{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T19:26:03Z","timestamp":1778181963978,"version":"3.51.4"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82160922"],"award-info":[{"award-number":["82160922"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s11033-024-10041-6","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T09:38:35Z","timestamp":1732527515000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Therapeutic effect of total glucosides of paeony on IgA vasculitis nephritis: progress and prospects"],"prefix":"10.1007","volume":"52","author":[{"given":"Zhifeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfen","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junfeng","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuangfeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihui","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujiang","family":"Xi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,25]]},"reference":[{"issue":"9","key":"10041_CR1","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1093\/rheumatology\/kez041","volume":"58","author":"S Ozen","year":"2019","unstructured":"Ozen S, Marks SD, Brogan P, Groot N, de Graeff N, Avcin T, Bader-Meunier B, Dolezalova P, Feldman BM, Kone-Paut I, Lahdenne P, McCann L, Pilkington C, Ravelli A, van Royen A, Uziel Y, Vastert B, Wulffraat N, Kamphuis S, Beresford MW (2019) European consensus-based recommendations for diagnosis and treatment of immunoglobulin A vasculitis-the SHARE initiative. Rheumatology (Oxford) 58(9):1607\u20131616","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"10041_CR2","first-page":"30","volume":"2","author":"TS Trindade","year":"2023","unstructured":"Trindade TS, Morais CG, Maia A, Rodrigues M, Brito I (2023) Demographic and clinical features of pediatric vasculitis: a single-center study. ARP Rheumatol 2(1):30\u201340","journal-title":"ARP Rheumatol"},{"issue":"4","key":"10041_CR3","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2174\/18756336MTA2lNDYc2","volume":"16","author":"AKC Leung","year":"2020","unstructured":"Leung AKC, Barankin B, Leong KF (2020) Henoch\u2013Sch\u00f6nlein purpura in children: an updated review. Curr Pediatr Rev 16(4):265\u2013276","journal-title":"Curr Pediatr Rev"},{"key":"10041_CR4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2147\/PHMT.S379862","volume":"14","author":"M Sestan","year":"2023","unstructured":"Sestan M, Jelusic M (2023) Diagnostic and management strategies of IgA vasculitis nephritis\/Henoch\u2013Sch\u00f6nlein purpura nephritis in pediatric patients: current perspectives. Pediatric Health Med Ther 14:89\u201398","journal-title":"Pediatric Health Med Ther"},{"issue":"12","key":"10041_CR5","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/jpc.12403","volume":"49","author":"P Trnka","year":"2013","unstructured":"Trnka P (2013) Henoch\u2013Sch\u00f6nlein purpura in children. J Paediatr Child Health 49(12):995\u20131003","journal-title":"J Paediatr Child Health"},{"issue":"10","key":"10041_CR6","volume":"11","author":"A Zhang","year":"2023","unstructured":"Zhang A, Chen S, Lin R (2023) Combined use of total glucosides of paeony and hydroxychloroquine in primary Sj\u00f6gren\u2019s syndrome: a systematic review. Immun Inflamm Dis 11(10):e1044","journal-title":"Immun Inflamm Dis"},{"key":"10041_CR7","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106842","volume":"195","author":"K Yang","year":"2023","unstructured":"Yang K, Zeng L, Long Z, He Q, Xiang W, Ge A, Zhen H, Xiao W, Ge J (2023) Efficacy and safety of total glucosides of paeony in the treatment of 5 types of inflammatory arthritis: a systematic review and meta-analysis. Pharmacol Res 195:106842","journal-title":"Pharmacol Res"},{"key":"10041_CR8","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2019.107452","volume":"207","author":"L