{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:42:25Z","timestamp":1791207745656,"version":"4.1.0"},"reference-count":100,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T00:00:00Z","timestamp":1733529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T00:00:00Z","timestamp":1733529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s11033-024-10139-x","type":"journal-article","created":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T06:22:33Z","timestamp":1733552553000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Adipocyte-derived fatty acid uptake induces obesity-related breast cancer progression: a review"],"prefix":"10.1007","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7294-1307","authenticated-orcid":false,"given":"Selin","family":"Kisar Tunca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1365-2310","authenticated-orcid":false,"given":"Resat","family":"Unal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,7]]},"reference":[{"key":"10139_CR1","doi-asserted-by":"publisher","unstructured":"Rosen ED, Spiegelman BM (2006) \u2018Adipocytes as regulators of energy balance and glucose homeostasis\u2019. Nature (444)7121:847\u2013853, Dec. https:\/\/doi.org\/10.1038\/nature05483","DOI":"10.1038\/nature05483"},{"key":"10139_CR2","doi-asserted-by":"publisher","unstructured":"Goossens GH (2017) \u2018The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function\u2019, Obes Facts (10)3:207\u2013215, https:\/\/doi.org\/10.1159\/000471488","DOI":"10.1159\/000471488"},{"key":"10139_CR3","doi-asserted-by":"publisher","unstructured":"Sung H, \u2018Global Cancer Statistics (2020): GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries\u2019, CA: A Cancer Journal for Clinicians (71)3:209\u2013249, 2021, https:\/\/doi.org\/10.3322\/caac.21660","DOI":"10.3322\/caac.21660"},{"key":"10139_CR4","doi-asserted-by":"publisher","unstructured":"Chan DSM, \u2018World Cancer Research Fund International (2019 Nov.) Continuous Update Project\u2014systematic literature review and meta-analysis of observational cohort studies on physical activity, sedentary behavior, adiposity, and weight change and breast cancer risk\u2019, Cancer Causes Control (30)11:1183\u20131200, https:\/\/doi.org\/10.1007\/s10552-019-01223-w","DOI":"10.1007\/s10552-019-01223-w"},{"key":"10139_CR5","doi-asserted-by":"publisher","unstructured":"Merdad A et al (Jan. 2015) Transcriptomics profiling study of breast cancer from Kingdom of Saudi Arabia revealed altered expression of Adiponectin and fatty acid binding Protein4: is lipid metabolism associated with breast cancer? BMC Genomics 16(1). https:\/\/doi.org\/10.1186\/1471-2164-16-S1-S11","DOI":"10.1186\/1471-2164-16-S1-S11"},{"key":"10139_CR6","doi-asserted-by":"publisher","unstructured":"Zahid H, Simpson ER, Brown KA (Dec. 2016) Inflammation, dysregulated metabolism and aromatase in obesity and breast cancer. Curr Opin Pharmacol 31:90\u201396. https:\/\/doi.org\/10.1016\/j.coph.2016.11.003","DOI":"10.1016\/j.coph.2016.11.003"},{"key":"10139_CR7","doi-asserted-by":"publisher","first-page":"227","DOI":"10.4137\/BCBCR.S7707","volume":"5","author":"RJ Esfahlan","year":"2011","unstructured":"Esfahlan RJ, Zarghami N, Esfahlan AJ, Mollazadeh M, Nejati K, Nasiri M (2011) The possible impact of obesity on Androgen, Progesterone and Estrogen Receptors (ER\u03b1 and ER\u03b2) gene expression in breast Cancer patients. Breast Cancer (Auckl) 5:227\u2013237. https:\/\/doi.org\/10.4137\/BCBCR.S7707","journal-title":"Breast Cancer (Auckl)"},{"key":"10139_CR8","doi-asserted-by":"publisher","unstructured":"Aird R et al (Oct. 2022) Hypoxia-driven metabolic reprogramming of adipocytes fuels cancer cell proliferation. Front Endocrinol (Lausanne) 13:989523. https:\/\/doi.org\/10.3389\/fendo.2022.989523","DOI":"10.3389\/fendo.2022.989523"},{"key":"10139_CR9","doi-asserted-by":"publisher","unstructured":"Panaroni C et al (2022) Feb., \u2018Multiple myeloma cells induce lipolysis in adipocytes and uptake fatty acids through fatty acid transporter proteins\u2019. Blood (139)6:876\u2013888, https:\/\/doi.org\/10.1182\/blood.2021013832","DOI":"10.1182\/blood.2021013832"},{"key":"10139_CR10","doi-asserted-by":"publisher","unstructured":"Mukherjee A, Bilecz AJ, Lengyel E (2022) \u2018The adipocyte microenvironment and cancer\u2019. Cancer Metastasis Rev (41)3:575\u2013587, Sep. https:\/\/doi.org\/10.1007\/s10555-022-10059-x","DOI":"10.1007\/s10555-022-10059-x"},{"key":"10139_CR11","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.ejcb.2013.06.001","volume":"92","author":"AT Ali","year":"2013","unstructured":"Ali AT, Hochfeld WE, Myburgh R, Pepper MS (2013) Adipocyte and adipogenesis. Eur J Cell Biol 92:6\u20137. https:\/\/doi.org\/10.1016\/j.ejcb.2013.06.001","journal-title":"Eur J Cell Biol"},{"issue":"9","key":"10139_CR12","doi-asserted-by":"publisher","first-page":"3113","DOI":"10.1096\/fj.09-133546","volume":"23","author":"MC Zingaretti","year":"2009","unstructured":"Zingaretti MC et al (2009) The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J 23(9):3113\u20133120. https:\/\/doi.org\/10.1096\/fj.09-133546","journal-title":"FASEB J"},{"key":"10139_CR13","doi-asserted-by":"publisher","unstructured":"Cinti S (2018) \u2018Pink Adipocytes\u2019. Trends in Endocrinology & Metabolism (29)9:651\u2013666, Sep. https:\/\/doi.org\/10.1016\/j.tem.2018.05.007","DOI":"10.1016\/j.tem.2018.05.007"},{"key":"10139_CR14","doi-asserted-by":"publisher","unstructured":"Attan\u00e9 C et al (2020) Jan., \u2018Human Bone Marrow Is Comprised of Adipocytes with Specific Lipid Metabolism\u2019, Cell Reports, vol. 30, no. 4, pp. 949\u2013958.e6, https:\/\/doi.org\/10.1016\/j.celrep.2019.12.089","DOI":"10.1016\/j.celrep.2019.12.089"},{"key":"10139_CR15","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1146\/annurev.nutr.27.061406.093734","volume":"27","author":"RE Duncan","year":"2007","unstructured":"Duncan RE, Ahmadian M, Jaworski K, Sarkadi-Nagy E, Sul HS (2007) Regulation of Lipolysis in Adipocytes. Annu Rev Nutr 27:79\u2013101. https:\/\/doi.org\/10.1146\/annurev.nutr.27.061406.093734","journal-title":"Annu Rev Nutr"},{"key":"10139_CR16","doi-asserted-by":"publisher","unstructured":"Ghaben AL, Scherer PE (2019) \u2018Adipogenesis and metabolic health\u2019. Nat Rev Mol Cell Biol (20)4:242\u2013258, Apr. https:\/\/doi.org\/10.1038\/s41580-018-0093-z","DOI":"10.1038\/s41580-018-0093-z"},{"key":"10139_CR17","doi-asserted-by":"publisher","unstructured":"Hu L et al (May 2021) Single-cell RNA sequencing reveals the Cellular Origin and evolution of breast Cancer in BRCA1 mutation carriers. Cancer Res 81(10):2600\u20132611. https:\/\/doi.org\/10.1158\/0008-5472.CAN-20-2123","DOI":"10.1158\/0008-5472.CAN-20-2123"},{"key":"10139_CR18","doi-asserted-by":"publisher","unstructured":"Taurin S, Alkhalifa H (2020) \u2018Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses\u2019. Neoplasia (22)12:663\u2013678, Oct. https:\/\/doi.org\/10.1016\/j.neo.2020.09.009","DOI":"10.1016\/j.neo.2020.09.009"},{"key":"10139_CR19","doi-asserted-by":"publisher","unstructured":"Pavlopoulou A, Oktay Y, Vougas K, Louka M, Vorgias CE, Georgakilas AG (Oct. 2016) Determinants of resistance to chemotherapy and ionizing radiation in breast cancer stem cells. Cancer Lett 380(2):485\u2013493. https:\/\/doi.org\/10.1016\/j.canlet.2016.07.018","DOI":"10.1016\/j.canlet.2016.07.018"},{"key":"10139_CR20","doi-asserted-by":"publisher","unstructured":"Barzaman K et al (2020) Jul., \u2018Breast cancer: Biology, biomarkers, and treatments\u2019, International Immunopharmacology, vol. 84, p. 106535, https:\/\/doi.org\/10.1016\/j.intimp.2020.106535","DOI":"10.1016\/j.intimp.2020.106535"},{"key":"10139_CR21","doi-asserted-by":"publisher","unstructured":"Prat A et al (2015) Nov., \u2018Clinical implications of the intrinsic molecular subtypes of breast cancer\u2019, Breast, vol. 24 Suppl 2, pp. S26-35, https:\/\/doi.org\/10.1016\/j.breast.2015.07.008","DOI":"10.1016\/j.breast.2015.07.008"},{"key":"10139_CR22","doi-asserted-by":"crossref","unstructured":"Orrantia-Borunda E, Anchondo-Nu\u00f1ez P, Acu\u00f1a-Aguilar LE, G\u00f3mez-Valles FO, Ram\u00edrez-Valdespino CA \u2018Subtypes of Breast Cancer\u2019, in Breast Cancer, H. N. Mayrovitz, Ed., Brisbane (AU): Exon Publications, 2022. Accessed: Sep. 13, 2023. [Online]. Available: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK583808\/","DOI":"10.36255\/exon-publications-breast-cancer-subtypes"},{"key":"10139_CR23","doi-asserted-by":"publisher","unstructured":"Zhang L, Wang XI, Zhang S (Oct. 2018) Tumor-infiltrating lymphocyte volume is a better predictor of neoadjuvant therapy response and overall survival in triple-negative invasive breast cancer. Hum Pathol 80:47\u201354. https:\/\/doi.org\/10.1016\/j.humpath.2018.05.024","DOI":"10.1016\/j.humpath.2018.05.024"},{"key":"10139_CR24","doi-asserted-by":"publisher","unstructured":"Monaco