{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:38:28Z","timestamp":1793824708761,"version":"4.6.1"},"reference-count":98,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100014824","name":"Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s11033-025-10297-6","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T13:19:51Z","timestamp":1738156791000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Recent advancements in the understanding of the alterations in mitochondrial biogenesis in Alzheimer\u2019s disease"],"prefix":"10.1007","volume":"52","author":[{"given":"Shreya","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"10297_CR1","doi-asserted-by":"publisher","first-page":"103750","DOI":"10.1016\/j.drudis.2023.103750","volume":"28","author":"S Pati","year":"2023","unstructured":"Pati S, Singh Gautam A, Dey M, Tiwari A, Kumar Singh R (2023) Molecular and functional characteristics of receptor-interacting protein kinase 1 (RIPK1) and its therapeutic potential in Alzheimer\u2019s disease. Drug Discov Today 28:103750. https:\/\/doi.org\/10.1016\/j.drudis.2023.103750","journal-title":"Drug Discov Today"},{"key":"10297_CR2","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.3233\/jad-170585","volume":"62","author":"RH Swerdlow","year":"2018","unstructured":"Swerdlow RH (2018) Mitochondria and mitochondrial cascades in Alzheimer\u2019s disease. J Alzheimers Dis 62:1403\u20131416. https:\/\/doi.org\/10.3233\/jad-170585","journal-title":"J Alzheimers Dis"},{"key":"10297_CR3","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1080\/01616412.2016.1251711","volume":"39","author":"MT Islam","year":"2017","unstructured":"Islam MT (2017) Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders. Neurol Res 39:73\u201382. https:\/\/doi.org\/10.1080\/01616412.2016.1251711","journal-title":"Neurol Res"},{"key":"10297_CR4","doi-asserted-by":"publisher","first-page":"4892","DOI":"10.1111\/jcmm.15194","volume":"24","author":"LD Popov","year":"2020","unstructured":"Popov LD (2020) Mitochondrial biogenesis: An update. J Cell Mol Med 24:4892\u20134899. https:\/\/doi.org\/10.1111\/jcmm.15194","journal-title":"J Cell Mol Med"},{"key":"10297_CR5","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/cns.12655","volume":"23","author":"M Golpich","year":"2017","unstructured":"Golpich M, Amini E, Mohamed Z, Azman Ali R, Mohamed Ibrahim N, Ahmadiani A (2017) Mitochondrial dysfunction and biogenesis in Neurodegenerative diseases: Pathogenesis and treatment. CNS Neurosci Ther 23:5\u201322. https:\/\/doi.org\/10.1111\/cns.12655","journal-title":"CNS Neurosci Ther"},{"key":"10297_CR6","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.biopsych.2017.12.014","volume":"83","author":"AA Nierenberg","year":"2018","unstructured":"Nierenberg AA, Ghaznavi SA, Sande Mathias I, Ellard KK, Janos JA, Sylvia LG (2018) Peroxisome proliferator-activated receptor gamma coactivator-1 alpha as a novel target for bipolar disorder and other neuropsychiatric disorders. Biol Psychiatry 83:761\u2013769. https:\/\/doi.org\/10.1016\/j.biopsych.2017.12.014","journal-title":"Biol Psychiatry"},{"key":"10297_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/cells8050488","author":"PH Reddy","year":"2019","unstructured":"Reddy PH, Oliver DM (2019) Amyloid beta and phosphorylated tau-induced defective autophagy and mitophagy in Alzheimer\u2019s disease. Cells. https:\/\/doi.org\/10.3390\/cells8050488","journal-title":"Cells"},{"key":"10297_CR8","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1007\/s11064-020-02993-5","volume":"45","author":"S W\u00f3jtowicz","year":"2020","unstructured":"W\u00f3jtowicz S, Strosznajder AK, Je\u017cyna M, Strosznajder JB (2020) The novel role of PPAR alpha in the brain: Promising target in therapy of Alzheimer\u2019s disease and other neurodegenerative disorders. Neurochem Res 45:972\u2013988. https:\/\/doi.org\/10.1007\/s11064-020-02993-5","journal-title":"Neurochem Res"},{"key":"10297_CR9","doi-asserted-by":"publisher","first-page":"336","DOI":"10.2174\/1567205014666170517150037","volume":"15","author":"E Benedetti","year":"2018","unstructured":"Benedetti E, Cristiano L, Antonosante A et al (2018) PPARs in neurodegenerative and neuroinflammatory pathways. Curr Alzheimer Res 15:336\u2013344. https:\/\/doi.org\/10.2174\/1567205014666170517150037","journal-title":"Curr Alzheimer Res"},{"key":"10297_CR10","doi-asserted-by":"publisher","first-page":"2046","DOI":"10.1111\/brv.12320","volume":"92","author":"JM Zolezzi","year":"2017","unstructured":"Zolezzi JM, Santos MJ, Bast\u00edas-Candia S, Pinto C, Godoy JA, Inestrosa NC (2017) PPARs in the central nervous system: roles in neurodegeneration and neuroinflammation. Biol Rev Camb Philos Soc 92:2046\u20132069. https:\/\/doi.org\/10.1111\/brv.12320","journal-title":"Biol Rev Camb Philos Soc"},{"key":"10297_CR11","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s12974-021-02099-x","volume":"18","author":"AF Batista","year":"2021","unstructured":"Batista AF, Rody T, Forny-Germano L et al (2021) Interleukin-1\u03b2 mediates alterations in mitochondrial fusion\/fission proteins and memory impairment induced by amyloid-\u03b2 oligomers. J