{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:16:06Z","timestamp":1785330966295,"version":"3.55.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","award":["67867"],"award-info":[{"award-number":["67867"]}],"id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s11033-025-10218-7","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T06:56:08Z","timestamp":1736319368000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Role of NEAT1 and HOTAIR long non-coding RNAs in Behcet\u2019s Disease pathogenesis and their correlation with target inflammatory cytokines"],"prefix":"10.1007","volume":"52","author":[{"given":"Kamran","family":"Javidi-Aghdam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Faghfouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Jafarpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Akbarzadeh-Khiavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8997-2003","authenticated-orcid":false,"given":"Azam","family":"Safary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omid","family":"Pourbagherian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9482-6967","authenticated-orcid":false,"given":"Alireza","family":"Khabbazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"issue":"5","key":"10218_CR1","doi-asserted-by":"publisher","first-page":"324","DOI":"10.3109\/09273948.2012.723112","volume":"20","author":"M Khairallah","year":"2012","unstructured":"Khairallah M, Accorinti M, Muccioli C, Kahloun R, Kempen JH (2012) Epidemiology of Beh\u00e7et disease. Ocul Immunol Inflamm 20(5):324\u2013335. https:\/\/doi.org\/10.3109\/09273948.2012.723112","journal-title":"Ocul Immunol Inflamm"},{"issue":"1","key":"10218_CR2","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.rdc.2017.09.007","volume":"44","author":"I Hatemi","year":"2018","unstructured":"Hatemi I, Hatemi G, \u00c7elik AF (2018) Gastrointestinal involvement in Beh\u00e7et disease. Rheum Dis Clin 44(1):45\u201364. https:\/\/doi.org\/10.1016\/j.rdc.2017.09.007","journal-title":"Rheum Dis Clin"},{"key":"10218_CR3","doi-asserted-by":"publisher","first-page":"109661","DOI":"10.1016\/j.clim.2023.109661","volume":"253","author":"AF Al-Obeidi","year":"2023","unstructured":"Al-Obeidi AF, Nowatzky J (2023) Immunopathogenesis of Beh\u00e7et\u2019s disease. Clin Immunol 253:109661. https:\/\/doi.org\/10.1016\/j.clim.2023.109661","journal-title":"Clin Immunol"},{"key":"10218_CR4","doi-asserted-by":"publisher","first-page":"625710","DOI":"10.3389\/fmed.2021.625710","volume":"8","author":"L Ortiz-Fern\u00e1ndez","year":"2021","unstructured":"Ortiz-Fern\u00e1ndez L, Sawalha AH (2021) Genetics of Beh\u00e7et\u2019s Disease: functional genetic analysis and estimating Disease Heritability. Front Med (Lausanne) 8:625710. https:\/\/doi.org\/10.3389\/fmed.2021.625710","journal-title":"Front Med (Lausanne)"},{"issue":"5","key":"10218_CR5","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1111\/1756-185x.12512","volume":"21","author":"A Khabbazi","year":"2018","unstructured":"Khabbazi A, Noshad H, Shayan FK, Kavandi H, Hajialiloo M, Kolahi S (2018) Demographic and clinical features of Behcet\u2019s disease in Azerbaijan. Int J Rheum Dis 21(5):1114\u20131119. https:\/\/doi.org\/10.1111\/1756-185x.12512","journal-title":"Int J Rheum Dis"},{"key":"10218_CR6","doi-asserted-by":"publisher","unstructured":"Kirino Y, Bertsias G, Ishigatsubo Y, Mizuki N, Tugal-Tutkun I, Seyahi E et al (2013) Genome-wide association analysis identifies new susceptibility loci for Behcet\u2019s disease and epistasis between HLA-B* 51 and ERAP1. 