ME (2017) \u2018Fatty acid metabolism in breast cancer subtypes\u2019, Oncotarget, vol. 8, no. 17, pp. 29487\u201329500, Feb. https:\/\/doi.org\/10.18632\/oncotarget.15494","DOI":"10.18632\/oncotarget.15494"},{"key":"10139_CR25","doi-asserted-by":"publisher","unstructured":"Nik-Zainal S et al (2016) Landscape of somatic mutations in 560 breast cancer whole-genome sequences. Nature 534 7605, Art. 7605, Jun. https:\/\/doi.org\/10.1038\/nature17676","DOI":"10.1038\/nature17676"},{"key":"10139_CR26","doi-asserted-by":"publisher","unstructured":"Liang Y, Zhang H, Song X, Yang Q (Feb. 2020) Metastatic heterogeneity of breast cancer: molecular mechanism and potential therapeutic targets. Sem Cancer Biol 60:14\u201327. https:\/\/doi.org\/10.1016\/j.semcancer.2019.08.012","DOI":"10.1016\/j.semcancer.2019.08.012"},{"key":"10139_CR27","doi-asserted-by":"publisher","unstructured":"Valencia OM, Samuel SE, Viscusi RK, Riall TS, Neumayer LA, Aziz H (2017) \u2018The Role of Genetic Testing in Patients With Breast Cancer: A Review\u2019, JAMA Surgery, vol. 152, no. 6, pp. 589\u2013594, Jun. https:\/\/doi.org\/10.1001\/jamasurg.2017.0552","DOI":"10.1001\/jamasurg.2017.0552"},{"key":"10139_CR28","doi-asserted-by":"publisher","unstructured":"Ilhan M et al (Apr. 2020) Pro-metastatic functions of notch signaling is mediated by CYR61 in breast cells. Eur J Cell Biol 99:2\u20133. https:\/\/doi.org\/10.1016\/j.ejcb.2020.151070","DOI":"10.1016\/j.ejcb.2020.151070"},{"key":"10139_CR29","doi-asserted-by":"publisher","unstructured":"Cordenonsi M et al (2011) Nov., \u2018The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells\u2019, Cell, vol. 147, no. 4, pp. 759\u2013772, https:\/\/doi.org\/10.1016\/j.cell.2011.09.048","DOI":"10.1016\/j.cell.2011.09.048"},{"key":"10139_CR30","doi-asserted-by":"publisher","unstructured":"Brown KA (Jun. 2021) Metabolic pathways in obesity-related breast cancer. Nat Rev Endocrinol 17(6):350\u2013363. https:\/\/doi.org\/10.1038\/s41574-021-00487-0","DOI":"10.1038\/s41574-021-00487-0"},{"key":"10139_CR31","doi-asserted-by":"publisher","unstructured":"Zhang H, Wang M, Xu Y (Apr. 2023) Understanding the mechanisms underlying obesity in remodeling the breast tumor immune microenvironment: from the perspective of inflammation. Cancer Biol Med 20(4):268\u2013286. https:\/\/doi.org\/10.20892\/j.issn.2095-3941.2022.0547","DOI":"10.20892\/j.issn.2095-3941.2022.0547"},{"key":"10139_CR32","unstructured":"Feingold KR \u2018Introduction to Lipids and Lipoproteins\u2019, in Endotext, K. R. Feingold, B. Anawalt, M. R. Blackman, A. Boyce, G. Chrousos, E. Corpas, W. W. de Herder, K. Dhatariya, K. Dungan, J. Hofland, S. Kalra, G. Kaltsas, N. Kapoor, C. Koch, P. Kopp, M. Korbonits, C. S. Kovacs, W. Kuohung, B. Laferr\u00e8re, M. Levy, E. A. McGee, R. McLachlan, M. New, J. Purnell, R. Sahay, A. S. Shah, F. Singer, M. A. Sperling, C. A. Stratakis, D. L. Trence, and D. P. Wilson, Eds., South Dartmouth (MA): MDText.com, Inc., 2000. Accessed: Oct. 05, 2023. [Online]. Available: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK305896\/"},{"key":"10139_CR33","doi-asserted-by":"publisher","unstructured":"Zipinotti dos Santos D et al (Jun. 2023) The impact of lipid metabolism on breast cancer: a review about its role in tumorigenesis and immune escape. Cell Communication Signal 21(1):161. https:\/\/doi.org\/10.1186\/s12964-023-01178-1","DOI":"10.1186\/s12964-023-01178-1"},{"key":"10139_CR34","doi-asserted-by":"publisher","unstructured":"Bernlohr DA, Coe NR, LiCata VJ (1999) \u2018Fatty acid trafficking in the adipocyte\u2019, Seminars in Cell & Developmental Biology, vol. 10, no. 1, pp. 43\u201349, Feb. https:\/\/doi.org\/10.1006\/scdb.1998.0271","DOI":"10.1006\/scdb.1998.0271"},{"key":"10139_CR35","doi-asserted-by":"publisher","unstructured":"Lobo S, Wiczer BM, Smith AJ, Hall AM, Bernlohr DA (2007) \u2018Fatty acid metabolism in adipocytes: functional analysis of fatty acid transport proteins 1 and 4\u2019, Journal of Lipid Research, vol. 48, no. 3, pp. 609\u2013620, Mar. https:\/\/doi.org\/10.1194\/jlr.M600441-JLR200","DOI":"10.1194\/jlr.M600441-JLR200"},{"key":"10139_CR36","doi-asserted-by":"publisher","unstructured":"Rupert JE, Kolonin MG (2022) \u2018Fatty acid translocase: a culprit of lipid metabolism dysfunction in disease\u2019, Immunometabolism (Cobham), vol. 4, no. 3, p. e00001, Aug. https:\/\/doi.org\/10.1097\/IN9.0000000000000001","DOI":"10.1097\/IN9.0000000000000001"},{"key":"10139_CR37","doi-asserted-by":"publisher","unstructured":"Hall