{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T11:14:49Z","timestamp":1783077289117,"version":"3.54.6"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Malaysian Ministry of Higher Education","doi-asserted-by":"crossref","award":["FRGS\/1\/2019\/SKK08\/TAYLOR\/02\/2"],"award-info":[{"award-number":["FRGS\/1\/2019\/SKK08\/TAYLOR\/02\/2"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003093","name":"Malaysian Ministry of Higher Education","doi-asserted-by":"crossref","award":["FRGS\/1\/2019\/SKK08\/TAYLOR\/02\/2"],"award-info":[{"award-number":["FRGS\/1\/2019\/SKK08\/TAYLOR\/02\/2"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003093","name":"Malaysian Ministry of Higher Education","doi-asserted-by":"crossref","award":["FRGS\/1\/2019\/SKK08\/TAYLOR\/02\/2"],"award-info":[{"award-number":["FRGS\/1\/2019\/SKK08\/TAYLOR\/02\/2"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s11033-024-09946-z","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T13:02:59Z","timestamp":1727442179000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The senescent marker p16INK4a enhances macrophage foam cells formation"],"prefix":"10.1007","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8803-9035","authenticated-orcid":false,"given":"Wei Sheng","family":"Siew","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7327-2830","authenticated-orcid":false,"given":"Yin Quan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1006-3649","authenticated-orcid":false,"given":"Bey Hing","family":"Goh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8116-6018","authenticated-orcid":false,"given":"Wei Hsum","family":"Yap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"key":"9946_CR1","unstructured":"WHO (2021) Cardiovascular diseases (CVDs). World Health Organization. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cardiovascular-diseases-(cvds) Accessed 21 August 2024"},{"issue":"4","key":"9946_CR2","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.tem.2015.01.008","volume":"26","author":"SA Hannou","year":"2015","unstructured":"Hannou SA, Wouters K, Paumelle R, Staels B (2015) Functional genomics of the CDKN2A\/B locus in cardiovascular and metabolic disease: what have we learned from GWASs? Trends Endocrinol Metabolism 26(4):176\u2013184. https:\/\/doi.org\/10.1016\/j.tem.2015.01.008","journal-title":"Trends Endocrinol Metabolism"},{"issue":"4","key":"9946_CR3","doi-asserted-by":"publisher","first-page":"3100","DOI":"10.3892\/etm.2019.7884","volume":"18","author":"S Nikulina","year":"2019","unstructured":"Nikulina S, Artyukhov I, Shesternya P, Gavrilyuk O, Maksimov V, Voyevoda M, Brusentsov D (2019) Clinical application of chromosome 9p21.3 genotyping in patients with coronary artery disease. Exp Ther Med 18(4):3100\u20133108. https:\/\/doi.org\/10.3892\/etm.2019.7884","journal-title":"Exp Ther Med"},{"issue":"7287","key":"9946_CR4","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/nature08801","volume":"464","author":"A Visel","year":"2010","unstructured":"Visel A, Zhu Y, May D, Afzal V, Gong E, Attanasio C, Blow MJ, Cohen JC, Rubin EM, Pennacchio LA (2010) Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice. Nature 464(7287):409\u2013412. https:\/\/doi.org\/10.1038\/nature08801","journal-title":"Nature"},{"issue":"3","key":"9946_CR5","doi-asserted-by":"publisher","first-page":"e32440","DOI":"10.1371\/journal.pone.0032440","volume":"7","author":"K