{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:17:33Z","timestamp":1790824653699,"version":"4.1.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Jongwha Kim","award":["2017R1D1A1B0403430314"],"award-info":[{"award-number":["2017R1D1A1B0403430314"]}]},{"name":"Yong-Han Paik","award":["NRF-2017R1A2B2002735"],"award-info":[{"award-number":["NRF-2017R1A2B2002735"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s11033-024-09868-w","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T04:02:15Z","timestamp":1725249735000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Exogenous S1P via S1P receptor 2 induces CTGF expression through Src-RhoA-ROCK-YAP pathway in hepatic stellate cells"],"prefix":"10.1007","volume":"51","author":[{"given":"Suhyun","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonghwa","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sera","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Hee","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wonseok","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Han","family":"Paik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,2]]},"reference":[{"key":"9868_CR1","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/s41575-023-00807-x","volume":"20","author":"L Hammerich","year":"2023","unstructured":"Hammerich L, Tacke F (2023) Hepatic inflammatory responses in liver fibrosis. Nat Rev Gastroenterol Hepatol 20:633\u2013646. https:\/\/doi.org\/10.1038\/s41575-023-00807-x","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"9868_CR2","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.addr.2017.05.007","volume":"121","author":"T Higashi","year":"2017","unstructured":"Higashi T, Friedman SL, Hoshida Y (2017) Hepatic stellate cells as key target in liver fibrosis. Adv Drug Deliv Rev 121:27\u201342. https:\/\/doi.org\/10.1016\/j.addr.2017.05.007","journal-title":"Adv Drug Deliv Rev"},{"key":"9868_CR3","doi-asserted-by":"publisher","unstructured":"Roehlen N, Crouchet E, Baumert TF (2020) Liver fibrosis: mechanistic concepts and therapeutic perspectives. Cells 9. https:\/\/doi.org\/10.3390\/cells9040875","DOI":"10.3390\/cells9040875"},{"key":"9868_CR4","doi-asserted-by":"publisher","first-page":"21018","DOI":"10.1038\/s41598-020-78056-0","volume":"10","author":"J Kim","year":"2020","unstructured":"Kim J et al (2020) Proline-rich tyrosine kinase 2 mediates transforming growth factor-beta-induced hepatic stellate cell activation and liver fibrosis. Sci Rep 10:21018. https:\/\/doi.org\/10.1038\/s41598-020-78056-0","journal-title":"Sci Rep"},{"key":"9868_CR5","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.jhep.2015.04.011","volume":"63","author":"I Mannaerts","year":"2015","unstructured":"Mannaerts I et al (2015) The Hippo pathway effector YAP controls mouse hepatic stellate cell activation. J Hepatol 63:679\u2013688. https:\/\/doi.org\/10.1016\/j.jhep.2015.04.011","journal-title":"J Hepatol"},{"key":"9868_CR6","doi-asserted-by":"publisher","unstructured":"Kim CL, Choi SH, Mo JS (2019) Role of the Hippo Pathway in Fibrosis and Cancer. Cells 8. https:\/\/doi.org\/10.3390\/cells8050468","DOI":"10.3390\/cells8050468"},{"key":"9868_CR7","doi-asserted-by":"publisher","unstructured":"Yu FX et al (2012) Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell 150, 780\u2013791 https:\/\/doi.org\/10.1016\/j.cell.2012.06.037; Correction : Volume 187, ISSUE 6, P1563-1564, March 4, (2024)","DOI":"10.1016\/j.cell.2012.06.037"},{"key":"9868_CR8","doi-asserted-by":"publisher","first-page":"2138","DOI":"10.1101\/gad.197582.112","volume":"26","author":"JS Mo","year":"2012","unstructured":"Mo JS, Yu FX, Gong R, Brown JH, Guan KL (2012) Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs). Genes Dev 26:2138\u20132143. https:\/\/doi.org\/10.1101\/gad.197582.112","journal-title":"Genes