{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T09:53:07Z","timestamp":1768557187198,"version":"3.49.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T00:00:00Z","timestamp":1729296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T00:00:00Z","timestamp":1729296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","award":["69493"],"award-info":[{"award-number":["69493"]}],"id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s11033-024-10019-4","type":"journal-article","created":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T09:02:14Z","timestamp":1729328534000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Immunoregulatory role of AC007278.3 and HOTAIR long non-coding RNAs in lupus nephritis: potential biomarkers and therapeutic targets"],"prefix":"10.1007","volume":"51","author":[{"given":"Elahe","family":"Rasuli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamran","family":"Javidi-Aghdam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa","family":"Akbarzadeh-Khiavi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Abdshah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leyla","family":"Gadakchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Jafarpour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Khabbazi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safar","family":"Farajnia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8997-2003","authenticated-orcid":false,"given":"Azam","family":"Safary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8883-0548","authenticated-orcid":false,"given":"Nima","family":"Shaykh-Baygloo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,19]]},"reference":[{"issue":"3","key":"10019_CR1","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/ng.3192","volume":"47","author":"MK Iyer","year":"2015","unstructured":"Iyer MK, Niknafs YS, Malik R, Singhal U, Sahu A, Hosono Y et al (2015) The landscape of long noncoding RNAs in the human transcriptome. Nat Genet 47(3):199\u2013208. https:\/\/doi.org\/10.1038\/ng.3192","journal-title":"Nat Genet"},{"key":"10019_CR2","doi-asserted-by":"publisher","first-page":"100044","DOI":"10.1016\/j.jtauto.2020.100044","volume":"3","author":"Y Zou","year":"2020","unstructured":"Zou Y, Xu H (2020) Involvement of long noncoding RNAs in the pathogenesis of autoimmune diseases. J Transl Autoimmun 3:100044. https:\/\/doi.org\/10.1016\/j.jtauto.2020.100044","journal-title":"J Transl Autoimmun"},{"issue":"1","key":"10019_CR3","doi-asserted-by":"publisher","first-page":"e12404","DOI":"10.1111\/cpr.12404","volume":"51","author":"Z Li","year":"2018","unstructured":"Li Z, Li X, Jiang C, Qian W, Tse G, Chan MT, Wu WK (2018) Long non-coding RNA s in rheumatoid arthritis. Cell Prolif 51(1):e12404. https:\/\/doi.org\/10.1111\/cpr.12404","journal-title":"Cell Prolif"},{"issue":"14","key":"10019_CR4","doi-asserted-by":"publisher","first-page":"23650","DOI":"10.18632\/oncotarget.15569","volume":"8","author":"GC Wu","year":"2017","unstructured":"Wu GC, Li J, Leng RX, Li XP, Li XM, Wang DG et al (2017) Identification of long non-coding RNAs GAS5, linc0597 and lnc-DC in plasma as novel biomarkers for systemic lupus erythematosus. Oncotarget 8(14):23650\u201323663. https:\/\/doi.org\/10.18632\/oncotarget.15569","journal-title":"Oncotarget"},{"issue":"2","key":"10019_CR5","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.autrev.2012.08.018","volume":"12","author":"AT Borchers","year":"2012","unstructured":"Borchers AT, Leibushor N, Naguwa SM, Cheema GS, Shoenfeld Y, Gershwin ME (2012) Lupus nephritis: a critical review. Autoimmun Rev 12(2):174\u2013194. https:\/\/doi.org\/10.1016\/j.autrev.2012.08.018","journal-title":"Autoimmun