in human iPSC-derived retinal organoids"],"prefix":"10.1007","volume":"51","author":[{"given":"Ambily","family":"Vincent","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subramanian","family":"Krishnakumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sowmya","family":"Parameswaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,5,5]]},"reference":[{"issue":"7","key":"9564_CR1","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1158\/2159-8290.CD-14-0215","volume":"4","author":"CH Coschi","year":"2014","unstructured":"Coschi CH, Ishak CA, Gallo D, Marshall A, Talluri S, Wang J, Cecchini MJ, Martens AL, Percy V, Welch I, Boutros PC, Brown GW, Dick FA (2014) Haploinsufficiency of an RB-E2F1-condensin II complex leads to aberrant replication and aneuploidy. Cancer Discov 4(7):840\u2013853. https:\/\/doi.org\/10.1158\/2159-8290.CD-14-0215","journal-title":"Cancer Discov"},{"issue":"1","key":"9564_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2020.112263","volume":"396","author":"A Vincent","year":"2020","unstructured":"Vincent A, Natarajan V, Khetan V, Krishnakumar S, Parameswaran S (2020) Heterozygous retinoblastoma gene mutation compromises in vitro osteogenesis of adipose mesenchymal stem cells\u2014a temporal gene expression study. Exp Cell Res 396(1):112263. https:\/\/doi.org\/10.1016\/j.yexcr.2020.112263","journal-title":"Exp Cell Res"},{"issue":"2","key":"9564_CR3","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s00418-022-02105-0","volume":"158","author":"A Vincent","year":"2022","unstructured":"Vincent A, Natarajan V, Khetan V, Krishnakumar S, Parameswaran S (2022) Retinoblastoma patient-derived stem cells-an in vivo model to study the role of RB1 in adipogenesis. Histochem Cell Biol 158(2):181\u2013192. https:\/\/doi.org\/10.1007\/s00418-022-02105-0","journal-title":"Histochem Cell Biol"},{"issue":"16","key":"9564_CR4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2117857119","volume":"119","author":"J Tu","year":"2022","unstructured":"Tu J, Huo Z, Yu Y, Zhu D, Xu A, Huang MF, Hu R, Wang R, Gingold JA, Chen YH, Tsai KL, Forcioli-Conti NR, Huang SXL, Webb TR, Su J, Bazer DA, Jia P, Yustein JT, Wang LL, Hung MC, Zhao Z, Huff CD, Shen J, Zhao R, Lee DF (2022) Hereditary retinoblastoma iPSC model reveals aberrant spliceosome function driving bone malignancies. Proc Natl Acad Sci USA 119(16):e2117857119. https:\/\/doi.org\/10.1073\/pnas.2117857119","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"9564_CR5","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/ng.527","volume":"42","author":"AH Berger","year":"2010","unstructured":"Berger AH, Niki M, Morotti A, Taylor BS, Socci ND, Viale A, Brennan C, Szoke J, Motoi N, Rothman PB, Teruya-Feldstein J, Gerald WL, Ladanyi MPP, Pandolfi (2010) Identification of DOK genes as lung tumor suppressors. Nat Genet 42(3):216\u2013223. https:\/\/doi.org\/10.1038\/ng.527","journal-title":"Nat Genet"},{"issue":"7359","key":"9564_CR6","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/nature10275","volume":"476","author":"AH Berger","year":"2011","unstructured":"Berger AH, Knudson AG, Pandolfi PP (2011) A continuum model for tumour suppression. Nature 476(7359):163\u2013169. https:\/\/doi.org\/10.1038\/nature10275","journal-title":"Nature"},{"key":"9564_CR7","doi-asserted-by":"publisher","DOI":"10.1093\/pnasnexus\/pgac162","author":"YP Li","year":"2022","unstructured":"Li YP, Wang YT, Wang W, Zhang X, Shen RJ, Jin K, Jin LW, Jin ZB (2022) Second hit impels oncogenesis of retinoblastoma in patient-induced pluripotent stem cell-derived retinal organoids: direct evidence for Knudson\u2019s theory. PNAS Nexus. https:\/\/doi.org\/10.1093\/pnasnexus\/pgac162","journal-title":"PNAS Nexus"},{"issue":"4","key":"9564_CR8","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1093\/stcltm\/szac008","volume":"11","author":"A Rozanska","year":"2022","unstructured":"Rozanska A, Cerna-Chavez R, Queen R, Collin J, Zerti D, Dorgau B, Beh CS, Davey T, Coxhead J, Hussain R, Al-Aama J, Steel DH, Benvenisty N, Armstrong L, Parulekar M, Lako M (2022) pRB-depleted pluripotent stem cell retinal organoids recapitulate cell state transitions of retinoblastoma development and suggest an important role for pRB in retinal cell differentiation. Stem Cells Transl Med 