{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:28:48Z","timestamp":1772119728993,"version":"3.50.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Science Foundation of Nanjing Medical University Affiliated Changzhou Second People\u2019s Hospital","award":["2022K007"],"award-info":[{"award-number":["2022K007"]}]},{"name":"Changzhou Sci & Tech Program","award":["CJ20220071"],"award-info":[{"award-number":["CJ20220071"]}]},{"name":"Changzhou Sci & Tech Program","award":["CJ20230073"],"award-info":[{"award-number":["CJ20230073"]}]},{"name":"Changzhou Sci & Tech Program","award":["grant no. CJ20220077"],"award-info":[{"award-number":["grant no. CJ20220077"]}]},{"name":"Youth Program of Changzhou Health Commission","award":["QN202233"],"award-info":[{"award-number":["QN202233"]}]},{"name":"\"Longcheng Medical Star\" Health Youth Science and Technology Talent Promotion Project","award":["LCYX202201"],"award-info":[{"award-number":["LCYX202201"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s11033-024-10096-5","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T05:02:13Z","timestamp":1731474133000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Down-regulation of miR-138-5p in PP2A KO mice promoted apoptosis of spermatocytes"],"prefix":"10.1007","volume":"51","author":[{"given":"Danni","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuwei","family":"Shang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiting","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,13]]},"reference":[{"issue":"1","key":"10096_CR1","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1093\/biolre\/ioac089","volume":"107","author":"H Jiang","year":"2022","unstructured":"Jiang H et al (2022) Identification of pathogenic mutations from nonobstructive azoospermia patients\u2020. Biol Reprod 107(1):85\u201394","journal-title":"Biol Reprod"},{"key":"10096_CR2","doi-asserted-by":"crossref","unstructured":"Kamenz J, Gelens L, Ferrell JE Jr. (2021) Bistable, Biphasic Regulation of PP2A-B55 accounts for the dynamics of mitotic substrate phosphorylation. Curr Biol 31(4):794\u2013808e6","DOI":"10.1016\/j.cub.2020.11.058"},{"issue":"1","key":"10096_CR3","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.bbamcr.2018.07.010","volume":"1866","author":"S Reynhout","year":"2019","unstructured":"Reynhout S, Janssens V (2019) Physiologic functions of PP2A: lessons from genetically modified mice. Biochim Biophys Acta Mol Cell Res 1866(1):31\u201350","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"issue":"2","key":"10096_CR4","doi-asserted-by":"publisher","first-page":"188453","DOI":"10.1016\/j.bbcan.2020.188453","volume":"1874","author":"M Dzulko","year":"2020","unstructured":"Dzulko M et al (2020) The PP2A subunit PR130 is a key regulator of cell development and oncogenic transformation. Biochim Biophys Acta Rev Cancer 1874(2):188453","journal-title":"Biochim Biophys Acta Rev Cancer"},{"issue":"3","key":"10096_CR5","doi-asserted-by":"publisher","first-page":"162","DOI":"10.3109\/10409238.2016.1143913","volume":"51","author":"N Wlodarchak","year":"2016","unstructured":"Wlodarchak N, Xing Y (2016) PP2A as a master regulator of the cell cycle. Crit Rev Biochem Mol Biol 51(3):162\u2013184","journal-title":"Crit Rev Biochem Mol Biol"},{"issue":"6","key":"10096_CR6","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1016\/j.cell.2006.11.033","volume":"127","author":"Y Xu","year":"2006","unstructured":"Xu Y et al (2006) Structure of the protein phosphatase 2A holoenzyme. Cell 127(6):1239\u20131251","journal-title":"Cell"},{"issue":"5","key":"10096_CR7","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1530\/EJE-19-0067","volume":"180","author":"T Guran","year":"2019","unstructured":"Guran T et al (2019) PPP2R3C gene variants cause syndromic 46,XY gonadal dysgenesis and impaired spermatogenesis in humans. Eur J Endocrinol 