{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T15:52:19Z","timestamp":1779292339103,"version":"3.51.4"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s11033-024-09604-4","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T16:01:52Z","timestamp":1715616112000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Intracerebroventricular PROK2 infusion could increase the secretion of male reproductive hormones by stimulating the HPG axis"],"prefix":"10.1007","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5527-8507","authenticated-orcid":false,"given":"Nesibe","family":"Yilmaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5686-7867","authenticated-orcid":false,"given":"Azibe","family":"Yildiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,5,13]]},"reference":[{"issue":"2","key":"9604_CR1","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1515\/hmbci-2015-0040","volume":"24","author":"W Traboulsi","year":"2015","unstructured":"Traboulsi W, Brouillet S, Sergent F, Boufettal H, Samouh N, Aboussaouira T et al (2015) Prokineticins in central and peripheral control of human reproduction. Horm Mol Biol Clin Investig 24(2):73\u201381. https:\/\/doi.org\/10.1515\/hmbci-2015-0040","journal-title":"Horm Mol Biol Clin Investig"},{"issue":"44","key":"9604_CR2","doi-asserted-by":"publisher","first-page":"17447","DOI":"10.1073\/pnas.0707173104","volume":"104","author":"N Pitteloud","year":"2007","unstructured":"Pitteloud N, Zhang C, Pignatelli D, Li JD, Raivio T, Cole LW et al (2007) Loss-of-function mutation in the prokineticin 2 gene causes Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism. Proc Natl Acad Sci USA 104(44):17447\u201317452. https:\/\/doi.org\/10.1073\/pnas.0707173104","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"9604_CR3","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.tem.2006.12.002","volume":"18","author":"D Maldonado-P\u00e9rez","year":"2007","unstructured":"Maldonado-P\u00e9rez D, Evans J, Denison F, Millar RP, Jabbour HN (2007) Potential roles of the prokineticins in reproduction. Trends Endocrinol Metab 18(2):66\u201372. https:\/\/doi.org\/10.1016\/j.tem.2006.12.002","journal-title":"Trends Endocrinol Metab"},{"issue":"2","key":"9604_CR4","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1210\/er.2010-0007","volume":"32","author":"C Martin","year":"2011","unstructured":"Martin C, Balasubramanian R, Dwyer AA, Au MG, Sidis Y, Kaiser UB et al (2011) The role of the prokineticin 2 pathway in human reproduction: evidence from the study of human and murine gene mutations. Endocr Rev 32(2):225\u2013246. https:\/\/doi.org\/10.1210\/er.2010-0007","journal-title":"Endocr Rev"},{"key":"9604_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10102389","author":"C Petrella","year":"2022","unstructured":"Petrella C, Spaziani M, D\u2019Orazi V, Tarani L, Terracina S, Tarani F et al (2022) Prokineticin 2\/PROK2 and male infertility. Biomedicines. https:\/\/doi.org\/10.3390\/biomedicines10102389","journal-title":"Biomedicines"},{"issue":"6","key":"9604_CR6","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1002\/cne.21087","volume":"498","author":"MY Cheng","year":"2006","unstructured":"Cheng MY, Leslie FM, Zhou QY (2006) Expression of prokineticins and their receptors in the adult mouse brain. J Comp Neurol 498(6):796\u2013809. https:\/\/doi.org\/10.1002\/cne.21087","journal-title":"J Comp Neurol"},{"key":"9604_CR7","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3390\/ijms222312735","volume":"22","author":"OO Oduwole","year":"2021","unstructured":"Oduwole OO, Huhtaniemi IT, Misrahi M (2021) The roles of luteinizing hormone, follicle-stimulating hormone and testosterone in spermatogenesis and folliculogenesis revisited. Int J Mol Sci 22:23","journal-title":"Int J Mol Sci"},{"issue":"3","key":"9604_CR8","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.ando.2022.04.010","volume":"83","author":"S Christin-Maitre","year":"2022","unstructured":"Christin-Maitre S, Young J (2022) Androgens and spermatogenesis. Ann Endocrinol 83(3):155\u2013158. https:\/\/doi.org\/10.1016\/j.ando.2022.04.010","journal-title":"Ann Endocrinol"},{"key":"9604_CR9","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.brainres.2009.03.021","volume":"1271","author":"Y Ji","year":"2009","unstructured":"Ji Y, Li X (2009) Cloning and developmental expression analysis of prokineticin 2 and its receptor PKR2 in the Syrian hamster surpachiasmatic nucleus. Brain Res 1271:18\u201326. https:\/\/doi.org\/10.1016\/j.brainres.2009.03.021","journal-title":"Brain Res"},{"issue":"9","key":"9604_CR10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007151","volume":"4","author":"C Zhang","year":"2009","unstructured":"Zhang