11(4):415\u2013433. https:\/\/doi.org\/10.1093\/stcltm\/szac008","journal-title":"Stem Cells Transl Med"},{"issue":"9","key":"9564_CR9","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.3390\/cancers14092166","volume":"14","author":"D Kanber","year":"2022","unstructured":"Kanber D, Woestefeld J, D\u00f6pper H, Bozet M, Brenzel A, Altm\u00fcller J, Kilpert F, Lohmann D, Pommerenke C, Steenpass L (2022) RB1-negative retinal organoids display proliferation of cone photoreceptors and loss of retinal differentiation. Cancers 14(9):2166. https:\/\/doi.org\/10.3390\/cancers14092166","journal-title":"Cancers"},{"issue":"1","key":"9564_CR10","doi-asserted-by":"publisher","first-page":"4535","DOI":"10.1038\/s41467-021-24781-7","volume":"12","author":"JL Norrie","year":"2021","unstructured":"Norrie JL, Nityanandam A, Lai K, Chen X, Wilson M, Stewart E, Griffiths L, Jin H, Wu G, Orr B, Tran Q, Allen S, Reilly C, Zhou X, Zhang J, Newman K, Johnson D, Brennan R, Dyer MA (2021) Retinoblastoma from human stem cell-derived retinal organoids. Nat Commun 12(1):4535. https:\/\/doi.org\/10.1038\/s41467-021-24781-7","journal-title":"Nat Commun"},{"issue":"2","key":"9564_CR11","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.ydbio.2020.03.011","volume":"462","author":"C Zheng","year":"2020","unstructured":"Zheng C, Schneider JW, Hsieh J (2020) Role of RB1 in human embryonic stem cell-derived retinal organoids. Dev Biol 462(2):197\u2013207. https:\/\/doi.org\/10.1016\/j.ydbio.2020.03.011","journal-title":"Dev Biol"},{"key":"9564_CR12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2011780117","author":"H Liu","year":"2020","unstructured":"Liu H, Zhang Y, Zhang YY, Li YP, Hua ZQ, Zhang CJ, Wu KC, Yu F, Zhang Y, Su J, Jin ZB (2020) Human embryonic stem cell-derived organoid retinoblastoma reveals a cancerous origin. Proc Natl Acad Sci USA. https:\/\/doi.org\/10.1073\/pnas.2011780117","journal-title":"Proc Natl Acad Sci USA"},{"key":"9564_CR13","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.scr.2018.03.012","volume":"29","author":"A Vincent","year":"2018","unstructured":"Vincent A, Khetan V, Rishi P, Suganeswari G, Krishnakumar S, Krishnan UM, Parameswaran S (2018) Generation of a human induced pluripotent stem cell line (VRFi001-A) from orbital adipose tissue of a bilateral retinoblastoma patient with heterozygous RB1 gene deletion. Stem Cell Res 29:42\u201345. https:\/\/doi.org\/10.1016\/j.scr.2018.03.012","journal-title":"Stem Cell Res"},{"key":"9564_CR14","doi-asserted-by":"publisher","first-page":"4047","DOI":"10.1038\/ncomms5047","volume":"5","author":"X Zhong","year":"2014","unstructured":"Zhong X, Gutierrez C, Xue T, Hampton C, Vergara MN, Cao LH, Peters A, Park TS, Zambidis ET, Meyer JS, Gamm DM, Yau KW, Canto-Soler MV (2014) Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs. Nat Commun 5:4047. https:\/\/doi.org\/10.1038\/ncomms5047","journal-title":"Nat Commun"},{"issue":"20","key":"9564_CR15","doi-asserted-by":"publisher","first-page":"3182","DOI":"10.3390\/cells11203182","volume":"11","author":"V Suresh Babu","year":"2022","unstructured":"Suresh Babu V, Dudeja G, Sa D, Bisht A, Shetty R, Heymans S, Guha N, Ghosh A (2022) Lack of retinoblastoma protein shifts tumor metabolism from glycolysis to OXPHOS and allows the use of alternate fuels. Cells 11(20):3182. https:\/\/doi.org\/10.3390\/cells11203182","journal-title":"Cells"},{"issue":"2","key":"9564_CR16","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s00418-012-1028-y","volume":"139","author":"A Weise","year":"2013","unstructured":"Weise A, D\u00fcnker N (2013) High trefoil factor 1 (TFF1) expression in human retinoblastoma cells correlates with low growth kinetics, increased cyclin-dependent kinase (CDK) inhibitor levels and a selective down-regulation of CDK6. Histochem Cell Biol 139(2):323\u2013338. https:\/\/doi.org\/10.1007\/s00418-012-1028-y","journal-title":"Histochem Cell Biol"},{"issue":"6","key":"9564_CR17","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/j.cell.2005.04.017","volume":"121","author":"IG Kolfschoten","year":"2005","unstructured":"Kolfschoten IG, van Leeuwen B, Berns K, Mullenders J, Beijersbergen RL, Bernards R, Voorhoeve PM, Agami R (2005) A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity. Cell 