45(2):202\u2013207. https:\/\/doi.org\/10.1038\/ng.2520","DOI":"10.1038\/ng.2520"},{"issue":"4","key":"10218_CR7","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1002\/art.41998","volume":"74","author":"G Su","year":"2022","unstructured":"Su G, Zhong Z, Zhou Q, Du L, Ye Z, Li F et al (2022) Identification of novel risk loci for Beh\u00e7et\u2019s disease\u2013related uveitis in a Chinese population in a genome-wide association study. Arthritis Rheumatol 74(4):671\u2013681. https:\/\/doi.org\/10.1002\/art.41998","journal-title":"Arthritis Rheumatol"},{"issue":"9","key":"10218_CR8","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1093\/rheumatology\/kez043","volume":"58","author":"H Yu","year":"2019","unstructured":"Yu H, Du L, Yi S, Wang Q, Zhu Y, Qiu Y et al (2019) Epigenome-wide association study identifies Behcet\u2019s disease-associated methylation loci in Han Chinese. Rheumatology (Oxford) 58(9):1574\u20131584. https:\/\/doi.org\/10.1093\/rheumatology\/kez043","journal-title":"Rheumatology (Oxford)"},{"issue":"5","key":"10218_CR9","doi-asserted-by":"publisher","first-page":"462","DOI":"10.18502\/ijaai.v18i5.1890","volume":"18","author":"J Farhadi","year":"2019","unstructured":"Farhadi J, Nouri M, Sakhinia E, Samadi N, Babaloo Z, Alipour S et al (2019) Epigenetics and Beh\u00e7et\u2019s Disease: DNA methylation specially highlighted. Iran J Allergy Asthma Immunol 18(5):462\u2013472. https:\/\/doi.org\/10.18502\/ijaai.v18i5.1890","journal-title":"Iran J Allergy Asthma Immunol"},{"issue":"3","key":"10218_CR10","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1093\/cvr\/cvr097","volume":"90","author":"MU Kaikkonen","year":"2011","unstructured":"Kaikkonen MU, Lam MT, Glass CK (2011) Non-coding RNAs as regulators of gene expression and epigenetics. Cardiovasc Res 90(3):430\u2013440. https:\/\/doi.org\/10.1093\/cvr\/cvr097","journal-title":"Cardiovasc Res"},{"key":"10218_CR11","doi-asserted-by":"publisher","unstructured":"Chowdhary A, Satagopam V, Schneider R (2021) Long non-coding RNAs: mechanisms, experimental, and computational approaches in identification, characterization, and their biomarker potential in Cancer. Front Genet 12. https:\/\/doi.org\/10.3389\/fgene.2021.649619","DOI":"10.3389\/fgene.2021.649619"},{"issue":"2","key":"10218_CR12","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/s41580-020-00315-9","volume":"22","author":"L Statello","year":"2021","unstructured":"Statello L, Guo C-J, Chen L-L, Huarte M (2021) Gene regulation by long non-coding RNAs and its biological functions. Nat Rev Mol Cell Biol 22(2):96\u2013118. https:\/\/doi.org\/10.1038\/s41580-020-00315-9","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"10218_CR13","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.gendis.2016.01.004","volume":"3","author":"H Geng","year":"2016","unstructured":"Geng H, Tan X-D (2016) Functional diversity of long non-coding RNAs in immune regulation. Genes Dis 3(1):72\u201381. https:\/\/doi.org\/10.1016\/j.gendis.2016.01.004","journal-title":"Genes Dis"},{"issue":"11","key":"10218_CR14","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.molmed.2014.09.002","volume":"20","author":"MK Atianand","year":"2014","unstructured":"Atianand MK, Fitzgerald KA (2014) Long non-coding RNAs and control of gene expression in the immune system. Trends Mol Med 20(11):623\u2013631. https:\/\/doi.org\/10.1016\/j.molmed.2014.09.002","journal-title":"Trends Mol Med"},{"issue":"9","key":"10218_CR15","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1016\/j.autrev.2015.05.004","volume":"14","author":"G-C Wu","year":"2015","unstructured":"Wu G-C, Pan H-F, Leng R-X, Wang D-G, Li X-P, Li X-M, Ye