Wouters","year":"2012","unstructured":"Wouters K, Cudejko C, Gijbels MJJ, Fuentes L, Bantubungi K, Vanhoutte J, Di\u00e8vart R, Paquet C, Bouchaert E, Hannou SA, Gizard F, Tailleux A, de Winther MPJ, Staels B, Paumelle R (2012) Bone marrow p16INK4a-deficiency does not modulate obesity, glucose homeostasis or atherosclerosis development. PLoS ONE 7(3):e32440\u2013e32440. https:\/\/doi.org\/10.1371\/journal.pone.0032440","journal-title":"PLoS ONE"},{"issue":"1","key":"9946_CR6","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.cardiores.2006.06.004","volume":"72","author":"I Gorenne","year":"2006","unstructured":"Gorenne I, Kavurma M, Scott S, Bennett M (2006) Vascular smooth muscle cell senescence in atherosclerosis. Cardiovascular Res 72(1):9\u201317. https:\/\/doi.org\/10.1016\/j.cardiores.2006.06.004","journal-title":"Cardiovascular Res"},{"issue":"11","key":"9946_CR7","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1161\/ATVBAHA.111.234492","volume":"31","author":"C-L Kuo","year":"2011","unstructured":"Kuo C-L, Murphy AJ, Sayers S, Li R, Yvan-Charvet L, Davis JZ, Krishnamurthy J, Liu Y, Puig O, Sharpless NE, Tall AR, Welch CL (2011) Cdkn2a is an atherosclerosis modifier locus that regulates monocyte\/macrophage proliferation. Arterioscler Thromb Vasc Biol 31(11):2483\u20132492. https:\/\/doi.org\/10.1161\/ATVBAHA.111.234492","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"9","key":"9946_CR8","doi-asserted-by":"publisher","first-page":"2556","DOI":"10.1182\/blood-2010-10-313106","volume":"118","author":"C Cudejko","year":"2011","unstructured":"Cudejko C, Wouters K, Fuentes L, Hannou SA, Paquet C, Bantubungi K, Bouchaert E, Vanhoutte J, Fleury S, Remy P, Tailleux A, Chinetti-Gbaguidi G, Dombrowicz D, Staels B, Paumelle R (2011) p16INK4a deficiency promotes IL-4-induced polarization and inhibits proinflammatory signaling in macrophages. Blood 118(9):2556\u20132566. https:\/\/doi.org\/10.1182\/blood-2010-10-313106","journal-title":"Blood"},{"issue":"6311","key":"9946_CR9","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1126\/science.aaf6659","volume":"354","author":"BG Childs","year":"2016","unstructured":"Childs BG, Baker DJ, Wijshake T, Conover CA, Campisi J, van Deursen JM (2016) Senescent intimal foam cells are deleterious at all stages of atherosclerosis. Science 354(6311):472\u2013477. https:\/\/doi.org\/10.1126\/science.aaf6659","journal-title":"Science"},{"issue":"7","key":"9946_CR10","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1093\/cvr\/cvab208","volume":"118","author":"AM Garrido","year":"2021","unstructured":"Garrido AM, Kaistha A, Uryga AK, Oc S, Foote K, Shah A, Finigan A, Figg N, Dobnikar L, J\u00f8rgensen H, Bennett M (2021) Efficacy and limitations of senolysis in atherosclerosis. Cardiovascular Res 118(7):1713\u20131727. https:\/\/doi.org\/10.1093\/cvr\/cvab208","journal-title":"Cardiovascular Res"},{"key":"9946_CR11","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.trsl.2018.08.003","volume":"203","author":"\u00c1 Vinu\u00c9","year":"2019","unstructured":"Vinu\u00c9 \u00c1, Mart\u00cdnez-Herv\u00c1s S, Herrero-Cervera A, S\u00c1nchez-Garc\u00cda V, Andr\u00c9s-Blasco I, Piqueras L, Sanz MJ, Real JT, Ascaso JF, Burks DJ, Gonz\u00c1lez-Navarro H (2019) Changes in CDKN2A\/2B expression associate