Dev"},{"key":"9868_CR9","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1101\/gad.262816.115","volume":"29","author":"T Moroishi","year":"2015","unstructured":"Moroishi T et al (2015) A YAP\/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis. Genes Dev 29:1271\u20131284. https:\/\/doi.org\/10.1101\/gad.262816.115","journal-title":"Genes Dev"},{"key":"9868_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1101\/gad.274027.115","volume":"30","author":"Z Meng","year":"2016","unstructured":"Meng Z, Moroishi T, Guan KL (2016) Mechanisms of Hippo pathway regulation. Genes Dev 30:1\u201317. https:\/\/doi.org\/10.1101\/gad.274027.115","journal-title":"Genes Dev"},{"key":"9868_CR11","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1038\/s41556-018-0142-z","volume":"20","author":"A Totaro","year":"2018","unstructured":"Totaro A, Panciera T, Piccolo S (2018) YAP\/TAZ upstream signals and downstream responses. Nat Cell Biol 20:888\u2013899. https:\/\/doi.org\/10.1038\/s41556-018-0142-z","journal-title":"Nat Cell Biol"},{"key":"9868_CR12","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1002\/cm.20472","volume":"67","author":"M Amano","year":"2010","unstructured":"Amano M, Nakayama M, Kaibuchi K (2010) Rho-kinase\/ROCK: a key regulator of the cytoskeleton and cell polarity. Cytoskeleton (Hoboken) 67:545\u2013554. https:\/\/doi.org\/10.1002\/cm.20472","journal-title":"Cytoskeleton (Hoboken)"},{"key":"9868_CR13","doi-asserted-by":"publisher","first-page":"579","DOI":"10.3389\/fphar.2017.00579","volume":"8","author":"B Gonzalez-Fernandez","year":"2017","unstructured":"Gonzalez-Fernandez B, Sanchez DI, Gonzalez-Gallego J, Tunon MJ (2017) Sphingosine 1-Phosphate signaling as a target in hepatic fibrosis therapy. Front Pharmacol 8:579. https:\/\/doi.org\/10.3389\/fphar.2017.00579","journal-title":"Front Pharmacol"},{"key":"9868_CR14","doi-asserted-by":"publisher","unstructured":"Kleuser B (2018) Divergent role of sphingosine 1-Phosphate in Liver Health and Disease. Int J Mol Sci 19. https:\/\/doi.org\/10.3390\/ijms19030722","DOI":"10.3390\/ijms19030722"},{"key":"9868_CR15","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.3892\/mmr.2014.2036","volume":"9","author":"X Cui","year":"2014","unstructured":"Cui X et al (2014) F\u2013actin cytoskeleton reorganization is associated with hepatic stellate cell activation. Mol Med Rep 9:1641\u20131647. https:\/\/doi.org\/10.3892\/mmr.2014.2036","journal-title":"Mol Med Rep"},{"key":"9868_CR16","doi-asserted-by":"publisher","first-page":"3788","DOI":"10.1158\/0008-5472.CAN-04-2311","volume":"65","author":"D Lepley","year":"2005","unstructured":"Lepley D, Paik JH, Hla T, Ferrer F (2005) The G protein-coupled receptor S1P2 regulates Rho\/Rho kinase pathway to inhibit tumor cell migration. Cancer Res 65:3788\u20133795. https:\/\/doi.org\/10.1158\/0008-5472.CAN-04-2311","journal-title":"Cancer Res"},{"key":"9868_CR17","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/j.chembiol.2012.07.005","volume":"19","author":"E Miller","year":"2012","unstructured":"Miller E et al (2012) Identification of serum-derived sphingosine-1-phosphate as a small molecule regulator of YAP. Chem Biol 19:955\u2013962. https:\/\/doi.org\/10.1016\/j.chembiol.2012.07.005","journal-title":"Chem Biol"},{"key":"9868_CR18","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1101\/gad.210773.112","volume":"27","author":"FX Yu","year":"2013","unstructured":"Yu FX, Guan KL (2013) The Hippo pathway: regulators and regulations. Genes Dev 27:355\u2013371. https:\/\/doi.org\/10.1101\/gad.210773.112","journal-title":"Genes Dev"},{"key":"9868_CR19","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1016\/j.bbamem.2006.06.015","volume":"1758","author":"C Donati","year":"2006","unstructured":"Donati C, Bruni P (2006) Sphingosine 