Neuroinflammation 18:54. https:\/\/doi.org\/10.1186\/s12974-021-02099-x","journal-title":"J Neuroinflammation"},{"key":"10297_CR12","doi-asserted-by":"publisher","first-page":"100469","DOI":"10.1016\/j.jbc.2021.100469","volume":"296","author":"LY Shields","year":"2021","unstructured":"Shields LY, Li H, Nguyen K et al (2021) Mitochondrial fission is a critical modulator of mutant APP-induced neural toxicity. J Biol Chem 296:100469. https:\/\/doi.org\/10.1016\/j.jbc.2021.100469","journal-title":"J Biol Chem"},{"key":"10297_CR13","doi-asserted-by":"publisher","first-page":"e12912","DOI":"10.1111\/acel.12912","volume":"18","author":"S Jiang","year":"2019","unstructured":"Jiang S, Shao C, Tang F, Wang W, Zhu X (2019) Dynamin-like protein 1 cleavage by calpain in Alzheimer\u2019s disease. Aging Cell 18:e12912. https:\/\/doi.org\/10.1111\/acel.12912","journal-title":"Aging Cell"},{"key":"10297_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/cells9010150","author":"Q Cai","year":"2020","unstructured":"Cai Q, Jeong YY (2020) Mitophagy in Alzheimer\u2019s disease and other age-related neurodegenerative diseases. Cells. https:\/\/doi.org\/10.3390\/cells9010150","journal-title":"Cells"},{"key":"10297_CR15","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1080\/15548627.2024.2340408","volume":"20","author":"K Veverov\u00e1","year":"2024","unstructured":"Veverov\u00e1 K, Lacz\u00f3 J, Katonov\u00e1 A et al (2024) Alterations of human CSF and serum-based mitophagy biomarkers in the continuum of Alzheimer disease. Autophagy 20:1868\u20131878. https:\/\/doi.org\/10.1080\/15548627.2024.2340408","journal-title":"Autophagy"},{"key":"10297_CR16","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1083\/jcb.201801044","volume":"217","author":"JJ Lee","year":"2018","unstructured":"Lee JJ, Sanchez-Martinez A, Martinez Zarate A et al (2018) Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin. J Cell Biol 217:1613\u20131622. https:\/\/doi.org\/10.1083\/jcb.201801044","journal-title":"J Cell Biol"},{"key":"10297_CR17","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s40035-022-00305-1","volume":"11","author":"K Zeng","year":"2022","unstructured":"Zeng K, Yu X, Mahaman YAR et al (2022) Defective mitophagy and the etiopathogenesis of Alzheimer\u2019s disease. Translational Neurodegeneration 11:32. https:\/\/doi.org\/10.1186\/s40035-022-00305-1","journal-title":"Translational Neurodegeneration"},{"key":"10297_CR18","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1093\/hmg\/ddv616","volume":"25","author":"P Mart\u00edn-Maestro","year":"2016","unstructured":"Mart\u00edn-Maestro P, Gargini R, Perry G, Avila J, Garc\u00eda-Escudero V (2016) PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer\u2019s disease. Hum Mol Genet 25:792\u2013806. https:\/\/doi.org\/10.1093\/hmg\/ddv616","journal-title":"Hum Mol Genet"},{"key":"10297_CR19","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/s41593-018-0332-9","volume":"22","author":"EF Fang","year":"2019","unstructured":"Fang EF, Hou Y, Palikaras K et al (2019) Mitophagy inhibits amyloid-\u03b2 and tau pathology and reverses cognitive deficits in models of Alzheimer\u2019s disease. Nat Neurosci 22:401\u2013412. https:\/\/doi.org\/10.1038\/s41593-018-0332-9","journal-title":"Nat Neurosci"},{"key":"10297_CR20","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.tcb.2018.02.009","volume":"28","author":"G Csord\u00e1s","year":"2018","unstructured":"Csord\u00e1s G, Weaver D, Hajn\u00f3czky G (2018) Endoplasmic reticulum-mitochondrial contactology: Structure and signaling functions. Trends Cell Biol 28:523\u2013540. https:\/\/doi.org\/10.1016\/j.tcb.2018.02.009","journal-title":"Trends Cell Biol"},{"key":"10297_CR21","doi-asserted-by":"publisher","first-page":"3356","DOI":"10.15252\/embj.201796797","volume":"36","author":"M Pera","year":"2017","unstructured":"Pera M, Larrea D, Guardia-Laguarta C et al (2017) Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease. Embo J 36:3356\u20133371. https:\/\/doi.org\/10.15252\/embj.201796797","journal-title":"Embo J"},{"key":"10297_CR22","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s13105-023-00966-0","volume":"79","author":"Y Xin","year":"2023","unstructured":"Xin Y, Zhao L, Peng R (2023) HIF-1 signaling: an emerging mechanism for mitochondrial dynamics. J Physiol Biochem 79:489\u2013500. https:\/\/doi.org\/10.1007\/s13105-023-00966-0","journal-title":"J Physiol Biochem"},{"key":"10297_CR23","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1080\/1061186X.2023.2230522","volume":"31","author":"Q-Y Wu","year":"2023","unstructured":"Wu Q-Y, Liu H-L, Wang H-Y et al (2023) Syntaphilin mediates axonal growth and synaptic changes through regulation of mitochondrial transport: a potential pharmacological target for neurodegenerative diseases. J Drug Target 31:685\u2013692. https:\/\/doi.org\/10.1080\/1061186X.2023.2230522","journal-title":"J Drug Target"},{"key":"10297_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1146564","author":"YA Jagtap","year":"2023","unstructured":"Jagtap YA, Kumar P, Kinger S et al (2023) Disturb mitochondrial associated proteostasis: Neurodegeneration and imperfect ageing. Front Cell Dev