AM, Smith AJ, Bernlohr DA (2003) \u2018Characterization of the Acyl-CoA Synthetase Activity of Purified Murine Fatty Acid Transport Protein 1*\u2019, Journal of Biological Chemistry, vol. 278, no. 44, pp. 43008\u201343013, Oct. https:\/\/doi.org\/10.1074\/jbc.M306575200","DOI":"10.1074\/jbc.M306575200"},{"key":"10139_CR38","doi-asserted-by":"crossref","unstructured":"Black PN, Sandoval A, Arias-Barrau E, DiRusso CC (2009) \u2018Targeting the fatty acid transport proteins (FATP) to understand the mechanisms linking fatty acid transport to metabolism\u2019, Immunol Endocr Metab Agents Med Chem, vol. 9, no. 1, pp. 11\u201317, Sep","DOI":"10.2174\/187152209788009850"},{"key":"10139_CR39","doi-asserted-by":"publisher","unstructured":"Prentice KJ, Saksi J, Hotamisligil GS (2019) \u2018Adipokine FABP4 integrates energy stores and counterregulatory metabolic responses\u2019, Journal of Lipid Research, vol. 60, no. 4, pp. 734\u2013740, Apr. https:\/\/doi.org\/10.1194\/jlr.S091793","DOI":"10.1194\/jlr.S091793"},{"key":"10139_CR40","doi-asserted-by":"publisher","unstructured":"Xu H, Diolintzi A, Storch J (2019) \u2018Fatty acid-binding proteins: functional understanding and diagnostic implications\u2019, Curr Opin Clin Nutr Metab Care, vol. 22, no. 6, pp. 407\u2013412, Nov. https:\/\/doi.org\/10.1097\/MCO.0000000000000600","DOI":"10.1097\/MCO.0000000000000600"},{"key":"10139_CR41","doi-asserted-by":"publisher","unstructured":"He Q, Chen Y, Wang Z, He H, Yu P (2023) \u2018Cellular Uptake, Metabolism and Sensing of Long-Chain Fatty Acids\u2019, FBL, vol. 28, no. 1, Art. no. 1, Jan. https:\/\/doi.org\/10.31083\/j.fbl2801010","DOI":"10.31083\/j.fbl2801010"},{"key":"10139_CR42","doi-asserted-by":"publisher","unstructured":"Gan L, Liu Z, Cao W, Zhang Z, Sun C (2015) \u2018FABP4 reversed the regulation of leptin on mitochondrial fatty acid oxidation in mice adipocytes\u2019, Sci Rep, vol. 5, no. 1, Art. no. 1, Aug. https:\/\/doi.org\/10.1038\/srep13588","DOI":"10.1038\/srep13588"},{"key":"10139_CR43","doi-asserted-by":"publisher","unstructured":"Corn KC, Windham MA, Rafat M (Nov. 2020) Lipids in the Tumor Microenvironment: from Cancer Progression to Treatment. Prog Lipid Res 80:101055. https:\/\/doi.org\/10.1016\/j.plipres.2020.101055","DOI":"10.1016\/j.plipres.2020.101055"},{"key":"10139_CR44","doi-asserted-by":"publisher","unstructured":"Zanotelli MR et al (Jan. 2018) Regulation of ATP utilization during metastatic cell migration by collagen architecture. Mol Biol Cell 29(1):1\u20139. https:\/\/doi.org\/10.1091\/mbc.E17-01-0041","DOI":"10.1091\/mbc.E17-01-0041"},{"key":"10139_CR45","doi-asserted-by":"publisher","unstructured":"Kamphorst JJ et al (May 2013) Hypoxic and ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proc Natl Acad Sci U S A 110(22):8882\u20138887. https:\/\/doi.org\/10.1073\/pnas.1307237110","DOI":"10.1073\/pnas.1307237110"},{"key":"10139_CR46","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.addr.2020.07.013","volume":"159","author":"L Butler","year":"2020","unstructured":"Butler L et al (2020) Lipids and cancer: emerging roles in pathogenesis, diagnosis and therapeutic intervention. Adv Drug Deliv Rev 159:245\u2013293. https:\/\/doi.org\/10.1016\/j.addr.2020.07.013","journal-title":"Adv Drug Deliv Rev"},{"key":"10139_CR47","doi-asserted-by":"publisher","unstructured":"Hilvo M et al (2011) Apr., \u2018Novel Theranostic Opportunities Offered by Characterization of Altered Membrane Lipid Metabolism in Breast Cancer Progression\u2019, Cancer Research, vol. 71, no. 9, pp. 3236\u20133245, https:\/\/doi.org\/10.1158\/0008-5472.CAN-10-3894","DOI":"10.1158\/0008-5472.CAN-10-3894"},{"key":"10139_CR48","doi-asserted-by":"publisher","unstructured":"Snaebjornsson MT, Janaki-Raman S, Schulze A (Jan. 2020) Greasing the Wheels of the Cancer machine: the role of lipid metabolism in Cancer. Cell Metabol 31(1):62\u201376. https:\/\/doi.org\/10.1016\/j.cmet.2019.11.010","DOI":"10.1016\/j.cmet.2019.11.010"},{"key":"10139_CR49","doi-asserted-by":"publisher","unstructured":"Jarc E, Kump A, Malava\u0161i\u010d P, Eichmann TO, Zimmermann R, Petan T (2018) \u2018Lipid droplets induced by secreted phospholipase A2 and unsaturated fatty acids protect breast cancer cells from nutrient and lipotoxic stress\u2019, Biochim Biophys Acta Mol Cell Biol Lipids, vol. 1863, no. 3, pp. 247\u2013265, Mar. https:\/\/doi.org\/10.1016\/j.bbalip.2017.12.006","DOI":"10.1016\/j.bbalip.2017.12.006"},{"key":"10139_CR50","doi-asserted-by":"publisher","unstructured":"Cadenas C et al (2019) Aug., \u2018LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer\u2019, Int J Cancer, vol. 145, no. 4, pp. 901\u2013915, https:\/\/doi.org\/10.1002\/ijc.32138","DOI":"10.1002\/ijc.32138"},{"key":"10139_CR51","doi-asserted-by":"publisher","unstructured":"Koundouros N, Poulogiannis G (Jan. 2020) Reprogramming of fatty acid metabolism in cancer. Br J Cancer 122(1):4\u201322. https:\/\/doi.org\/10.1038\/s41416-019-0650-z","DOI":"10.1038\/s41416-019-0650-z"},{"key":"10139_CR52","doi-asserted-by":"publisher","unstructured":"Mallick R, Bhowmik P, Duttaroy AK (Nov. 2023) Targeting fatty acid uptake and metabolism in cancer cells: a promising strategy for cancer treatment. Biomed Pharmacother 167:115591. https:\/\/doi.org\/10.1016\/j.biopha.2023.115591","DOI":"10.1016\/j.biopha.2023.115591"},{"key":"10139_CR53","doi-asserted-by":"crossref","unstructured":"Watt MJ et al (Feb. 2019) Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer. Sci Transl Med 11:eaau5758. no. 47810.1126\/scitranslmed.aau5758","DOI":"10.1126\/scitranslmed.aau5758"},{"key":"10139_CR54","doi-asserted-by":"publisher","unstructured":"Yang P-B et al (2020) Nov., \u2018Blocking PPAR\u03b3 interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression\u2019, Proc Natl Acad Sci U S A, vol. 117, no. 44, pp. 27412\u201327422, https:\/\/doi.org\/10.1073\/pnas.2002997117","DOI":"10.1073\/pnas.2002997117"},{"key":"10139_CR55","doi-asserted-by":"publisher","unstructured":"Hoy AJ, Balaban S, Saunders DN (May 2017) Adipocyte-tumor cell metabolic crosstalk in breast Cancer. Trends Mol Med 23(5):381\u2013392. https:\/\/doi.org\/10.1016\/j.molmed.2017.02.009","DOI":"10.1016\/j.molmed.2017.02.009"},{"key":"10139_CR56","doi-asserted-by":"publisher","unstructured":"Fletcher SJ et al (Feb. 2017) Human breast adipose tissue: characterization of factors that change during tumor progression in human breast cancer. J Exp Clin Cancer Res 36(1):26. https:\/\/doi.org\/10.1186\/s13046-017-0494-4","DOI":"10.1186\/s13046-017-0494-4"},{"key":"10139_CR57","doi-asserted-by":"publisher","unstructured":"Bl\u00fccher C et al (2020) Dec., \u2018Secreted Factors from Adipose Tissue Reprogram Tumor Lipid Metabolism and Induce Motility by Modulating PPAR\u03b1\/ANGPTL4 and FAK\u2019, Mol Cancer Res, vol. 18, no. 12, pp. 1849\u20131862, https:\/\/doi.org\/10.1158\/1541-7786.MCR-19-1223","DOI":"10.1158\/1541-7786.MCR-19-1223"},{"key":"10139_CR58","doi-asserted-by":"publisher","unstructured":"Balaban S et al (2017) Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration. Cancer Metab 5(1). https:\/\/doi.org\/10.1186\/s40170-016-0163-7","DOI":"10.1186\/s40170-016-0163-7"},{"key":"10139_CR59","doi-asserted-by":"publisher","unstructured":"Balaban S et al (Sep. 2018) Heterogeneity of fatty acid metabolism in breast cancer cells underlies differential sensitivity to palmitate-induced apoptosis. Mol Oncol 12:1623. https:\/\/doi.org\/10.1002\/1878-0261.12368","DOI":"10.1002\/1878-0261.12368"},{"key":"10139_CR60","doi-asserted-by":"publisher","unstructured":"Zaoui M et al (2012) \u2018Breast-Associated Adipocytes Secretome Induce Fatty Acid Uptake and Invasiveness in Breast Cancer Cells via CD36 Independently of Body Mass Index, Menopausal Status and Mammary Density\u2019, Cancers (Basel), vol. 11, no. 12, p. Dec. 2019, https:\/\/doi.org\/10.3390\/cancers11122012","DOI":"10.3390\/cancers11122012"},{"key":"10139_CR61","doi-asserted-by":"publisher","unstructured":"Anvari G, Bellas E (Nov. 2021) Hypoxia induces stress fiber formation in adipocytes in the early stage of obesity. Sci Rep 11(1):21473. https:\/\/doi.org\/10.1038\/s41598-021-00335-1","DOI":"10.1038\/s41598-021-00335-1"},{"key":"10139_CR62","doi-asserted-by":"publisher","unstructured":"Luis G et al (May 2021) Tumor resistance to ferroptosis driven by Stearoyl-CoA Desaturase-1 (SCD1) in cancer cells and fatty acid biding Protein-4 (FABP4) in tumor microenvironment promote tumor recurrence. Redox Biol 43:102006. https:\/\/doi.org\/10.1016\/j.redox.2021.102006","DOI":"10.1016\/j.redox.2021.102006"},{"key":"10139_CR63","doi-asserted-by":"publisher","unstructured":"Wrzosek M, Zawadzka Z, Sawicka A, Bobrowska-Korczak B, Bia\u0142ek A (Feb. 2022) Impact of fatty acids on obesity-Associated diseases and Radical Weight reduction. OBES SURG 