1-phosphate regulates cytoskeleton dynamics: implications in its biological response. Biochim Biophys Acta 1758:2037\u20132048. https:\/\/doi.org\/10.1016\/j.bbamem.2006.06.015","journal-title":"Biochim Biophys Acta"},{"key":"9868_CR20","doi-asserted-by":"publisher","unstructured":"McGarrigle D, Huang XY (2007) GPCRs signaling directly through src-family kinases. Sci STKE 2007(pe35). https:\/\/doi.org\/10.1126\/stke.3922007pe35","DOI":"10.1126\/stke.3922007pe35"},{"key":"9868_CR21","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1080\/08923973.2016.1263860","volume":"39","author":"A Mohammadalipour","year":"2017","unstructured":"Mohammadalipour A et al (2017) Dasatinib prevent hepatic fibrosis induced by carbon tetrachloride (CCl(4)) via anti-inflammatory and antioxidant mechanism. Immunopharmacol Immunotoxicol 39:19\u201327. https:\/\/doi.org\/10.1080\/08923973.2016.1263860","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"9868_CR22","doi-asserted-by":"publisher","unstructured":"Seo HY et al (2020) Src inhibition attenuates liver fibrosis by preventing hepatic stellate cell activation and decreasing connetive tissue growth factor. Cells 9. https:\/\/doi.org\/10.3390\/cells9030558","DOI":"10.3390\/cells9030558"},{"key":"9868_CR23","doi-asserted-by":"publisher","first-page":"1183808","DOI":"10.3389\/fmolb.2023.1183808","volume":"10","author":"YQ Zhao","year":"2023","unstructured":"Zhao YQ et al (2023) Mechanical homeostasis imbalance in hepatic stellate cells activation and hepatic fibrosis. Front Mol Biosci 10:1183808. https:\/\/doi.org\/10.3389\/fmolb.2023.1183808","journal-title":"Front Mol Biosci"},{"key":"9868_CR24","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1016\/j.jhep.2010.08.028","volume":"54","author":"C Li","year":"2011","unstructured":"Li C et al (2011) Sphingosine 1-phosphate (S1P)\/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility. J Hepatol 54:1205\u20131213. https:\/\/doi.org\/10.1016\/j.jhep.2010.08.028","journal-title":"J Hepatol"},{"key":"9868_CR25","doi-asserted-by":"publisher","first-page":"2370","DOI":"10.1002\/jcp.22572","volume":"226","author":"X Liu","year":"2011","unstructured":"Liu X et al (2011) Essential roles of sphingosine 1-phosphate receptor types 1 and 3 in human hepatic stellate cells motility and activation. J Cell Physiol 226:2370\u20132377. https:\/\/doi.org\/10.1002\/jcp.22572","journal-title":"J Cell Physiol"},{"key":"9868_CR26","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.jhep.2013.02.021","volume":"59","author":"L Yang","year":"2013","unstructured":"Yang L et al (2013) Sphingosine kinase\/sphingosine 1-phosphate (S1P)\/S1P receptor axis is involved in liver fibrosis-associated angiogenesis. J Hepatol 59:114\u2013123. https:\/\/doi.org\/10.1016\/j.jhep.2013.02.021","journal-title":"J Hepatol"},{"key":"9868_CR27","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1053\/gast.2003.50049","volume":"124","author":"H Ikeda","year":"2003","unstructured":"Ikeda H et al (2003) Antiproliferative property of sphingosine 1-phosphate in rat hepatocytes involves activation of rho via Edg-5. Gastroenterology 124:459\u2013469. https:\/\/doi.org\/10.1053\/gast.2003.50049","journal-title":"Gastroenterology"},{"key":"9868_CR28","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1194\/jlr.M800496-JLR200","volume":"50","author":"H Ikeda","year":"2009","unstructured":"Ikeda H et al (2009) Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2. J Lipid Res 50:556\u2013564. https:\/\/doi.org\/10.1194\/jlr.M800496-JLR200","journal-title":"J Lipid Res"},{"key":"9868_CR29","doi-asserted-by":"publisher","first-page":"G304","DOI":"10.1152\/ajpgi.2000.279.2.G304","volume":"279","author":"H Ikeda","year":"2000","unstructured":"Ikeda H et al (2000) Biological activities of novel lipid mediator