Zhang","year":"2020","unstructured":"Zhang L, Wei W (2020) Anti-inflammatory and immunoregulatory effects of paeoniflorin and total glucosides of paeony. Pharmacol Ther 207:107452","journal-title":"Pharmacol Ther"},{"issue":"8","key":"10041_CR9","first-page":"1143","volume":"33","author":"DL Liu","year":"2013","unstructured":"Liu DL, Ma ST (2013) Progress of pharmacological actions of total glucosides of paeony in treating diabetic nephropathy. Zhongguo Zhong Xi Yi Jie He Za Zhi 33(8):1143\u20131146 (Chinese)","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"10041_CR10","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3389\/fphar.2019.00268","volume":"10","author":"J Yu","year":"2019","unstructured":"Yu J, Zhao Z, Peng R, Pan L, Fu J, Ma S, Han P, Cong L, Zhang Z, Sun L, Jiang J, Wang Y (2019) Gut microbiota-based pharmacokinetics and the antidepressant mechanism of paeoniflorin. Front Pharmacol 10:268","journal-title":"Front Pharmacol"},{"issue":"2","key":"10041_CR11","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/03639045.2020.1862178","volume":"47","author":"C Shen","year":"2021","unstructured":"Shen C, Shen B, Zhu J, Wang J, Yuan H, Li X (2021) Glycyrrhizic acid-based self-assembled micelles for improving oral bioavailability of paeoniflorin. Drug Dev Ind Pharm 47(2):207\u2013214","journal-title":"Drug Dev Ind Pharm"},{"issue":"7","key":"10041_CR12","first-page":"1179","volume":"40","author":"X Li","year":"2018","unstructured":"Li X, Zhang X, Zhang H, Zhao Q, Deng F (2018) Observations on the correlation between Wnt\/\u03b2-catenin signaling pathway and allergic purpura in children. Chin J Cell Biol 40(7):1179\u20131183 (Chinese)","journal-title":"Chin J Cell Biol"},{"issue":"3","key":"10041_CR13","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/s41581-020-00343-w","volume":"17","author":"SJ Schunk","year":"2021","unstructured":"Schunk SJ, Floege J, Fliser D, Speer T (2021) WNT-\u03b2-catenin signalling-a versatile player in kidney injury and repair. Nat Rev Nephrol 17(3):172\u2013184","journal-title":"Nat Rev Nephrol"},{"issue":"12","key":"10041_CR14","first-page":"878","volume":"90","author":"O Naija","year":"2012","unstructured":"Naija O, Bouzaraa J, Goucha-Louzir R, Lakhoua MR (2012) Les facteurs pr\u00e9\u00e9dictifs des atteintes r\u00e9nales s\u00e9v\u00e8res du purpura rhumato\u00efde chez l\u2019enfant: a propos de 34 cas. Tunis Med 90(12):878\u2013881","journal-title":"Tunis Med"},{"key":"10041_CR15","volume":"12","author":"S Li","year":"2021","unstructured":"Li S, Sun Q, Hua M, Suo P, Chen J, Yu X, Zhao Y (2021) Targeting the Wnt\/\u03b2-catenin signaling pathway as a potential therapeutic strategy in renal tubulointerstitial fibrosis. Front Pharmacol 12:719880","journal-title":"Front Pharmacol"},{"issue":"2","key":"10041_CR16","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s13020-024-01024-7","volume":"114","author":"T Zang","year":"2024","unstructured":"Zang T, Zhuang L, Zhang Z, Xin D, Guo Y (2024) Expression of beta-catenin in renal cell carcinoma. Chin Med J (Engl) 114(2):152\u2013154","journal-title":"Chin Med J (Engl)"},{"issue":"53","key":"10041_CR17","first-page":"9182","volume":"17","author":"Y Fu","year":"2013","unstructured":"Fu Y, Liu X, Chen N, Zhang S, Chang H, Zhang Q, Chen X, Gao X (2013) Signal transduction pathways of Toll-like receptors 3 and 4 in peripheral blood mononuclear cells from patients with purpura nephritis. Tissue Eng Res China 17(53):9182\u20139188 (Chinese)","journal-title":"Tissue Eng Res China"},{"issue":"2","key":"10041_CR18","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.cellsig.2013.11.021","volume":"26","author":"L Ring","year":"2014","unstructured":"Ring L, Neth P, Weber C, Steffens S, Faussner A (2014) \u03b2-Catenin-dependent pathway activation by both promiscuous \u201ccanonical\u201d