with T-cell phenotype modulation in atherosclerosis and type 2 diabetes mellitus. Translational Res 203:31\u201348. https:\/\/doi.org\/10.1016\/j.trsl.2018.08.003","journal-title":"Translational Res"},{"key":"9946_CR12","doi-asserted-by":"publisher","first-page":"116531","DOI":"10.1016\/j.taap.2023.116531","volume":"468","author":"AC Postmus","year":"2023","unstructured":"Postmus AC, Kruit JK, Eilers RE, Havinga R, Koster MH, Johmura Y, Nakanishi M, van de Sluis B, Jonker JW (2023) The chemotherapeutic drug doxorubicin does not exacerbate p16Ink4a-positive senescent cell accumulation and cardiometabolic disease development in young adult female LDLR-deficient mice. Toxicol Appl Pharmcol 468:116531. https:\/\/doi.org\/10.1016\/j.taap.2023.116531","journal-title":"Toxicol Appl Pharmcol"},{"issue":"7","key":"9946_CR13","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.4049\/jimmunol.2100284","volume":"207","author":"S Sadhu","year":"2021","unstructured":"Sadhu S, Decker C, Sansbury BE, Marinello M, Seyfried A, Howard J, Mori M, Hosseini Z, Arunachalam T, Finn AV, Lamar JM, Jourd\u2019heuil D, Guo L, MacNamara KC, Spite M, Fredman G (2021) Radiation-Induced Macrophage Senescence impairs Resolution Programs and drives Cardiovascular inflammation. J Immunol 207(7):1812\u20131823. https:\/\/doi.org\/10.4049\/jimmunol.2100284","journal-title":"J Immunol"},{"issue":"1","key":"9946_CR14","doi-asserted-by":"publisher","first-page":"e2055","DOI":"10.1038\/cddis.2015.416","volume":"7","author":"L Wang","year":"2016","unstructured":"Wang L, Jiang Y, Song X, Guo C, Zhu F, Wang X, Wang Q, Shi Y, Wang J, Gao F, Zhao W, Chen YH, Zhang L (2016) Pdcd4 deficiency enhances macrophage lipoautophagy and attenuates foam cell formation and atherosclerosis in mice. Cell Death Dis 7(1):e2055\u2013e2055. https:\/\/doi.org\/10.1038\/cddis.2015.416","journal-title":"Cell Death Dis"},{"key":"9946_CR15","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.yjmcc.2016.08.002","volume":"98","author":"T Wang","year":"2016","unstructured":"Wang T, Zhang L, Hu J, Duan Y, Zhang M, Lin J, Man W, Pan X, Jiang Z, Zhang G, Gao B, Wang H, Sun D (2016) Mst1 participates in the atherosclerosis progression through macrophage autophagy inhibition and macrophage apoptosis enhancement. J Mol Cell Cardiol 98:108\u2013116. https:\/\/doi.org\/10.1016\/j.yjmcc.2016.08.002","journal-title":"J Mol Cell Cardiol"},{"issue":"1","key":"9946_CR16","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1080\/15548627.2017.1327942","volume":"14","author":"S-J Jeong","year":"2018","unstructured":"Jeong S-J, Kim S, Park J-G, Jung I-h, Lee M-N, Jeon S, Kweon HY, Yu D-Y, Lee S-H, Jang Y, Kang SW, Han K-H, Miller YI, Park YM, Cheong C, Choi J-H, Oh GT (2018) Prdx1 (peroxiredoxin 1) deficiency reduces cholesterol efflux via impaired macrophage lipophagic flux. Autophagy 14(1):120\u2013133. https:\/\/doi.org\/10.1080\/15548627.2017.1327942","journal-title":"Autophagy"},{"key":"9946_CR17","doi-asserted-by":"publisher","first-page":"119658","DOI":"10.1016\/j.lfs.2021.119658","volume":"278","author":"BK Ooi","year":"2021","unstructured":"Ooi BK, Phang SW, Yong PVC, Chellappan DK, Dua K, Khaw K-Y, Goh BH, Pusparajah P, Yap WH (2021) In vitro evaluation of the involvement of Nrf2 in maslinic acid-mediated anti-inflammatory effects in atheroma pathogenesis. Life Sci 