32(2):428\u2013440. https:\/\/doi.org\/10.1007\/s11695-021-05789-w","DOI":"10.1007\/s11695-021-05789-w"},{"key":"10139_CR64","doi-asserted-by":"publisher","unstructured":"YAO-BORENGASSER A, MONZAVI-KARBASSI B, HEDGES RA, ROGERS LJ, KADLUBAR SA, KIEBER-EMMONS T (2015) \u2018Adipocyte hypoxia promotes epithelial-mesenchymal transition-related gene expression and estrogen receptor-negative phenotype in breast cancer cells\u2019, Oncol Rep, vol. 33, no. 6, pp. 2689\u20132694, Jun. https:\/\/doi.org\/10.3892\/or.2015.3880","DOI":"10.3892\/or.2015.3880"},{"key":"10139_CR65","doi-asserted-by":"publisher","unstructured":"Rausch LK, Netzer NC, Hoegel J, Pramsohler S (Sep. 2017) The linkage between breast Cancer, Hypoxia, and adipose tissue. Front Oncol 7:211. https:\/\/doi.org\/10.3389\/fonc.2017.00211","DOI":"10.3389\/fonc.2017.00211"},{"key":"10139_CR66","doi-asserted-by":"publisher","unstructured":"Omoto Y et al (Jan. 2002) Evaluation of oestrogen receptor \u03b2 wild-type and variant protein expression, and relationship with clinicopathological factors in breast cancers. Eur J Cancer 38(3):380\u2013386. https:\/\/doi.org\/10.1016\/S0959-8049(01)00383-5","DOI":"10.1016\/S0959-8049(01)00383-5"},{"key":"10139_CR67","doi-asserted-by":"publisher","unstructured":"Bensaad K et al (Oct. 2014) Fatty acid uptake and lipid Storage Induced by HIF-1\u03b1 contribute to cell growth and survival after Hypoxia-Reoxygenation. Cell Rep 9(1):349\u2013365. https:\/\/doi.org\/10.1016\/j.celrep.2014.08.056","DOI":"10.1016\/j.celrep.2014.08.056"},{"key":"10139_CR68","doi-asserted-by":"publisher","unstructured":"Pascual G et al (Jan. 2017) Targeting metastasis-initiating cells through the fatty acid receptor CD36. Nature 541(7635):41\u201345. https:\/\/doi.org\/10.1038\/nature20791","DOI":"10.1038\/nature20791"},{"key":"10139_CR69","doi-asserted-by":"publisher","unstructured":"Munir R, Lisec J, Swinnen JV, Zaidi N (Jun. 2019) Lipid metabolism in cancer cells under metabolic stress. Br J Cancer 120(12):1090. https:\/\/doi.org\/10.1038\/s41416-019-0451-4","DOI":"10.1038\/s41416-019-0451-4"},{"key":"10139_CR70","doi-asserted-by":"publisher","unstructured":"Kothari C, Diorio C, Durocher F (Aug. 2020) The importance of breast adipose tissue in breast Cancer. Int J Mol Sci 21(16):5760. https:\/\/doi.org\/10.3390\/ijms21165760","DOI":"10.3390\/ijms21165760"},{"key":"10139_CR71","doi-asserted-by":"publisher","unstructured":"Hachiya R, Tanaka M, Itoh M, Suganami T (May 2022) Molecular mechanism of crosstalk between immune and metabolic systems in metabolic syndrome. Inflamm Regen 42(1):13. https:\/\/doi.org\/10.1186\/s41232-022-00198-7","DOI":"10.1186\/s41232-022-00198-7"},{"key":"10139_CR72","doi-asserted-by":"publisher","unstructured":"Engin AB, Engin A, Gonul II (Apr. 2019) The effect of adipocyte\u2013macrophage crosstalk in obesity-related breast cancer. J Mol Endocrinol 62(3):R201\u2013R222. https:\/\/doi.org\/10.1530\/JME-18-0252","DOI":"10.1530\/JME-18-0252"},{"key":"10139_CR73","doi-asserted-by":"publisher","unstructured":"Vaysse C et al (May 2017) Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer. NPJ Breast Cancer 3:19. https:\/\/doi.org\/10.1038\/s41523-017-0015-9","DOI":"10.1038\/s41523-017-0015-9"},{"key":"10139_CR74","doi-asserted-by":"publisher","unstructured":"Tokumaru Y et al (2020) Aug., \u2018Intratumoral Adipocyte-High Breast Cancer Enrich for Metastatic and Inflammation-Related Pathways but Associated with Less Cancer Cell Proliferation\u2019, Int J Mol Sci, vol. 21, no. 16, p. 5744, https:\/\/doi.org\/10.3390\/ijms21165744","DOI":"10.3390\/ijms21165744"},{"key":"10139_CR75","doi-asserted-by":"publisher","unstructured":"Simpson ER, Brown KA (Dec. 2013) Obesity and breast cancer: role of inflammation and aromatase. J Mol Endocrinol 51(3):T51\u2013T59. https:\/\/doi.org\/10.1530\/JME-13-0217","DOI":"10.1530\/JME-13-0217"},{"key":"10139_CR76","doi-asserted-by":"crossref","unstructured":"Samarajeewa NU et al (2013) \u2018HIF-1a stimulates aromatase expression driven by prostaglandin E2 in breast adipose stroma\u2019,  Breast Cancer Res, 15(2):R30. doi: 10.1186\/bcr3410.","DOI":"10.1186\/bcr3410"},{"key":"10139_CR77","doi-asserted-by":"publisher","unstructured":"Sheikholeslami A, Nabiuni M, Arefian E (2017) \u2018Suppressing the molecular signaling pathways involved in inflammation and cancer in breast cancer cell lines MDA-MB-231 and MCF-7 by miR-590\u2019, Tumour Biol, vol. 39, no. 4, p. 1010428317697570, Apr. https:\/\/doi.org\/10.1177\/1010428317697570","DOI":"10.1177\/1010428317697570"},{"key":"10139_CR78","doi-asserted-by":"publisher","unstructured":"Jurga L et al (May 2007) NF-\u03baB is important for TNF-\u03b1-induced lipolysis in human adipocytes. J Lipid Res 48(5):1069\u20131077. https:\/\/doi.org\/10.1194\/jlr.M600471-JLR200","DOI":"10.1194\/jlr.M600471-JLR200"},{"key":"10139_CR79","doi-asserted-by":"publisher","unstructured":"Mentoor I, Engelbrecht A-M, Nell T (2019) \u2018Fatty acids: Adiposity and breast cancer chemotherapy, a bad synergy?