D-Q (2015) Emerging role of long noncoding RNAs in autoimmune diseases. Autoimmun Rev 14(9):798\u2013805. https:\/\/doi.org\/10.1016\/j.autrev.2015.05.004","journal-title":"Autoimmun Rev"},{"issue":"1","key":"10218_CR16","doi-asserted-by":"publisher","first-page":"e12404","DOI":"10.1111\/cpr.12404","volume":"51","author":"Z Li","year":"2018","unstructured":"Li Z, Li X, Jiang C, Qian W, Tse G, Chan MT, Wu WK (2018) Long non-coding RNA s in rheumatoid arthritis. Cell Prolif 51(1):e12404. https:\/\/doi.org\/10.1111\/cpr.12404","journal-title":"Cell Prolif"},{"issue":"12","key":"10218_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-018-0188-9","volume":"50","author":"R Yarani","year":"2018","unstructured":"Yarani R, Mirza AH, Kaur S, Pociot F (2018) The emerging role of lncRNAs in inflammatory bowel disease. Exp Mol Med 50(12):1\u201314. https:\/\/doi.org\/10.1038\/s12276-018-0188-9","journal-title":"Exp Mol Med"},{"key":"10218_CR18","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.msard.2018.07.044","volume":"25","author":"R Dastmalchi","year":"2018","unstructured":"Dastmalchi R, Ghafouri-Fard S, Omrani MD, Mazdeh M, Sayad A, Taheri M (2018) Dysregulation of long non-coding RNA profile in peripheral blood of multiple sclerosis patients. Mult Scler Relat Disord 25:219\u2013226. https:\/\/doi.org\/10.1016\/j.msard.2018.07.044","journal-title":"Mult Scler Relat Disord"},{"key":"10218_CR19","doi-asserted-by":"publisher","first-page":"101716","DOI":"10.1016\/j.trim.2022.101716","volume":"75","author":"D Jing","year":"2022","unstructured":"Jing D, Zhu F, Xu Z, Zhang G, Zhou G (2022) The role of long noncoding RNA (lncRNA) nuclear-enriched abundant transcript 1 (NEAT1) in immune diseases. Transpl Immunol 75:101716. https:\/\/doi.org\/10.1016\/j.trim.2022.101716","journal-title":"Transpl Immunol"},{"issue":"8","key":"10218_CR20","doi-asserted-by":"publisher","first-page":"e0268176","DOI":"10.1371\/journal.pone.0268176","volume":"17","author":"RH Mahmoud","year":"2022","unstructured":"Mahmoud RH, Fouad NA, Hefzy EM, Shaker OG, Ahmed TI, Hussein HA et al (2022) The potential role of serum expression profile of long non coding RNAs, Cox2 and HOTAIR as novel diagnostic biomarkers in systemic lupus erythematosus. PLoS ONE 17(8):e0268176. https:\/\/doi.org\/10.1371\/journal.pone.0268176","journal-title":"PLoS ONE"},{"key":"10218_CR21","doi-asserted-by":"publisher","first-page":"713052","DOI":"10.3389\/fmed.2021.713052","volume":"8","author":"I Mattioli","year":"2021","unstructured":"Mattioli I, Bettiol A, Saruhan-Direskeneli G, Direskeneli H, Emmi G (2021) Pathogenesis of Beh\u00e7et\u2019s syndrome: genetic, environmental and immunological factors. Front Med (Lausanne) 8:713052. https:\/\/doi.org\/10.3389\/fmed.2021.713052","journal-title":"Front Med (Lausanne)"},{"issue":"3","key":"10218_CR22","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.reuma.2018.06.006","volume":"16","author":"S Alipour","year":"2020","unstructured":"Alipour S, Sakhinia E, Khabbazi A, Samadi N, Babaloo Z, Azad M et al (2020) Methylation status of interleukin-6 gene promoter in patients with Beh\u00e7et\u2019s disease. Reumatol Clin (Engl Ed) 16(3):229\u2013234. https:\/\/doi.org\/10.1016\/j.reuma.2018.06.006","journal-title":"Reumatol Clin (Engl Ed)"},{"issue":"5","key":"10218_CR23","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1080\/1354750x.2020.1754912","volume":"25","author":"SG Aziz","year":"2020","unstructured":"Aziz SG, Aziz SG, Khabbazi A, Alipour S (2020) The methylation status of TNF-\u03b1 and SOCS3 promoters and the regulation of these gene expressions in patients