sphingosine 1-phosphate in rat hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 279:G304\u2013310. https:\/\/doi.org\/10.1152\/ajpgi.2000.279.2.G304","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"9868_CR30","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1159\/000315108","volume":"26","author":"MH Graler","year":"2010","unstructured":"Graler MH (2010) Targeting sphingosine 1-phosphate (S1P) levels and S1P receptor functions for therapeutic immune interventions. Cell Physiol Biochem 26:79\u201386. https:\/\/doi.org\/10.1159\/000315108","journal-title":"Cell Physiol Biochem"},{"key":"9868_CR31","doi-asserted-by":"publisher","first-page":"e1800370","DOI":"10.1002\/pmic.201800370","volume":"19","author":"V Brovkovych","year":"2019","unstructured":"Brovkovych V, Aldrich A, Li N, Atilla-Gokcumen GE, Frasor J (2019) Removal of serum lipids and lipid-derived metabolites to investigate breast Cancer Cell Biology. Proteomics 19:e1800370. https:\/\/doi.org\/10.1002\/pmic.201800370","journal-title":"Proteomics"},{"key":"9868_CR32","doi-asserted-by":"publisher","first-page":"117","DOI":"10.3389\/fphar.2018.00117","volume":"9","author":"S Onder","year":"2018","unstructured":"Onder S, Tacal O, Lockridge O (2018) Delipidation of plasma has minimal effects on Human Butyrylcholinesterase. Front Pharmacol 9:117. https:\/\/doi.org\/10.3389\/fphar.2018.00117","journal-title":"Front Pharmacol"},{"key":"9868_CR33","doi-asserted-by":"publisher","first-page":"113341","DOI":"10.1016\/j.biopha.2022.113341","volume":"153","author":"H Chen","year":"2022","unstructured":"Chen H et al (2022) Sphingosine 1-phosphate receptor, a new therapeutic direction in different diseases. Biomed Pharmacother 153:113341. https:\/\/doi.org\/10.1016\/j.biopha.2022.113341","journal-title":"Biomed Pharmacother"},{"key":"9868_CR34","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1177\/2040622315617354","volume":"7","author":"D D\u2019Ambrosio","year":"2016","unstructured":"D\u2019Ambrosio D, Freedman MS, Prinz J (2016) Ponesimod, a selective S1P1 receptor modulator: a potential treatment for multiple sclerosis and other immune-mediated diseases. Ther Adv Chronic Dis 7:18\u201333. https:\/\/doi.org\/10.1177\/2040622315617354","journal-title":"Ther Adv Chronic Dis"},{"key":"9868_CR35","doi-asserted-by":"publisher","first-page":"892097","DOI":"10.3389\/fphar.2022.892097","volume":"13","author":"JV Selkirk","year":"2022","unstructured":"Selkirk JV, Bortolato A, Yan YG, Ching N, Hargreaves R (2022) Competitive binding of Ozanimod and other Sphingosine 1-Phosphate receptor modulators at receptor subtypes 1 and 5. Front Pharmacol 13:892097. https:\/\/doi.org\/10.3389\/fphar.2022.892097","journal-title":"Front Pharmacol"},{"key":"9868_CR36","doi-asserted-by":"publisher","first-page":"9731","DOI":"10.1038\/s41598-019-46282-w","volume":"9","author":"S Wang","year":"2019","unstructured":"Wang S et al (2019) Actin stabilizing compounds show specific biological effects due to their binding mode. Sci Rep 9:9731. https:\/\/doi.org\/10.1038\/s41598-019-46282-w","journal-title":"Sci Rep"},{"key":"9868_CR37","doi-asserted-by":"publisher","unstructured":"Fujiwara I, Zweifel ME, Courtemanche N, Pollard TD (2018) Latrunculin A accelerates actin filament depolymerization in addition to sequestering actin monomers. Curr Biol 28(3183\u20133192 e3182). https:\/\/doi.org\/10.1016\/j.cub.2018.07.082","DOI":"10.1016\/j.cub.2018.07.082"},{"key":"9868_CR38","doi-asserted-by":"publisher","first-page":"e0147005","DOI":"10.1371\/journal.pone.0147005","volume":"11","author":"FF Cruz","year":"2016","unstructured":"Cruz FF et al (2016) Dasatinib reduces lung inflammation and fibrosis in Acute Experimental Silicosis. PLoS ONE 11:e0147005. https:\/\/doi.org\/10.1371\/journal.pone.0147005","journal-title":"PLoS