C, Truong KK, Zhou Q-Y (2009) Efferent projections of prokineticin 2 expressing neurons in the mouse suprachiasmatic nucleus. PLoS ONE 4(9):e7151. https:\/\/doi.org\/10.1371\/journal.pone.0007151","journal-title":"PLoS ONE"},{"issue":"11","key":"9604_CR11","doi-asserted-by":"publisher","first-page":"4140","DOI":"10.1073\/pnas.0508881103","volume":"103","author":"S-I Matsumoto","year":"2006","unstructured":"Matsumoto S-I, Yamazaki C, Masumoto K-H, Nagano M, Naito M, Soga T et al (2006) Abnormal development of the olfactory bulb and reproductive system in mice lacking prokineticin receptor PKR2. Proc Natl Acad Sci USA 103(11):4140\u20134145. https:\/\/doi.org\/10.1073\/pnas.0508881103","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"9604_CR12","doi-asserted-by":"publisher","first-page":"397","DOI":"10.2337\/db09-1198","volume":"59","author":"JV Gardiner","year":"2010","unstructured":"Gardiner JV, Bataveljic A, Patel NA, Bewick GA, Roy D, Campbell D et al (2010) Prokineticin 2 is a hypothalamic neuropeptide that potently inhibits food intake. Diabetes 59(2):397\u2013406. https:\/\/doi.org\/10.2337\/db09-1198","journal-title":"Diabetes"},{"key":"9604_CR13","volume-title":"The rat brain in stereotaxic coordinates: hard cover","author":"G Paxinos","year":"2006","unstructured":"Paxinos G, Watson C (2006) The rat brain in stereotaxic coordinates: hard cover. Elsevier, Amsterdam"},{"issue":"6","key":"9604_CR14","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1007\/s12576-018-0595-7","volume":"68","author":"U Yilmaz","year":"2018","unstructured":"Yilmaz U, Tekin S, Demir M, Cigremis Y, Sandal S (2018) Effects of central FGF21 infusion on the hypothalamus-pituitary-thyroid axis and energy metabolism in rats. J Physiol Sci 68(6):781\u2013788. https:\/\/doi.org\/10.1007\/s12576-018-0595-7","journal-title":"J Physiol Sci"},{"key":"9604_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2023.114401","volume":"273","author":"U Yilmaz","year":"2023","unstructured":"Yilmaz U, Tanbek K (2023) Spexin may induce mitochondrial biogenesis in white and brown adipocytes via the hypothalamus-pituitary-thyroid (HPT) axis. Physiol Behav 273:114401. https:\/\/doi.org\/10.1016\/j.physbeh.2023.114401","journal-title":"Physiol Behav"},{"issue":"29","key":"9604_CR16","doi-asserted-by":"publisher","first-page":"74301","DOI":"10.1007\/s11356-023-27692-w","volume":"30","author":"A Yildiz","year":"2023","unstructured":"Yildiz A, Ozhan O, Ulu A, Dogan T, Bakar B, Ugur Y et al (2023) Effects of the apricot diets containing sulfur dioxide at different concentrations on rat testicles. Environ Sci Pollut Res Int 30(29):74301\u201374313. https:\/\/doi.org\/10.1007\/s11356-023-27692-w","journal-title":"Environ Sci Pollut Res Int"},{"issue":"5730","key":"9604_CR17","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1126\/science.1112103","volume":"308","author":"KL Ng","year":"2005","unstructured":"Ng KL, Li J-D, Cheng MY, Leslie FM, Lee AG, Zhou Q-Y (2005) Dependence of olfactory bulb neurogenesis on prokineticin 2 signaling. Science 308(5730):1923\u20131927","journal-title":"Science"},{"key":"9604_CR18","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.regpep.2013.10.002","volume":"187","author":"CK Boughton","year":"2013","unstructured":"Boughton CK, Patel SA, Thompson EL, Patterson M, Curtis AE, Amin A et al (2013) Neuromedin B stimulates the hypothalamic-pituitary-gonadal axis in male rats. Regul Pept 187:6\u201311. https:\/\/doi.org\/10.1016\/j.regpep.2013.10.002","journal-title":"Regul Pept"},{"issue":"4","key":"9604_CR19","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1111\/1440-1681.13061","volume":"46","author":"A Suszka-\u015awitek","year":"2019","unstructured":"Suszka-\u015awitek A, Pa\u0142asz A, Filipczyk \u0141, Menezes IC, Mordecka-Chamera K, Angelone T et al (2019) The GnRH analogues affect novel neuropeptide SMIM20\/phoenixin and GPR173 receptor expressions in the female rat hypothalamic-pituitary-gonadal (HPG) axis. Clin Exp Pharmacol Physiol 46(4):350\u2013359. https:\/\/doi.org\/10.1111\/1440-1681.13061","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"9604_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2022.102299","volume":"97","author":"T Parlak Ak","year":"2023","unstructured":"Parlak Ak T, Yaman M, Bayrakdar A, Bulmus O (2023) Expression of phoenixin-14 and nesfatin-1 in the hypothalamo-pituitary-gonadal axis in the phases of the estrous cycle. Neuropeptides 97:102299. https:\/\/doi.org\/10.1016\/j.npep.2022.102299","journal-title":"Neuropeptides"},{"issue":"2","key":"9604_CR21","doi-asserted-by":"publisher","first-page":"E278","DOI":"10.1152\/ajpendo.00028.2008","volume":"295","author":"BM McGowan","year":"2008","unstructured":"McGowan