WNT3a-, and specific \u201cnoncanonical\u201d WNT4- and WNT5a-FZD receptor combinations with strong differences in LRP5 and LRP6 dependency. Cell Signal 26(2):260\u2013267","journal-title":"Cell Signal"},{"issue":"7","key":"10041_CR19","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1242\/dev.057646","volume":"138","author":"CM Karner","year":"2011","unstructured":"Karner CM, Das A, Ma Z, Self M, Chen C, Lum L, Oliver G, Carroll TJ (2011) Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development. Development 138(7):1247\u20131257","journal-title":"Development"},{"issue":"3","key":"10041_CR20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120347","volume":"10","author":"FJ Boivin","year":"2015","unstructured":"Boivin FJ, Sarin S, Lim J, Javidan A, Svajger B, Khalili H, Bridgewater D (2015) Stromally expressed \u03b2-catenin modulates Wnt9b signaling in the ureteric epithelium. PLoS ONE 10(3):e0120347","journal-title":"PLoS ONE"},{"key":"10041_CR21","doi-asserted-by":"crossref","unstructured":"Tzeng CP, Shen K (2023) Wnt signaling and contact-mediated repulsion shape sensory dendritic fields. bioRxiv 2023.09.14.557812","DOI":"10.1101\/2023.09.14.557812"},{"issue":"19","key":"10041_CR22","first-page":"3829","volume":"39","author":"BC Chang","year":"2014","unstructured":"Chang BC, Chen WD, Zhang Y, Yang P, Liu L, Wang J (2014) Effect of total glucosides of paeony on Wnt\/\u03b2-catenin signal transduction pathway expression in kidney of diabetic rats. Zhongguo Zhong Yao Za Zhi 39(19):3829\u20133835 (Chinese)","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"issue":"5","key":"10041_CR23","first-page":"208","volume":"75","author":"LY Li","year":"2020","unstructured":"Li LY, Ma L, Dong WL (2020) Total glucosides of paeony (Paeonia lactiflora) alleviates blood\u2013brain barrier disruption and cerebral ischemia\/reperfusion injury in rats via suppressing inflammation and apoptosis. Pharmazie 75(5):208\u2013212","journal-title":"Pharmazie"},{"issue":"4","key":"10041_CR24","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1159\/000489241","volume":"46","author":"M Wu","year":"2018","unstructured":"Wu M, Yiang G, Liao W, Tsai A, Cheng Y, Cheng P, Li C, Li C (2018) Current mechanistic concepts in ischemia and reperfusion injury. Cell Physiol Biochem 46(4):1650\u20131667","journal-title":"Cell Physiol Biochem"},{"key":"10041_CR25","volume":"96","author":"X Han","year":"2022","unstructured":"Han X, Hu S, Yang Q, Sang X, Tang D, Cao G (2022) Paeoniflorin ameliorates airway inflammation and immune response in ovalbumin induced asthmatic mice: from oxidative stress to autophagy. Phytomedicine 96:153835","journal-title":"Phytomedicine"},{"issue":"6","key":"10041_CR26","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1007\/s10753-015-0182-5","volume":"38","author":"T Zhang","year":"2015","unstructured":"Zhang T, Yang Z, Yang S, Du J, Wang S (2015) Immunoregulatory effects of paeoniflorin exerts anti-asthmatic effects via modulation of the Th1\/Th2 equilibrium. Inflammation 38(6):2017\u20132025","journal-title":"Inflammation"},{"issue":"6","key":"10041_CR27","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1080\/15548627.2017.1309485","volume":"13","author":"T Kimura","year":"2017","unstructured":"Kimura T, Isaka Y, Yoshimori T (2017) Autophagy and kidney inflammation. Autophagy 13(6):997\u20131003","journal-title":"Autophagy"},{"key":"10041_CR28","volume":"146","author":"J Wen","year":"2019","unstructured":"Wen J, Xu B, Sun Y, Lian M, Li Y, Lin Y, Chen D, Diao Y, Almoiliqy M, Wang L (2019) Paeoniflorin protects against intestinal ischemia\/reperfusion by activating LKB1\/AMPK and promoting autophagy. Pharmacol Res 146:104308","journal-title":"Pharmacol Res"},{"issue":"1","key":"10041_CR29","doi-asserted-by":"crossref","first-page":"F1","DOI":"10.1152\/ajprenal.00012.2023","volume":"325","author":"D