Biol. https:\/\/doi.org\/10.3389\/fcell.2023.1146564","journal-title":"Front Cell Dev Biol"},{"key":"10297_CR25","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.tcb.2020.01.008","volume":"30","author":"B Lu","year":"2020","unstructured":"Lu B, Guo S (2020) Mechanisms linking mitochondrial dysfunction and proteostasis failure. Trends Cell Biol 30:317\u2013328. https:\/\/doi.org\/10.1016\/j.tcb.2020.01.008","journal-title":"Trends Cell Biol"},{"key":"10297_CR26","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1016\/j.bbamcr.2018.10.016","volume":"1866","author":"A Rossi","year":"2019","unstructured":"Rossi A, Pizzo P, Filadi R (2019) Calcium, mitochondria and cell metabolism: A functional triangle in bioenergetics. Biochim Biophys Acta Mol Cell Res 1866:1068\u20131078. https:\/\/doi.org\/10.1016\/j.bbamcr.2018.10.016","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"issue":"3","key":"10297_CR27","doi-asserted-by":"publisher","first-page":"501","DOI":"10.4103\/1673-5374.380898","volume":"19","author":"L Song","year":"2024","unstructured":"Song L, Tang Y, Law BYK (2024) Targeting calcium signaling in Alzheimer\u2019s disease: challenges and promising therapeutic avenues. Neural Regen Res 19(3):501","journal-title":"Neural Regen Res"},{"key":"10297_CR28","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.mito.2021.01.002","volume":"57","author":"S Patra","year":"2021","unstructured":"Patra S, Mahapatra KK, Praharaj PP et al (2021) Intricate role of mitochondrial calcium signalling in mitochondrial quality control for regulation of cancer cell fate. Mitochondrion 57:230\u2013240. https:\/\/doi.org\/10.1016\/j.mito.2021.01.002","journal-title":"Mitochondrion"},{"key":"10297_CR29","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.tins.2020.10.004","volume":"44","author":"M Calvo-Rodriguez","year":"2021","unstructured":"Calvo-Rodriguez M, Bacskai BJ (2021) Mitochondria and calcium in Alzheimer\u2019s disease: From cell signaling to neuronal cell death. Trends Neurosci 44:136\u2013151. https:\/\/doi.org\/10.1016\/j.tins.2020.10.004","journal-title":"Trends Neurosci"},{"key":"10297_CR30","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.abb.2019.03.016","volume":"666","author":"L Boyman","year":"2019","unstructured":"Boyman L, Coleman AK, Zhao G et al (2019) Dynamics of the mitochondrial permeability transition pore: Transient and permanent opening events. Arch Biochem Biophys 666:31\u201339. https:\/\/doi.org\/10.1016\/j.abb.2019.03.016","journal-title":"Arch Biochem Biophys"},{"key":"10297_CR31","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/bs.mcb.2019.10.004","volume":"155","author":"M Carraro","year":"2020","unstructured":"Carraro M, Bernardi P (2020) Measurement of membrane permeability and the mitochondrial permeability transition. Methods Cell Biol 155:369\u2013379. https:\/\/doi.org\/10.1016\/bs.mcb.2019.10.004","journal-title":"Methods Cell Biol"},{"key":"10297_CR32","doi-asserted-by":"publisher","first-page":"7839","DOI":"10.1007\/s12035-018-0955-6","volume":"55","author":"K V\u00f6lgyi","year":"2018","unstructured":"V\u00f6lgyi K, Badics K, Sialana FJ et al (2018) Early presymptomatic changes in the proteome of mitochondria-associated membrane in the APP\/PS1 mouse model of Alzheimer\u2019s disease. Mol Neurobiol 55:7839\u20137857. https:\/\/doi.org\/10.1007\/s12035-018-0955-6","journal-title":"Mol Neurobiol"},{"key":"10297_CR33","doi-asserted-by":"publisher","first-page":"102757","DOI":"10.1016\/j.ceca.2023.102757","volume":"113","author":"P Garcia-Casas","year":"2023","unstructured":"Garcia-Casas P, Rossini M, Filadi R, Pizzo P (2023) Mitochondrial Ca(2+) signaling and Alzheimer\u2019s disease: Too much or too little? Cell Calcium 113:102757. https:\/\/doi.org\/10.1016\/j.ceca.2023.102757","journal-title":"Cell Calcium"},{"key":"10297_CR34","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.3233\/jad-160953","volume":"55","author":"D Del Prete","year":"2017","unstructured":"Del Prete D, Suski JM, Oul\u00e8s B et al (2017) Localization and processing of the amyloid-\u03b2 protein precursor in mitochondria-associated membranes. J Alzheimers Dis 55:1549\u20131570. https:\/\/doi.org\/10.3233\/jad-160953","journal-title":"J Alzheimers Dis"},{"key":"10297_CR35","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/s41583-019-0132-6","volume":"20","author":"DA Butterfield","year":"2019","unstructured":"Butterfield DA, Halliwell B (2019) Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease. Nat Rev Neurosci 20:148\u2013160. https:\/\/doi.org\/10.1038\/s41583-019-0132-6","journal-title":"Nat Rev Neurosci"},{"key":"10297_CR36","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1111\/os.13302","volume":"14","author":"DK Wang","year":"2022","unstructured":"Wang DK, Zheng HL, Zhou WS et al (2022) Mitochondrial dysfunction in oxidative stress-mediated intervertebral disc degeneration. Orthop Surg 14:1569\u20131582. https:\/\/doi.org\/10.1111\/os.13302","journal-title":"Orthop Surg"},{"key":"10297_CR37","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","volume":"21","author":"H Sies","year":"2020","unstructured":"Sies H, Jones DP (2020) Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nat Rev Mol Cell Biol 21:363\u2013383. https:\/\/doi.org\/10.1038\/s41580-020-0230-3","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10297_CR38","doi-asserted-by":"publisher","first-page":"101674","DOI":"10.1016\/j.redox.2020.101674","volume":"37","author":"D Nolfi-Donegan","year":"2020","unstructured":"Nolfi-Donegan D, Braganza A, Shiva S (2020) Mitochondrial electron transport chain: Oxidative phosphorylation, oxidant production, and methods of measurement. Redox Biol 37:101674. https:\/\/doi.org\/10.1016\/j.redox.2020.101674","journal-title":"Redox Biol"},{"key":"10297_CR39","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3892\/ijmm.2019.4188","volume":"44","author":"RZ Zhao","year":"2019","unstructured":"Zhao RZ, Jiang S, Zhang L, Yu ZB (2019) Mitochondrial electron transport chain, ROS generation and uncoupling (Review). Int J Mol Med 44:3\u201315. https:\/\/doi.org\/10.3892\/ijmm.2019.4188","journal-title":"Int J Mol Med"},{"key":"10297_CR40","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111520","author":"A Johri","year":"2021","unstructured":"Johri A (2021) Disentangling mitochondria in Alzheimer\u2019s disease. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms222111520","journal-title":"Int J Mol Sci"},{"key":"10297_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/cells10030546","author":"C Vidal","year":"2021","unstructured":"Vidal C, Zhang L (2021) An analysis of the neurological and molecular alterations underlying the pathogenesis of Alzheimer\u2019s disease. Cells. https:\/\/doi.org\/10.3390\/cells10030546","journal-title":"Cells"},{"key":"10297_CR42","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/nature25143","volume":"552","author":"V Sorrentino","year":"2017","unstructured":"Sorrentino V, Romani M, Mouchiroud L et al (2017) Enhancing mitochondrial proteostasis reduces amyloid-\u03b2 proteotoxicity. Nature 552:187\u2013193. https:\/\/doi.org\/10.1038\/nature25143","journal-title":"Nature"},{"key":"10297_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2016.02.030","volume":"42","author":"SW Scheff","year":"2016","unstructured":"Scheff SW, Ansari MA, Mufson EJ (2016) Oxidative stress and hippocampal synaptic protein levels in elderly cognitively intact individuals with Alzheimer\u2019s disease pathology. Neurobiol Aging 42:1\u201312. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2016.02.030","journal-title":"Neurobiol Aging"},{"key":"10297_CR44","doi-asserted-by":"publisher","DOI":"10.3390\/genes13101789","author":"R Gao","year":"2022","unstructured":"Gao R, Ma SL (2022) Is mitochondria DNA variation a biomarker for AD? Genes Basel. https:\/\/doi.org\/10.3390\/genes13101789","journal-title":"Genes Basel"},{"key":"10297_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s40142-018-0132-2","volume":"6","author":"PG Ridge","year":"2018","unstructured":"Ridge PG, Kauwe JSK (2018) Mitochondria and Alzheimer\u2019s disease: the role of mitochondrial genetic variation. Curr Genet Med Rep 6:1\u201310. https:\/\/doi.org\/10.1007\/s40142-018-0132-2","journal-title":"Curr Genet Med Rep"},{"key":"10297_CR46","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/s0005-2728(98)00161-3","volume":"1410","author":"JW Taanman","year":"1999","unstructured":"Taanman JW (1999) The mitochondrial genome: structure, transcription, translation and replication. Biochim Biophys Acta 1410:103\u2013123. https:\/\/doi.org\/10.1016\/s0005-2728(98)00161-3","journal-title":"Biochim Biophys Acta"},{"key":"10297_CR47","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1042\/ebc20170102","volume":"62","author":"AR D'Souza","year":"2018","unstructured":"D\u2019Souza AR, Minczuk M (2018) Mitochondrial transcription and translation: Overview. Essays Biochem 62:309\u2013320. https:\/\/doi.org\/10.1042\/ebc20170102","journal-title":"Essays Biochem"},{"key":"10297_CR48","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1042\/ebc20170103","volume":"62","author":"V Boczonadi","year":"2018","unstructured":"Boczonadi V, Ricci G, Horvath R (2018) Mitochondrial DNA transcription and translation: clinical syndromes. Essays Biochem 62:321\u2013340. https:\/\/doi.org\/10.1042\/ebc20170103","journal-title":"Essays Biochem"},{"key":"10297_CR49","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1093\/arclin\/acu016","volume":"29","author":"G Inczedy-Farkas","year":"2014","unstructured":"Inczedy-Farkas G, Trampush JW, Perczel Forintos D et al (2014) Mitochondrial DNA mutations and cognition: A case-series report. Arch Clin Neuropsychol 29:315\u2013321. https:\/\/doi.org\/10.1093\/arclin\/acu016","journal-title":"Arch Clin Neuropsychol"},{"key":"10297_CR50","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s13195-018-0460-1","volume":"11","author":"G Salvad\u00f3","year":"2019","unstructured":"Salvad\u00f3 G, Brugulat-Serrat A, Sudre CH et al (2019) Spatial patterns of white matter hyperintensities associated with Alzheimer\u2019s disease risk factors in a cognitively healthy middle-aged cohort. Alzheimers Res Ther 11:12. https:\/\/doi.org\/10.1186\/s13195-018-0460-1","journal-title":"Alzheimers Res Ther"},{"key":"10297_CR51","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.neurobiolaging.2018.09.015","volume":"73","author":"DT Soltys","year":"2019","unstructured":"Soltys DT, Pereira CPM, Rowies FT et al (2019) Lower mitochondrial DNA content but not increased mutagenesis associates with decreased base excision repair activity in brains of AD subjects. Neurobiol Aging 73:161\u2013170. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2018.09.015","journal-title":"Neurobiol Aging"},{"key":"10297_CR52","doi-asserted-by":"publisher","first-page":"e0276169","DOI":"10.1371\/journal.pone.0276169","volume":"17","author":"J Wong","year":"2022","unstructured":"Wong J, Steyn JS, Pienaar IS, Elson JL (2022) Mitochondrial DNA population variation is not associated with Alzheimer\u2019s in the Japanese population: A consistent finding across global populations. PLoS ONE 17:e0276169. https:\/\/doi.org\/10.1371\/journal.pone.0276169","journal-title":"PLoS ONE"},{"key":"10297_CR53","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3233\/jad-180661","volume":"67","author":"S Strobel","year":"2019","unstructured":"Strobel S, Gr\u00fcnblatt E, Heinsen H et al (2019) Astrocyte- and microglia-specific mitochondrial DNA deletions levels in sporadic Alzheimer\u2019s disease. J Alzheimers Dis 67:149\u2013157. https:\/\/doi.org\/10.3233\/jad-180661","journal-title":"J Alzheimers Dis"},{"key":"10297_CR54","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.ajpath.2015.10.004","volume":"186","author":"M Blanch","year":"2016","unstructured":"Blanch M, Mosquera JL, Ansoleaga B, Ferrer I, Barrachina M (2016) Altered mitochondrial DNA methylation pattern in Alzheimer disease-related pathology and in Parkinson disease. Am J Pathol 186:385\u2013397. https:\/\/doi.org\/10.1016\/j.ajpath.2015.10.004","journal-title":"Am J Pathol"},{"key":"10297_CR55","doi-asserted-by":"publisher","first-page":"2210","DOI":"10.1016\/j.neurobiolaging.2011.08.009","volume":"33","author":"KJ Krishnan","year":"2012","unstructured":"Krishnan KJ, Ratnaike TE, De Gruyter HL, Jaros E, Turnbull DM (2012) Mitochondrial DNA deletions cause the biochemical defect observed in Alzheimer\u2019s disease. Neurobiol Aging 33:2210\u20132214. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2011.08.009","journal-title":"Neurobiol Aging"},{"key":"10297_CR56","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.4103\/1673-5374.165313","volume":"10","author":"S Moreno","year":"2015","unstructured":"Moreno S, Cer\u00f9 MP (2015) In search for novel strategies towards neuroprotection and neuroregeneration: is PPAR\u03b1 a promising therapeutic target? Neural Regen Res 10:1409\u20131412. https:\/\/doi.org\/10.4103\/1673-5374.165313","journal-title":"Neural Regen Res"},{"key":"10297_CR57","doi-asserted-by":"publisher","first-page":"2803","DOI":"10.2174\/0929867321666140303143455","volume":"21","author":"M Fidaleo","year":"2014","unstructured":"Fidaleo M, Fanelli F, Ceru MP, Moreno S (2014) Neuroprotective properties of peroxisome proliferator-activated receptor alpha (PPAR\u03b1) and its lipid ligands. Curr Med Chem 21:2803\u20132821. https:\/\/doi.org\/10.2174\/0929867321666140303143455","journal-title":"Curr Med Chem"},{"key":"10297_CR58","doi-asserted-by":"publisher","DOI":"10.3390\/nu14163310","author":"CL Ho","year":"2022","unstructured":"Ho CL, Kao NJ, Lin CI, Cross TL, Lin SH (2022) Quercetin increases mitochondrial biogenesis and reduces free radicals in neuronal SH-SY5Y cells. Nutrients. https:\/\/doi.org\/10.3390\/nu14163310","journal-title":"Nutrients"},{"key":"10297_CR59","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232315105","author":"L Ciccone","year":"2022","unstructured":"Ciccone L, Piragine E, Brogi S et al (2022) Resveratrol-like compounds as SIRT1 activators. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms232315105","journal-title":"Int J Mol Sci"},{"key":"10297_CR60","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1080\/15548627.2019.1596488","volume":"16","author":"R Luo","year":"2020","unstructured":"Luo R, Su LY, Li G et al (2020) Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model. Autophagy 16:52\u201369. https:\/\/doi.org\/10.1080\/15548627.2019.1596488","journal-title":"Autophagy"},{"key":"10297_CR61","doi-asserted-by":"publisher","first-page":"7495","DOI":"10.1038\/s41598-017-07181-0","volume":"7","author":"S Bido","year":"2017","unstructured":"Bido S, Soria FN, Fan RZ, Bezard E, Tieu K (2017) Mitochondrial division inhibitor-1 is neuroprotective in the A53T-\u03b1-synuclein rat model of Parkinson\u2019s disease. Sci Rep 7:7495. https:\/\/doi.org\/10.1038\/s41598-017-07181-0","journal-title":"Sci Rep"},{"key":"10297_CR62","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1093\/hmg\/ddy335","volume":"28","author":"M Manczak","year":"2019","unstructured":"Manczak M, Kandimalla R, Yin X, Reddy PH (2019) Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity. Hum Mol Genet 28:177\u2013199. https:\/\/doi.org\/10.1093\/hmg\/ddy335","journal-title":"Hum Mol Genet"},{"key":"10297_CR63","doi-asserted-by":"publisher","first-page":"3375","DOI":"10.1093\/hmg\/ddx226","volume":"26","author":"CS Kuruva","year":"2017","unstructured":"Kuruva CS, Manczak M, Yin