BM, Stanley SA, Donovan J, Thompson EL, Patterson M, Semjonous NM et al (2008) Relaxin-3 stimulates the hypothalamic-pituitary-gonadal axis. Am J Physiol Endocrinol Metab 295(2):E278\u2013E286. https:\/\/doi.org\/10.1152\/ajpendo.00028.2008","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1","key":"9604_CR22","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1159\/000357809","volume":"99","author":"H Matsui","year":"2014","unstructured":"Matsui H, Asami T (2014) Effects and therapeutic potentials of kisspeptin analogs: regulation of the hypothalamic-pituitary-gonadal axis. Neuroendocrinology 99(1):49\u201360. https:\/\/doi.org\/10.1159\/000357809","journal-title":"Neuroendocrinology"},{"issue":"10","key":"9604_CR23","doi-asserted-by":"publisher","first-page":"4113","DOI":"10.1210\/jc.2008-0958","volume":"93","author":"AP Abreu","year":"2008","unstructured":"Abreu AP, Trarbach EB, de Castro M, Frade Costa EM, Versiani B, Matias Baptista MT et al (2008) Loss-of-function mutations in the genes encoding prokineticin-2 or prokineticin receptor-2 cause autosomal recessive Kallmann syndrome. J Clin Endocrinol Metab 93(10):4113\u20134118. https:\/\/doi.org\/10.1210\/jc.2008-0958","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"9604_CR24","doi-asserted-by":"publisher","first-page":"3551","DOI":"10.1210\/jc.2007-2654","volume":"93","author":"LW Cole","year":"2008","unstructured":"Cole LW, Sidis Y, Zhang C, Quinton R, Plummer L, Pignatelli D et al (2008) Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophin-releasing hormone deficiency: molecular genetics and clinical spectrum. J Clin Endocrinol Metab 93(9):3551\u20133559. https:\/\/doi.org\/10.1210\/jc.2007-2654","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"9604_CR25","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1093\/hmg\/ddn318","volume":"18","author":"C Monnier","year":"2009","unstructured":"Monnier C, Dod\u00e9 C, Fabre L, Teixeira L, Labesse G, Pin JP et al (2009) PROKR2 missense mutations associated with Kallmann syndrome impair receptor signalling activity. Hum Mol Genet 18(1):75\u201381. https:\/\/doi.org\/10.1093\/hmg\/ddn318","journal-title":"Hum Mol Genet"},{"issue":"2","key":"9604_CR26","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1210\/jc.2009-0843","volume":"95","author":"J Sarfati","year":"2010","unstructured":"Sarfati J, Guiochon-Mantel A, Rondard P, Arnulf I, Garcia-Pinero A, Wolczynski S et al (2010) A comparative phenotypic study of kallmann syndrome patients carrying monoallelic and biallelic mutations in the prokineticin 2 or prokineticin receptor 2 genes. J Clin Endocrinol Metab 95(2):659\u2013669. https:\/\/doi.org\/10.1210\/jc.2009-0843","journal-title":"J Clin Endocrinol Metab"},{"key":"9604_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2012.05.033","author":"LH Tu","year":"2012","unstructured":"Tu LH, Yu LL, Xiong CL, Zhang HP (2012) Potential role of prokineticin 2 in experimental varicocele-induced rat testes. Urology. https:\/\/doi.org\/10.1016\/j.urology.2012.05.033","journal-title":"Urology"},{"issue":"5","key":"9604_CR28","doi-asserted-by":"publisher","first-page":"500","DOI":"10.4103\/aja.aja_109_19","volume":"22","author":"Y Li","year":"2020","unstructured":"Li Y, Zhou T, Su YF, Hu ZY, Wei JJ, Wang W et al (2020) Prokineticin 2 overexpression induces spermatocyte apoptosis in varicocele in rats. Asian J Androl 22(5):500\u2013506. https:\/\/doi.org\/10.4103\/aja.aja_109_19","journal-title":"Asian J Androl"},{"key":"9604_CR29","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1071\/RD23136","volume":"36","author":"H Wang","year":"2024","unstructured":"Wang H, Zhu B, Jing T, Yu L, Zhang K, Liu Y et al (2024) Lycopene inhibits apoptosis of mouse spermatocytes in varicocele via miR-23a\/b-induced downregulation of PROK2. Reprod Fertil Dev 36:4","journal-title":"Reprod Fertil Dev"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-024-09604-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-024-09604-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-024-09604-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T03:12:06Z","timestamp":1738725126000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-024-09604-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,13]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["9604"],"URL":"https:\/\/doi.org\/10.1007\/s11033-024-09604-4","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,13]]},"assertion":[{"value":"22 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The present study was approved by the Karabuk University Animal Experiments Local Ethics Committee on 09.06.2022 (22\/6\/8).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"656"}}