Bhatia","year":"2023","unstructured":"Bhatia D, Choi ME (2023) Autophagy and mitophagy: physiological implications in kidney inflammation and diseases. Am J Physiol Renal Physiol 325(1):F1\u2013F21","journal-title":"Am J Physiol Renal Physiol"},{"issue":"4","key":"10041_CR30","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","volume":"22","author":"X Jiang","year":"2021","unstructured":"Jiang X, Stockwell BR, Conrad M (2021) Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol 22(4):266\u2013282","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"10041_CR31","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.nefroe.2020.09.006","volume":"40","author":"D Martin-Sanchez","year":"2020","unstructured":"Martin-Sanchez D, Fontecha-Barriuso M, Martinez-Moreno JM, Ramos AM, Sanchez-Ni\u00f1o MD, Guerrero-Hue M, Moreno JA, Ortiz A, Sanz AB (2020) Ferroptosis and kidney disease. Nefrologia (Engl Ed) 40(4):384\u2013394","journal-title":"Nefrologia (Engl Ed)"},{"key":"10041_CR32","doi-asserted-by":"crossref","first-page":"118107","DOI":"10.1016\/j.jep.2024.118107","volume":"329","author":"Y Li","year":"2024","unstructured":"Li Y, Deng X, Hu Q, Chen Y, Zhang W, Qin X, Wei F, Lu X, Ma X, Zeng J, Efferth T (2024) Paeonia lactiflora Pall. ameliorates acetaminophen-induced oxidative stress and apoptosis via inhibiting the PKC-ERK pathway. J Ethnopharmacol 329:118107","journal-title":"J Ethnopharmacol"},{"issue":"4","key":"10041_CR33","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.tcb.2023.07.009","volume":"34","author":"X Liu","year":"2024","unstructured":"Liu X, Zhuang L, Gan B (2024) Disulfidptosis: disulfide stress-induced cell death. Trends Cell Biol 34(4):327\u2013337","journal-title":"Trends Cell Biol"},{"issue":"10","key":"10041_CR34","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.21037\/tp-22-437","volume":"11","author":"L Huang","year":"2022","unstructured":"Huang L, Li Y, Wang P, Xie Y, Liu F, Mao J, Miao J (2022) Integrated analysis of immune- and apoptosis-related lncRNA-miRNA-mRNA regulatory network in children with Henoch Sch\u00f6nlein purpura nephritis. Transl Pediatr 11(10):1682\u20131696","journal-title":"Transl Pediatr"},{"issue":"6","key":"10041_CR35","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.kint.2022.07.034","volume":"102","author":"Y Ye","year":"2022","unstructured":"Ye Y, Chen A, Li L, Liang Q, Wang S, Dong Q, Fu M, Lan Z, Li Y, Liu X, Ou JS, Lu L, Yan J (2022) Repression of the antiporter SLC7A11\/glutathione\/glutathione peroxidase 4 axis drives ferroptosis of vascular smooth muscle cells to facilitate vascular calcification. Kidney Int 102(6):1259\u20131275","journal-title":"Kidney Int"},{"key":"10041_CR36","volume":"116","author":"L Ma","year":"2023","unstructured":"Ma L, Liu X, Zhang M, Zhou L, Jiang L, Gao L, Wang X, Huang Y, Zeng H, Wu Y (2023) Paeoniflorin alleviates ischemia\/reperfusion induced acute kidney injury by inhibiting Slc7a11-mediated ferroptosis. Int Immunopharmacol 116:109754","journal-title":"Int Immunopharmacol"},{"key":"10041_CR37","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.redox.2015.01.002","volume":"4","author":"H Sies","year":"2015","unstructured":"Sies H (2015) Oxidative stress: a concept in redox biology and medicine. Redox Biol 4:180\u2013183","journal-title":"Redox Biol"},{"issue":"40","key":"10041_CR38","doi-asserted-by":"crossref","first-page":"4794","DOI":"10.2174\/1381612825666190112165206","volume":"24","author":"G Coppolino","year":"2018","unstructured":"Coppolino G, Leonardi G, Andreucci M, Bolignano D (2018) Oxidative stress and kidney function: a brief update. Curr Pharm Des 24(40):4794\u20134799","journal-title":"Curr Pharm Des"},{"key":"10041_CR39","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.biopha.2016.12.105","volume":"87","author":"S