121(6):849\u2013858. https:\/\/doi.org\/10.1016\/j.cell.2005.04.017","journal-title":"Cell"},{"issue":"43","key":"9564_CR18","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102(43):15545\u201315550. https:\/\/doi.org\/10.1073\/pnas.0506580102","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"9564_CR19","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s12177-011-9064-8","volume":"3","author":"SS Zhang","year":"2010","unstructured":"Zhang SS, Li H, Huang P, Lou LX, Fu XY, Barnstable CJ (2010) MAPK signaling during M\u00fcller glial cell development in retina explant cultures. J Ocul Biol Dis Informat 3(4):129\u2013133. https:\/\/doi.org\/10.1007\/s12177-011-9064-8","journal-title":"J Ocul Biol Dis Informat"},{"issue":"6","key":"9564_CR20","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/s0896-6273(03)00158-2","volume":"37","author":"DS Campbell","year":"2003","unstructured":"Campbell DS, Holt CE (2003) Apoptotic pathway and MAPKs differentially regulate chemotropic responses of retinal growth cones. Neuron 37(6):939\u2013952. https:\/\/doi.org\/10.1016\/s0896-6273(03)00158-2","journal-title":"Neuron"},{"key":"9564_CR21","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10447","author":"A Rajala","year":"2016","unstructured":"Rajala A, Wang Y, Rajala RV (2016) Activation of oncogenic tyrosine kinase signaling promotes insulin receptor-mediated cone photoreceptor survival. Oncotarget. https:\/\/doi.org\/10.18632\/oncotarget.10447","journal-title":"Oncotarget"},{"issue":"4","key":"9564_CR22","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1085\/jgp.201711919","volume":"150","author":"X Wen","year":"2018","unstructured":"Wen X, Van Hook MJ, Grassmeyer JJ, Wiesman AI, Rich GM, Cork KM, Thoreson WB (2018) Endocytosis sustains release at photoreceptor ribbon synapses by restoring fusion competence. J Gen Physiol 150(4):591\u2013611. https:\/\/doi.org\/10.1085\/jgp.201711919","journal-title":"J Gen Physiol"},{"issue":"1","key":"9564_CR23","doi-asserted-by":"publisher","first-page":"16075","DOI":"10.1038\/s41598-020-72828-4","volume":"10","author":"S Lalitha","year":"2020","unstructured":"Lalitha S, Basu B, Surya S, Meera V, Riya PA, Parvathy S, Das AV, Sivakumar KC, Nelson-Sathi S, James J (2020) Pax6 modulates intra-retinal axon guidance and fasciculation of retinal ganglion cells during retinogenesis. Sci Rep 10(1):16075. https:\/\/doi.org\/10.1038\/s41598-020-72828-4","journal-title":"Sci Rep"},{"key":"9564_CR24","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.trsl.2023.07.001","volume":"261","author":"VS Babu","year":"2023","unstructured":"Babu VS, Mallipatna A, Dudeja G, Shetty R, Nair AP, Tun SBB, Ho CEH, Chaurasia SS, Bhattacharya SS, Verma NK, Lakshminarayanan R, Guha N, Heymans S, Barathi VA, Ghosh A (2023) Depleted hexokinase1 and lack of AMPK\u03b1 activation favor OXPHOS-dependent energetics in retinoblastoma tumors. Transl Res: J Lab Clin Med 261:41\u201356. https:\/\/doi.org\/10.1016\/j.trsl.2023.07.001","journal-title":"Transl Res: J Lab Clin Med"},{"issue":"13","key":"9564_CR25","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1158\/0008-5472.CAN-21-4087","volume":"82","author":"AR Elhamamsy","year":"2022","unstructured":"Elhamamsy AR, Metge BJ, Alsheikh HA, Shevde LA, Samant RS (2022) Ribosome biogenesis: a central player in cancer metastasis and therapeutic resistance. Can Res 82(13):2344\u20132353. https:\/\/doi.org\/10.1158\/0008-5472.CAN-21-4087","journal-title":"Can Res"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-024-09564-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-024-09564-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-024-09564-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T03:05:31Z","timestamp":1738724731000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-024-09564-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,5]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["9564"],"URL":"https:\/\/doi.org\/10.1007\/s11033-024-09564-9","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,5]]},"assertion":[{"value":"9 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was conducted after obtaining approval from Institutional ethics committee (442\u20132015-P) and Institutional Committee for Stem Cell Research and Therapy (IC-SCRT) (04\u20132015-P).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"606"}}