180(5):291\u2013309","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"10096_CR8","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1530\/EJE-21-0910","volume":"186","author":"D Cicek","year":"2021","unstructured":"Cicek D et al (2021) Broad-spectrum XX and XY gonadal dysgenesis in patients with a homozygous L193S variant in PPP2R3C. Eur J Endocrinol 186(1):65\u201372","journal-title":"Eur J Endocrinol"},{"issue":"5","key":"10096_CR9","doi-asserted-by":"publisher","first-page":"e21564","DOI":"10.1096\/fj.202002810R","volume":"35","author":"M Du","year":"2021","unstructured":"Du M et al (2021) PPP2R1B is modulated by ubiquitination and is essential for spermatogenesis. Faseb j 35(5):e21564","journal-title":"Faseb j"},{"key":"10096_CR10","doi-asserted-by":"crossref","unstructured":"Jang JK et al (2021) Multiple pools of PP2A regulate spindle assembly, kinetochore attachments and cohesion in Drosophila oocytes. J Cell Sci, 134(14)","DOI":"10.1242\/jcs.254037"},{"issue":"6","key":"10096_CR11","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.cub.2013.02.004","volume":"23","author":"JP Chambon","year":"2013","unstructured":"Chambon JP et al (2013) The PP2A inhibitor I2PP2A is essential for sister chromatid segregation in oocyte meiosis II. Curr Biol 23(6):485\u2013490","journal-title":"Curr Biol"},{"key":"10096_CR12","doi-asserted-by":"crossref","unstructured":"Keating L, Touati SA, Wassmann K (2020) A PP2A-B56-Centered view on metaphase-to-anaphase transition in mouse oocyte meiosis I. Cells, 9(2)","DOI":"10.3390\/cells9020390"},{"issue":"16","key":"10096_CR13","doi-asserted-by":"publisher","first-page":"26979","DOI":"10.18632\/oncotarget.15927","volume":"8","author":"S Liang","year":"2017","unstructured":"Liang S et al (2017) Protein phosphatase 2A regulatory subunit B55\u03b1 functions in mouse oocyte maturation and early embryonic development. Oncotarget 8(16):26979\u201326991","journal-title":"Oncotarget"},{"issue":"11","key":"10096_CR14","doi-asserted-by":"publisher","first-page":"3201","DOI":"10.1007\/s43032-022-00843-z","volume":"29","author":"X Chen","year":"2022","unstructured":"Chen X et al (2022) Catalytic subunit of protein phosphatase 2A (PP2Ac) influences the meiosis initiation during Spermatocyte Meiosis Prophase I. Reprod Sci 29(11):3201\u20133211","journal-title":"Reprod Sci"},{"key":"10096_CR15","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.semcdb.2021.05.009","volume":"121","author":"WH Walker","year":"2022","unstructured":"Walker WH (2022) Regulation of mammalian spermatogenesis by miRNAs. Semin Cell Dev Biol 121:24\u201331","journal-title":"Semin Cell Dev Biol"},{"key":"10096_CR16","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3389\/fonc.2015.00043","volume":"5","author":"PP Ruvolo","year":"2015","unstructured":"Ruvolo PP (2015) The interplay between PP2A and microRNAs in Leukemia. Front Oncol 5:43","journal-title":"Front Oncol"},{"key":"10096_CR17","doi-asserted-by":"crossref","unstructured":"Li J et al (2020) Regulation of XPO5 phosphorylation by PP2A in hepatocellular carcinoma. MedComm 2022. 3(2): p. e125","DOI":"10.1002\/mco2.125"},{"issue":"10","key":"10096_CR18","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1101\/gad.1884710","volume":"24","author":"HR Chiang","year":"2010","unstructured":"Chiang HR et al (2010) Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. Genes Dev 24(10):992\u20131009","journal-title":"Genes Dev"},{"issue":"7","key":"10096_CR19","doi-asserted-by":"publisher","first-page":"e22783","DOI":"10.1002\/jbt.22783","volume":"35","author":"L He","year":"2021","unstructured":"He L et al (2021) miRNA-138-5p suppresses cigarette smoke-induced apoptosis in testicular cells by targeting Caspase-3 through the Bcl-2 signaling pathway. J Biochem Mol Toxicol 35(7):e22783","journal-title":"J Biochem Mol Toxicol"},{"issue":"4","key":"10096_CR20","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1080\/15384101.2019.1577650","volume":"18","author":"Y