ONE"},{"key":"9868_CR39","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1242\/jcs.039446","volume":"122","author":"S Huveneers","year":"2009","unstructured":"Huveneers S, Danen EH (2009) Adhesion signaling - crosstalk between integrins, Src and Rho. J Cell Sci 122:1059\u20131069. https:\/\/doi.org\/10.1242\/jcs.039446","journal-title":"J Cell Sci"},{"key":"9868_CR40","doi-asserted-by":"publisher","unstructured":"Sen B, M Johnson F (2011) Regulation of SRC family kinases in human cancers. J Signal Transduct 2011(865819). https:\/\/doi.org\/10.1155\/2011\/865819","DOI":"10.1155\/2011\/865819"},{"key":"9868_CR41","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1038\/s41573-020-0070-z","volume":"19","author":"A Dey","year":"2020","unstructured":"Dey A, Varelas X, Guan KL (2020) Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine. Nat Rev Drug Discov 19:480\u2013494. https:\/\/doi.org\/10.1038\/s41573-020-0070-z","journal-title":"Nat Rev Drug Discov"},{"key":"9868_CR42","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1016\/S0140-6736(23)00061-2","volume":"401","author":"WJ Sandborn","year":"2023","unstructured":"Sandborn WJ et al (2023) Etrasimod as induction and maintenance therapy for ulcerative colitis (ELEVATE): two randomised, double-blind, placebo-controlled, phase 3 studies. Lancet 401:1159\u20131171. https:\/\/doi.org\/10.1016\/S0140-6736(23)00061-2","journal-title":"Lancet"},{"key":"9868_CR43","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.jhep.2023.03.018","volume":"79","author":"S Baweja","year":"2023","unstructured":"Baweja S et al (2023) Hepatopulmonary syndrome is associated with low sphingosine-1-phosphate levels and can be ameliorated by the functional agonist fingolimod. J Hepatol 79:167\u2013180. https:\/\/doi.org\/10.1016\/j.jhep.2023.03.018","journal-title":"J Hepatol"},{"key":"9868_CR44","doi-asserted-by":"publisher","first-page":"e22905","DOI":"10.1096\/fj.202201954R","volume":"37","author":"Y Liao","year":"2023","unstructured":"Liao Y et al (2023) Liver sinusoidal endothelial S1pr2 regulates experimental liver fibrosis through YAP\/TGF-beta signaling pathway. FASEB J 37:e22905. https:\/\/doi.org\/10.1096\/fj.202201954R","journal-title":"FASEB J"},{"key":"9868_CR45","doi-asserted-by":"publisher","unstructured":"Zhou J et al (2023) JTE-013 alleviates pulmonary fibrosis by affecting the RhoA\/YAP Pathway and mitochondrial Fusion\/Fission. Pharmaceuticals (Basel) 16. https:\/\/doi.org\/10.3390\/ph16101444","DOI":"10.3390\/ph16101444"},{"key":"9868_CR46","doi-asserted-by":"publisher","first-page":"F752","DOI":"10.1152\/ajprenal.00596.2017","volume":"315","author":"X Zhang","year":"2018","unstructured":"Zhang X, Ritter JK, Li N (2018) Sphingosine-1-phosphate pathway in renal fibrosis. Am J Physiol Ren Physiol 315:F752\u2013F756. https:\/\/doi.org\/10.1152\/ajprenal.00596.2017","journal-title":"Am J Physiol Ren Physiol"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-024-09868-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-024-09868-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-024-09868-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T23:15:05Z","timestamp":1738710905000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-024-09868-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,2]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["9868"],"URL":"https:\/\/doi.org\/10.1007\/s11033-024-09868-w","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,2]]},"assertion":[{"value":"19 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All cells were handled at the institute\u2019s (Samsung Medical Center Laboratory Animal Research Center, Seoul, Korea) facility. The study was performed in accordance with the legal and institutional guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"950"}}