X, Ogunmokun G, Reddy AP, Reddy PH (2017) Aqua-soluble DDQ reduces the levels of Drp1 and A\u03b2 and inhibits abnormal interactions between A\u03b2 and Drp1 and protects Alzheimer\u2019s disease neurons from A\u03b2- and Drp1-induced mitochondrial and synaptic toxicities. Hum Mol Genet 26:3375\u20133395. https:\/\/doi.org\/10.1093\/hmg\/ddx226","journal-title":"Hum Mol Genet"},{"key":"10297_CR64","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2023.1166879","author":"O Sbai","year":"2023","unstructured":"Sbai O, Bazzani V, Tapaswi S, McHale J, Vascotto C, Perrone L (2023) Is Drp1 a link between mitochondrial dysfunction and inflammation in Alzheimer\u2019s disease? Front Mol Neurosci. https:\/\/doi.org\/10.3389\/fnmol.2023.1166879","journal-title":"Front Mol Neurosci"},{"key":"10297_CR65","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s40035-022-00305-1","volume":"11","author":"K Zeng","year":"2022","unstructured":"Zeng K, Yu X, Mahaman YAR et al (2022) Defective mitophagy and the etiopathogenesis of Alzheimer\u2019s disease. Transl Neurodegener 11:32. https:\/\/doi.org\/10.1186\/s40035-022-00305-1","journal-title":"Transl Neurodegener"},{"key":"10297_CR66","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/s41467-018-08276-6","volume":"10","author":"JCB Ferreira","year":"2019","unstructured":"Ferreira JCB, Campos JC, Qvit N et al (2019) A selective inhibitor of mitofusin 1-\u03b2IIPKC association improves heart failure outcome in rats. Nat Commun 10:329. https:\/\/doi.org\/10.1038\/s41467-018-08276-6","journal-title":"Nat Commun"},{"key":"10297_CR67","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.chembiol.2017.12.001","volume":"25","author":"L Miret-Casals","year":"2018","unstructured":"Miret-Casals L, Sebasti\u00e1n D, Brea J et al (2018) Identification of new activators of mitochondrial fusion reveals a link between mitochondrial morphology and pyrimidine metabolism. Cell Chem Biol 25:268-278.e264. https:\/\/doi.org\/10.1016\/j.chembiol.2017.12.001","journal-title":"Cell Chem Biol"},{"key":"10297_CR68","doi-asserted-by":"publisher","first-page":"3783","DOI":"10.1007\/s12035-016-9944-9","volume":"54","author":"K Peng","year":"2017","unstructured":"Peng K, Yang L, Wang J et al (2017) The interaction of mitochondrial biogenesis and fission\/fusion mediated by PGC-1\u03b1 regulates rotenone-induced dopaminergic neurotoxicity. Mol Neurobiol 54:3783\u20133797. https:\/\/doi.org\/10.1007\/s12035-016-9944-9","journal-title":"Mol Neurobiol"},{"key":"10297_CR69","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.molmed.2019.07.002","volume":"26","author":"G Lou","year":"2020","unstructured":"Lou G, Palikaras K, Lautrup S, Scheibye-Knudsen M, Tavernarakis N, Fang EF (2020) Mitophagy and neuroprotection. Trends Mol Med 26:8\u201320. https:\/\/doi.org\/10.1016\/j.molmed.2019.07.002","journal-title":"Trends Mol Med"},{"key":"10297_CR70","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1038\/nm.4132","volume":"22","author":"D Ryu","year":"2016","unstructured":"Ryu D, Mouchiroud L, Andreux PA et al (2016) Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nat Med 22:879\u2013888. https:\/\/doi.org\/10.1038\/nm.4132","journal-title":"Nat Med"},{"key":"10297_CR71","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.jalz.2016.08.001","volume":"13","author":"JG Geisler","year":"2017","unstructured":"Geisler JG, Marosi K, Halpern J, Mattson MP (2017) DNP, mitochondrial uncoupling, and neuroprotection: A little dab\u2019ll do ya. Alzheimers Dement 13:582\u2013591. https:\/\/doi.org\/10.1016\/j.jalz.2016.08.001","journal-title":"Alzheimers Dement"},{"key":"10297_CR72","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1083\/jcb.201504062","volume":"211","author":"U Richter","year":"2015","unstructured":"Richter U, Lahtinen T, Marttinen P, Suomi F, Battersby BJ (2015) Quality control of mitochondrial protein synthesis is required for membrane integrity and cell fitness. J Cell Biol 211:373\u2013389. https:\/\/doi.org\/10.1083\/jcb.201504062","journal-title":"J Cell Biol"},{"key":"10297_CR73","doi-asserted-by":"publisher","first-page":"e13895","DOI":"10.1111\/acel.13895","volume":"22","author":"D Marinho","year":"2023","unstructured":"Marinho D, Ferreira IL, Lorenzoni R, Cardoso SM, Santana I, Rego AC (2023) Reduction of class I histone deacetylases ameliorates ER-mitochondria cross-talk in Alzheimer\u2019s disease. Aging Cell 22:e13895. https:\/\/doi.org\/10.1111\/acel.13895","journal-title":"Aging Cell"},{"key":"10297_CR74","doi-asserted-by":"publisher","DOI":"10.1172\/jci168554","author":"SH Berth","year":"2023","unstructured":"Berth SH, Lloyd TE (2023) Disruption of axonal transport in neurodegeneration. J Clin Invest. https:\/\/doi.org\/10.1172\/jci168554","journal-title":"J Clin Invest"},{"key":"10297_CR75","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202305105","author":"Y Wu","year":"2024","unstructured":"Wu Y, Ding C, Sharif B et al (2024) Polarized localization of kinesin-1 and RIC-7 drives axonal mitochondria anterograde transport. J Cell Biol. https:\/\/doi.org\/10.1083\/jcb.202305105","journal-title":"J Cell