Samarghandian","year":"2017","unstructured":"Samarghandian S, Azimi-Nezhad M, Farkhondeh T, Samini F (2017) Anti-oxidative effects of curcumin on immobilization-induced oxidative stress in rat brain, liver and kidney. Biomed Pharmacother 87:223\u2013229","journal-title":"Biomed Pharmacother"},{"key":"10041_CR40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175823","volume":"953","author":"T Ding","year":"2023","unstructured":"Ding T, Yi T, Li Y, Zhang W, Wang X, Liu J, Fan Y, Ji J, Xu L (2023) Luteolin attenuates lupus nephritis by regulating macrophage oxidative stress via HIF-1\u03b1 pathway. Eur J Pharmacol 953:175823","journal-title":"Eur J Pharmacol"},{"key":"10041_CR41","doi-asserted-by":"crossref","first-page":"536","DOI":"10.3389\/fphar.2020.00536","volume":"11","author":"J Yuan","year":"2020","unstructured":"Yuan J, Lu Y, Wang H, Feng Y, Jiang S, Gao XH, Qi R, Wu Y, Chen HD (2020) Paeoniflorin resists H2O2-induced oxidative stress in melanocytes by JNK\/Nrf2\/HO-1 pathway. Front Pharmacol 11:536","journal-title":"Front Pharmacol"},{"issue":"3","key":"10041_CR42","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1142\/S0192415X12500401","volume":"40","author":"K Wang","year":"2012","unstructured":"Wang K, Wu Y, Su J, Zhang J, Zhang P, Qi X (2012) Total glucosides of paeony regulates JAK2\/STAT3 activation and macrophage proliferation in diabetic rat kidneys. Am J Chin Med 40(3):521\u2013536","journal-title":"Am J Chin Med"},{"issue":"1","key":"10041_CR43","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1080\/0886022X.2022.2079522","volume":"44","author":"Y Dai","year":"2022","unstructured":"Dai Y, Quan J, Xiong L, Luo Y, Yi B (2022) Probiotics improve renal function, glucose, lipids, inflammation and oxidative stress in diabetic kidney disease: a systematic review and meta-analysis. Ren Fail 44(1):862\u2013880","journal-title":"Ren Fail"},{"issue":"1","key":"10041_CR44","first-page":"49","volume":"23","author":"K Shao","year":"2021","unstructured":"Shao K, Guan F, Dong C (2021) Efficacy and mechanism of the adjuvant treatment of purpura nephritis in children with total white peony glycosides: a prospective randomized controlled study. Chin J Contemp Pediatr 23(1):49\u201354 (Chinese)","journal-title":"Chin J Contemp Pediatr"},{"key":"10041_CR45","volume":"116","author":"Y Cao","year":"2023","unstructured":"Cao Y, Xiong J, Guan X, Yin S, Chen J, Yuan S, Liu H, Lin S, Zhou Y, Qiu J, Wang D, Liu B, Zhou J (2023) Paeoniflorin suppresses kidney inflammation by regulating macrophage polarization via KLF4-mediated mitophagy. Phytomedicine 116:154901","journal-title":"Phytomedicine"},{"key":"10041_CR46","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2022.170834","volume":"155","author":"EM da Silva","year":"2022","unstructured":"da Silva EM, Yariwake VY, Alves RW, de Araujo DR, Andrade-Oliveira V (2022) Crosstalk between incretin hormones, Th17 and Treg cells in inflammatory diseases. Peptides 155:170834","journal-title":"Peptides"},{"issue":"06","key":"10041_CR47","first-page":"202","volume":"16","author":"Y Wang","year":"2019","unstructured":"Wang Y, Chen Y (2019) Clinical study on the combination therapy of leukotriene receptor antagonist and paeoniflorin for mild purpura nephritis. J Pract Hosp Clin 16(06):202\u2013204 (Chinese)","journal-title":"J Pract Hosp Clin"},{"issue":"6","key":"10041_CR48","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1016\/j.transproceed.2019.04.067","volume":"51","author":"J Zhang","year":"2019","unstructured":"Zhang J, Jin H, Xu Y, Shan J (2019) Rapamycin modulate Treg\/Th17 balance via regulating metabolic pathways: a study in mice. Transplant Proc 51(6):2136\u20132140","journal-title":"Transplant Proc"},{"issue":"8","key":"10041_CR49","first-page":"1430","volume":"48","author":"Y Deng","year":"2019","unstructured":"Deng