\u2019, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 140, pp. 18\u201333, Jan. https:\/\/doi.org\/10.1016\/j.plefa.2018.11.009","DOI":"10.1016\/j.plefa.2018.11.009"},{"key":"10139_CR80","doi-asserted-by":"publisher","unstructured":"Lazar I et al (Jul. 2016) Adipocyte exosomes promote Melanoma aggressiveness through fatty acid oxidation: a novel mechanism linking obesity and Cancer. Cancer Res 76:4051\u20134057. https:\/\/doi.org\/10.1158\/0008-5472.CAN-16-0651","DOI":"10.1158\/0008-5472.CAN-16-0651"},{"key":"10139_CR81","doi-asserted-by":"publisher","unstructured":"Jafari N et al (2021) Nov., \u2018Adipocyte-derived exosomes may promote breast cancer progression in type 2 diabetes\u2019, Sci Signal, vol. 14, no. 710, p. eabj2807, https:\/\/doi.org\/10.1126\/scisignal.abj2807","DOI":"10.1126\/scisignal.abj2807"},{"key":"10139_CR82","doi-asserted-by":"publisher","unstructured":"Zhou X et al (2022) The pleiotropic roles of adipocyte secretome in remodeling breast cancer. J Experimental Clin Cancer Research: CR 41. https:\/\/doi.org\/10.1186\/s13046-022-02408-z","DOI":"10.1186\/s13046-022-02408-z"},{"key":"10139_CR83","doi-asserted-by":"publisher","unstructured":"Clement E et al (Feb. 2020) Adipocyte extracellular vesicles carry enzymes and fatty acids that stimulate mitochondrial metabolism and remodeling in tumor cells. EMBO J 39(3):e102525. https:\/\/doi.org\/10.15252\/embj.2019102525","DOI":"10.15252\/embj.2019102525"},{"key":"10139_CR84","doi-asserted-by":"publisher","unstructured":"Ye L, Li Y, Zhang S, Wang J, Lei B (Oct. 2023) Exosomes-regulated lipid metabolism in tumorigenesis and cancer progression. Cytokine Growth Factor Rev 73:27\u201339. https:\/\/doi.org\/10.1016\/j.cytogfr.2023.05.002","DOI":"10.1016\/j.cytogfr.2023.05.002"},{"key":"10139_CR85","doi-asserted-by":"publisher","unstructured":"Jeurissen S et al (2017) Mar., \u2018The isolation of morphologically intact and biologically active extracellular vesicles from the secretome of cancer-associated adipose tissue\u2019, Cell Adh Migr, vol. 11, no. 2, pp. 196\u2013204, https:\/\/doi.org\/10.1080\/19336918.2017.1279784","DOI":"10.1080\/19336918.2017.1279784"},{"key":"10139_CR86","doi-asserted-by":"publisher","unstructured":"Wang S et al (Apr. 2019) Exosomes secreted by mesenchymal stromal\/stem cell-derived adipocytes promote breast cancer cell growth via activation of Hippo signaling pathway. Stem Cell Res Ther 10(1):117. https:\/\/doi.org\/10.1186\/s13287-019-1220-2","DOI":"10.1186\/s13287-019-1220-2"},{"key":"10139_CR87","doi-asserted-by":"publisher","unstructured":"Li Y et al (Dec. 2023) Adipocyte-derived exosomes promote the progression of triple-negative breast cancer through circCRIM1-dependent OGA activation. Environ Res 239:117266. https:\/\/doi.org\/10.1016\/j.envres.2023.117266","DOI":"10.1016\/j.envres.2023.117266"},{"key":"10139_CR88","doi-asserted-by":"publisher","unstructured":"Moghadasian MH, Shahidi F (2017) Fatty acids. International Encyclopedia of Public Health. Elsevier, pp 114\u2013122. doi: https:\/\/doi.org\/10.1016\/B978-0-12-803678-5.00157-0.","DOI":"10.1016\/B978-0-12-803678-5.00157-0"},{"key":"10139_CR89","doi-asserted-by":"publisher","unstructured":"Ducharme NA, Bickel PE (2008) \u2018Minireview: Lipid Droplets in Lipogenesis and Lipolysis\u2019, Endocrinology, vol. 149, no. 3, pp. 942\u2013949, Mar. https:\/\/doi.org\/10.1210\/en.2007-1713","DOI":"10.1210\/en.2007-1713"},{"key":"10139_CR90","doi-asserted-by":"publisher","unstructured":"Dierge E et al (2021) Aug., \u2018Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects\u2019, Cell Metab, vol. 33, no. 8, pp. 1701\u20131715.e5, https:\/\/doi.org\/10.1016\/j.cmet.2021.05.016","DOI":"10.1016\/j.cmet.2021.05.016"},{"key":"10139_CR91","doi-asserted-by":"publisher","unstructured":"AL-Jawadi A et al (Mar. 2018) Protective properties of n-3 fatty acids and