Biol"},{"key":"10297_CR76","doi-asserted-by":"publisher","first-page":"1146564","DOI":"10.3389\/fcell.2023.1146564","volume":"11","author":"YA Jagtap","year":"2023","unstructured":"Jagtap YA, Kumar P, Kinger S et al (2023) Disturb mitochondrial associated proteostasis: Neurodegeneration and imperfect ageing. Front Cell Dev Biol 11:1146564. https:\/\/doi.org\/10.3389\/fcell.2023.1146564","journal-title":"Front Cell Dev Biol"},{"key":"10297_CR77","doi-asserted-by":"publisher","first-page":"e110476","DOI":"10.15252\/embj.2021110476","volume":"41","author":"M Patron","year":"2022","unstructured":"Patron M, Tarasenko D, Nolte H et al (2022) Regulation of mitochondrial proteostasis by the proton gradient. Embo J 41:e110476. https:\/\/doi.org\/10.15252\/embj.2021110476","journal-title":"Embo J"},{"key":"10297_CR78","doi-asserted-by":"publisher","first-page":"eadh8228","DOI":"10.1126\/sciadv.adh8228","volume":"9","author":"L Uoselis","year":"2023","unstructured":"Uoselis L, Lindblom R, Lam WK et al (2023) Temporal landscape of mitochondrial proteostasis governed by the UPR(mt). Sci Adv 9:eadh8228. https:\/\/doi.org\/10.1126\/sciadv.adh8228","journal-title":"Sci Adv"},{"key":"10297_CR79","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1111\/cbdd.14175","volume":"101","author":"M Joshi","year":"2023","unstructured":"Joshi M, Joshi S, Khambete M, Degani M (2023) Role of calcium dysregulation in Alzheimer\u2019s disease and its therapeutic implications. Chem Biol Drug Des 101:453\u2013468. https:\/\/doi.org\/10.1111\/cbdd.14175","journal-title":"Chem Biol Drug Des"},{"key":"10297_CR80","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24109067","author":"D Baracaldo-Santamar\u00eda","year":"2023","unstructured":"Baracaldo-Santamar\u00eda D, Avenda\u00f1o-Lopez SS, Ariza-Salamanca DF et al (2023) Role of calcium modulation in the pathophysiology and treatment of Alzheimer\u2019s disease. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms24109067","journal-title":"Int J Mol Sci"},{"key":"10297_CR81","doi-asserted-by":"publisher","first-page":"2146","DOI":"10.1038\/s41467-020-16074-2","volume":"11","author":"M Calvo-Rodriguez","year":"2020","unstructured":"Calvo-Rodriguez M, Hou SS, Snyder AC et al (2020) Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer\u2019s disease. Nat Commun 11:2146. https:\/\/doi.org\/10.1038\/s41467-020-16074-2","journal-title":"Nat Commun"},{"key":"10297_CR82","doi-asserted-by":"publisher","first-page":"790","DOI":"10.3389\/fneur.2019.00790","volume":"10","author":"C Fiuza-Luces","year":"2019","unstructured":"Fiuza-Luces C, Valenzuela PL, Laine-Men\u00e9ndez S et al (2019) Physical exercise and mitochondrial disease: insights from a mouse model. Front Neurol 10:790. https:\/\/doi.org\/10.3389\/fneur.2019.00790","journal-title":"Front Neurol"},{"key":"10297_CR83","doi-asserted-by":"publisher","first-page":"100072","DOI":"10.1016\/j.aggp.2024.100072","volume":"1","author":"A Tiwari","year":"2024","unstructured":"Tiwari A, Gautam AS, Panda ES, Singh RK (2024) Lipids and carotenoids may influence the neuropathology of Alzheimer\u2019s disease: A meta-analysis. Arch Gerontol Geriatr Plus 1:100072. https:\/\/doi.org\/10.1016\/j.aggp.2024.100072","journal-title":"Arch Gerontol Geriatr Plus"},{"key":"10297_CR84","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1159\/000507023","volume":"19","author":"J Xing","year":"2019","unstructured":"Xing J, Han D, Xu D, Li X, Sun L (2019) CREB Protects against temporal lobe epilepsy associated with cognitive impairment by controlling oxidative neuronal damage. Neurodegener Dis 19:225\u2013237. https:\/\/doi.org\/10.1159\/000507023","journal-title":"Neurodegener Dis"},{"key":"10297_CR85","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.freeradbiomed.2014.03.035","volume":"72","author":"Q Jiang","year":"2014","unstructured":"Jiang Q (2014) Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapy. Free Radic Biol Med 72:76\u201390. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2014.03.035","journal-title":"Free Radic Biol Med"},{"key":"10297_CR86","doi-asserted-by":"publisher","first-page":"8444","DOI":"10.1016\/j.tet.2015.09.014","volume":"71","author":"VJ Jameson","year":"2015","unstructured":"Jameson VJ, Cochem\u00e9 HM, Logan A, Hanton LR, Smith RA, Murphy MP (2015) Synthesis of triphenylphosphonium vitamin E derivatives as mitochondria-targeted antioxidants. Tetrahedron 71:8444\u20138453. https:\/\/doi.org\/10.1016\/j.tet.2015.09.014","journal-title":"Tetrahedron"},{"key":"10297_CR87","doi-asserted-by":"publisher","first-page":"435","DOI":"10.3233\/jad-221088","volume":"93","author":"L Qian","year":"2023","unstructured":"Qian L, Bian W, Wang D et al (2023) Adeno-associated virus-mediated immunotherapy based on bispecific tandem scFv for Alzheimer\u2019s disease. J Alzheimers Dis 93:435\u2013448. https:\/\/doi.org\/10.3233\/jad-221088","journal-title":"J Alzheimers Dis"},{"key":"10297_CR88","doi-asserted-by":"publisher","first-page":"755665","DOI":"10.3389\/fnagi.2021.755665","volume":"13","author":"J Liang","year":"2021","unstructured":"Liang J, Wang C, Zhang H, Huang J, Xie J, Chen N (2021) Exercise-induced benefits for Alzheimer\u2019s disease by stimulating mitophagy and improving