278:119658. https:\/\/doi.org\/10.1016\/j.lfs.2021.119658","journal-title":"Life Sci"},{"key":"9946_CR18","doi-asserted-by":"publisher","first-page":"106675","DOI":"10.1016\/j.vph.2020.106675","volume":"128\u2013129","author":"SW Phang","year":"2020","unstructured":"Phang SW, Ooi BK, Ahemad N, Yap WH (2020) Maslinic acid suppresses macrophage foam cells formation: regulation of monocyte recruitment and macrophage lipids homeostasis. Vascul Pharmacol 128\u2013129:106675. https:\/\/doi.org\/10.1016\/j.vph.2020.106675","journal-title":"Vascul Pharmacol"},{"issue":"5","key":"9946_CR19","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s10616-010-9290-0","volume":"62","author":"S Xu","year":"2010","unstructured":"Xu S, Huang Y, Xie Y, Lan T, Le K, Chen J, Chen S, Gao S, Xu X, Shen X, Huang H, Liu P (2010) Evaluation of foam cell formation in cultured macrophages: an improved method with Oil Red O staining and DiI-oxLDL uptake. Cytotechnology 62(5):473\u2013481. https:\/\/doi.org\/10.1007\/s10616-010-9290-0","journal-title":"Cytotechnology"},{"issue":"4","key":"9946_CR20","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2009\u2013 \u2206\u2206CT method. Methods 25(4):402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"key":"9946_CR21","doi-asserted-by":"crossref","unstructured":"Ooi BK, Ahemad N (2019) Yap WH A reliable and reproducible assay for determining the effect of natural product on macrophages lipid uptake and cholesterol efflux: a case study of maslinic acid. In","DOI":"10.36877\/pddbs.a0000031"},{"key":"9946_CR22","doi-asserted-by":"publisher","unstructured":"Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proceedings of the National Academy of Sciences 92 (20):9363\u20139367. doi:https:\/\/doi.org\/10.1073\/pnas.92.20.9363","DOI":"10.1073\/pnas.92.20.9363"},{"key":"9946_CR23","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.atherosclerosis.2018.12.009","volume":"281","author":"K Ackermann","year":"2019","unstructured":"Ackermann K, Bonaterra GA, Kinscherf R, Schwarz A (2019) Growth differentiation factor-15 regulates oxLDL-induced lipid homeostasis and autophagy in human macrophages. Atherosclerosis 281:128\u2013136. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2018.12.009","journal-title":"Atherosclerosis"},{"issue":"4","key":"9946_CR24","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.3892\/ijmm.2019.4300","volume":"44","author":"T Sun","year":"2019","unstructured":"Sun T, Chen Q, Zhu SY, Wu Q, Liao CR, Wang Z, Wu XH, Wu HT, Chen JT (2019) Hydroxytyrosol promotes autophagy by regulating SIRT1 against advanced oxidation protein product\u2013induced NADPH oxidase and inflammatory response. Int J Mol Med 44(4):1531\u20131540. https:\/\/doi.org\/10.3892\/ijmm.2019.4300","journal-title":"Int J Mol Med"},{"issue":"23","key":"9946_CR25","doi-asserted-by":"publisher","first-page":"6093","DOI":"10.3390\/ijms20236093","volume":"20","author":"H Cao","year":"2019","unstructured":"Cao H, Jia Q, Yan L, Chen C, Xing S, Shen D (2019) Quercetin suppresses the progression of atherosclerosis by regulating MST1-Mediated autophagy in ox-LDL-Induced RAW264.7 macrophage foam cells. Int J Mol Sci 20(23):6093. https:\/\/doi.org\/10.3390\/ijms20236093","journal-title":"Int J Mol Sci"},{"issue":"1","key":"9946_CR26","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1161\/ATVBAHA.108.176644","volume":"29","author":"JJ Manning-Tobin","year":"2009","unstructured":"Manning-Tobin JJ, Moore KJ, Seimon TA, Bell SA, Sharuk M, Alvarez-Leite JI, Winther MPJd, Tabas I, Freeman MW (2009) Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating Foam cell formation in hyperlipidemic mice. Arterioscler Thromb Vasc Biol 29(1):19\u201326. https:\/\/doi.org\/10.1161\/ATVBAHA.108.176644","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"9946_CR27","unstructured":"Mehta JL (2004) The role of LOX-1, a novel lectin-like receptor for oxidized low density lipoprotein, in atherosclerosis. Can J Cardiol 20 Suppl B:32B-36B"},{"issue":"21","key":"9946_CR28","doi-asserted-by":"publisher","first-page":"13059","DOI":"10.3390\/ijms232113059","volume":"23","author":"DM Vellasamy","year":"2022","unstructured":"Vellasamy DM, Lee S-J, Goh KW, Goh B-H, Tang Y-Q, Ming LC, Yap WH (2022) Targeting Immune Senescence in Atherosclerosis. Int J Mol Sci 23(21):13059","journal-title":"Int J Mol Sci"},{"issue":"12","key":"9946_CR29","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1161\/CIRCRESAHA.108.172064","volume":"102","author":"K Chen","year":"2008","unstructured":"Chen K, Febbraio M, Li W, Silverstein RL (2008) A specific CD36-Dependent signaling pathway is required for platelet activation by oxidized Low-Density Lipoprotein. Circul Res 102(12):1512\u20131519. https:\/\/doi.org\/10.1161\/CIRCRESAHA.108.172064","journal-title":"Circul Res"},{"issue":"4","key":"9946_CR30","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1039\/C8MO00099A","volume":"14","author":"M Saitou","year":"2018","unstructured":"Saitou M, Lizardo DY, Taskent RO, Millner A, Gokcumen O, Atilla-Gokcumen GE (2018) An evolutionary transcriptomics approach links CD36 to membrane remodeling in replicative senescence. Mol Omics 14(4):237\u2013246. https:\/\/doi.org\/10.1039\/C8MO00099A","journal-title":"Mol Omics"},{"issue":"4","key":"9946_CR31","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.3892\/ijmm.2018.3416","volume":"41","author":"PY Hsu","year":"2018","unstructured":"Hsu PY, Lin WY, Lin RT, Juo SHH (2018) MicroRNA let-7\u00a0g inhibits angiotensin II-induced endothelial senescence via the LOX-1-independent mechanism. Int J Mol Med 41(4):2243\u20132251. https:\/\/doi.org\/10.3892\/ijmm.2018.3416","journal-title":"Int J Mol Med"},{"issue":"1","key":"9946_CR32","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3892\/etm.2020.9457","volume":"21","author":"L Yan","year":"2021","unstructured":"Yan L, Jia Q, Cao H, Chen C, Xing S, Huang Y, Shen D (2021) Fisetin ameliorates atherosclerosis by regulating PCSK9 and LOX\u20131 in apoE\u2013\/\u2013 mice. Exp Ther Med 21(1):25. https:\/\/doi.org\/10.3892\/etm.2020.9457","journal-title":"Exp Ther Med"},{"issue":"8","key":"9946_CR33","doi-asserted-by":"publisher","first-page":"e024754","DOI":"10.1161\/JAHA.121.024754","volume":"11","author":"BA Kingwell","year":"2022","unstructured":"Kingwell BA, Nicholls SJ, Velkoska E, Didichenko SA, Duffy D, Korjian S, Gibson CM (2022) Antiatherosclerotic effects of CSL112 mediated by enhanced cholesterol efflux capacity. J Am Heart Association 11(8):e024754. https:\/\/doi.org\/10.1161\/JAHA.121.024754","journal-title":"J Am Heart Association"},{"issue":"2","key":"9946_CR34","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1194\/jlr.M600167-JLR200","volume":"48","author":"H