implications in obesity-associated breast cancer. J Nutr Biochem 53:1\u20138. https:\/\/doi.org\/10.1016\/j.jnutbio.2017.09.018","DOI":"10.1016\/j.jnutbio.2017.09.018"},{"key":"10139_CR92","doi-asserted-by":"publisher","unstructured":"Liu J, Ma DWL (2014) \u2018The Role of n-3 Polyunsaturated Fatty Acids in the Prevention and Treatment of Breast Cancer\u2019, Nutrients, vol. 6, no. 11, Art. no. 11, Nov. https:\/\/doi.org\/10.3390\/nu6115184","DOI":"10.3390\/nu6115184"},{"key":"10139_CR93","doi-asserted-by":"publisher","unstructured":"Hou TY, McMurray DN, Chapkin RS (Aug. 2016) Omega-3 fatty acids, lipid rafts, and T cell signaling. Eur J Pharmacol 785:2\u20139. https:\/\/doi.org\/10.1016\/j.ejphar.2015.03.091","DOI":"10.1016\/j.ejphar.2015.03.091"},{"key":"10139_CR94","doi-asserted-by":"publisher","unstructured":"Bhowmick S, Biswas T, Ahmed M, Roy D, Mondal S (2023) \u2018Caveolin-1 and lipids: Association and their dualism in oncogenic regulation\u2019, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, vol. 1878, no. 6, p. 189002, Nov. https:\/\/doi.org\/10.1016\/j.bbcan.2023.189002","DOI":"10.1016\/j.bbcan.2023.189002"},{"key":"10139_CR95","doi-asserted-by":"publisher","unstructured":"Al-Jawadi A et al (Jan. 2020) Protective effects of eicosapentaenoic acid in adipocyte-breast cancer cell cross talk. J Nutr Biochem 75:108244. https:\/\/doi.org\/10.1016\/j.jnutbio.2019.108244","DOI":"10.1016\/j.jnutbio.2019.108244"},{"key":"10139_CR96","doi-asserted-by":"publisher","unstructured":"Khan S, Shukla S, Sinha S, Meeran SM (2013) \u2018Role of adipokines and cytokines in obesity-associated breast cancer: Therapeutic targets\u2019, Cytokine & Growth Factor Reviews, vol. 24, no. 6, pp. 503\u2013513, Dec. https:\/\/doi.org\/10.1016\/j.cytogfr.2013.10.001","DOI":"10.1016\/j.cytogfr.2013.10.001"},{"key":"10139_CR97","doi-asserted-by":"publisher","unstructured":"Hannafon BN, Carpenter KJ, Berry WL, Janknecht R, Dooley WC, Ding W-Q (2015) \u2018Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA)\u2019, Mol Cancer, vol. 14, p. 133, Jul. https:\/\/doi.org\/10.1186\/s12943-015-0400-7","DOI":"10.1186\/s12943-015-0400-7"},{"key":"10139_CR98","doi-asserted-by":"publisher","unstructured":"Treeck O, Sch\u00fcler-Toprak S, Ortmann O (2020) \u2018Estrogen Actions in Triple-Negative Breast Cancer\u2019, Cells, vol. 9, no. 11, p. 2358, Oct. https:\/\/doi.org\/10.3390\/cells9112358","DOI":"10.3390\/cells9112358"},{"issue":"6","key":"10139_CR99","doi-asserted-by":"publisher","first-page":"e24872","DOI":"10.1002\/jcla.24872","volume":"37","author":"N He","year":"2023","unstructured":"He N, Liu M, Wu Y (2023) Adipose tissue and hematopoiesis: friend or foe? J Clin Lab Anal 37(6):e24872. https:\/\/doi.org\/10.1002\/jcla.24872","journal-title":"J Clin Lab Anal"},{"key":"10139_CR100","doi-asserted-by":"publisher","unstructured":"Zorena K, Jachimowicz-Duda O, \u015al\u0119zak D, Robakowska M, Mrugacz M (2020) \u2018Adipokines and Obesity. Potential Link to Metabolic Disorders and Chronic Complications\u2019, International Journal of Molecular Sciences, vol. 21, no. 10, Art. no. 10, Jan. https:\/\/doi.org\/10.3390\/ijms21103570","DOI":"10.3390\/ijms21103570"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-024-10139-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-024-10139-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-024-10139-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T16:36:33Z","timestamp":1766853393000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-024-10139-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,7]]},"references-count":100,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10139"],"URL":"https:\/\/doi.org\/10.1007\/s11033-024-10139-x","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,7]]},"assertion":[{"value":"24 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"It is not applicable. This is a review of the literature and does not contain any human or animal experiments. Ethics committee approval is not required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"It is not applicable. This study does not involve human subjects and informed consent to participate is not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"It is not applicable. The authors confirm that individual person\u2019s data are not included in the manuscript and that informed consent for publication is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"39"}}