Rev"},{"issue":"1","key":"10019_CR6","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.autrev.2010.08.016","volume":"10","author":"PP Smith","year":"2010","unstructured":"Smith PP, Gordon C (2010) Systemic lupus erythematosus: clinical presentations. Autoimmun Rev 10(1):43\u201345. https:\/\/doi.org\/10.1016\/j.autrev.2010.08.016","journal-title":"Autoimmun Rev"},{"issue":"3","key":"10019_CR7","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1111\/sji.12330","volume":"82","author":"N Hagberg","year":"2015","unstructured":"Hagberg N, R\u00f6nnblom L (2015) Systemic lupus erythematosus\u2013a disease with a dysregulated type I interferon system. Scand J Immunol 82(3):199\u2013207. https:\/\/doi.org\/10.1111\/sji.12330","journal-title":"Scand J Immunol"},{"issue":"3","key":"10019_CR8","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1002\/art.1780350310","volume":"35","author":"D Deafen","year":"1992","unstructured":"Deafen D, Escalante A, Weinrib L, Horwitz D, Bachman B, Roy-Burman P et al (1992) A revised estimate of twin concordance in systemic lupus erythematosus. Arthritis Rheum 35(3):311\u2013318. https:\/\/doi.org\/10.1002\/art.1780350310","journal-title":"Arthritis Rheum"},{"key":"10019_CR9","doi-asserted-by":"publisher","first-page":"919973","DOI":"10.3389\/fimmu.2022.919973","volume":"13","author":"SA Ihim","year":"2022","unstructured":"Ihim SA, Abubakar SD, Zian Z, Sasaki T, Saffarioun M, Maleknia S, Azizi G (2022) Interleukin-18 cytokine in immunity, inflammation, and autoimmunity: biological role in induction, regulation, and treatment. Front Immunol 13:919973. https:\/\/doi.org\/10.3389\/fimmu.2022.919973","journal-title":"Front Immunol"},{"key":"10019_CR10","doi-asserted-by":"publisher","first-page":"615859","DOI":"10.3389\/fimmu.2021.615859","volume":"12","author":"Y You","year":"2021","unstructured":"You Y, Zhao X, Wu Y, Mao J, Ge L, Guo J et al (2021) Integrated Transcriptome Profiling revealed that elevated long non-coding RNA-AC007278.2 expression repressed CCR7 transcription in systemic Lupus Erythematosus. Front Immunol 12:615859. https:\/\/doi.org\/10.3389\/fimmu.2021.615859","journal-title":"Front Immunol"},{"issue":"7291","key":"10019_CR11","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1038\/nature08975","volume":"464","author":"RA Gupta","year":"2010","unstructured":"Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, Wong DJ et al (2010) Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 464(7291):1071\u20131076. https:\/\/doi.org\/10.1038\/nature08975","journal-title":"Nature"},{"issue":"1","key":"10019_CR12","doi-asserted-by":"publisher","first-page":"15670","DOI":"10.1038\/s41598-018-33722-2","volume":"8","author":"M Obaid","year":"2018","unstructured":"Obaid M, Udden SMN, Deb P, Shihabeddin N, Zaki MH, Mandal SS (2018) LncRNA HOTAIR regulates lipopolysaccharide-induced cytokine expression and inflammatory response in macrophages. Sci Rep 8(1):15670. https:\/\/doi.org\/10.1038\/s41598-018-33722-2","journal-title":"Sci Rep"},{"issue":"5","key":"10019_CR13","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1016\/j.gendis.2021.07.006","volume":"9","author":"W Kong","year":"2022","unstructured":"Kong W, Yin G, Zheng S, Liu X, Zhu A, Yu P et al (2022) Long noncoding RNA (lncRNA) HOTAIR: pathogenic roles and therapeutic opportunities in gastric cancer. Genes Dis 9(5):1269\u20131280. https:\/\/doi.org\/10.1016\/j.gendis.2021.07.006","journal-title":"Genes Dis"},{"issue":"1","key":"10019_CR14","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.bbrc.2016.01.117","volume":"471","author":"H