Liu","year":"2019","unstructured":"Liu Y et al (2019) Atypical GATA protein TRPS1 plays indispensable roles in mouse two-cell embryo. Cell Cycle 18(4):437\u2013451","journal-title":"Cell Cycle"},{"issue":"3\u20134","key":"10096_CR21","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1101\/gad.331371.119","volume":"34","author":"LM Cornelissen","year":"2020","unstructured":"Cornelissen LM et al (2020) TRPS1 acts as a context-dependent regulator of mammary epithelial cell growth\/differentiation and breast cancer development. Genes Dev 34(3\u20134):179\u2013193","journal-title":"Genes Dev"},{"issue":"1","key":"10096_CR22","doi-asserted-by":"publisher","first-page":"3115","DOI":"10.1038\/s41467-018-05370-7","volume":"9","author":"D Elster","year":"2018","unstructured":"Elster D et al (2018) TRPS1 shapes YAP\/TEAD-dependent transcription in breast cancer cells. Nat Commun 9(1):3115","journal-title":"Nat Commun"},{"issue":"5","key":"10096_CR23","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1002\/cam4.1421","volume":"7","author":"H Liu","year":"2018","unstructured":"Liu H et al (2018) Trps1 is associated with the multidrug resistance of lung cancer cell by regulating MGMT gene expression. Cancer Med 7(5):1921\u20131932","journal-title":"Cancer Med"},{"issue":"6","key":"10096_CR24","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1111\/andr.13072","volume":"9","author":"J Sun","year":"2021","unstructured":"Sun J et al (2021) Trps1 targets Ccnd1 to regulate mouse leydig cell proliferation. Andrology 9(6):1923\u20131933","journal-title":"Andrology"},{"issue":"4","key":"10096_CR25","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1530\/REP-14-0231","volume":"149","author":"X Pan","year":"2015","unstructured":"Pan X et al (2015) Ppp2ca knockout in mice spermatogenesis. Reproduction 149(4):385\u2013391","journal-title":"Reproduction"},{"issue":"13","key":"10096_CR26","doi-asserted-by":"publisher","first-page":"5691","DOI":"10.1039\/D1CS00991E","volume":"51","author":"T Bilbrough","year":"2022","unstructured":"Bilbrough T, Piemontese E, Seitz O (2022) Dissecting the role of protein phosphorylation: a chemical biology toolbox. Chem Soc Rev 51(13):5691\u20135730","journal-title":"Chem Soc Rev"},{"issue":"1","key":"10096_CR27","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1111\/j.1582-4934.2008.00249.x","volume":"12","author":"R Liu","year":"2008","unstructured":"Liu R et al (2008) Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology. J Cell Mol Med 12(1):241\u2013257","journal-title":"J Cell Mol Med"},{"key":"10096_CR28","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.toxlet.2020.05.035","volume":"331","author":"Y Zhang","year":"2020","unstructured":"Zhang Y et al (2020) Reduced methylation of PP2Ac promotes ethanol-induced lipid accumulation through FOXO1 phosphorylation in vitro and in vivo. Toxicol Lett 331:65\u201374","journal-title":"Toxicol Lett"},{"issue":"2","key":"10096_CR29","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1080\/15384047.2015.1121345","volume":"17","author":"SJ Gong","year":"2016","unstructured":"Gong SJ et al (2016) Upregulation of PP2Ac predicts poor prognosis and contributes to aggressiveness in hepatocellular carcinoma. Cancer Biol Ther 17(2):151\u2013162","journal-title":"Cancer Biol Ther"},{"issue":"11","key":"10096_CR30","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1080\/15384101.2016.1175256","volume":"15","author":"A Tang","year":"2016","unstructured":"Tang A et al (2016) PP2A regulates kinetochore-microtubule attachment during meiosis I in oocyte. Cell Cycle 15(11):1450\u20131461","journal-title":"Cell Cycle"},{"issue":"2","key":"10096_CR31","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1111\/brv.12459","volume":"94","author":"A Reza","year":"2019","unstructured":"Reza A et al (2019) Roles