with Beh\u00e7et\u2019s disease. Biomarkers 25(5):384\u2013390. https:\/\/doi.org\/10.1080\/1354750x.2020.1754912","journal-title":"Biomarkers"},{"key":"10218_CR24","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s11739-013-1036-5","volume":"9","author":"G Emmi","year":"2014","unstructured":"Emmi G, Silvestri E, Squatrito D, D\u2019Elios MM, Ciucciarelli L, Prisco D, Emmi L (2014) Beh\u00e7et\u2019s syndrome pathophysiology and potential therapeutic targets. Intern Emerg Med 9:257\u2013265. https:\/\/doi.org\/10.1007\/s11739-013-1036-5","journal-title":"Intern Emerg Med"},{"issue":"1","key":"10218_CR25","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1093\/rheumatology\/keac230","volume":"62","author":"J Zhang","year":"2022","unstructured":"Zhang J, Qi J, Shu J, Su G, Cao Q, Zhou C et al (2022) SNP rs7130280 in lncRNA NONHSAT159216.1 confers susceptibility to Beh\u00e7et\u2019s disease uveitis in a Chinese Han population. Rheumatology (Oxford) 62(1):384\u2013396. https:\/\/doi.org\/10.1093\/rheumatology\/keac230","journal-title":"Rheumatology (Oxford)"},{"issue":"5","key":"10218_CR26","doi-asserted-by":"publisher","first-page":"536","DOI":"10.3109\/s10165-009-0191-z","volume":"19","author":"F Shahram","year":"2009","unstructured":"Shahram F, Khabbazi A, Nadji A, Ziaie N, Banihashemi AT, Davatchi F (2009) Comparison of existing disease activity indices in the follow-up of patients with Beh\u00e7et\u2019s disease. Mod Rheumatol 19(5):536\u2013541. https:\/\/doi.org\/10.3109\/s10165-009-0191-z","journal-title":"Mod Rheumatol"},{"issue":"6","key":"10218_CR27","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1080\/14397595.2021.1886623","volume":"31","author":"A Malek Mahdavi","year":"2021","unstructured":"Malek Mahdavi A, Khabbazi A, Hajialilo M (2021) Long-term outcome and predictors of remission in Beh\u00e7et\u2019s disease in daily practice. Mod Rheumatol 31(6):1148\u20131157. https:\/\/doi.org\/10.1080\/14397595.2021.1886623","journal-title":"Mod Rheumatol"},{"issue":"3","key":"10218_CR28","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1111\/bju.14640","volume":"123","author":"M Assel","year":"2019","unstructured":"Assel M, Sjoberg D, Elders A, Wang X, Huo D, Botchway A et al (2019) Guidelines for reporting of statistics for clinical research in urology. BJU Int 123(3):401\u2013410. https:\/\/doi.org\/10.1111\/bju.14640","journal-title":"BJU Int"},{"issue":"1","key":"10218_CR29","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41421-024-00671-2","volume":"10","author":"Q Wang","year":"2024","unstructured":"Wang Q, Ma J, Gong Y, Zhu L, Tang H, Ye X et al (2024) Sex-specific circulating unconventional neutrophils determine immunological outcome of auto-inflammatory Beh\u00e7et\u2019s uveitis. Cell Discov 10(1):47. https:\/\/doi.org\/10.1038\/s41421-024-00671-2","journal-title":"Cell Discov"},{"key":"10218_CR30","doi-asserted-by":"publisher","unstructured":"Hadjicharalambous MR, Lindsay MA (2019) Long non-coding RNAs and the Innate Immune Response. Non-coding RNA 5(2). https:\/\/doi.org\/10.3390\/ncrna5020034","DOI":"10.3390\/ncrna5020034"},{"key":"10218_CR31","doi-asserted-by":"publisher","first-page":"100044","DOI":"10.1016\/j.jtauto.2020.100044","volume":"3","author":"Y Zou","year":"2020","unstructured":"Zou Y, Xu H (2020) Involvement of long noncoding RNAs in the pathogenesis of autoimmune diseases. J Transl Autoimmun 3:100044. https:\/\/doi.org\/10.1016\/j.jtauto.2020.100044","journal-title":"J Transl Autoimmun"},{"key":"10218_CR32","doi-asserted-by":"publisher","first-page":"797689","DOI":"10.3389\/fmolb.2021.797689","volume":"8","author":"SR