Wu","year":"2016","unstructured":"Wu H, Liu J, Li W, Liu G, Li Z (2016) LncRNA-HOTAIR promotes TNF-\u03b1 production in cardiomyocytes of LPS-induced sepsis mice by activating NF-\u03baB pathway. Biochem Biophys Res Commun 471(1):240\u2013246. https:\/\/doi.org\/10.1016\/j.bbrc.2016.01.117","journal-title":"Biochem Biophys Res Commun"},{"issue":"9","key":"10019_CR15","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1002\/art.40930","volume":"71","author":"M Aringer","year":"2019","unstructured":"Aringer M, Costenbader K, Daikh D, Brinks R, Mosca M, Ramsey-Goldman R et al (2019) 2019 European League Against Rheumatism\/American College of Rheumatology Classification Criteria for systemic Lupus Erythematosus. Arthritis Rheumatol 71(9):1400\u20131412. https:\/\/doi.org\/10.1002\/art.40930","journal-title":"Arthritis Rheumatol"},{"issue":"2","key":"10019_CR16","first-page":"288","volume":"29","author":"DD Gladman","year":"2002","unstructured":"Gladman DD, Iba\u00f1ez D, Urowitz MB (2002) Systemic lupus erythematosus disease activity index 2000. J Rheumatol 29(2):288\u2013291","journal-title":"J Rheumatol"},{"key":"10019_CR17","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.biopha.2018.06.175","volume":"106","author":"CN Zhao","year":"2018","unstructured":"Zhao CN, Mao YM, Liu LN, Li XM, Wang DG, Pan HF (2018) Emerging role of lncRNAs in systemic lupus erythematosus. Biomed Pharmacother 106:584\u2013592. https:\/\/doi.org\/10.1016\/j.biopha.2018.06.175","journal-title":"Biomed Pharmacother"},{"key":"10019_CR18","doi-asserted-by":"publisher","unstructured":"Wang Y, Yi K, Liu X, Tan Y, Jin W, Li Y et al (2021) HOTAIR Up-Regulation activates NF-\u03baB to Induce Immunoescape in Gliomas. Front Immunol 12. https:\/\/doi.org\/10.3389\/fimmu.2021.785463","DOI":"10.3389\/fimmu.2021.785463"},{"issue":"5","key":"10019_CR19","doi-asserted-by":"publisher","first-page":"3959","DOI":"10.3892\/etm.2019.8063","volume":"18","author":"J Chen","year":"2019","unstructured":"Chen J, Gu X, Zhou L, Wang S, Zhu L, Huang Y, Cao F (2019) Long non\u2013coding RNA\u2013HOTAIR promotes the progression of sepsis by acting as a sponge of miR\u2013211 to induce IL\u20136R expression. Exp Ther Med 18(5):3959\u20133967. https:\/\/doi.org\/10.3892\/etm.2019.8063","journal-title":"Exp Ther Med"},{"key":"10019_CR20","unstructured":"Dagenais M (2018) Regulation of tissue homeostasis and tumorigenesis by innate immunity and cell death pathways. McGill University (Canada)"},{"issue":"4","key":"10019_CR21","doi-asserted-by":"publisher","first-page":"614","DOI":"10.52547\/rbmb.10.4.697","volume":"10","author":"E Medhat","year":"2022","unstructured":"Medhat E, Ayeldeen G, Ahmed HH, Shaker O, Gheita T, Ashour SS (2022) HOTAIR and THRIL long non coding RNAs and their target genes in rheumatoid arthritis patients. Rep Biochem Mol Biol 10(4):614. https:\/\/doi.org\/10.52547\/rbmb.10.4.697","journal-title":"Rep Biochem Mol Biol"},{"issue":"8","key":"10019_CR22","doi-asserted-by":"publisher","first-page":"e0268176","DOI":"10.1371\/journal.pone.0268176","volume":"17","author":"RH Mahmoud","year":"2022","unstructured":"Mahmoud RH, Fouad NA, Hefzy EM, Shaker OG, Ahmed TI, Hussein HA et al (2022) The potential role of serum expression profile of long non coding RNAs, Cox2 and HOTAIR as novel diagnostic biomarkers in systemic lupus erythematosus. PLoS ONE 17(8):e0268176. https:\/\/doi.org\/10.1371\/journal.pone.0268176","journal-title":"PLoS ONE"},{"issue":"10","key":"10019_CR23","doi-asserted-by":"publisher","first-page":"e594","DOI":"10.1016\/S2665-9913(23)00211-4","volume":"5","author":"RJ Black","year":"2023","unstructured":"Black RJ, Cross M, Haile