Berrougui","year":"2007","unstructured":"Berrougui H, Isabelle M, Cloutier M, Grenier G, Khalil A (2007) Age-related impairment of HDL-mediated cholesterol efflux. J Lipid Res 48(2):328\u2013336. https:\/\/doi.org\/10.1194\/jlr.M600167-JLR200","journal-title":"J Lipid Res"},{"issue":"4","key":"9946_CR35","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.cmet.2013.03.009","volume":"17","author":"A Sene","year":"2013","unstructured":"Sene A, Khan Aslam A, Cox D, Nakamura Rei EI, Santeford A, Kim Bryan M, Sidhu R, Onken Michael D, Harbour JW, Hagbi-Levi S, Chowers I, Edwards Peter A, Baldan A, Parks John S, Ory Daniel S, Apte Rajendra S (2013) Impaired cholesterol efflux in senescent macrophages promotes Age-Related Macular Degeneration. Cell Metab 17(4):549\u2013561. https:\/\/doi.org\/10.1016\/j.cmet.2013.03.009","journal-title":"Cell Metab"},{"issue":"9","key":"9946_CR36","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.1161\/ATVBAHA.115.305896","volume":"35","author":"SE Gardner","year":"2015","unstructured":"Gardner SE, Humphry M, Bennett MR, Clarke MCH (2015) Senescent vascular smooth muscle cells drive inflammation through an Interleukin-1\u03b1-Dependent senescence-Associated Secretory phenotype. Arterioscler Thromb Vasc Biol 35(9):1963\u20131974. https:\/\/doi.org\/10.1161\/ATVBAHA.115.305896","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"9946_CR37","doi-asserted-by":"publisher","first-page":"120677","DOI":"10.1016\/j.biomaterials.2021.120677","volume":"269","author":"LM Pham","year":"2021","unstructured":"Pham LM, Kim E-C, Ou W, Phung CD, Nguyen TT, Pham TT, Poudel K, Gautam M, Nguyen HT, Jeong J-H, Yong CS, Park S-Y, Kim J-R, Kim JO (2021) Targeting and clearance of senescent foamy macrophages and senescent endothelial cells by antibody-functionalized mesoporous silica nanoparticles for alleviating aorta atherosclerosis. Biomaterials 269:120677. https:\/\/doi.org\/10.1016\/j.biomaterials.2021.120677","journal-title":"Biomaterials"},{"key":"9946_CR38","doi-asserted-by":"publisher","unstructured":"Liu J-Y, Souroullas GP, Diekman BO, Krishnamurthy J, Hall BM, Sorrentino JA, Parker JS, Sessions GA, Gudkov AV, Sharpless NE (2019) Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence. Proceedings of the National Academy of Sciences 116 (7):2603\u20132611. doi:https:\/\/doi.org\/10.1073\/pnas.1818313116","DOI":"10.1073\/pnas.1818313116"},{"issue":"6","key":"9946_CR39","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/s41419-021-03811-8","volume":"12","author":"L Su","year":"2021","unstructured":"Su L, Dong Y, Wang Y, Wang Y, Guan B, Lu Y, Wu J, Wang X, Li D, Meng A, Fan F (2021) Potential role of senescent macrophages in radiation-induced pulmonary fibrosis. Cell Death Dis 12(6):527. https:\/\/doi.org\/10.1038\/s41419-021-03811-8","journal-title":"Cell Death Dis"},{"key":"9946_CR40","doi-asserted-by":"publisher","unstructured":"Sun J, Zhou L, Yang T, Deng B, Bao Y, Gu L, Wang H, Wang L (2023) P16INK4a Regulates ROS-Related Autophagy and CDK4\/6-Mediated Proliferation: A New Target of Myocardial Regeneration Therapy. Oxid Med Cell Longev 2023:1696190. https:\/\/doi.org\/10.1155\/2023\/1696190","DOI":"10.1155\/2023\/1696190"},{"issue":"4","key":"9946_CR41","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.cmet.2012.02.011","volume":"15","author":"B Razani","year":"2012","unstructured":"Razani B, Feng