of microRNAs in mammalian reproduction: from the commitment of germ cells to peri-implantation embryos. Biol Rev Camb Philos Soc 94(2):415\u2013438","journal-title":"Biol Rev Camb Philos Soc"},{"key":"10096_CR32","doi-asserted-by":"crossref","unstructured":"Bott A et al (2017) miRNA-1246 induces pro-inflammatory responses in mesenchymal stem\/stromal cells by regulating PKA and PP2A. 8(27):43897\u201343914Oncotarget","DOI":"10.18632\/oncotarget.14915"},{"issue":"1","key":"10096_CR33","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1158\/0008-5472.BCD-19-0039","volume":"1","author":"G Silvestri","year":"2020","unstructured":"Silvestri G et al (2020) Persistence of drug-resistant leukemic stem cells and impaired NK Cell immunity in CML patients depend on MIR300 Antiproliferative and PP2A-Activating functions. Blood Cancer Discov 1(1):48\u201367","journal-title":"Blood Cancer Discov"},{"issue":"1","key":"10096_CR34","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s12943-016-0569-4","volume":"15","author":"R Yang","year":"2016","unstructured":"Yang R et al (2016) Mir-138-5p contributes to cell proliferation and invasion by targeting survivin in bladder cancer cells. Mol Cancer 15(1):82","journal-title":"Mol Cancer"},{"issue":"8","key":"10096_CR35","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.neo.2021.05.015","volume":"23","author":"AT da Cruz","year":"2021","unstructured":"da Cruz AT et al (2021) Mir-138-5p induces aggressive traits by targeting Trp53 expression in murine melanoma cells, and correlates with poor prognosis of melanoma patients. Neoplasia 23(8):823\u2013834","journal-title":"Neoplasia"},{"key":"10096_CR36","doi-asserted-by":"crossref","unstructured":"Taraz\u00f3n E et al (2021) MiR-138-5p suppresses Cell Growth and Migration in Melanoma by Targeting Telomerase Reverse Transcriptase. Genes (Basel), 12(12).","DOI":"10.3390\/genes12121931"},{"key":"10096_CR37","first-page":"p7809882","volume":"2022","author":"J Gong","year":"2022","unstructured":"Gong J et al (2022) Mir-138-5p inhibits the Growth and Invasion of Glioma cells by regulating WEE1. Anal Cell Pathol (Amst) 2022:p7809882","journal-title":"Anal Cell Pathol (Amst)"},{"issue":"7","key":"10096_CR38","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.1080\/10495398.2022.2095642","volume":"34","author":"C Yu","year":"2023","unstructured":"Yu C et al (2023) Mir-138-5p promotes chicken granulosa cell apoptosis via targeting SIRT1. Anim Biotechnol 34(7):2449\u20132458","journal-title":"Anim Biotechnol"},{"key":"10096_CR39","unstructured":"Yu C et al (2022) Mir-138-5p promotes chicken granulosa cell apoptosis via targeting SIRT1. Anim Biotechnol, p. 1\u201310"},{"key":"10096_CR40","doi-asserted-by":"crossref","unstructured":"Song Y et al (2023) Loss of circSRY reduces \u03b3H2AX level in germ cells and impairs mouse spermatogenesis. Life Sci Alliance, 6(2)","DOI":"10.26508\/lsa.202201617"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-024-10096-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-024-10096-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-024-10096-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T23:47:20Z","timestamp":1738712840000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-024-10096-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,13]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10096"],"URL":"https:\/\/doi.org\/10.1007\/s11033-024-10096-5","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4091053\/v1","asserted-by":"object"}]},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,13]]},"assertion":[{"value":"13 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in this study involving were in accordance with the laboratory animal ethics committee of Nanjing Medical University Affiliated Changzhou Second People\u2019s Hospital.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1147"}}