Mohammed","year":"2021","unstructured":"Mohammed SR, Abdelaleem OO, Ahmed FA, Abdelaziz AA, Hussein HA, Eid HM et al (2021) Expression of lncRNAs NEAT1 and lnc-DC in serum from patients with Beh\u00e7et\u2019s Disease can be used as predictors of Disease. Front Mol Biosci 8:797689. https:\/\/doi.org\/10.3389\/fmolb.2021.797689","journal-title":"Front Mol Biosci"},{"issue":"8","key":"10218_CR33","doi-asserted-by":"publisher","first-page":"103344","DOI":"10.1016\/j.sjbs.2022.103344","volume":"29","author":"A Mohammed","year":"2022","unstructured":"Mohammed A, Shaker OG, Khalil MAF, Elsabagh YA, Gomaa M, Ahmed AM, Erfan R (2022) Association of long non-coding RNAs NEAT1, and MALAT1 expression and pathogenesis of Beh\u00e7et\u2019s disease among Egyptian patients. Saudi J Biol Sci 29(8):103344. https:\/\/doi.org\/10.1016\/j.sjbs.2022.103344","journal-title":"Saudi J Biol Sci"},{"issue":"3","key":"10218_CR34","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1007\/s00441-020-03248-z","volume":"382","author":"L-H Zhang","year":"2020","unstructured":"Zhang L-H, Xiao B, Zhong M, Li Q, Chen J-Y, Huang J-R, Rao H (2020) LncRNA NEAT1 accelerates renal mesangial cell injury via modulating the miR-146b\/TRAF6\/NF-\u03baB axis in lupus nephritis. Cell Tissue Res 382(3):627\u2013638. https:\/\/doi.org\/10.1007\/s00441-020-03248-z","journal-title":"Cell Tissue Res"},{"key":"10218_CR35","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.jaut.2016.07.012","volume":"75","author":"F Zhang","year":"2016","unstructured":"Zhang F, Wu L, Qian J, Qu B, Xia S, La T et al (2016) Identification of the long noncoding RNA NEAT1 as a novel inflammatory regulator acting through MAPK pathway in human lupus. J Autoimmun 75:96\u2013104. https:\/\/doi.org\/10.1016\/j.jaut.2016.07.012","journal-title":"J Autoimmun"},{"key":"10218_CR36","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1007\/s10067-010-1430-6","volume":"29","author":"F Davatchi","year":"2010","unstructured":"Davatchi F, Shahram F, Chams-Davatchi C, Shams H, Nadji A, Akhlaghi M et al (2010) Behcet\u2019s disease: from East to West. Clin Rheumatol 29:823\u2013833. https:\/\/doi.org\/10.1007\/s10067-010-1430-6","journal-title":"Clin Rheumatol"},{"issue":"4","key":"10218_CR37","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1530\/JME-18-0098","volume":"61","author":"Y-h Bai","year":"2018","unstructured":"Bai Y-h, Lv Y, Wang W-q, Sun G-l, Zhang H-h (2018) LncRNA NEAT1 promotes inflammatory response and induces corneal neovascularization. J Mol Endocrinol 61(4):231\u2013239. https:\/\/doi.org\/10.1530\/JME-18-0098","journal-title":"J Mol Endocrinol"},{"issue":"1","key":"10218_CR38","doi-asserted-by":"publisher","first-page":"188316","DOI":"10.1016\/j.bbcan.2019.188316","volume":"1873","author":"SC Gupta","year":"2020","unstructured":"Gupta SC, Awasthee N, Rai V, Chava S, Gunda V, Challagundla KB (2020) Long non-coding RNAs and nuclear factor-\u03baB crosstalk in cancer and other human diseases. Biochim Biophys Acta Rev Cancer 1873(1):188316. https:\/\/doi.org\/10.1016\/j.bbcan.2019.188316","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"10218_CR39","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s10238-013-0271-4","volume":"15","author":"J Song","year":"2015","unstructured":"Song J, Kim D, Han J, Kim Y, Lee M, Jin E-J (2015) PBMC and exosome-derived Hotair is a critical regulator and potent marker for rheumatoid arthritis. Clin Exp Med 15:121\u2013126. https:\/\/doi.org\/10.1007\/s10238-013-0271-4","journal-title":"Clin Exp Med"},{"key":"10218_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01975","author":"Y Wang","year":"2020","unstructured":"Wang Y, Hou L, Yuan X, Xu N, Zhao S, Yang L, Zhang N (2020) LncRNA NEAT1 targets Fibroblast-Like synoviocytes in Rheumatoid Arthritis via the miR-410-3p\/YY1 Axis. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2020.01975. 11","journal-title":"Front Immunol"},{"issue":"3","key":"10218_CR41","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1089\/jir.2018.0117","volume":"39","author":"OG Shaker","year":"2019","unstructured":"Shaker OG, Mahmoud RH, Abdelaleem OO, Ahmed TI, Fouad NA, Hussein HA et al (2019) Expression Profile of Long Noncoding RNAs, lnc-Cox2, and HOTAIR in Rheumatoid Arthritis patients. J Interferon Cytokine Res 39(3):174\u2013180. https:\/\/doi.org\/10.1089\/jir.2018.0117","journal-title":"J Interferon Cytokine Res"},{"issue":"4","key":"10218_CR42","doi-asserted-by":"publisher","first-page":"614","DOI":"10.52547\/rbmb.10.4.697","volume":"10","author":"E Medhat","year":"2022","unstructured":"Medhat E, Ayeldeen G, Hosni Ahmed H, Shaker O, Gheita T, Salama Ashour S (2022) HOTAIR and THRIL Long non Coding RNAs and their target genes in rheumatoid arthritis patients. Rep Biochem Mol Biol 10(4):614\u2013621. https:\/\/doi.org\/10.52547\/rbmb.10.4.697","journal-title":"Rep Biochem Mol Biol"},{"issue":"2","key":"10218_CR43","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.gene.2016.04.016","volume":"586","author":"C Zhang","year":"2016","unstructured":"Zhang C, Wang P, Jiang P, Lv Y, Dong C, Dai X et al (2016) Upregulation of lncRNA HOTAIR contributes to IL-1\u03b2-induced MMP overexpression and chondrocytes apoptosis in temporomandibular joint osteoarthritis. Gene 586(2):248\u2013253. https:\/\/doi.org\/10.1016\/j.gene.2016.04.016","journal-title":"Gene"},{"issue":"1","key":"10218_CR44","doi-asserted-by":"publisher","first-page":"e23023","DOI":"10.1002\/jcla.23023","volume":"34","author":"X Li","year":"2020","unstructured":"Li X, Ye S, Lu Y (2020) Long non-coding RNA NEAT1 overexpression associates with increased exacerbation risk, severity, and inflammation, as well as decreased lung function through the interaction with microRNA\u2010124 in asthma. J Clin Lab Anal 34(1):e23023. https:\/\/doi.org\/10.1002\/jcla.23023","journal-title":"J Clin Lab Anal"},{"issue":"4","key":"10218_CR45","doi-asserted-by":"publisher","first-page":"3290","DOI":"10.3892\/etm.2020.9079","volume":"20","author":"L Liu","year":"2020","unstructured":"Liu L, Liu F, Sun Z, Peng Z, You T, Yu Z (2020) LncRNA NEAT1 promotes apoptosis and inflammation in LPS\u2013induced sepsis models by targeting miR\u2013590\u20133p. Exp Ther Med 20(4):3290\u20133300. https:\/\/doi.org\/10.3892\/etm.2020.9079","journal-title":"Exp Ther Med"},{"issue":"1","key":"10218_CR46","doi-asserted-by":"publisher","first-page":"2226492","DOI":"10.1080\/15592294.2023.2226492","volume":"18","author":"M Xiang","year":"2023","unstructured":"Xiang M, Wang Y, Chen Q, Wang J, Gao Z, Liang J, Xu J (2023) LncRNA NEAT1 promotes IL-6 secretion in monocyte-derived dendritic cells via sponging miR-365a-3p in systemic lupus erythematosus. Epigenetics 18(1):2226492. https:\/\/doi.org\/10.1080\/15592294.2023.2226492","journal-title":"Epigenetics"},{"issue":"1","key":"10218_CR47","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.bbrc.2016.01.117","volume":"471","author":"H Wu","year":"2016","unstructured":"Wu H, Liu J, Li W, Liu G, Li Z (2016) LncRNA-HOTAIR promotes TNF-\u03b1 production in cardiomyocytes of LPS-induced sepsis mice by activating NF-\u03baB pathway. Biochem Biophys Res Commun 471(1):240\u2013246. https:\/\/doi.org\/10.1016\/j.bbrc.2016.01.117","journal-title":"Biochem