C, Coleman T, Emanuel R, Wen H, Hwang S, Ting Jenny P, Virgin Herbert W, Kastan Michael B, Semenkovich Clay F (2012) Autophagy links inflammasomes to atherosclerotic progression. Cell Metab 15(4):534\u2013544. https:\/\/doi.org\/10.1016\/j.cmet.2012.02.011","journal-title":"Cell Metab"},{"key":"9946_CR42","doi-asserted-by":"publisher","first-page":"809955","DOI":"10.3389\/fcell.2021.809955","volume":"9","author":"L Lin","year":"2022","unstructured":"Lin L, Zhang M-X, Zhang L, Zhang D, Li C, Li Y-L (2022) Autophagy, Pyroptosis, and ferroptosis: New Regulatory mechanisms for atherosclerosis. Front cell Dev Biology 9:809955\u2013809955. https:\/\/doi.org\/10.3389\/fcell.2021.809955","journal-title":"Front cell Dev Biology"},{"issue":"9","key":"9946_CR43","doi-asserted-by":"publisher","first-page":"607","DOI":"10.14348\/molcells.2017.0151","volume":"40","author":"K Yoojin","year":"2017","unstructured":"Yoojin K, Ji Wook K, Jo Ae J, Mi-Sung K, Chanhee K (2017) Autophagy is Pro-senescence when seen in Close-Up, but Anti-senescence in Long-Shot. Mol Cells 40(9):607\u2013612. https:\/\/doi.org\/10.14348\/molcells.2017.0151","journal-title":"Mol Cells"},{"issue":"7","key":"9946_CR44","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1101\/gad.519709","volume":"23","author":"ARJ Young","year":"2009","unstructured":"Young ARJ, Narita M, Ferreira M, Kirschner K, Sadaie M, Darot JFJ, Tavar\u00e9 S, Arakawa S, Shimizu S, Watt FM, Narita M (2009) Autophagy mediates the mitotic senescence transition. Genes Dev 23(7):798\u2013803. https:\/\/doi.org\/10.1101\/gad.519709","journal-title":"Genes Dev"},{"issue":"10","key":"9946_CR45","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1038\/s41556-020-00579-5","volume":"22","author":"C Xu","year":"2020","unstructured":"Xu C, Wang L, Fozouni P, Evjen G, Chandra V, Jiang J, Lu C, Nicastri M, Bretz C, Winkler JD, Amaravadi R, Garcia BA, Adams PD, Ott M, Tong W, Johansen T, Dou Z, Berger SL (2020) SIRT1 is downregulated by autophagy in senescence and ageing. Nat Cell Biol 22(10):1170\u20131179. https:\/\/doi.org\/10.1038\/s41556-020-00579-5","journal-title":"Nat Cell Biol"},{"issue":"4","key":"9946_CR46","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.cmet.2012.01.022","volume":"15","author":"X Liao","year":"2012","unstructured":"Liao X, Sluimer Judith C, Wang Y, Subramanian M, Brown K, Pattison JS, Robbins J, Martinez J, Tabas I (2012) Macrophage autophagy plays a protective role in Advanced Atherosclerosis. Cell Metab 15(4):545\u2013553. https:\/\/doi.org\/10.1016\/j.cmet.2012.01.022","journal-title":"Cell Metab"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-024-09946-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-024-09946-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-024-09946-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T04:25:52Z","timestamp":1738729552000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-024-09946-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,27]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["9946"],"URL":"https:\/\/doi.org\/10.1007\/s11033-024-09946-z","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,27]]},"assertion":[{"value":"24 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"was obtained from all individual participants included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1021"}}