Y, Yu C (2019) Analysis of the effect of dipyridamole and vitamin C on the efficacy indexes of children with allergic purpura. Chongqing Med 48(8):1430\u20131432 (Chinese)","journal-title":"Chongqing Med"},{"issue":"22","key":"10041_CR50","first-page":"1703","volume":"35","author":"X Yang","year":"2020","unstructured":"Yang X, Guo W, Luo M, Lin B, Gu S, Shen T (2020) Study of helper T-lymphocyte\/regulatory T-lymphocyte imbalance in children with allergic purpura and Helicobacter pylori infection. Chin J Pract Pediatr 35(22):1703\u20131707 (Chinese)","journal-title":"Chin J Pract Pediatr"},{"issue":"3","key":"10041_CR51","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.intimp.2012.07.012","volume":"14","author":"Z Zhou","year":"2012","unstructured":"Zhou Z, Lin J, Huo R, Huang W, Zhang J, Wang L, Sun Y, Shen B, Li N (2012) Total glucosides of paeony attenuated functional maturation of dendritic cells via blocking TLR4\/5 signaling in vivo. Int Immunopharmacol 14(3):275\u2013282","journal-title":"Int Immunopharmacol"},{"key":"10041_CR52","doi-asserted-by":"crossref","first-page":"116716","DOI":"10.1016\/j.jep.2023.116716","volume":"316","author":"Z Zhou","year":"2023","unstructured":"Zhou Z, Wang Y, Sun S, Zhang K, Wang L, Zhao H, Zhang Y (2023) Paeonia lactiflora Pall. polysaccharide alleviates depression in CUMS mice by inhibiting the NLRP3\/ASC\/Caspase-1 signaling pathway and affecting the composition of their intestinal flora. J Ethnopharmacol 316:116716","journal-title":"J Ethnopharmacol"},{"issue":"2","key":"10041_CR53","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s12519-019-00318-3","volume":"16","author":"S Cheng","year":"2020","unstructured":"Cheng S, Zhu C, Zhang A, Huang S (2020) MiR-29b expression is altered in crescent formation of HSPN and accelerates Ang II-induced mesangial cell activation. World J Pediatr 16(2):201\u2013212","journal-title":"World J Pediatr"},{"issue":"2","key":"10041_CR54","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.jep.2011.03.045","volume":"135","author":"J Li","year":"2011","unstructured":"Li J, Chen C, Shen Y (2011) Effects of total glucosides from paeony (Paeonia lactiflora Pall) roots on experimental atherosclerosis in rats. J Ethnopharmacol 135(2):469\u2013475","journal-title":"J Ethnopharmacol"},{"issue":"01","key":"10041_CR55","first-page":"207","volume":"37","author":"S Lv","year":"2022","unstructured":"Lv S, Wang Y, Zhang W, Zhang J (2022) Progress of cardiovascular protective effect of total white peony glycosides and its mechanism of action. Modern Drugs Clin 37(01):207\u2013210 (Chinese)","journal-title":"Modern Drugs Clin"},{"key":"10041_CR56","doi-asserted-by":"crossref","first-page":"113054","DOI":"10.1016\/j.jep.2020.113054","volume":"261","author":"L Kang","year":"2020","unstructured":"Kang L, Miao J, Cao L, Miao Y, Miao M, Liu H, Xiang L, Song Y (2020) Total glucosides of herbaceous peony (Paeonia lactiflora Pall) flower attenuate adenine- and ethambutol-induced hyperuricaemia in rats. J Ethnopharmacol 261:113054","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"10041_CR57","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1254\/jphs.13173FP","volume":"125","author":"W Zhang","year":"2014","unstructured":"Zhang W, Zhao L, Su SQ, Xu XX, Wu YG (2014) Total glucosides of paeony attenuate renal tubulointerstitial injury in STZ-induced diabetic rats: role of Toll-like receptor 2. J Pharmacol Sci 125(1):59\u201367","journal-title":"J Pharmacol Sci"},{"issue":"8\u20139","key":"10041_CR58","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.phymed.2013.02.010","volume":"20","author":"J Zeng","year":"2013","unstructured":"Zeng J, Dou Y, Guo J, Wu X, Dai Y (2013) Paeoniflorin of Paeonia lactiflora prevents renal interstitial fibrosis induced by unilateral ureteral obstruction in