Biophys Res Commun"},{"key":"10218_CR48","doi-asserted-by":"publisher","unstructured":"Wang Y, Yi K, Liu X, Tan Y, Jin W, Li Y et al (2021) HOTAIR Up-Regulation activates NF-\u03baB to Induce Immunoescape in Gliomas. Front Immunol 12. https:\/\/doi.org\/10.3389\/fimmu.2021.785463","DOI":"10.3389\/fimmu.2021.785463"},{"issue":"1","key":"10218_CR49","doi-asserted-by":"publisher","first-page":"15670","DOI":"10.1038\/s41598-018-33722-2","volume":"8","author":"M Obaid","year":"2018","unstructured":"Obaid M, Udden SMN, Deb P, Shihabeddin N, Zaki MH, Mandal SS (2018) LncRNA HOTAIR regulates lipopolysaccharide-induced cytokine expression and inflammatory response in macrophages. Sci Rep 8(1):15670. https:\/\/doi.org\/10.1038\/s41598-018-33722-2","journal-title":"Sci Rep"},{"key":"10218_CR50","doi-asserted-by":"publisher","unstructured":"Cie\u015bla M, Darmochwa\u0142-Kolarz D, Pa\u0142ka A, \u0141agowska K, Tabarkiewicz J, Kolarz B (2024) Expression of NEAT1, PACERR, and GAS5 circulating long noncoding RNAs can be associated with disease activity in rheumatoid arthritis patients. Pol Arch Intern Med 134(12). https:\/\/doi.org\/10.20452\/pamw.16866","DOI":"10.20452\/pamw.16866"},{"issue":"1","key":"10218_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11033-024-10019-4","volume":"51","author":"E Rasuli","year":"2024","unstructured":"Rasuli E, Javidi-Aghdam K, Akbarzadeh-Khiavi M, Abdshah A, Gadakchi L, Jafarpour M et al (2024) Immunoregulatory role of AC007278. 3 and HOTAIR long non-coding RNAs in lupus nephritis: potential biomarkers and therapeutic targets. Mol Biol Rep 51(1):1\u20139. https:\/\/doi.org\/10.1007\/s11033-024-10019-4","journal-title":"Mol Biol Rep"},{"key":"10218_CR52","doi-asserted-by":"publisher","first-page":"106992","DOI":"10.1016\/j.intimp.2020.106992","volume":"88","author":"L Ye","year":"2020","unstructured":"Ye L, Shi H, Yu C, Fu J, Chen C, Wu S et al (2020) LncRNA NEAT1 positively regulates MAPK signaling and is involved in the pathogenesis of Sj\u00f6gren\u2019s syndrome. Int Immunopharmacol 88:106992. https:\/\/doi.org\/10.1016\/j.intimp.2020.106992","journal-title":"Int Immunopharmacol"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-10218-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-025-10218-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-10218-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T16:31:00Z","timestamp":1766853060000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-025-10218-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,8]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10218"],"URL":"https:\/\/doi.org\/10.1007\/s11033-025-10218-7","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,8]]},"assertion":[{"value":"3 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was approved by the ethical committee of Tabriz University of Medical Sciences (IR.TBZMED.REC.1400.646). Informed consent forms were obtained from all study participants under the relevant guidelines and regulations. Written consent was obtained from the patients to publish their clinical information.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The lead author, Azam Safary, affirms that this manuscript is an honest, accurate, and transparent account of the study being reported, that no important aspects of the study have been omitted, and that any discrepancies from the study as planned (and if relevant, registered) have been explained.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Transparency statement"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"111"}}