LM, Culbreth GT, Steinmetz JD, Hagins H et al (2023) Global, regional, and national burden of rheumatoid arthritis, 1990\u20132020, and projections to 2050: a systematic analysis of the global burden of Disease Study 2021. Lancet Rheumatol 5(10):e594\u2013e610. https:\/\/doi.org\/10.1016\/S2665-9913(23)00211-4","journal-title":"Lancet Rheumatol"},{"issue":"1","key":"10019_CR24","doi-asserted-by":"publisher","first-page":"4707","DOI":"10.1038\/s41598-021-84170-4","volume":"11","author":"M Xiang","year":"2021","unstructured":"Xiang M, Feng Y, Wang Y, Wang J, Zhang Z, Liang J, Xu J (2021) Correlation between circulating interleukin-18 level and systemic lupus erythematosus: a meta-analysis. Sci Rep 11(1):4707. https:\/\/doi.org\/10.1038\/s41598-021-84170-4","journal-title":"Sci Rep"},{"key":"10019_CR25","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.3389\/fimmu.2018.01250","volume":"9","author":"R Mende","year":"2018","unstructured":"Mende R, Vincent FB, Kandane-Rathnayake R, Koelmeyer R, Lin E, Chang J et al (2018) Analysis of serum interleukin (IL)-1\u03b2 and IL-18 in systemic Lupus Erythematosus. Front Immunol 9:1250. https:\/\/doi.org\/10.3389\/fimmu.2018.01250","journal-title":"Front Immunol"},{"issue":"4","key":"10019_CR26","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1177\/0961203319834677","volume":"28","author":"V Umare","year":"2019","unstructured":"Umare V, Pradhan V, Nath S, Rajadhyaksha A, Ghosh K, Nadkarni AH (2019) Impact of functional IL-18 polymorphisms on genetic predisposition and diverse clinical manifestations of the disease in Indian SLE patients. Lupus 28(4):545\u2013554. https:\/\/doi.org\/10.1177\/0961203319834677","journal-title":"Lupus"},{"key":"10019_CR27","doi-asserted-by":"publisher","unstructured":"Wu D, Jin Y, Xing Y, Abate MD, Abbasian M, Abbasi-Kangevari M et al Global, regional, and national incidence of six major immune-mediated inflammatory diseases: findings from the global burden of disease study 2019. EClinicalMedicine. 2023;64. https:\/\/doi.org\/10.1016\/j.eclinm.2023.102193","DOI":"10.1016\/j.eclinm.2023.102193"},{"key":"10019_CR28","doi-asserted-by":"publisher","first-page":"104619","DOI":"10.1016\/j.yexmp.2021.104619","volume":"119","author":"A Sattari","year":"2021","unstructured":"Sattari A, Hussen BM, Ghafouri-Fard S, Alihashemi A, Omrani MD, Zekri A, Taheri M (2021) Expression of T helper 1-associated lncRNAs in breast cancer. Exp Mol Pathol 119:104619. https:\/\/doi.org\/10.1016\/j.yexmp.2021.104619","journal-title":"Exp Mol Pathol"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-024-10019-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-024-10019-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-024-10019-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T04:40:27Z","timestamp":1738730427000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-024-10019-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,19]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10019"],"URL":"https:\/\/doi.org\/10.1007\/s11033-024-10019-4","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,19]]},"assertion":[{"value":"1 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study protocol was approved by the ethical committee of Tabriz University of Medical Sciences (IR.TBZMED.REC.1401.365).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from all participants under the relevant guidelines and regulations.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent"}},{"value":"Written consent from the patients was obtained for publishing their clinical information.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1075"}}