mice. Phytomedicine 20(8\u20139):753\u2013759","journal-title":"Phytomedicine"},{"issue":"2","key":"10041_CR59","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.kint.2021.10.023","volume":"101","author":"Q Hong","year":"2022","unstructured":"Hong Q, Cai H, Zhang L, Li Z, Zhong F, Ni Z, Cai G, Chen X, He J, Lee K (2022) Modulation of transforming growth factor-\u03b2-induced kidney fibrosis by leucine-rich \u237a-2 glycoprotein-1. Kidney Int 101(2):299\u2013314","journal-title":"Kidney Int"},{"key":"10041_CR60","doi-asserted-by":"crossref","first-page":"1349259","DOI":"10.3389\/fphar.2024.1349259","volume":"15","author":"M He","year":"2024","unstructured":"He M, Hu Z, Yang M (2024) Effects of total glucosides of paeony on serum inflammatory cytokines in animal models of rheumatoid arthritis: a systematic review and meta-analysis. Front Pharmacol 15:1349259","journal-title":"Front Pharmacol"},{"key":"10041_CR61","unstructured":"Xie Y, Zhou H, Liu L (2022) A composition containing total white peony glycosides, a self-microemulsion formulation and a preparation method and application thereof: CN202111575976.8"},{"issue":"16","key":"10041_CR62","first-page":"3569","volume":"44","author":"Q Du","year":"2019","unstructured":"Du Q, Luo J, Guan Y, Xiao F, Zang Z, Jin C, Chen L (2019) Pharmacokinetics of skin and blood of Tripterygium wilfordii and Paeonia lactiflora micro-emulsion gel based on micro-dialysis technology. Zhongguo Zhong Yao Za Zhi 44(16):3569\u20133575 (Chinese)","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"issue":"1\u20132","key":"10041_CR63","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ijpharm.2017.05.005","volume":"526","author":"SP Callender","year":"2017","unstructured":"Callender SP, Mathews JA, Kobernyk K, Wettig SD (2017) Microemulsion utility in pharmaceuticals: implications for multi-drug delivery. Int J Pharm 526(1\u20132):425\u2013442","journal-title":"Int J Pharm"},{"issue":"3","key":"10041_CR64","first-page":"240","volume":"46","author":"L Lin","year":"2011","unstructured":"Lin L, Chen JY, Bao M, Wei H, Zhang L, Zhou H, Zhang X, Wei W (2011) Comparison of the effects of paeoniflorin microemulsion and paeoniflorin on adjuvant arthritis in rats. J Anhui Med Univ 46(3):240\u2013244 (Chinese)","journal-title":"J Anhui Med Univ"},{"key":"10041_CR65","doi-asserted-by":"crossref","first-page":"7304107","DOI":"10.1155\/2021\/7304107","volume":"2021","author":"G Shi","year":"2021","unstructured":"Shi G, Shen J, Wei T, Ren F, Guo F, Zhou Y (2021) UPLC-ESI-MS\/MS analysis and evaluation of antioxidant activity of total flavonoid extract from Paeonia lactiflora seed peel and optimization by response surface methodology (RSM). Biomed Res Int 2021:7304107","journal-title":"Biomed Res Int"},{"issue":"6","key":"10041_CR66","doi-asserted-by":"crossref","first-page":"466","DOI":"10.2174\/1389557519666191015204223","volume":"20","author":"J Wang","year":"2020","unstructured":"Wang J, Wu G, Chu H, Wu Z, Sun J (2020) Paeonol derivatives and pharmacological activities: a review of recent progress. Mini Rev Med Chem 20(6):466\u2013482","journal-title":"Mini Rev Med Chem"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-024-10041-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-024-10041-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-024-10041-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T16:37:28Z","timestamp":1766853448000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-024-10041-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,25]]},"references-count":66,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10041"],"URL":"https:\/\/doi.org\/10.1007\/s11033-024-10041-6","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,25]]},"assertion":[{"value":"31 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}],"article-number":"13"}}