mitochondrial function. Front Aging Neurosci 13:755665. https:\/\/doi.org\/10.3389\/fnagi.2021.755665","journal-title":"Front Aging Neurosci"},{"key":"10297_CR89","doi-asserted-by":"publisher","first-page":"e12470","DOI":"10.1002\/trc2.12470","volume":"10","author":"DJ Finneran","year":"2024","unstructured":"Finneran DJ, Desjarlais T, Henry A, Jackman BM, Gordon MN, Morgan D (2024) Induction of tauopathy in a mouse model of amyloidosis using intravenous administration of adeno-associated virus vectors expressing human P301L tau. Alzheimers Dement (N Y) 10:e12470. https:\/\/doi.org\/10.1002\/trc2.12470","journal-title":"Alzheimers Dement (N Y)"},{"key":"10297_CR90","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.mito.2022.04.006","volume":"65","author":"S Hosseinian","year":"2022","unstructured":"Hosseinian S, Ali Pour P, Kheradvar A (2022) Prospects of mitochondrial transplantation in clinical medicine: Aspirations and challenges. Mitochondrion 65:33\u201344. https:\/\/doi.org\/10.1016\/j.mito.2022.04.006","journal-title":"Mitochondrion"},{"key":"10297_CR91","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12091214","author":"M Lenart-Bugla","year":"2022","unstructured":"Lenart-Bugla M, \u0141uc M, Paw\u0142owski M et al (2022) What do we know about social and non-social factors influencing the pathway from cognitive health to Dementia? A systematic review of reviews. Brain Sci. https:\/\/doi.org\/10.3390\/brainsci12091214","journal-title":"Brain Sci"},{"key":"10297_CR92","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mito.2022.02.004","volume":"64","author":"A Vodi\u010dkov\u00e1","year":"2022","unstructured":"Vodi\u010dkov\u00e1 A, Koren SA, Wojtovich AP (2022) Site-specific mitochondrial dysfunction in neurodegeneration. Mitochondrion 64:1\u201318. https:\/\/doi.org\/10.1016\/j.mito.2022.02.004","journal-title":"Mitochondrion"},{"key":"10297_CR93","doi-asserted-by":"publisher","DOI":"10.3390\/biom12030371","author":"A Payne","year":"2022","unstructured":"Payne A, Nahashon S, Taka E, Adinew GM, Soliman KFA (2022) Epigallocatechin-3-Gallate (EGCG): New therapeutic perspectives for neuroprotection, aging, and neuroinflammation for the modern age. Biomolecules. https:\/\/doi.org\/10.3390\/biom12030371","journal-title":"Biomolecules"},{"key":"10297_CR94","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.brainres.2013.02.021","volume":"1514","author":"J Yao","year":"2013","unstructured":"Yao J, Zhao L, Mao Z et al (2013) Potentiation of brain mitochondrial function by S-equol and R\/S-equol estrogen receptor \u03b2-selective phytoSERM treatments. Brain Res 1514:128\u2013141. https:\/\/doi.org\/10.1016\/j.brainres.2013.02.021","journal-title":"Brain Res"},{"key":"10297_CR95","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.freeradbiomed.2014.03.003","volume":"71","author":"LF Ng","year":"2014","unstructured":"Ng LF, Gruber J, Cheah IK et al (2014) The mitochondria-targeted antioxidant MitoQ extends lifespan and improves healthspan of a transgenic Caenorhabditis elegans model of Alzheimer disease. Free Radic Biol Med 71:390\u2013401. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2014.03.003","journal-title":"Free Radic Biol Med"},{"key":"10297_CR96","doi-asserted-by":"publisher","first-page":"136","DOI":"10.14283\/jpad.2017.24","volume":"4","author":"MN Sabbagh","year":"2017","unstructured":"Sabbagh MN (2017) Clinical effects of oral tramiprosate in APOE4\/4 homozygous patients with mild alzheimer\u2019s disease suggest disease modification. J Prev Alzheimers Dis 4:136\u2013137. https:\/\/doi.org\/10.14283\/jpad.2017.24","journal-title":"J Prev Alzheimers Dis"},{"key":"10297_CR97","doi-asserted-by":"publisher","first-page":"617","DOI":"10.4161\/auto.23487","volume":"9","author":"JW Steele","year":"2013","unstructured":"Steele JW, Gandy S (2013) Latrepirdine (Dimebon\u00ae), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model. Autophagy 9:617\u2013618. https:\/\/doi.org\/10.4161\/auto.23487","journal-title":"Autophagy"},{"key":"10297_CR98","doi-asserted-by":"publisher","first-page":"418","DOI":"10.18097\/pbmc20166204418","volume":"62","author":"AV Alessenko","year":"2016","unstructured":"Alessenko AV, Bachurin SO, Gurianova SV, Karatasso YO, Shevtsova EF, Shingarova LN (2016) Tumor necrosis fac tor\u2013alpha \u2013 potential target for neuroprotector dimebon. Biomed Khim 62:418\u2013425. https:\/\/doi.org\/10.18097\/pbmc20166204418","journal-title":"Biomed Khim"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-10297-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-025-10297-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-10297-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T16:30:20Z","timestamp":1766853020000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-025-10297-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,29]]},"references-count":98,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10297"],"URL":"https:\/\/doi.org\/10.1007\/s11033-025-10297-6","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,29]]},"assertion":[{"value":"12 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publication"}}],"article-number":"173"}}